JP6933394B2 - 組織再生誘導のためのバイオマテリアルデバイスおよび局所用組成物 - Google Patents
組織再生誘導のためのバイオマテリアルデバイスおよび局所用組成物 Download PDFInfo
- Publication number
- JP6933394B2 JP6933394B2 JP2019157784A JP2019157784A JP6933394B2 JP 6933394 B2 JP6933394 B2 JP 6933394B2 JP 2019157784 A JP2019157784 A JP 2019157784A JP 2019157784 A JP2019157784 A JP 2019157784A JP 6933394 B2 JP6933394 B2 JP 6933394B2
- Authority
- JP
- Japan
- Prior art keywords
- mct
- chitosan
- collagen
- complex
- sponge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/616—Echinodermata, e.g. starfish, sea cucumbers or sea urchins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/655—Aquatic animals other than those covered by groups A61K35/57 - A61K35/65
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Marine Sciences & Fisheries (AREA)
- Birds (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Composite Materials (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oceanography (AREA)
- Surgery (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Description
本出願は、2018年9月6日に出願した米国特許出願第16/123,942号明細書の利益を主張すると共に、参照によりこの特許出願の全体を援用する。
薬学グレードのキトサン(1H NMRによる算出で92%の脱アセチル化度;特定の粘度測定法による算出で185kDaの平均分子量)を、Sigma Aldrich(St.Louis,MO,USA)から購入した。脱アセチル化度および平均分子量分布は、脱アセチル化度がより高くもしくは低く、および/または、平均分子量がより高くもしくは低くなるよう、キトサンを生成するためのMCT−キトサン複合体の生成において制御可能である。
膨潤度(%)=[(Ws−Wd)/Ws]×100
キトサン(CHT)は、生体適合性および生体吸収性であると報告されている。特に、CHTは、良好な創傷治癒促進剤であると考えられている。他方で、コラーゲン(MCT)は、ティッシュエンジニアリングにおいてもっとも広範に用いられているマトリックスバイオマテリアルの一種である。高度に多孔性であるMCT単成分3Dスポンジが多くの種類の組織のインビトロ成長を支持するために用いられてきた。ハイブリッド3Dスポンジバイオマテリアルを、CHTおよびMCT(ナマコ試料から単離した)を異なる質量比で混合し、溶剤流延および凍結乾燥を含む既述の方法を適用することにより作成した。MCT/CHTハイブリッド3Dスポンジを、それらの吸水能、機械特性、熱挙動(TGA)および形態(SEM)に従って特徴付けた。ハイブリッド3Dスポンジは、単成分3Dスポンジと比して、向上した安定性、大きい間隙率、高い熱安定性および機械特性、ならびに、高い生分解性を示した。脂肪由来幹細胞(ADSC)との細胞培養インキュベーションおよびSEM画像化で、MCT/CHTハイブリッド3Dスポンジによって、インビトロでのADSC付着、拡散および増殖が可能であることが示された。
MCT−キトサンハイブリッド3Dスポンジの物理的および化学的特徴付け:キトサンは、利用可能なアミンおよび水酸基によってもたらされる水素結合相互作用によってコラーゲンに物理的に結合する。この相互作用によって、ナノ粒子、バイオフィルム、バイオフォームおよび組織スポンジなどの安定なバイオマテリアルの形成が可能となる(Madrigal−Carballo et al.,Polymer−liposome nanoparticles obtained by the electrostatic bio−adsorption of natural polymers onto soybean lecithin liposomes,Intl.J.Nanoparticles 5(3)(2012)196−209;Madrigal−Carballo et al.,Protein−loaded chitosan nanoparticles modulate uptake and antigen presentation of hen egg−white lysozyme by murine peritoneal macrophages,Intl.J.Nanoparticles 3(2)(2010)179−191;Ma et al.,‘A preliminary in vitro study on the fabrication and tissue engineering applications of a novel chitosan bilayer material as a sponge of human neofetal dermal fibroblasts’,Biomaterials,22(4)(2001),pp.331−336)。図13Aは、作成されたMCT−キトサンハイブリッド3Dスポンジを示す。図13Aから分かるとおり、図示のハイブリッド3Dスポンジは、異なるMCT/CHT質量比(50:50、60:40、80:20および100:0)で作成されている。図13Bはスポンジの光学顕微鏡画像を示し、および、図13Cは、作成された3Dスポンジの各々のSEM顕微鏡写真である。図13Cにおいて、スケールバーは500μmである。
