JP6956424B2 - 管状構造のための硬化性充填材料 - Google Patents
管状構造のための硬化性充填材料 Download PDFInfo
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- JP6956424B2 JP6956424B2 JP2019500881A JP2019500881A JP6956424B2 JP 6956424 B2 JP6956424 B2 JP 6956424B2 JP 2019500881 A JP2019500881 A JP 2019500881A JP 2019500881 A JP2019500881 A JP 2019500881A JP 6956424 B2 JP6956424 B2 JP 6956424B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0089—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Composite Materials (AREA)
- Inorganic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Description
i)少なくとも3mmAl/mm、理想的には少なくとも6mmAl/mmの不透過密度であって、不透過密度は、1ミリメートルのアルミニウムのウェッジと比較して、1ミリメートルの材料によって吸収されるX線の量を意味し(例えば、6mmAl/mmは、1mmの材料が、厚さ6ミリメートルのアルミニウムのウェッジと同じ放射線不透過性の厚さ/同じX線吸収を有することを意味する)、および
ii)2×10−4から1×103Pa*sの間の粘度
を有する、組成物を提供することである。
Claims (16)
- 液体キャリア、架橋性ポリマー材料、架橋剤および放射線不透過性剤を含む中空構造のための充填剤としての使用のための、液体または半固体組成物であって、前記組成物が、
i)少なくとも3mmAl/mmの不透過密度、および
ii)2×10−4から1×103Pa*sの間の粘度を有するように、
前記放射線不透過性剤は、造影剤または液体溶液に懸濁された放射線不透過性材料の粒子を含む、前記組成物。 - 架橋性材料は、350から600nmの間の波長で1000cm−1未満の吸収係数をもたらす光学密度を有する、請求項1に記載の組成物。
- 架橋性材料は、組成物100mlあたり約0.5gから約40gの間、好ましくは、組成物100mlあたり約5gから約15gの間、より好ましくは組成物100mlあたり約10gの量で存在する、請求項1または2に記載の組成物。
- 架橋性材料は、熱硬化性材料を含む、請求項1〜3のいずれか1項に記載の組成物。
- キャリアは、ハイドロゲルとして製剤されている、請求項1〜4のいずれか1項に記載の組成物。
- 架橋性ポリマー材料は、700Daから25kDaの間に含まれる分子量を有する親水性ポリマー材料を含み、50kPaから10MPaの間に含まれる注入時に中空構造の壁に対する浸透圧を提供する、請求項1〜5のいずれか1項に記載の組成物。
- 架橋剤は、光開始剤である、請求項1〜6のいずれか1項に記載の組成物。
- 光開始剤は、組成物の、少なくとも約0.001重量%、好ましくは、少なくとも約0.05重量%の量、および組成物の、約15重量%未満、好ましくは、約5重量%未満の量で存在する、請求項7に記載の組成物。
- 光開始剤に対するモル比が約100:1から約1:100の間、好ましくは、約1:1から約1:10の間で存在する共開始剤をさらに含む、請求項7または8に記載の組成物。
- 放射線不透過性剤は、1つまたはいくつかの種類の放射線不透過性原子またはその分子を含む、請求項1〜9のいずれか1項に記載の組成物。
- 放射線不透過性剤は、組成物100mlあたり約1gから約200gの間、好ましくは、組成物100mlあたり約60gから約90gの間の量で存在する、請求項1〜10のいずれか1項に記載の組成物。
- 放射線不透過性剤は、硫酸バリウム、酸化ジルコニウム、酸化亜鉛、タングステン酸カルシウム、金、ガドリニウム、銀、白金、タンタル、および前述のものの組合せを含むリストから選択される金属または金属系材料を含む、請求項1〜11のいずれか1項に記載の組成物。
- 放射線不透過性剤は、ヨウ素またはヨウ素系材料を含む、請求項1〜12のいずれか1項に記載の組成物。
- ヨウ素系材料および他の放射線不透過性材料の間の比率は、重量で、約2:1から1:2の間である、請求項13に記載の組成物。
- 中空構造は、管状構造であり、10μmから20mmの間、好ましくは、50μmから1000μmの間の直径を有する、請求項1〜14のいずれか1項に記載の組成物。
- 中空構造は、歯根管および副根管、髄腔、血管、リンパ管、気管支および細気管支、ならびに人工的に作成された管状構造である、請求項1〜15のいずれか1項に記載の組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16178912 | 2016-07-11 | ||
EP16178912.8 | 2016-07-11 | ||
PCT/IB2017/054099 WO2018011680A1 (en) | 2016-07-11 | 2017-07-07 | Curable filler material for tubular structures |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019521783A JP2019521783A (ja) | 2019-08-08 |
JP6956424B2 true JP6956424B2 (ja) | 2021-11-02 |
Family
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Application Number | Title | Priority Date | Filing Date |
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JP2019500881A Active JP6956424B2 (ja) | 2016-07-11 | 2017-07-07 | 管状構造のための硬化性充填材料 |
Country Status (5)
Country | Link |
---|---|
US (1) | US11364320B2 (ja) |
EP (1) | EP3481444A1 (ja) |
JP (1) | JP6956424B2 (ja) |
CA (1) | CA3069655A1 (ja) |
WO (1) | WO2018011680A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US20230172813A1 (en) | 2020-07-20 | 2023-06-08 | Lumendo Ag | A highly flowable prepolymer composition of high radiopacity allowing for high depth photopolymerization |
Family Cites Families (26)
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JPH03112843A (ja) * | 1989-09-25 | 1991-05-14 | Mitsubishi Materials Corp | 水硬性リン酸カルシウムセメント組成物 |
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EP1708763A4 (en) * | 2004-01-07 | 2011-03-23 | Trivascular Inc | METHODS, COMPOSITIONS, AND DEVICES FOR EMBOLIZING BODY LIGHTS |
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EP2229929B1 (en) * | 2009-03-18 | 2017-06-14 | DENTSPLY DETREY GmbH | Temporary root canal sealer dispersion |
RU2537130C2 (ru) * | 2009-11-20 | 2014-12-27 | Митсуи Кемикалс, Инк. | Композиция для восстановления твердой ткани |
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-
2017
- 2017-07-07 EP EP17757563.6A patent/EP3481444A1/en active Pending
- 2017-07-07 US US16/315,901 patent/US11364320B2/en active Active
- 2017-07-07 CA CA3069655A patent/CA3069655A1/en active Pending
- 2017-07-07 WO PCT/IB2017/054099 patent/WO2018011680A1/en unknown
- 2017-07-07 JP JP2019500881A patent/JP6956424B2/ja active Active
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US20190231921A1 (en) | 2019-08-01 |
WO2018011680A1 (en) | 2018-01-18 |
CA3069655A1 (en) | 2018-01-18 |
EP3481444A1 (en) | 2019-05-15 |
US11364320B2 (en) | 2022-06-21 |
JP2019521783A (ja) | 2019-08-08 |
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