JP6844187B2 - Oral liquid composition - Google Patents
Oral liquid composition Download PDFInfo
- Publication number
- JP6844187B2 JP6844187B2 JP2016200497A JP2016200497A JP6844187B2 JP 6844187 B2 JP6844187 B2 JP 6844187B2 JP 2016200497 A JP2016200497 A JP 2016200497A JP 2016200497 A JP2016200497 A JP 2016200497A JP 6844187 B2 JP6844187 B2 JP 6844187B2
- Authority
- JP
- Japan
- Prior art keywords
- oral liquid
- liquid composition
- acid
- ethyl
- licorice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007788 liquid Substances 0.000 title claims description 67
- 239000000203 mixture Substances 0.000 title claims description 63
- 239000000284 extract Substances 0.000 claims description 28
- 241001465754 Metazoa Species 0.000 claims description 14
- 235000003599 food sweetener Nutrition 0.000 claims description 13
- 239000003765 sweetening agent Substances 0.000 claims description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 229940088594 vitamin Drugs 0.000 claims description 12
- 229930003231 vitamin Natural products 0.000 claims description 12
- 235000013343 vitamin Nutrition 0.000 claims description 12
- 239000011782 vitamin Substances 0.000 claims description 12
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 claims description 11
- 235000013736 caramel Nutrition 0.000 claims description 11
- 239000000419 plant extract Substances 0.000 claims description 11
- 235000000346 sugar Nutrition 0.000 claims description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 8
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000005715 Fructose Substances 0.000 claims description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- 239000008103 glucose Substances 0.000 claims description 6
- 229930091371 Fructose Natural products 0.000 claims description 5
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 5
- 239000004376 Sucralose Substances 0.000 claims description 5
- 244000223014 Syzygium aromaticum Species 0.000 claims description 5
- 235000016639 Syzygium aromaticum Nutrition 0.000 claims description 5
- 244000273928 Zingiber officinale Species 0.000 claims description 5
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 5
- 235000013361 beverage Nutrition 0.000 claims description 5
- 235000008397 ginger Nutrition 0.000 claims description 5
- 235000019408 sucralose Nutrition 0.000 claims description 5
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims description 4
- 240000002234 Allium sativum Species 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
- 239000004386 Erythritol Substances 0.000 claims description 4
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 4
- 241000340987 Ptychopetalum olacoides Species 0.000 claims description 4
- 244000228451 Stevia rebaudiana Species 0.000 claims description 4
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
- 235000010358 acesulfame potassium Nutrition 0.000 claims description 4
- 229960004998 acesulfame potassium Drugs 0.000 claims description 4
- 239000000619 acesulfame-K Substances 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 4
- 235000010323 ascorbic acid Nutrition 0.000 claims description 4
- 239000011668 ascorbic acid Substances 0.000 claims description 4
- 229960005070 ascorbic acid Drugs 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- 235000015165 citric acid Nutrition 0.000 claims description 4
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 4
- 229940009714 erythritol Drugs 0.000 claims description 4
- 235000019414 erythritol Nutrition 0.000 claims description 4
- 235000004611 garlic Nutrition 0.000 claims description 4
- 239000004310 lactic acid Substances 0.000 claims description 4
- 235000014655 lactic acid Nutrition 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 4
- 235000011007 phosphoric acid Nutrition 0.000 claims description 4
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims description 4
- 229940109850 royal jelly Drugs 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 229960002920 sorbitol Drugs 0.000 claims description 4
- 235000010356 sorbitol Nutrition 0.000 claims description 4
- 239000011975 tartaric acid Substances 0.000 claims description 4
- 235000002906 tartaric acid Nutrition 0.000 claims description 4
- 239000000811 xylitol Substances 0.000 claims description 4
- 235000010447 xylitol Nutrition 0.000 claims description 4
- 229960002675 xylitol Drugs 0.000 claims description 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 4
- 239000009538 yokuinin Substances 0.000 claims description 4
- 244000000626 Daucus carota Species 0.000 claims description 3
- 235000002767 Daucus carota Nutrition 0.000 claims description 3
- 229960002737 fructose Drugs 0.000 claims description 3
- 229960001031 glucose Drugs 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 239000002535 acidifier Substances 0.000 claims description 2
- 241000202807 Glycyrrhiza Species 0.000 claims 6
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims 6
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims 6
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims 6
- 229940010454 licorice Drugs 0.000 claims 6
- 235000019640 taste Nutrition 0.000 description 16
- 108090000765 processed proteins & peptides Proteins 0.000 description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 235000001014 amino acid Nutrition 0.000 description 12
- 229940024606 amino acid Drugs 0.000 description 12
- 150000001413 amino acids Chemical class 0.000 description 12
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 10
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 10
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 9
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 9
- 235000019136 lipoic acid Nutrition 0.000 description 9
- 235000013824 polyphenols Nutrition 0.000 description 9
- 229960002663 thioctic acid Drugs 0.000 description 9
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 8
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 8
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 8
- 229960002442 glucosamine Drugs 0.000 description 8
- 150000008442 polyphenolic compounds Chemical class 0.000 description 8
- 229920001282 polysaccharide Polymers 0.000 description 8
- 239000005017 polysaccharide Substances 0.000 description 8
- 150000004804 polysaccharides Chemical class 0.000 description 8
- 235000018102 proteins Nutrition 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 7
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 238000000605 extraction Methods 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 229960003080 taurine Drugs 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N Alanine Chemical compound CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 4
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 4
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 4
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 4
- 229960000367 inositol Drugs 0.000 description 4
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 4
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 206010013911 Dysgeusia Diseases 0.000 description 3
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 3
- RWAXQWRDVUOOGG-UHFFFAOYSA-N N,2,3-Trimethyl-2-(1-methylethyl)butanamide Chemical compound CNC(=O)C(C)(C(C)C)C(C)C RWAXQWRDVUOOGG-UHFFFAOYSA-N 0.000 description 3
- 244000131415 Zanthoxylum piperitum Species 0.000 description 3
- 235000008853 Zanthoxylum piperitum Nutrition 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 3
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 2
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 description 2
- 108010085443 Anserine Proteins 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 229920002567 Chondroitin Polymers 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 244000160089 Crataegus cuneata Species 0.000 description 2
- 235000008440 Crataegus cuneata Nutrition 0.000 description 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 229920001353 Dextrin Polymers 0.000 description 2
- 239000004375 Dextrin Substances 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 229920002148 Gellan gum Polymers 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JUUBCHWRXWPFFH-UHFFFAOYSA-N Hydroxytyrosol Chemical compound OCCC1=CC=C(O)C(O)=C1 JUUBCHWRXWPFFH-UHFFFAOYSA-N 0.000 description 2
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 2
- SLRNWACWRVGMKD-UHFFFAOYSA-N L-anserine Natural products CN1C=NC(CC(NC(=O)CCN)C(O)=O)=C1 SLRNWACWRVGMKD-UHFFFAOYSA-N 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
- 229930182844 L-isoleucine Natural products 0.000 description 2
- 239000004395 L-leucine Substances 0.000 description 2
- 235000019454 L-leucine Nutrition 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- 229930195722 L-methionine Natural products 0.000 description 2
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
- 241000210053 Potentilla elegans Species 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- OHSHFZJLPYLRIP-BMZHGHOISA-M Riboflavin sodium phosphate Chemical compound [Na+].OP(=O)([O-])OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O OHSHFZJLPYLRIP-BMZHGHOISA-M 0.000 description 2
- 241001125048 Sardina Species 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000000783 alginic acid Substances 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 229960001126 alginic acid Drugs 0.000 description 2
- 150000004781 alginic acids Chemical class 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- MYYIAHXIVFADCU-QMMMGPOBSA-N anserine Chemical compound CN1C=NC=C1C[C@H](NC(=O)CC[NH3+])C([O-])=O MYYIAHXIVFADCU-QMMMGPOBSA-N 0.000 description 2
- 229960005261 aspartic acid Drugs 0.000 description 2
- QUQPHWDTPGMPEX-UTWYECKDSA-N aurantiamarin Natural products COc1ccc(cc1O)[C@H]1CC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)cc2O1 QUQPHWDTPGMPEX-UTWYECKDSA-N 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 235000005487 catechin Nutrition 0.000 description 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 2
- 229950001002 cianidanol Drugs 0.000 description 2
- -1 citrulin Chemical compound 0.000 description 2
- APSNPMVGBGZYAJ-GLOOOPAXSA-N clematine Natural products COc1cc(ccc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 APSNPMVGBGZYAJ-GLOOOPAXSA-N 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
- 229960002104 cyanocobalamin Drugs 0.000 description 2
- 235000000639 cyanocobalamin Nutrition 0.000 description 2
- 239000011666 cyanocobalamin Substances 0.000 description 2
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 2
- 235000019425 dextrin Nutrition 0.000 description 2
- 229950010030 dl-alanine Drugs 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 229960000304 folic acid Drugs 0.000 description 2
- 235000019152 folic acid Nutrition 0.000 description 2
- 239000011724 folic acid Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 229950006836 fursultiamine Drugs 0.000 description 2
- JTLXCMOFVBXEKD-FOWTUZBSSA-N fursultiamine Chemical compound C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N JTLXCMOFVBXEKD-FOWTUZBSSA-N 0.000 description 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 2
- 239000000216 gellan gum Substances 0.000 description 2
- 235000010492 gellan gum Nutrition 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- 229940025878 hesperidin Drugs 0.000 description 2
- VUYDGVRIQRPHFX-UHFFFAOYSA-N hesperidin Natural products COc1cc(ccc1O)C2CC(=O)c3c(O)cc(OC4OC(COC5OC(O)C(O)C(O)C5O)C(O)C(O)C4O)cc3O2 VUYDGVRIQRPHFX-UHFFFAOYSA-N 0.000 description 2
- QUQPHWDTPGMPEX-QJBIFVCTSA-N hesperidin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@@H]([C@H](O)[C@@H](O)[C@H](C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-QJBIFVCTSA-N 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 229960000310 isoleucine Drugs 0.000 description 2
- 229960003136 leucine Drugs 0.000 description 2
- 229960004452 methionine Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- ARGKVCXINMKCAZ-UHFFFAOYSA-N neohesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(CO)O3)OC3C(C(O)C(O)C(C)O3)O)=CC(O)=C2C(=O)C1 ARGKVCXINMKCAZ-UHFFFAOYSA-N 0.000 description 2
- 239000001814 pectin Substances 0.000 description 2
- 235000010987 pectin Nutrition 0.000 description 2
- 229920001277 pectin Polymers 0.000 description 2
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 2
- 239000011764 pyridoxine hydrochloride Substances 0.000 description 2
- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 2
- 235000019512 sardine Nutrition 0.000 description 2
- GQTHJBOWLPZUOI-FJXQXJEOSA-M sodium D-pantothenate Chemical compound [Na+].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O GQTHJBOWLPZUOI-FJXQXJEOSA-M 0.000 description 2
- 229940068459 sodium pantothenate Drugs 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 229920001864 tannin Polymers 0.000 description 2
- 235000018553 tannin Nutrition 0.000 description 2
- 239000001648 tannin Substances 0.000 description 2
- 229940026510 theanine Drugs 0.000 description 2
- 229960003495 thiamine Drugs 0.000 description 2
- 229960002898 threonine Drugs 0.000 description 2
- 229940042585 tocopherol acetate Drugs 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- XFZJEEAOWLFHDH-UHFFFAOYSA-N (2R,2'R,3R,3'R,4R)-3,3',4',5,7-Pentahydroxyflavan(48)-3,3',4',5,7-pentahydroxyflavan Natural products C=12OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C(O)C=C(O)C=1C(C1=C(O)C=C(O)C=C1O1)C(O)C1C1=CC=C(O)C(O)=C1 XFZJEEAOWLFHDH-UHFFFAOYSA-N 0.000 description 1
- GGTYBZJRPHEQDG-WCCKRBBISA-N (2s)-2,5-diaminopentanoic acid hydrochloride Chemical compound Cl.NCCC[C@H](N)C(O)=O GGTYBZJRPHEQDG-WCCKRBBISA-N 0.000 description 1
- QZNNVYOVQUKYSC-JEDNCBNOSA-N (2s)-2-amino-3-(1h-imidazol-5-yl)propanoic acid;hydron;chloride Chemical compound Cl.OC(=O)[C@@H](N)CC1=CN=CN1 QZNNVYOVQUKYSC-JEDNCBNOSA-N 0.000 description 1
- AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 description 1
- YTKBWWKAVMSYHE-OALUTQOASA-N (3s)-3-[3-(3-hydroxy-4-methoxyphenyl)propylamino]-4-[[(2s)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid Chemical compound C([C@@H](C(=O)OC)NC(=O)[C@H](CC(O)=O)NCCCC=1C=C(O)C(OC)=CC=1)C1=CC=CC=C1 YTKBWWKAVMSYHE-OALUTQOASA-N 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 1
- 239000004394 Advantame Substances 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 1
- 235000017647 Brassica oleracea var italica Nutrition 0.000 description 1
- 244000308180 Brassica oleracea var. italica Species 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 240000003538 Chamaemelum nobile Species 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 description 1
- 244000124209 Crocus sativus Species 0.000 description 1
- 235000015655 Crocus sativus Nutrition 0.000 description 1
- 244000019459 Cynara cardunculus Species 0.000 description 1
- 235000019106 Cynara scolymus Nutrition 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- LKDRXBCSQODPBY-JDJSBBGDSA-N D-allulose Chemical compound OCC1(O)OC[C@@H](O)[C@@H](O)[C@H]1O LKDRXBCSQODPBY-JDJSBBGDSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 description 1
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 description 1
- 229920002079 Ellagic acid Polymers 0.000 description 1
- 241000195620 Euglena Species 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- 239000006000 Garlic extract Substances 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000208251 Gymnema Species 0.000 description 1
- 235000005206 Hibiscus Nutrition 0.000 description 1
- 235000007185 Hibiscus lunariifolius Nutrition 0.000 description 1
- 244000284380 Hibiscus rosa sinensis Species 0.000 description 1
- 235000019766 L-Lysine Nutrition 0.000 description 1
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- BVHLGVCQOALMSV-JEDNCBNOSA-N L-lysine hydrochloride Chemical compound Cl.NCCCC[C@H](N)C(O)=O BVHLGVCQOALMSV-JEDNCBNOSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 108010093901 N-(N-(3-(3-hydroxy-4-methoxyphenyl) propyl)-alpha-aspartyl)-L-phenylalanine 1-methyl ester Proteins 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 239000004384 Neotame Substances 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 108010020346 Polyglutamic Acid Proteins 0.000 description 1
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 1
- MOJZMWJRUKIQGL-FWCKPOPSSA-N Procyanidin C2 Natural products O[C@@H]1[C@@H](c2cc(O)c(O)cc2)Oc2c([C@H]3[C@H](O)[C@@H](c4cc(O)c(O)cc4)Oc4c3c(O)cc(O)c4)c(O)cc(O)c2[C@@H]1c1c(O)cc(O)c2c1O[C@@H]([C@H](O)C2)c1cc(O)c(O)cc1 MOJZMWJRUKIQGL-FWCKPOPSSA-N 0.000 description 1
- 241000241413 Propolis Species 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 description 1
- 244000000231 Sesamum indicum Species 0.000 description 1
- 235000003434 Sesamum indicum Nutrition 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 241001261506 Undaria pinnatifida Species 0.000 description 1
- 229930003451 Vitamin B1 Natural products 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 229960004308 acetylcysteine Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000019453 advantame Nutrition 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229960003121 arginine Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 229960003589 arginine hydrochloride Drugs 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 235000016520 artichoke thistle Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical compound C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 229960000678 carnitine chloride Drugs 0.000 description 1
- 229940008396 carrot extract Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 229920002770 condensed tannin Polymers 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000035597 cooling sensation Effects 0.000 description 1
- 235000012754 curcumin Nutrition 0.000 description 1
- 239000004148 curcumin Substances 0.000 description 1
- 229940109262 curcumin Drugs 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 229960002852 ellagic acid Drugs 0.000 description 1
- 235000004132 ellagic acid Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 235000015897 energy drink Nutrition 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 235000020706 garlic extract Nutrition 0.000 description 1
- 229940002508 ginger extract Drugs 0.000 description 1
- 235000020708 ginger extract Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229960002743 glutamine Drugs 0.000 description 1
- 229960002449 glycine Drugs 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 229940093915 gynecological organic acid Drugs 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 235000001497 healthy food Nutrition 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229940095066 hydroxytyrosol Drugs 0.000 description 1
- 235000003248 hydroxytyrosol Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 229960003646 lysine Drugs 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 235000019412 neotame Nutrition 0.000 description 1
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 description 1
- 108010070257 neotame Proteins 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 229940100688 oral solution Drugs 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 235000008729 phenylalanine Nutrition 0.000 description 1
- 235000018192 pine bark supplement Nutrition 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920002643 polyglutamic acid Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 229920002414 procyanidin Polymers 0.000 description 1
- HGVVOUNEGQIPMS-UHFFFAOYSA-N procyanidin Chemical compound O1C2=CC(O)=CC(O)=C2C(O)C(O)C1(C=1C=C(O)C(O)=CC=1)OC1CC2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 HGVVOUNEGQIPMS-UHFFFAOYSA-N 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 229940106796 pycnogenol Drugs 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 description 1
- TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000013974 saffron Nutrition 0.000 description 1
- 239000004248 saffron Substances 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000011496 sports drink Nutrition 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 235000021147 sweet food Nutrition 0.000 description 1
- ZQZCOBSUOFHDEE-UHFFFAOYSA-N tetrapropyl silicate Chemical group CCCO[Si](OCCC)(OCCC)OCCC ZQZCOBSUOFHDEE-UHFFFAOYSA-N 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 229940074410 trehalose Drugs 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
- Seasonings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
本発明は、エチル−3−p−メンタン−3−カルボキサミドアセテートを含有する経口液体組成物に関する。 The present invention relates to an oral liquid composition containing ethyl-3-p-menthane-3-carboxamide acetate.
栄養ドリンクやスポーツドリンクといった、ビタミン類やアミノ酸を配合した経口液体組成物は広く消費者に受け入れられており、これらの経口液体組成物には嗜好性の観点から、飲みやすさが常に求められている。経口液体組成物の飲みやすさに影響する因子の1つとして、後味の残らない、いわゆる「キレ」のよさが挙げられる。
これまでに、経口液体組成物にキレを付与する方法として、例えば、チアミン又はその塩、タウリン又はカラメルを含有する経口液体組成物に、特定の香辛料成分を添加することで、ドライ感とキレが付与された飲料(特許文献1)やスクラロースなどの高甘味度甘味料に、l−メンチルアセテートなどの化合物を添加することで、さっぱりとした後味を有する甘味食品(特許文献2)に関するものが知られている。
しかしながら、特許文献1では、ドライ感やキレを付与するために配合する香辛料抽出物によって、飲料に独特の風味が付与されることがあり、特許文献2は、高甘味度甘味料に起因する後味のくどさのみを改善できるものであるため、ビタミン類やアミノ酸といったいわゆる健康成分を配合した飲料に対し、異味・異臭を付与することなくキレを付与することは困難であった。
Oral liquid compositions containing vitamins and amino acids, such as energy drinks and sports drinks, are widely accepted by consumers, and these oral liquid compositions are always required to be easy to drink from the viewpoint of palatability. There is. One of the factors that affect the ease of drinking of an oral liquid composition is the so-called "sharpness" that leaves no aftertaste.
So far, as a method of imparting sharpness to an oral liquid composition, for example, by adding a specific spice component to an oral liquid composition containing thiamine or a salt thereof, taurine or caramel, a dry feeling and sharpness can be obtained. A sweet food having a refreshing aftertaste (Patent Document 2) is known by adding a compound such as l-mentyl acetate to a given beverage (Patent Document 1) or a high-sweetness sweetener such as sucralose. Has been done.
However, in Patent Document 1, a unique flavor may be imparted to the beverage by the spice extract blended to impart a dry feeling and sharpness, and Patent Document 2 has an aftertaste due to a high-sweetness sweetener. Since it is possible to improve only the dullness, it has been difficult to impart sharpness to a beverage containing so-called healthy ingredients such as vitamins and amino acids without imparting an offensive taste or odor.
本発明の目的は、ビタミン類、動植物抽出物、ポリフェノール、アミノ酸、ペプチド又はタンパク質、多糖類、チオクト酸、リボース、グルコサミン、カラメルを含有する経口液体組成物の、味のキレを改善することである。 An object of the present invention is to improve the sharpness of the taste of an oral liquid composition containing vitamins, animal and plant extracts, polyphenols, amino acids, peptides or proteins, polysaccharides, thioctic acid, ribose, glucosamine, and caramel. ..
本発明者らは、上記課題を解決するために鋭意検討を重ねた結果、上記成分を含む経口液体組成物に、エチル−3−p−メンタン−3−カルボキサミドアセテートを配合することにより、該経口液体組成物に異味・異臭を付与することなく、味のキレを改善できることを見出し、本発明を完成するに至った。 As a result of diligent studies to solve the above problems, the present inventors have added ethyl-3-p-menthane-3-carboxamide acetate to an oral liquid composition containing the above components to obtain the oral solution. We have found that the sharpness of the taste can be improved without imparting an offensive taste or odor to the liquid composition, and have completed the present invention.
即ち本発明は、
(1)A)エチル−3−p−メンタン−3−カルボキサミドアセテート、及びB)ビタミン類、動植物抽出物、ポリフェノール、アミノ酸、ペプチド又はタンパク質、多糖類、チオクト酸、D−リボース、グルコサミン及びカラメルからなる群より選ばれる1種又は2種以上を含有することを特徴とする経口液体組成物、
(2)エチル−3−p−メンタン−3−カルボキサミドアセテートの含量が、経口液体組成物中0.00001〜0.01W/V%であることを特徴とする、(1)に記載の経口液体組成物、
(3)さらに、甘味剤及び/又は酸味剤を含有することを特徴とする、(1)又は(2)に記載の経口液体組成物、
(4)甘味剤が、砂糖、ブドウ糖、果糖、ソルビトール、キシリトール、エリスリトール、アセスルファムカリウム、スクラロース及びステビア抽出物からなる群より選ばれる1種又は2種以上であることを特徴とする、(3)に記載の経口液体組成物、
(5)酸味剤が、クエン酸、リンゴ酸、酒石酸、乳酸、アスコルビン酸及びリン酸からなる群より選ばれる1種又は2種以上であることを特徴とする、(3)又は(4)に記載の経口液体組成物
(6)飲料又は経口液剤である(1)〜(5)のいずれかに記載の経口液体組成物、である。
That is, the present invention
(1) From A) ethyl-3-p-menthan-3-carboxamide acetate, and B) vitamins, animal and plant extracts, polyphenols, amino acids, peptides or proteins, polysaccharides, thioctic acid, D-ribose, glucosamine and caramel An oral liquid composition comprising one or more selected from the group consisting of
(2) The oral liquid according to (1), wherein the content of ethyl-3-p-mentanethane-3-carboxamide acetate is 0.00001 to 0.01 W / V% in the oral liquid composition. Composition,
(3) The oral liquid composition according to (1) or (2), which further contains a sweetening agent and / or an acidifying agent.
(4) The sweetener is one or more selected from the group consisting of sugar, glucose, fructose, sorbitol, xylitol, erythritol, acesulfame potassium, sucralose and stevia extract (3). Oral liquid composition, as described in
(5) The acidulant is one or more selected from the group consisting of citric acid, malic acid, tartaric acid, lactic acid, ascorbic acid and phosphoric acid, according to (3) or (4). The oral liquid composition according to any one of (1) to (5), which is a beverage or an oral liquid preparation.
ビタミン類、動植物抽出物、ポリフェノール、アミノ酸、ペプチド又はタンパク質、多糖類、チオクト酸、D−リボース、グルコサミン、カラメルを含有する経口液体組成物において、該経口液体組成物に異味・異臭を付与することなく味のキレを改善した製剤を提供することが可能となった。 In an oral liquid composition containing vitamins, animal and plant extracts, polyphenols, amino acids, peptides or proteins, polysaccharides, thioctic acid, D-ribose, glucosamine, and caramel, imparting an offensive taste and odor to the oral liquid composition. It has become possible to provide a formulation with improved sharpness of taste.
本発明の経口液体組成物は、エチル−3−p−メンタン−3−カルボキサミドアセテート、及び、ビタミン類、動植物抽出物、ポリフェノール、アミノ酸、ペプチド又はタンパク質、多糖類、チオクト酸、D−リボース、グルコサミン、カラメルからなる群より選ばれる1種又は2種以上の成分を含有するものである。 The oral liquid composition of the present invention comprises ethyl-3-p-menthan-3-carboxamide acetate and vitamins, animal and plant extracts, polyphenols, amino acids, peptides or proteins, polysaccharides, thioctic acid, D-ribose, glucosamine. , It contains one or more components selected from the group consisting of caramel.
本発明において、エチル−3−p−メンタン−3−カルボキサミドアセテートとは、別名WS−5とも呼ばれ、例えば、Penta Manufacturing社等より市販品を購入することができる、冷涼感に優れた化合物の一種であり、通常、香料として菓子類や清涼飲料等の添加剤として使用される。ビタミン類、動植物抽出物、ポリフェノール、アミノ酸、ペプチド又はタンパク質、多糖類、チオクト酸、D−リボース、グルコサミン及びカラメルを服用した際に味のキレを改善できるものである。一方、本化合物が経口液体組成物の味のキレを改善することが出来るという知見は、これまでに無い。エチル−3−p−メンタン−3−カルボキサミドアセテートの含有量は、経口液体組成物全量に対して通常0.00001〜0.01W/V%である。本発明の効果をよく発揮できる含有量は、「味のキレ」という効果の面から、経口液体組成物全量に対して0.00001〜0.01W/V%であり、異味・異臭を付与しないという点も含めた総合的観点からより好ましい含有量は、経口液体組成物全量に対して0.0001〜0.005W/V%であり、特に好ましくは0.0001〜0.004W/V%である。0.01W/V%を超える量を添加すると、エチル−3−p−メンタン−3−カルボキサミドアセテートに起因する不快な刺激味により、飲みやすさが著しく低下するため、好ましくない。 In the present invention, ethyl-3-p-menthane-3-carboxamide acetate is also known as WS-5, and is a compound having an excellent cooling sensation, for example, a commercially available product that can be purchased from Penta Manufacturing Co., Ltd. or the like. It is a kind and is usually used as an additive for confectionery and soft drinks as a fragrance. It can improve the sharpness of taste when taking vitamins, animal and plant extracts, polyphenols, amino acids, peptides or proteins, polysaccharides, thioctic acid, D-ribose, glucosamine and caramel. On the other hand, there has been no finding that this compound can improve the sharpness of the taste of an oral liquid composition. The content of ethyl-3-p-mentanethane-3-carboxamide acetate is usually 0.00001 to 0.01 W / V% with respect to the total amount of the oral liquid composition. The content at which the effect of the present invention can be exhibited well is 0.00001 to 0.01 W / V% with respect to the total amount of the oral liquid composition from the viewpoint of the effect of "taste sharpness", and does not impart an offensive taste or odor. From a comprehensive viewpoint including this point, a more preferable content is 0.0001 to 0.005 W / V%, particularly preferably 0.0001 to 0.004 W / V%, based on the total amount of the oral liquid composition. is there. If an amount exceeding 0.01 W / V% is added, the ease of drinking is significantly reduced due to the unpleasant pungent taste caused by ethyl-3-p-menthane-3-carboxamide acetate, which is not preferable.
本発明において、ビタミン類とは、動物の正常な発育と栄養を保つ上に微量でよいが欠くことのできない特殊な有機物質の総称であり、特に限定されないがビタミンB1、ビタミンB2、ビタミンB6、ビタミンB12、パンテノール、パントテン酸、ナイアシン、葉酸、ヘスペリジン、ビタミンE、イノシトール、ビオチン、オロト酸及びCoQ10等が挙げられ、これらは、塩や誘導体であっても良い。例えば、チアミン硝酸塩、塩酸フルスルチアミン、リン酸リボフラビンエステルナトリウム、ピリドキシン塩酸塩、シアノコバラミン、パントテン酸ナトリウム、ニコチン酸アミド、ビタミンEアセテート等である。好ましくは、チアミン硝酸塩、塩酸フルスルチアミン、リン酸リボフラビンエステルナトリウム、ピリドキシン塩酸塩、シアノコバラミン、パンテノール、パントテン酸ナトリウム、ニコチン酸アミド、葉酸、ヘスペリジン、ビタミンEアセテート、イノシトールである。ビタミン類の含有量は、経口液体組成物全量に対して通常0.0000001〜20W/V%であるが、好ましくは、経口液体組成物全量に対して0.000001〜1W/V%である。また、イノシトールを除くビタミン類1質量部に対して、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.00002〜84質量部含有することが好ましい。イノシトール1質量部に対しては、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.02〜0.1質量部含有することが好ましく、0.02〜0.06質量部がより好ましい。 In the present invention, vitamins are a general term for special organic substances that are indispensable for maintaining normal growth and nutrition of animals in a small amount, and are not particularly limited, but vitamin B1, vitamin B2, vitamin B6, Examples thereof include vitamin B12, pantenol, pantothenic acid, niacin, folic acid, hesperidin, vitamin E, inositol, biotin, orotonic acid and CoQ10, which may be salts or derivatives. For example, thiamine nitrate, fursultiamine hydrochloride, sodium riboflavin phosphate, pyridoxine hydrochloride, cyanocobalamin, sodium pantothenate, nicotinamide, vitamin E acetate and the like. Preferred are thiamine nitrate, fursultiamine hydrochloride, sodium riboflavin phosphate, pyridoxine hydrochloride, cyanocobalamin, panthenol, sodium pantothenate, nicotinamide, folic acid, hesperidin, vitamin E acetate, and inositol. The content of vitamins is usually 0.000000001 to 20 W / V% with respect to the total amount of the oral liquid composition, but preferably 0.000001 to 1 W / V% with respect to the total amount of the oral liquid composition. Further, it is preferable that ethyl-3-p-menthane-3-carboxamide acetate is contained in an amount of 0.00002 to 84 parts by mass with respect to 1 part by mass of vitamins excluding inositol. Ethyl-3-p-menthane-3-carboxamide acetate is preferably contained in an amount of 0.02 to 0.1 parts by mass, more preferably 0.02 to 0.06 parts by mass with respect to 1 part by mass of inositol.
本発明で用いる動植物抽出物は、動物又は植物、あるいはそれらの一部を、そのままあるいは必要に応じて、乾燥、破砕、粉砕処理等を行った後に抽出することによって得られる。抽出手段は特に限定されず、エタノール等の有機溶媒や水又はそれらの混合物を用いた攪拌・振盪・浸漬抽出法や、減圧水蒸気蒸留抽出法、二酸化炭素等の超臨界流体を用いた超臨界ガス抽出法等、公知の抽出方法で行えばよい。抽出に用いる動物・植物原料としては、特に限定されないが、ニンジン、ショウキョウ、カンゾウ、ガラナ、ケイヒ、ローヤルゼリー、リュウガンニク、ヨクイニン、ニクジュヨウ、シゴカ、クコシ、シャクヤク、チョウジ、トウキ、サンショウ、オウセイ、サンヤク、ジョテイシ、セイヨウサンザシ、トシシ、チンピ、ブクリョウ、タイソウ、トチュウ、ムイラプアマ、ニンニク、アセンヤク、ウイキョウ、コウジン、サフラン、サンザシ、シュクシャ、ウコン、モッコウ、ヤクチ、サラシア、アーティチョーク、桑葉、大豆、アシタバ、ギムネマ、アロエ、グリーンプロポリス、ブロッコリー、ルイボス、葛の花、白インゲン豆、ユーグレナ、ガルシニアカンボジア、アフリカマンゴ、黒酢、プラセンタ、スッポン、マカ、ホップ、パフィア(ブラジル人参)、ハイビスカス、ナルコユリ、冬虫夏草、セージ、サネブトナツメ、紅景天、カミツレ、ロゼア(イワベンケイ)、ウメ(梅肉エキス)及び黒ショウガ等が挙げられ、 好ましくは、ニンジン、ショウキョウ、カンゾウ、ガラナ、ケイヒ、ローヤルゼリー、リュウガンニク、ヨクイニン、ニクジュヨウ、シゴカ、クコシ、シャクヤク、チョウジ、トウキ、サンショウ、オウセイ、サンヤク、ジョテイシ、セイヨウサンザシ、トシシ、チンピ、ブクリョウ、タイソウ、トチュウ、ムイラプアマ、ニンニクである。動植物抽出物の含有量は、原生薬換算量として、経口液体組成物全量に対して通常0.0001〜20%であるが、好ましくは、経口液体組成物全量に対して0.001〜10W/V%である。また、動植物抽出物(原生薬換算量)1質量部に対して、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.00002〜0.05質量部含有することが好ましい。 The animal and plant extracts used in the present invention can be obtained by extracting animals or plants, or a part thereof, as they are or by subjecting them to, if necessary, drying, crushing, pulverizing and the like. The extraction means is not particularly limited, and a stirring / shaking / immersion extraction method using an organic solvent such as ethanol, water or a mixture thereof, a vacuum steam distillation extraction method, and a supercritical gas using a supercritical fluid such as carbon dioxide are used. A known extraction method such as an extraction method may be used. The animal / plant raw materials used for extraction are not particularly limited, but carrots, ginger, kanzo, galana, keihi, royal jelly, ryugannik, yokuinin, nikujuyou, shigoka, kukoshi, shakuyaku, clove, ginger, sansho, osei, Sanyaku, Joteishi, Seiyousanzashi, Toshishi, Chimpi, Bukuryo, Taisou, Tochu, Muirapuama, Garlic, Asenyaku, Fructus, Ginger, Saffron, Sanzashi, Fructus, Ukon, Mokko, Yakuchi, Saracia, Artichoke, Mulberry leaf, Soybean Gymnema, Aloe, Green Propolis, Broccoli, Louis Boss, Kuzunohana, White Green Bean, Euglena, Garsina Cambodia, African Mango, Black Vinegar, Placenta, Suppon, Maca, Hop, Paffia (Brazilian Ginseng), Hibiscus, Narukoyuri, Fuyubushi Natsukusa, Examples thereof include sage, sanebutonatsume, red sardine, chamomile, rosea (Iwabenkei), ume (plum extract) and black ginger, preferably carrot, ginger, kanzo, galana, keihi, royal jelly, ryugannik, yokuinin, etc. Nikujuyou, Shigoka, Kukoshi, Shakuyaku, Clove, Touki, Sansho, Ousei, Sanyaku, Joteishi, Seiyousanzashi, Toshishi, Chimpi, Bukuryo, Taisou, Tochu, Muirapuama, Ninnik. The content of the animal and plant extracts is usually 0.0001 to 20% with respect to the total amount of the oral liquid composition in terms of crude drug equivalent, but is preferably 0.001 to 10 W / with respect to the total amount of the oral liquid composition. It is V%. Further, it is preferable that ethyl-3-p-menthane-3-carboxamide acetate is contained in an amount of 0.00002 to 0.05 parts by mass with respect to 1 part by mass of the animal and plant extract (crude drug equivalent amount).
本発明においてポリフェノールとは、分子内に複数のフェノール性水酸基を有する化合物の総称であり、特に限定されないが、没食子酸プロピル、カテキン、タンニン、ルチン、ケルセチン、フェルラ酸、アントシアニン、レスベラトロール、プロシアニジン、テアフラビン、クルクミン、ピクノジェノール、ロズマリン酸、エラグ酸、キナ酸、クロロゲン酸及びヒドロキシチロソール等が挙げられ、好ましくは、没食子酸プロピル、カテキン、タンニンである。ポリフェノールの含有量は、経口液体組成物全量に対して通常0.0001〜5W/V%であるが、好ましくは、経口液体組成物全量に対して0.001〜2W/V%である。また、ポリフェノール1質量部に対して、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.0007〜1質量部含有することが好ましく、0.0007〜0.6質量部がより好ましい。 In the present invention, polyphenol is a general term for compounds having a plurality of phenolic hydroxyl groups in the molecule, and is not particularly limited, but is not particularly limited, but is propyl silicate, catechin, tannin, rutin, quercetin, ferulic acid, anthocyanin, resveratrol, procyanidin. , Teaflavin, curcumin, pycnogenol, rosmarinic acid, ellagic acid, quinic acid, chlorogenic acid, hydroxytyrosol and the like, preferably propyl caricate, catechin and tannin. The content of polyphenol is usually 0.0001 to 5 W / V% with respect to the total amount of the oral liquid composition, but preferably 0.001 to 2 W / V% with respect to the total amount of the oral liquid composition. Further, ethyl-3-p-menthane-3-carboxamide acetate is preferably contained in an amount of 0.0007 to 1 part by mass, more preferably 0.0007 to 0.6 part by mass, based on 1 part by mass of polyphenol.
本発明において、アミノ酸とは、特に限定されないが、アルギニン又はその塩、タウリン、L-アスパラギン酸又はその塩、グリシン、L-リジン又はその塩、ヒスチジン又はその塩、L-オルニチン又はその塩、L-バリン、L-ロイシン、L-イソロイシン、L-トレオニン、L-メチオニン、L-システイン、カルニチン又はその塩、シトルリン、GABA、テアニン、DL-アラニン、L-トリプトファン、シスチン、アセチルシステイン及びグルタミン等が挙げられ、好ましくは、アルギニン塩酸塩、タウリン、L-アスパラギン酸、グリシン、L-リジン塩酸塩、ヒスチジン塩酸塩、L-オルニチン塩酸塩、L-バリン、L-ロイシン、L-イソロイシン、L-トレオニン、L-メチオニン、L-システイン、塩化カルニチン、シトルリン、GABA、テアニン、DL-アラニン、L-トリプトファンである。アミノ酸の含有量は、経口液体組成物全量に対して通常0.0001〜10W/V%であるが、好ましくは、経口液体組成物全量に対して0.001〜5W/V%である。また、タウリンを除くアミノ酸1質量部に対して、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.0003〜0.5質量部含有することが好ましく、0.0006〜0.4質量部がより好ましい。タウリン1質量部に対しては、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.0001〜0.005質量部含有することが好ましい。 In the present invention, the amino acid is not particularly limited, but is arginine or a salt thereof, taurine, L-aspartic acid or a salt thereof, glycine, L-lysine or a salt thereof, histidine or a salt thereof, L-ornithine or a salt thereof, L. -Valin, L-leucine, L-isoleucine, L-threonine, L-methionine, L-cysteine, carnitine or a salt thereof, citrulin, GABA, theanine, DL-alanine, L-tryptophan, cystine, acetylcysteine, glutamine, etc. These include, preferably, arginine hydrochloride, taurine, L-aspartic acid, glycine, L-lysine hydrochloride, histidine hydrochloride, L-ornithine hydrochloride, L-valine, L-leucine, L-isoleucine, L-threonine. , L-methionine, L-cysteine, carnitine chloride, citrulin, GABA, theanine, DL-alanine, L-tryptophan. The content of amino acids is usually 0.0001 to 10 W / V% with respect to the total amount of the oral liquid composition, but is preferably 0.001 to 5 W / V% with respect to the total amount of the oral liquid composition. Further, ethyl-3-p-menthane-3-carboxamide acetate is preferably contained in an amount of 0.0003 to 0.5 parts by mass, preferably 0.0006 to 0.4 parts by mass, based on 1 part by mass of the amino acid excluding taurine. Is more preferable. It is preferable that ethyl-3-p-menthane-3-carboxamide acetate is contained in an amount of 0.0001 to 0.005 parts by mass with respect to 1 part by mass of taurine.
本発明において、ペプチド又はタンパク質とは、同種又は異種のアミノ酸がアミノ基とカルボキシル基との間で脱水縮合したものであり、特に限定されないが、コラーゲン、アンセリン、卵白ペプチド(タマゴペプチド)、ラクトフェリン、イワシペプチド、ゴマペプチド、わかめペプチド、小麦アルブミン、シルクフィブロイン、エラスチン、カゼイン加水分解物、グルタミンペプチド、乳清ペプチド、ポリグルタミン酸、ホエイプロテイン及びカルノシン等が挙げられ、好ましくは、コラーゲン及びアンセリンである。ペプチド又はタンパク質の含有量は、経口液体組成物全量に対して通常0.001〜20W/V%であるが、好ましくは、経口液体組成物全量に対して0.01〜10W/V%である。また、ペプチド又はタンパク質1質量部に対して、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.00008〜0.2質量部含有することが好ましい。 In the present invention, the peptide or protein is a dehydration-condensation of the same or different amino acids between an amino group and a carboxyl group, and is not particularly limited, but is limited to collagen, anserine, egg white peptide (tamago peptide), lactoferrin, and the like. Examples thereof include sardine peptide, sesame peptide, wakame peptide, wheat albumin, silk fibroin, elastin, casein hydrolyzate, glutamine peptide, lactate peptide, polyglutamic acid, whey protein and carnosin, and collagen and anserine are preferable. The content of the peptide or protein is usually 0.001 to 20 W / V% with respect to the total amount of the oral liquid composition, but is preferably 0.01 to 10 W / V% with respect to the total amount of the oral liquid composition. .. Further, it is preferable that ethyl-3-p-menthane-3-carboxamide acetate is contained in an amount of 0.00008 to 0.2 parts by mass with respect to 1 part by mass of the peptide or protein.
本発明において、多糖類とは加水分解によって2分子以上の単糖を生じる炭水化物の総称であり、特に限定されないが、ペクチン、コンドロイチン、ヒアルロン酸、難消化性デキストリン、ジェランガム及びアルギン酸等が挙げられ、これらは塩や誘導体であっても良い。好ましくは、ペクチン、コンドロイチン、ヒアルロン酸、難消化性デキストリン、ジェランガム及びアルギン酸である。多糖類の含有量は、経口液体組成物全量に対して通常0.001〜20W/V%であるが、好ましくは、経口液体組成物全量に対して0.01〜10W/V%である。また、多糖類1質量部に対して、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.00003〜0.1質量部含有することが好ましい。 In the present invention, polysaccharide is a general term for carbohydrates that produce two or more monosaccharides by hydrolysis, and is not particularly limited, and examples thereof include pectin, chondroitin, hyaluronic acid, indigestible dextrin, gellan gum, and alginic acid. These may be salts or derivatives. Preferred are pectin, chondroitin, hyaluronic acid, indigestible dextrin, gellan gum and alginic acid. The content of the polysaccharide is usually 0.001 to 20 W / V% with respect to the total amount of the oral liquid composition, but is preferably 0.01 to 10 W / V% with respect to the total amount of the oral liquid composition. Further, it is preferable that ethyl-3-p-menthane-3-carboxamide acetate is contained in an amount of 0.00003 to 0.1 parts by mass with respect to 1 part by mass of the polysaccharide.
本発明に用いるチオクト酸は、α−リポ酸とも呼ばれ、化学式が(R)−5−(1,2-ジチオラン−3−イル)ペンタン酸で表される化合物である。チオクト酸の含有量は、経口液体組成物全量に対して通常0.0005〜0.5W/V%であるが、好ましくは、経口液体組成物全量に対して0.001〜0.3W/V%である。また、チオクト酸1質量部に対して、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.02〜1質量部含有することが好ましい。 The thioctic acid used in the present invention is also called α-lipoic acid and is a compound having a chemical formula of (R) -5- (1,2-dithiolane-3-yl) pentanoic acid. The content of thioctic acid is usually 0.0005 to 0.5 W / V% with respect to the total amount of the oral liquid composition, but preferably 0.001 to 0.3 W / V with respect to the total amount of the oral liquid composition. %. Further, it is preferable that ethyl-3-p-menthane-3-carboxamide acetate is contained in an amount of 0.02 to 1 part by mass with respect to 1 part by mass of thioctic acid.
本発明に用いるD−リボースは、(3R,4S,5R)−5−(ヒドロキシメチル)テトラヒドロフラン−2,3,4−トリオールで表される化合物である。D−リボースの含有量は、経口液体組成物全量に対して通常0.001〜10W/V%であるが、好ましくは、経口液体組成物全量に対して0.01〜1W/V%である。また、D−リボース1質量部に対して、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.02〜0.15質量部含有することが好ましく、0.02〜0.12質量部がより好ましい。 The D-ribose used in the present invention is a compound represented by (3R, 4S, 5R) -5- (hydroxymethyl) tetrahydrofuran-2,3,4-triol. The content of D-ribose is usually 0.001 to 10 W / V% with respect to the total amount of the oral liquid composition, but is preferably 0.01 to 1 W / V% with respect to the total amount of the oral liquid composition. .. Further, it is preferable that ethyl-3-p-menthane-3-carboxamide acetate is contained in an amount of 0.02 to 0.15 parts by mass with respect to 1 part by mass of D-ribose, and 0.02 to 0.12 parts by mass is contained. More preferred.
本発明に用いるグルコサミンは、グルコースにアミノ基 (−NH2) が付いたアミノ糖であり、一般に、「関節の動きをなめらかにする」「関節の痛みを改善する」等といわれている化合物であり、グルコサミン若しくは誘導体又はそれらの塩を用いても良い。グルコサミンの含有量は、経口液体組成物全量に対して通常0.001〜10W/V%であるが、好ましくは、経口液体組成物全量に対して0.01〜5W/V%である。 Glucosamine used in the present invention is an amino sugar in which an amino group (-NH2) is attached to glucose, and is a compound generally said to "smooth joint movement" and "improve joint pain". , Glucosamine or derivatives or salts thereof may be used. The content of glucosamine is usually 0.001 to 10 W / V% with respect to the total amount of the oral liquid composition, but is preferably 0.01 to 5 W / V% with respect to the total amount of the oral liquid composition.
本発明に用いるカラメルは、砂糖及びブドウ糖等の食用炭水化物を熱処理して得られたものであり、例えば、カラメルIV等を用いることができる。カラメルの含有量は、経口液体組成物全量に対して通常0.001〜1W/V%であるが、好ましくは、経口液体組成物全量に対して0.01〜0.5W/V%である。また、カラメルIV1質量部に対して、エチル−3−p−メンタン−3−カルボキサミドアセテートは0.00005〜0.025質量部含有することが好ましく、0.00005〜0.015質量部がより好ましい。 The caramel used in the present invention is obtained by heat-treating edible carbohydrates such as sugar and glucose, and for example, caramel IV and the like can be used. The caramel content is usually 0.001 to 1 W / V% with respect to the total amount of the oral liquid composition, but is preferably 0.01 to 0.5 W / V% with respect to the total amount of the oral liquid composition. .. Further, the ethyl-3-p-menthane-3-carboxamide acetate is preferably contained in an amount of 0.00005 to 0.025 parts by mass, more preferably 0.00005 to 0.015 parts by mass with respect to 1 part by mass of caramel IV. ..
本発明の経口液体組成物には、服用性を向上させることを目的として、さらに糖類や高甘味度甘味料等の甘味剤、酸味剤を配合することが可能である。
本発明における甘味剤として、特に限定されないが、糖類には、砂糖、ブドウ糖、果糖、ブドウ糖果糖液糖、果糖ブドウ糖液糖、高果糖液糖、ソルビトール、キシリトール、エリスリトール、トレハロース、パラチノース、マルチトール、オリゴ糖、プシコース等を用いることができ、砂糖、ブドウ糖、果糖、ソルビトール、キシリトール、エリスリトールが好ましい。
The oral liquid composition of the present invention may further contain sweeteners such as sugars and high-sweetness sweeteners and acidulants for the purpose of improving ingestibility.
The sweetener in the present invention is not particularly limited, and the sugars include sugar, glucose, fructose, fructose-fructose liquid sugar, fructose-fructose liquid sugar, high fructose liquid sugar, sorbitol, xylitol, erythritol, trehalose, palatinose, martitol, and the like. Oligosaccharides, psicose and the like can be used, and sugar, glucose, fructose, sorbitol, xylitol, erythritol and the like are preferable.
本発明における甘味剤として、特に限定されないが、高甘味度甘味料には、アセスルファムカリウム、スクラロース、アスパルテーム、フェニルアラニン化合物、ネオテーム、アドバンテーム、サッカリン、ソーマチン、及びステビア抽出物等を用いることができ、アセスルファムカリウム、スクラロース、ステビア抽出物が好ましい。 The sweetener in the present invention is not particularly limited, but acesulfame potassium, sucralose, aspartame, phenylalanine compound, neotame, advantame, saccharin, thaumatin, stevia extract and the like can be used as the high sweetness sweetener. Acesulfame potassium, sucralose and stevia extracts are preferred.
本発明における酸味剤には、特に限定されないが、クエン酸、リンゴ酸、酒石酸、フマル酸、乳酸、コハク酸、アスコルビン酸、酢酸等の有機酸、塩酸、リン酸等の無機酸を用いることができ、クエン酸、リンゴ酸、酒石酸、乳酸、アスコルビン酸、リン酸が好ましい。 The acidulant in the present invention is not particularly limited, but organic acids such as citric acid, malic acid, tartaric acid, fumaric acid, lactic acid, succinic acid, ascorbic acid and acetic acid, and inorganic acids such as hydrochloric acid and phosphoric acid may be used. Citric acid, malic acid, tartaric acid, lactic acid, ascorbic acid, and phosphoric acid are preferable.
糖類の配合量は、エチル−3−p−メンタン−3−カルボキサミドアセテート1質量部に対して、通常1000〜1600000質量部であり、5000〜8000質量部であることが好ましい。高甘味度甘味料の配合量はエチル−3−p−メンタン−3−カルボキサミドアセテート1質量部に対して、通常1.5〜4500質量部であり、7.5〜22.5質量部であることが好ましい。また、酸味剤は、エチル−3−p−メンタン−3−カルボキサミドアセテート1質量部に対して、通常15〜60000質量部であり、75〜300質量部であることが好ましい。 The blending amount of the saccharide is usually 1000 to 1600000 parts by mass and preferably 5000 to 8000 parts by mass with respect to 1 part by mass of ethyl-3-p-menthane-3-carboxamide acetate. The amount of the high-sweetness sweetener blended is usually 1.5 to 4500 parts by mass and 7.5 to 22.5 parts by mass with respect to 1 part by mass of ethyl-3-p-menthane-3-carboxamide acetate. Is preferable. The acidulant is usually 15 to 60,000 parts by mass and preferably 75 to 300 parts by mass with respect to 1 part by mass of ethyl-3-p-menthane-3-carboxamide acetate.
本発明の経口液体組成物には、その他の成分として、必要に応じて、抗酸化剤、着色剤、香料、矯味剤、界面活性剤、溶解補助剤、結合剤、滑沢剤、崩壊剤、コーティング剤、懸濁化剤、乳化剤、保存剤などの添加物を本発明の効果を損なわない範囲で適宜に配合することができる。 The oral liquid composition of the present invention contains, as other components, antioxidants, colorants, fragrances, flavoring agents, surfactants, solubilizing agents, binders, lubricants, disintegrants, as required. Additives such as coating agents, suspending agents, emulsifiers and preservatives can be appropriately blended as long as the effects of the present invention are not impaired.
本発明の経口液体組成物は、常法により調製することができ、その方法は特に限定されるものではない。内服液剤の場合、通常、各成分を秤量し、適量の精製水で溶解した後、pHを所望の酸性域に調整し、さらに精製水を加えて容量調整し、必要に応じてろ過、殺菌処理を施すことにより得られる。 The oral liquid composition of the present invention can be prepared by a conventional method, and the method is not particularly limited. In the case of an internal liquid preparation, each component is usually weighed, dissolved in an appropriate amount of purified water, the pH is adjusted to a desired acidic range, and the volume is adjusted by adding purified water, and if necessary, filtration and sterilization treatment are performed. It is obtained by applying.
以下に実施例、比較例及び試験例を挙げ、本発明をさらに詳しく説明する。 Hereinafter, the present invention will be described in more detail with reference to Examples, Comparative Examples and Test Examples.
(実施例A−1)
チアミン硝酸塩10mgと、エチル−3−p−メンタン−3−カルボキサミドアセテート(Penta Manufacturing社より購入、純度99.7%)を予め2W/V%となるよう99.5%エタノールに溶解したものを精製水に溶解し、さらに精製水を加えて全量を100mLとし、ガラス瓶に充填しキャップを施して経口液体組成物を得た。
(Example A-1)
Purified by dissolving 10 mg of thiamine nitrate and ethyl-3-p-menthan-3-carboxamide acetate (purchased from Penta Manufacturing Co., Ltd., purity 99.7%) in 99.5% ethanol in advance to 2 W / V%. It was dissolved in water, and purified water was further added to make a total volume of 100 mL, which was filled in a glass bottle and capped to obtain an oral liquid composition.
以下の実施例A−2〜J−22、及び比較例A−1〜J−19も実施例A−1と同様に調製した。なお、l−メントール、N−エチル−p−メンタン−3−カルボキサミド(別名:WS−3)、2−イソプロピル−N,2,3−トリメチルブタンアミド(別名:WS−23)についても、予め2W/V%となるよう99.5%エタノールに溶解したものを使用した。
また、動植物抽出物について、ニンジンエキス130mgは原生薬換算で910mg、ショウキョウエキス1mLは原生薬換算で200mg、カンゾウエキス50mgは原生薬換算で200mg、ガラナエキス0.2mLは原生薬換算で200mg、ケイヒエキス0.2mLは原生薬換算で200mg、ローヤルゼリー抽出液0.2mLは原生薬換算で570mg、リュウガンニクエキス100mgは原生薬換算で200mg、ヨクイニンエキス0.2mLは原生薬換算で200mg、ニクジュヨウエキス60mgは原生薬換算で198mg、シゴカエキス0.8mLは原生薬換算で800mg、クコシエキス0.6mLは原生薬換算で600mg、シャクヤクエキス30mgは原生薬換算で120mg、チョウジ抽出液1200mgは原生薬換算で3636mg、トウキエキス0.2mLは原生薬換算で200mg、サンショウエキス67mgは原生薬換算で221mg、オウセイエキス0.6mLは原生薬換算で600mg、サンヤクエキス0.3mLは原生薬換算で300mg、ジョテイシエキス250mgは原生薬換算で1000mg、セイヨウサンザシ37.5mgは原生薬換算で150mg、トシシエキスは32mgは原生薬換算で291mg、チンピエキス1000mgは原生薬換算で5000mg、ブクリョウエキス17mgは原生薬換算で544mg、タイソウエキス120mgは原生薬換算で300mg、トチュウエキス300mgは原生薬換算で300mg、ムイラプアマエキス15mgは原生薬換算で300mgに相当する。ニンニク抽出物は、市販のニンニクを99.5%エタノールで抽出し、サンプル100mLあたりニンニクが400mg含まれるよう、エタノール抽出液を添加した。
The following Examples A-2 to J-22 and Comparative Examples A-1 to J-19 were also prepared in the same manner as in Example A-1. In addition, about l-menthol, N-ethyl-p-menthane-3-carboxamide (also known as WS-3), 2-isopropyl-N, 2,3-trimethylbutaneamide (also known as WS-23), 2W in advance The one dissolved in 99.5% ethanol was used so as to have / V%.
Regarding animal and plant extracts, 130 mg of carrot extract is 910 mg in terms of protozoa, 1 mL of ginger extract is 200 mg in terms of protozoa, 50 mg of kanzo extract is 200 mg in terms of protozoa, and 0.2 mL of galana extract is 200 mg in terms of protozoa. Keihi extract 0.2mL is 200mg in terms of protozoa, royal jelly extract 0.2mL is 570mg in terms of protozoa, Ryugannik extract 100mg is 200mg in terms of protozoa, Yokuinin extract 0.2mL is 200mg in terms of protozoa, Nikuju Yaw extract 60 mg is 198 mg in terms of protozoa, Shigoka extract 0.8 mL is in terms of protozoa 800 mg, Kukoshi extract 0.6 mL is in terms of protozoa 600 mg, Shakuyaku extract 30 mg is in terms of protozoa 120 mg, and Chouji extract 1200 mg is in terms of protozoa. 3636 mg, 0.2 mL of Touki extract is 200 mg in terms of protozoan, 67 mg of Sansho extract is 221 mg in terms of protozoa, 0.6 mL of Osei extract is 600 mg in terms of protozoa, and 0.3 mL of Sanyaku extract is 300 mg in terms of protozoa. Joteishi extract 250 mg is 1000 mg of protozoan, 37.5 mg of Sanzashi is 150 mg of protozoan, 32 mg of Toshishi extract is 291 mg of protozoan, 1000 mg of chimpi extract is 5000 mg of protozoan, and 17 mg of Bukuryo extract is converted to protozoa. 544 mg and 120 mg of Taisou extract correspond to 300 mg in terms of protozoa, 300 mg of Tochu extract corresponds to 300 mg in terms of protozoa, and 15 mg of muirapuama extract corresponds to 300 mg in terms of protozoa. For the garlic extract, commercially available garlic was extracted with 99.5% ethanol, and an ethanol extract was added so that 400 mg of garlic was contained in 100 mL of the sample.
(試験例1)
表1〜91に示す経口液体組成物を5〜15℃に冷却し、試験サンプルとした。得られた試験サンプルをカップに約10mL注ぎ、味のキレ、異味・異臭について専門パネル3名でブラインド評価した。表92に従い評価結果を数値化し、3名の評価結果の平均値を算出し、算出された平均値を表93の基準に従って示した。結果を表1〜91に示す。味のキレは「++」が最も良好な結果を表し、異味・異臭は「−−」が最も良好な結果を表す。
(Test Example 1)
The oral liquid compositions shown in Tables 1-91 were cooled to 5-15 ° C. and used as test samples. Approximately 10 mL of the obtained test sample was poured into a cup, and the sharpness of taste, off-flavor and off-flavor were blindly evaluated by three specialized panels. The evaluation results were quantified according to Table 92, the average value of the evaluation results of the three persons was calculated, and the calculated average value was shown according to the criteria of Table 93. The results are shown in Tables 1-91. For the sharpness of taste, "++" indicates the best result, and for the off-taste and off-flavor, "---" indicates the best result.
表1〜91から明らかなように、l−メントール、N−エチル−p−メンタン−3−カルボキサミド、2−イソプロピル−N,2,3−トリメチルブタンアミドを配合しても、該経口液体組成物の味のキレを改善することは出来なかったが、エチル−3−p−メンタン−3−カルボキサミドアセテートを配合することで、該経口液体組成物に異味・異臭を付与することなく、味のキレを改善することが出来た。また、甘味剤や酸味剤を配合した経口液体組成物においても、エチル−3−p−メンタン−3−カルボキサミドアセテートを配合することで、該経口液体組成物に異味・異臭を付与することなく味のキレを改善することが出来た。 As is clear from Tables 1 to 91, the oral liquid composition can also be blended with l-menthol, N-ethyl-p-menthane-3-carboxamide, 2-isopropyl-N, 2,3-trimethylbutaneamide. However, by blending ethyl-3-p-menthol-3-carboxamide acetate, the oral liquid composition was not given an offensive taste or odor, and the sharpness of the taste was not improved. Was able to be improved. Further, even in an oral liquid composition containing a sweetening agent or an acidulant, by adding ethyl-3-p-menthane-3-carboxamide acetate, the oral liquid composition can be tasted without giving an offensive taste or odor. I was able to improve the sharpness of.
本発明により、ビタミン類やアミノ酸といった健康成分を含有しつつ、味のキレが改善された経口液体組成物の提供を通じて、健全な食品業界の発達に寄与することが期待される。 INDUSTRIAL APPLICABILITY The present invention is expected to contribute to the development of a healthy food industry by providing an oral liquid composition having an improved sharpness of taste while containing healthy ingredients such as vitamins and amino acids.
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020152558A JP6939969B2 (en) | 2015-10-21 | 2020-09-11 | Oral liquid composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015207231 | 2015-10-21 | ||
JP2015207231 | 2015-10-21 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020152558A Division JP6939969B2 (en) | 2015-10-21 | 2020-09-11 | Oral liquid composition |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2017078059A JP2017078059A (en) | 2017-04-27 |
JP6844187B2 true JP6844187B2 (en) | 2021-03-17 |
Family
ID=58665776
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016200497A Active JP6844187B2 (en) | 2015-10-21 | 2016-10-12 | Oral liquid composition |
JP2020152558A Active JP6939969B2 (en) | 2015-10-21 | 2020-09-11 | Oral liquid composition |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020152558A Active JP6939969B2 (en) | 2015-10-21 | 2020-09-11 | Oral liquid composition |
Country Status (1)
Country | Link |
---|---|
JP (2) | JP6844187B2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6794758B2 (en) * | 2015-10-21 | 2020-12-02 | 大正製薬株式会社 | Oral liquid pharmaceutical composition |
WO2018216671A1 (en) * | 2017-05-23 | 2018-11-29 | 大正製薬株式会社 | Candy |
CN109875051A (en) * | 2018-12-27 | 2019-06-14 | 天津市上医科技有限公司 | A kind of HUIDOUBA oral liquor for treating diabetes |
JP7336970B2 (en) * | 2019-11-26 | 2023-09-01 | 株式会社ヤクルト本社 | Paffia-containing acidic food and drink |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2008530B1 (en) * | 2007-06-19 | 2011-01-19 | Symrise AG | Aroma composition for reducing or suppressing unwanted bitter and astringent impressions |
KR102153638B1 (en) * | 2013-02-13 | 2020-09-08 | 주식회사 엘지생활건강 | Composition of Flavor In Oral Care Products |
US10798961B2 (en) * | 2013-03-15 | 2020-10-13 | Altria Client Services Llc | Functional food and beverage compositions with improved taste through the use of sensates |
JP2015019658A (en) * | 2013-07-24 | 2015-02-02 | 三栄源エフ・エフ・アイ株式会社 | Gelatinous food and drink products having effect for facilitating deglutition |
JP5500664B1 (en) * | 2013-09-04 | 2014-05-21 | 長谷川香料株式会社 | Carbonic acid stimulation enhancer |
JP5575962B1 (en) * | 2013-09-06 | 2014-08-20 | 長谷川香料株式会社 | Alcohol feeling imparting agent |
JP2016141642A (en) * | 2015-01-30 | 2016-08-08 | 三栄源エフ・エフ・アイ株式会社 | Swallowing reflex promoter and adhesive paste formulation for food and drink |
ES2752575T3 (en) * | 2015-03-25 | 2020-04-06 | Takasago Perfumery Co Ltd | Derived from methyl menthol and containing refreshing agent composition |
JP6794758B2 (en) * | 2015-10-21 | 2020-12-02 | 大正製薬株式会社 | Oral liquid pharmaceutical composition |
-
2016
- 2016-10-12 JP JP2016200497A patent/JP6844187B2/en active Active
-
2020
- 2020-09-11 JP JP2020152558A patent/JP6939969B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2017078059A (en) | 2017-04-27 |
JP6939969B2 (en) | 2021-09-22 |
JP2021000111A (en) | 2021-01-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6939969B2 (en) | Oral liquid composition | |
ES2426580T3 (en) | Food that contains water | |
JP4428456B2 (en) | Collagen peptide-containing beverage and method for producing the same | |
JP6552097B2 (en) | Bitterness improving agent for food and drink, method for improving bitterness for food and drink, and composition for food and drink | |
JP5523303B2 (en) | Stabilizing composition containing high-intensity sweetener | |
JP2013169204A (en) | Sugar substitute sweetener | |
JP6756395B2 (en) | Beverage | |
CN105533618B (en) | Method for improving taste through high-sweetness sweetner of pepper extractive | |
JP6679845B2 (en) | Beverage | |
JP2017184696A (en) | Beverage composition | |
JP6466658B2 (en) | Container-packed beverage | |
WO2013062015A1 (en) | Sweet composition showing reduced bitterness of sweetener having bitter taste, method for reducing bitterness, and food, drink, drug or quasi drug having reduced bitterness | |
JP2016168013A (en) | Flavor improvement method of vinegar-containing drink, and vinegar-containing drink having improved flavor | |
JP2020000226A (en) | candy | |
JP7287446B2 (en) | candy | |
JP6234838B2 (en) | Beverage | |
JP5913395B2 (en) | Beverage | |
JP7489018B2 (en) | Drinking Composition | |
JP6528362B2 (en) | Beverage | |
JP2013252118A (en) | Beverage containing curcuma aromatica component, and method for regulating flavor by curcuma aromatica component | |
JP7350541B2 (en) | Beverage and its manufacturing method | |
JP6895762B2 (en) | A packaged hesperidin-containing beverage in which the offensive odor of hesperidin enhanced by the combined use of hesperidin and a high-intensity sweetener is suppressed. | |
JP6506985B2 (en) | Beverage | |
JP2019180337A (en) | Gingko leaf extract-containing food/beverage composition | |
JP2017200454A (en) | Acidic beverage |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20191001 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200728 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20200722 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200911 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201006 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201030 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210126 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210208 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6844187 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |