JP6894097B2 - 腎性貧血改善用組成物 - Google Patents
腎性貧血改善用組成物 Download PDFInfo
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- JP6894097B2 JP6894097B2 JP2018525243A JP2018525243A JP6894097B2 JP 6894097 B2 JP6894097 B2 JP 6894097B2 JP 2018525243 A JP2018525243 A JP 2018525243A JP 2018525243 A JP2018525243 A JP 2018525243A JP 6894097 B2 JP6894097 B2 JP 6894097B2
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Description
特許文献2には、ラクトバチルスなどのプロバイオティックス細菌が動物及びヒトの腎臓における***機能を増大させる組成物が開示されている。
特許文献3には、ラクトバチルス・ガセリの生菌が腎臓機能(腎臓の代謝機能)の低下や悪化を抑制する旨が記載されている。
特許文献4には、ラクトバチルス・プランタラムの一定の株が哺乳動物の金属イオン吸収を増大させることが記載されている。
非特許文献1には、ラクトバチルス・ブルガリクス及びストレプトコッカス・サーモフィルスに属する乳酸菌を用いた発酵乳は鉄の吸収を抑制し、鉄欠乏性貧血には有効ではないことが記載されている。
[1] ラクトバチルス属に属する乳酸菌及び/又はその処理物を有効成分として含有する腎性貧血改善用組成物。
[2] 乳酸菌が、ラクトバチルス・ガセリ及びラクトバチルス・アミロボラスからなる群より選択される少なくとも1種である、[1]に記載の組成物。
[3] 乳酸菌が、ラクトバチルス・ガセリCP2305株(受託番号FERM BP-11331)若しくはその変異株、ラクトバチルス・ガセリCP2305s株(受託番号NITE BP-1405)若しくはその変異株、又はラクトバチルス・アミロボラスCP1563株(受託番号FERM BP-11255)若しくはその変異株である、[1]又は[2]に記載の組成物。
[4] 乳酸菌が死菌である、[1]〜[3]のいずれかに記載の組成物。
[5] 乳酸菌処理物が菌体破砕処理物である、[1]〜[4]のいずれかに記載の組成物。
[5-1] 投与対象が腎臓の造血機能が低下した対象である、[1]〜[5]のいずれかに記載の組成物。
[5-2] 投与対象がヘモグロビンが低下した対象である、[1]〜[5]のいずれかに記載の組成物。
[6] 組成物が、飲食品、飼料、栄養補助剤及び医薬からなる群より選択される、[1]〜[5]のいずれかに記載の組成物。
[7] 飲食品が、発酵乳飲料、ヨーグルト、粉ミルク、ベビーフード、味噌汁、レトルト食品及びタブレットを含む、[6]に記載の組成物。
[8-1] 上記乳酸菌及び/又はその処理物を投与していない対照と比較して、上記対象における腎性貧血を改善する、[8]に記載の方法。
[9] 乳酸菌及び/又はその処理物を対象に投与し、対象において腎性貧血を改善するステップを含む、対象の腎性貧血を改善する方法。
酵素溶解処理は、例えばリゾチームなどの酵素を用いて、乳酸菌の細胞構造を破壊することができる。
薬品処理は、グリセリン脂肪酸エステル、ダイズリン脂質などの界面活性剤を使用して、乳酸菌の細胞構造を破壊することができる。
自己溶解処理は、一部の乳酸菌自身の酵素により菌体を溶解することができる。
(1)乳酸菌の準備
乳酸菌として、ラクトバチルス・ガセリCP2305株(受託番号FERM BP-11331)及びラクトバチルス・ガセリCP2305s株(受託番号NITE BP-1405)を準備した。
対象から血液を採取し、ラウリル硫酸ナトリウム-ヘモグロビン(SLS-Hb)法にてヘモグロビンを測定した。
対象からの血清を用いて、定法により電極法にて測定した。
対象から血液を採取し、電気抵抗検出法にて赤血球数、ヘマトクリット値を測定し、ラウリル硫酸ナトリウム-ヘモグロビン(SLS-Hb)法にてヘモグロビン濃度を測定した。
<試験飲料の調製>
ラクトバチルス・ガセリCP2305株及びラクトバチルス・ヘルベティカスを用いて、脱脂
粉乳及び酵母エキスを、32〜37℃にて12〜22時間発酵した後、得られた発酵乳に液糖、甘味料、酸味料、安定剤、香料で調合・殺菌した。
また、プラセボは、CP2305株を使用せずにラクトバチルス・ヘルベティカスを用いて同条件にて発酵した乳を用いて、上記と同様に調合・殺菌した。
殺菌液を紙容器に200ml充填し、試験飲料及びプラセボ飲料とした。
<ヒト飲用試験>
中高齢者(40〜90歳代)34名を対象として2群に分け、ラクトバチルス・ガセリCP2305株を含有した試験飲料(菌体量として1010個)、又はCP2305株を含まないプラセボ飲料を、1日1本で12週間にわたり投与した。
<試験飲料の調製>
ラクトバチルス・アミロボラスCP1563株をグルコース、ペプトン、酵母エキス、酢酸ナトリウム、リン酸水素二カリウム、硫酸マグネシウム、グリセリン脂肪酸エステルを用いた食添培地で37℃24時間発酵後、集菌、洗浄、殺菌後、凍結乾燥し、FS-4ジェットミル(セイシン企業)を用いて0.64MPa圧力下で0.5kg/hにて破砕菌体を得た。次に、脱脂粉乳、酸味料、甘味料、安定剤、乳化剤、香料、CP1563破砕菌体を混合、殺菌、充填し、試験飲料を調製した。
<ヒト飲用試験>
BMIが25〜30 kg/m2の被験者200名を対象に、プラセボ対照二重盲検比較試験を実施した。上記のCP1563破砕菌体200mgを含む500ml飲料、または含まない飲料を連日12週間摂取し、0、4、8、12週目で測定を実施した。
図3は、飲用時間(週)に対するそれぞれ赤血球数、ヘモグロビン濃度及びヘマトクリットの変化を示している。これらの赤血球の状態に関わる指標が乳酸菌であるCP1563株の摂取により維持されていることより、腎臓で産生される造血ホルモンの制御に乳酸菌(特にCP1563株)が関与していると考えられる。
受託番号NITE BP-1405(ラクトバチルス・ガセリCP2305s株、2012年8月14日付寄託)
受託番号FERM BP-11255(ラクトバチルス・アミロボラスCP1563株、2010年5月25日付寄託)
Claims (6)
- ラクトバチルス属に属する乳酸菌及び/又はその処理物を有効成分として含有する腎性貧血改善用組成物であって、乳酸菌が、ラクトバチルス・アミロボラスCP1563株(受託番号FERM BP-11255)若しくはその変異株である、組成物。
- 投与対象が腎臓の造血機能が低下した対象である、請求項1に記載の組成物。
- 乳酸菌が死菌である、請求項1又は2に記載の組成物。
- 乳酸菌処理物が菌体破砕処理物である、請求項1〜3のいずれか1項に記載の組成物。
- 組成物が、飲食品、栄養補助剤及び医薬からなる群より選択される、請求項1〜4のいずれか1項に記載の組成物。
- 飲食品が、発酵乳飲料、ヨーグルト、粉ミルク、ベビーフード、味噌汁、レトルト食品及びタブレットを含む、請求項5に記載の組成物。
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