JP6865466B2 - 分散質分析方法、および分析装置 - Google Patents
分散質分析方法、および分析装置 Download PDFInfo
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- JP6865466B2 JP6865466B2 JP2017525448A JP2017525448A JP6865466B2 JP 6865466 B2 JP6865466 B2 JP 6865466B2 JP 2017525448 A JP2017525448 A JP 2017525448A JP 2017525448 A JP2017525448 A JP 2017525448A JP 6865466 B2 JP6865466 B2 JP 6865466B2
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- 238000004458 analytical method Methods 0.000 title claims description 18
- 239000006185 dispersion Substances 0.000 title description 10
- 230000005291 magnetic effect Effects 0.000 claims description 128
- 239000003463 adsorbent Substances 0.000 claims description 40
- 125000000524 functional group Chemical group 0.000 claims description 31
- 239000002612 dispersion medium Substances 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 17
- 125000002091 cationic group Chemical group 0.000 claims description 16
- 239000000696 magnetic material Substances 0.000 claims description 15
- 239000002156 adsorbate Substances 0.000 claims description 14
- 125000000129 anionic group Chemical group 0.000 claims description 14
- 238000005259 measurement Methods 0.000 claims description 12
- 230000005484 gravity Effects 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 description 30
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 24
- 238000001179 sorption measurement Methods 0.000 description 21
- 229910021380 Manganese Chloride Inorganic materials 0.000 description 17
- GLFNIEUTAYBVOC-UHFFFAOYSA-L Manganese chloride Chemical compound Cl[Mn]Cl GLFNIEUTAYBVOC-UHFFFAOYSA-L 0.000 description 17
- 229940099607 manganese chloride Drugs 0.000 description 17
- 235000002867 manganese chloride Nutrition 0.000 description 17
- 239000011565 manganese chloride Substances 0.000 description 17
- 125000005372 silanol group Chemical group 0.000 description 9
- 238000003384 imaging method Methods 0.000 description 7
- 238000013508 migration Methods 0.000 description 7
- 230000005012 migration Effects 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 6
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 238000001962 electrophoresis Methods 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- -1 octadecylsilane compound Chemical class 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 241000238366 Cephalopoda Species 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000002296 dynamic light scattering Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- IJOOHPMOJXWVHK-UHFFFAOYSA-N trimethylsilyl-trifluoromethansulfonate Natural products C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 238000000838 magnetophoresis Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
- G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
- G01N27/76—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids by investigating susceptibility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/0656—Investigating concentration of particle suspensions using electric, e.g. electrostatic methods or magnetic methods
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/08—Investigating permeability, pore-volume, or surface area of porous materials
- G01N15/088—Investigating volume, surface area, size or distribution of pores; Porosimetry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1493—Particle size
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
Description
v=2(χs−χm)r2(1/9ημ0)B(dB/dx) (1)
20 磁場生成部
30 測定部
40 演算部
50 光源
m 分散媒
s 分散質
C キャピラリ
D 分散系
Claims (10)
- 第1分散質の体積磁化率を取得する工程と、
前記第1分散質に吸着質を吸着させた第2分散質を得る工程と、
前記第2分散質の体積磁化率を取得する工程と、
前記第1分散質の体積磁化率と前記第2分散質の体積磁化率とに基づき、前記第2分散質に吸着している前記吸着質の量を取得して、前記第1分散質の官能基の量を分析する工程と
を包含し、
前記吸着質の量を取得する際に、
前記第1分散質の体積磁化率と前記第2分散質の体積磁化率との差を示す体積磁化率差を求め、
前記体積磁化率差と、前記吸着質の比重と、前記吸着質のモル磁化率とに基づいて、前記吸着質の量を取得する、分散質分析方法。 - 前記吸着質の量は、モル濃度である、請求項1に記載の分散質分析方法。
- 前記第2分散質の体積磁化率から前記第1分散質の体積磁化率を減算して、前記体積磁化率差を求め、
前記体積磁化率差に前記吸着質の比重を乗算して、質量あたりの体積磁化率差を求め、
前記質量あたりの体積磁化率差をモル磁化率差に換算し、
前記吸着質のモル磁化率によって前記モル磁化率差を除算した結果から、前記吸着質の量を取得する、請求項1または請求項2に記載の分散質分析方法。 - 前記官能基がアニオン性である場合、前記吸着質はカチオン性の磁性体を含み、
前記官能基がカチオン性である場合、前記吸着質はアニオン性の磁性体を含む、請求項1から請求項3のいずれか1項に記載の分散質分析方法。 - 演算部を備えた分析装置であって、
前記演算部は、第1分散質の体積磁化率と、第2分散質の体積磁化率とに基づき、前記第2分散質に吸着している吸着質の量を算出し、
前記第2分散質は、前記第1分散質に前記吸着質を吸着させたものであり、
前記演算部は、
前記第1分散質の体積磁化率と前記第2分散質の体積磁化率との差を示す体積磁化率差を求め、
前記体積磁化率差と、前記吸着質の比重と、前記吸着質のモル磁化率とに基づいて、前記吸着質の量を取得する、分析装置。 - 前記演算部は、前記吸着質の量に基づいて、前記第1分散質の官能基の量を分析する、請求項5に記載の分析装置。
- 前記吸着質の量は、モル濃度である、請求項5または請求項6に記載の分析装置。
- 前記演算部は、
前記第2分散質の体積磁化率から前記第1分散質の体積磁化率を減算して、前記体積磁化率差を求め、
前記体積磁化率差に前記吸着質の比重を乗算して、質量あたりの体積磁化率差を求め、
前記質量あたりの体積磁化率差をモル磁化率差に換算し、
前記吸着質のモル磁化率によって前記モル磁化率差を除算した結果から、前記吸着質の量を取得する、請求項5から請求項7のいずれか1項に記載の分析装置。 - 磁場生成部と、
前記磁場生成部によって磁場が生成されている状態で、分散媒に分散された前記第1分散質の動き、および前記分散媒に分散された前記第2分散質の動きを測定する測定部と
を更に備え、
前記演算部は、前記測定部の測定結果に基づいて前記第1分散質の体積磁化率および前記第2分散質の体積磁化率を算出する、請求項5から請求項8のいずれか1項に記載の分析装置。 - 前記第1分散質の官能基がアニオン性である場合、前記吸着質はカチオン性の磁性体を含み、
前記第1分散質の官能基がカチオン性である場合、前記吸着質はアニオン性の磁性体を含む、請求項5から請求項9のいずれか1項に記載の分析装置。
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US10809228B2 (en) * | 2015-06-25 | 2020-10-20 | Kawano Lab. Inc. | Method and apparatus for quantitatively evaluating amount of dispersion medium adsorbed to dispersoid particles |
JP6842060B2 (ja) * | 2017-01-31 | 2021-03-17 | 株式会社カワノラボ | 分析方法、及び分析装置 |
US11988636B2 (en) | 2019-04-26 | 2024-05-21 | Kawano Lab. Inc. | Method for particle analysis and method for particle production |
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JP2005030883A (ja) | 2003-07-11 | 2005-02-03 | Fuji Xerox Co Ltd | 粒子の官能基定量方法 |
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