エレクトロスピニングによるナノファイバー(ESNF)をMCT−キトサン複合体材料から調製した。ポリビニルアルコール(PVA)を助剤として用いた。異なる体積比(100:0、80:20、60:40、40:60、20:80および0:100)のMCT−キトサン/PVA混合溶液を調製し、エレクトロスピニングに好適である粘度および導電性で同様となるよう調節した。ESNFの形態を、走査電子顕微鏡検査(SEM)、フーリエ変換赤外分光法(FTIR)および示差走査熱量測定法(DSC)を用いて試験した。研究は、ナノファイバー(NF)の化学的組成および熱特徴を特徴づけるために用いた。線維芽細胞増殖を支持するNFの能力を、最適化したMCT−キトサン/PVA溶液を用いてインビトロで調べた。結果は、MCT−キトサン系ESNFは線維芽細胞の成長にきわめて好適であり、PVAのESNFよりも相当に良好であることを示す。結果はまた、MCT−キトサンが、細胞増殖の支持に関して、キトサンのみの場合よりも良好であることを示す。
以下の配合物は、特にこれらに限定されないが、溶液、懸濁液、液体、ゲル、軟膏剤、ローションもしくはクリームを含む皮膚学的および/または薬学的に許容可能な局所的キャリアを利用する、本明細書に記載のMCTおよびMCT−キトサン(MCT−CHT)組成物の治療的または予防的投与に用いられ得る代表的な調合薬剤形を例示している。以下の例においては、ゲルまたはクリームが提供される。
1−150mgのビタミンEを計量し、これを、クリーム基剤分散体と穏やかに撹拌しながら混合する。
Claims (11)
- 棘皮動物から単離される易変性コラーゲン組織(MCT)およびキトサンであって、前記キトサンが前記MCTに静電結合してマトリックスを形成しており、前記キトサンおよびMCTの前記マトリックスがMCT−キトサン複合体材料の形態である、易変性コラーゲン組織(MCT)およびキトサンを含む、
組織再生誘導(GTR)デバイス。 - 前記MCTが、ウニおよびナマコからなる群から選択される棘皮動物から単離される、請求項1に記載のデバイス。
- 前記MCTがナマコから単離される、請求項2に記載のデバイス。
- 前記MCTがコラーゲンおよびグリコサミノグリカン(GAG)を含む、請求項1に記載のデバイス。
- 前記MCTが、I型、II型、III型、V型もしくはXI型から、または、I型、II型、III型、V型およびXI型の2種以上の混合物からなる群から選択される線維状コラーゲンからなる、請求項1に記載のデバイス。
- 前記MCTがI型線維状コラーゲンからなる、請求項5に記載のデバイス。
- 前記グリコサミノグリカンが、コンドロイチン硫酸、ヒアルロン酸、ヘパリン、ケラタン硫酸、ヘパラン硫酸もしくはデルマタン硫酸から、または、コンドロイチン硫酸、ヒアルロン酸、ヘパリン、ケラタン硫酸、ヘパラン硫酸およびデルマタン硫酸の2種以上の混合物からなる群から選択される、請求項4に記載のデバイス。
- 前記グリコサミノグリカンが、コンドロイチン硫酸およびヒアルロン酸から、または、コンドロイチン硫酸およびヒアルロン酸の混合物からなる群から選択される、請求項7に記載のデバイス。
- MCT対キトサンの質量比が、10:90、20:80、40:60、50:50、60:40、80:20、または90:10からなる群から選択される、請求項1に記載のデバイス。
- 前記MCT−キトサン複合体が、ヒドロゲル、バイオフィルム、3Dスポンジ、エレクトロスピニングによるナノファイバー、ナノ粒子、または、創傷被覆材テンプレートの表面上のコーティングからなる群から選択される形態を含む、請求項1に記載のデバイス。
- 前記MCT−キトサン複合体が、MCT中のGAGとコラーゲンとの間に高分子電解質架橋構造、および、キトサン上におけるN−グルコサミン単位とのその相互作用を含む、請求項4に記載のデバイス。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/123942 | 2018-09-06 | ||
US16/123,942 US10912822B2 (en) | 2018-06-26 | 2018-09-06 | Biomaterial devices and topical compositions for guided tissue regeneration |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2020058786A JP2020058786A (ja) | 2020-04-16 |
JP6933394B2 true JP6933394B2 (ja) | 2021-09-08 |
Family
ID=69999522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019157784A Active JP6933394B2 (ja) | 2018-09-06 | 2019-08-30 | 組織再生誘導のためのバイオマテリアルデバイスおよび局所用組成物 |
Country Status (4)
Country | Link |
---|---|
JP (1) | JP6933394B2 (ja) |
KR (1) | KR102308773B1 (ja) |
CN (1) | CN111012803B (ja) |
ES (1) | ES2906715T3 (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102439335B1 (ko) * | 2021-12-10 | 2022-09-02 | 주식회사 엠케이바이오텍 | 태반-유래 줄기세포를 함유하는 피부 재생용 바이오패치형 세포치료제 |
CN115645634B (zh) * | 2022-11-08 | 2023-10-17 | 四川大学 | 一种引导骨组织再生膜材料、其制备方法及应用 |
KR20240103455A (ko) * | 2022-12-27 | 2024-07-04 | 국립부경대학교 산학협력단 | 별불가사리 유래 폴리데옥시리보뉴클레오티드를 포함하는 피부 재생용 나노파이버 스캐폴드 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61253065A (ja) * | 1985-05-02 | 1986-11-10 | 片倉チツカリン株式会社 | キトサン誘導体およびコラ−ゲンの複合材の医用材料およびその製造法 |
US4820508A (en) * | 1987-06-23 | 1989-04-11 | Neutrogena Corporation | Skin protective composition |
US4992478A (en) * | 1988-04-04 | 1991-02-12 | Warner-Lambert Company | Antiinflammatory skin moisturizing composition and method of preparing same |
JPH07196520A (ja) * | 1993-12-28 | 1995-08-01 | Nobushige Enomoto | 変性キトサン組成物 |
US6565960B2 (en) * | 2000-06-01 | 2003-05-20 | Shriners Hospital Of Children | Polymer composite compositions |
KR20020017552A (ko) * | 2000-08-31 | 2002-03-07 | 장인순 | 중화 키토산 및/또는 중화 콜라겐 스폰지를 이용한인공진피 및 이의 제조방법 |
JP4757413B2 (ja) * | 2001-09-11 | 2011-08-24 | 株式会社高研 | ナマコ類あるいはヒトデ類コラーゲンからなるスポンジ及びその製造方法 |
CN101143155B (zh) * | 2006-09-15 | 2010-05-12 | 中国科学院大连化学物理研究所 | 一种双参组合物及其应用 |
CN100594948C (zh) * | 2006-09-15 | 2010-03-24 | 东华大学 | 一种含壳聚糖的纳米纤维组织修复支架的制备方法和应用 |
WO2010086754A2 (en) * | 2009-01-30 | 2010-08-05 | Beiersdorf Ag | Cosmetic or dermatological preparation comprising collagen, chitosan, glycosylaminoglycan and cell growth promoting peptide and/or cellular complex |
RU2468129C2 (ru) * | 2010-12-30 | 2012-11-27 | Государственное образовательное учреждение высшего профессионального образования "Саратовский государственный университет им. Н.Г. Чернышевского" | Биополимерное волокно, состав формовочного раствора для его получения, способ приготовления формовочного раствора, полотно биомедицинского назначения, способ его модификации, биологическая повязка и способ лечения ран |
AU2012283924A1 (en) * | 2011-07-19 | 2014-02-06 | Thrasos Innovation, Inc. | Anti-fibrotic peptides and their use in methods for treating diseases and disorders characterized by fibrosis |
BR112014015444A2 (pt) * | 2011-12-22 | 2017-07-04 | Agenta Biotechnologies Inc | composição, preparação e uso de materiais de membrana de quitosana densa |
US10106647B2 (en) * | 2013-09-05 | 2018-10-23 | The Penn State Research Foundation | Bioelastomers and applications thereof |
CN104474572A (zh) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | 一种医用止血封堵敷料及其制备方法 |
CN104546532B (zh) * | 2015-01-28 | 2017-07-18 | 广州丽丰化妆品制造有限公司 | 含有低聚壳聚糖和水母胶原蛋白的精华液及其制成的面膜 |
CN104874014A (zh) | 2015-05-22 | 2015-09-02 | 苏州市贝克生物科技有限公司 | 一种医用止血封堵敷料的制备方法 |
GB201508931D0 (en) * | 2015-05-26 | 2015-07-01 | Univ Glasgow The And Georgia Tech Res Corp | Materials and methods for tissue regeneration |
CN106492278A (zh) * | 2016-12-27 | 2017-03-15 | 广东泰宝医疗器械技术研究院有限公司 | 一种人工皮肤及其制备方法 |
JP6933393B2 (ja) * | 2018-09-06 | 2021-09-08 | マリン エッセンス バイオサイエンシズ コーポレーション オブ ユーエスエーMarine Essence Biosciences Corporation of USA | 皮膚異常の処置のための治療用化粧品 |
US20200354431A1 (en) * | 2019-05-07 | 2020-11-12 | Marine Essence Biosciences Corporation of U.S.A. | Mutable collagenous tissue from echinoderms |
-
2019
- 2019-08-30 ES ES19194642T patent/ES2906715T3/es active Active
- 2019-08-30 JP JP2019157784A patent/JP6933394B2/ja active Active
- 2019-09-03 CN CN201910828113.3A patent/CN111012803B/zh active Active
- 2019-09-05 KR KR1020190110383A patent/KR102308773B1/ko active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CN111012803B (zh) | 2023-12-19 |
CN111012803A (zh) | 2020-04-17 |
ES2906715T3 (es) | 2022-04-20 |
JP2020058786A (ja) | 2020-04-16 |
KR102308773B1 (ko) | 2021-10-06 |
KR20200029362A (ko) | 2020-03-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Chen et al. | Three-dimensionally printed silk-sericin-based hydrogel scaffold: a promising visualized dressing material for real-time monitoring of wounds | |
US11793905B2 (en) | Dressing | |
Aramwit | Introduction to biomaterials for wound healing | |
US10912822B2 (en) | Biomaterial devices and topical compositions for guided tissue regeneration | |
CA2672495C (en) | Novel injectable chitosan mixtures forming hydrogels | |
JP6933394B2 (ja) | 組織再生誘導のためのバイオマテリアルデバイスおよび局所用組成物 | |
JP6933393B2 (ja) | 皮膚異常の処置のための治療用化粧品 | |
Chak et al. | A review on collagen based drug delivery systems | |
ter Horst et al. | Natural polymers: Biomaterials for skin scaffolds | |
KR20140059238A (ko) | 주사 시술용 보형물 | |
Varma et al. | Biopolymers and their role in medicinal and pharmaceutical applications | |
Qin et al. | Hydroxybutyl chitosan/oxidized glucomannan self-healing hydrogels as BMSCs-derived exosomes carriers for advanced stretchable wounds | |
CN114452436B (zh) | 一种胶原基可注射自修复水凝胶及其制备方法 | |
US10758594B2 (en) | Biomaterial devices and topical compositions for treatment of skin abnormalities | |
Ilomuanya | Hydrogels as biodegradable biopolymer formulations | |
Singh et al. | Natural polymer-based thin film strategies for skin regeneration in lieu of regenerative dentistry | |
Tseomashko et al. | New hybrid materials for wound cover dressings | |
Tahir et al. | Biomolecules based hydrogels and their potential biomedical applications: A comprehensive review | |
Eshgh et al. | Nanocelluloses for tissue engineering and biomedical scaffolds | |
Huang et al. | Medical applications of collagen and hyaluronan in regenerative medicine | |
Kaur et al. | Biomedical applications of synthetic and natural biodegradable polymers | |
Dooley et al. | Dense chitosan surgical membranes produced by a coincident compression-dehydration process | |
Arunim et al. | Natural biopolymer-based hydrogels: an advanced material for diabetic wound healing | |
Maurya et al. | Smart polymeric biomaterials in tissue engineering | |
Ferrante et al. | Current applications of biomolecules in biomedical engineering |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20191220 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20191220 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201110 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210115 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210406 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210701 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210803 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210812 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6933394 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |