JP6821683B2 - ペットフード組成物 - Google Patents
ペットフード組成物 Download PDFInfo
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- JP6821683B2 JP6821683B2 JP2018534734A JP2018534734A JP6821683B2 JP 6821683 B2 JP6821683 B2 JP 6821683B2 JP 2018534734 A JP2018534734 A JP 2018534734A JP 2018534734 A JP2018534734 A JP 2018534734A JP 6821683 B2 JP6821683 B2 JP 6821683B2
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Description
例示的なペットフード組成物(実施例1)は、(下記)表2に記載されるように調製される。全ての量を、ペットフード組成物の総重量に基づいて、重量パーセントで示す。この組成物は、アメリカ飼料検査官協会(AAFCO)及び米国学術研究会議(NRC)によって規定される栄養基準に従って配合される。この組成物は、押出成形で製造され、乾燥され、次いで美味剤でコーティングされる。
* PA 2 = パルミトイル-アラキドノイル-グリセロホスホコリン (2)
* PA 3 = ステアロイル-アラキドノイル-グリセロホスホコリン (2)
* PA 4 = ステアロイル-アラキドノイル-グリセロホスホエタノールアミン (1)
* PA 5 = ステアロイル-アラキドノイル-グリセロホスホイノシトール (2)
第2の例示的なペットフード組成物の免疫最適化を決定するために、給餌試験を実施する。例示的なペットフード組成物(実施例2)は、下記の表8に記載されるように調製される。全ての量を、ペットフード組成物の総重量に基づいて、重量パーセントで示す。この組成物は、アメリカ飼料検査官協会(AAFCO)及び米国学術研究会議(NRC)によって規定される栄養基準に従って配合される。この組成物は、押出成形で製造され、乾燥され、次いで美味剤でコーティングされる。(下記)表8に記載される組成物を製造するのに使用される方法は、本発明の基材の生成を確実にする。
イヌに、対照食餌又は実施例2からなる食餌を、クロスオーバー試験(cross-over design)にて6週間与える。被検体は、本発明の例示的な組成物(実施例2)を摂取する前の3週間、維持食餌(maintenance diet;Hill’s Pet Nutrition、Inc.より市販のHill’s(登録商標)Science Diet(登録商標)Canine Adult)を摂取する予備給餌期(pre-feed phase)に参加した。ベースライン測定は、予備給餌期の終了時に実施される。対照食餌は、より低濃度の繊維結合ポリフェノール栄養源及び総繊維含量を含有し、繊維は主に不溶性形態である。
イヌに、対照食餌又は実施例3からなる食餌を、クロスオーバーなしで13週間連続して摂取させる。予備給餌期間はなかった。対照食餌は、試験食餌より低い濃度の繊維結合ポリフェノール栄養源を含有し、総繊維含有量が一致するが、繊維は主に不溶性の形態であった。
微生物由来のポストバイオティクスの血清濃度について、本発明の放出制御基材を含む本発明の例示的な組成物(実施例3)を与えたイヌ、及び本発明の放出制御基材を含む比較組成物を与えたイヌにて評価する。比較組成物及び実施例3を13週間与えられたイヌの血清サンプルの微生物ポリフェノール代謝産物及びそれらの第II相解毒共役体の濃度の違いについて分析する。ポリフェノールの(非)共役微生物代謝産物の相対血清濃度について、経路濃縮分析を行う。結果は、次のことを示す。すなわち、特定の食餌成分の細菌代謝産物は、比較組成物を与えられたイヌにおけるよりも、実施例3を与えられたイヌの血清において、より顕著に現れることを示している。これらの結果は、有益な薬剤、例えばポリフェノールの標的指向送達を提供する本発明の組成物の能力を更に示す。
Claims (15)
- 加水分解された動物性又は植物性タンパク質の源と、基材と、を含む、ポリフェノール源を哺乳動物の下部消化器(GI)管に送達するための放出制御ペットフード組成物であって、
前記基材は、溶解性繊維源および不溶性繊維源を含む繊維成分、並びにポリフェノール源を含み、
前記溶解性繊維源は、ビートパルプを含み、前記不溶性繊維源は、ピーカン繊維及びセルロースの組み合わせを含み、
前記ポリフェノールは、クランベリーかす、ザクロ抽出物、及び緑茶のうち1種以上を含み、
放出制御ペットフード組成物は、キブルの形態であり、
前記溶解性繊維源対前記不溶性繊維源の重量比が、1:20〜1:2である、放出制御ペットフード組成物。 - 前記溶解性繊維源対前記不溶性繊維源の重量比が、1:5〜1:3である、請求項1に記載のペットフード組成物。
- 前記溶解性繊維源は、オート麦ふすま、ソバ挽き割り、エンドウ豆ふすま、大麦、トマトかす、柑橘類パルプ、又はそれらの2つ以上の組み合わせをさらに含む、請求項1または2に記載のペットフード組成物。
- 前記不溶性繊維源は、オート麦をさらに含む、請求項1〜3のいずれかに記載のペットフード組成物。
- 前記ポリフェノール源は、食品又は植物由来である、請求項1〜4のいずれかに記載のペットフード組成物。
- 食品由来の前記ポリフェノール源は、果物又は野菜由来のポリフェノールを含む、請求項5に記載のペットフード組成物。
- 前記ポリフェノール源は、フラボノイド又はフェノール酸を含む、請求項1〜6のいずれかに記載のペットフード組成物。
- 前記ポリフェノール源は、デヒドロキシロスマリン酸、クマロイルネピトリン、ユーパフォリン、カルノソール、スクテラリン、ケンフェロール、ロスマリン酸、ロスマノール、シルシマリチン、ルテオリン、6−メトキシ−ルテオリン、7−エピロスマンノール、ケルセチン、カテキン、ヘスペリジン、シアニジン、及びこれらの2つ以上の組み合わせから選択されるポリフェノールを提供する、請求項1〜7のいずれかに記載のペットフード組成物。
- 前記加水分解された動物性又は植物性タンパク質の源は、鶏の肝臓を含む、請求項1に記載のペットフード組成物。
- 前記加水分解された動物性又は植物性タンパク質の源は、25〜45重量%の活性含有量で存在する、請求項1〜9のいずれか一項に記載のペットフード組成物。
- 高ドコサヘキサエン酸魚油を更に含む、請求項1〜10のいずれかに記載のペットフード組成物。
- 前記高ドコサヘキサエン酸魚油の前記活性含有量は、0.5〜2.5重量%である、請求項11に記載のペットフード組成物。
- ヒト以外の哺乳動物における炎症性の疾患、状態若しくは障害の症状を治療、予防、又は改善するためのペットフード組成物であって、それを必要とするヒト以外の哺乳動物に前記ペットフード組成物の有効量が投与される、請求項1〜12のいずれか一項に記載のペットフード組成物。
- 前記ペット組成物が、ヒト以外の哺乳動物の腸内ミクロフローラを有益に操作するための組成物であり、かつそれを必要とするヒト以外の哺乳動物に前記ペットフード組成物の有効量が投与される、請求項1〜12のいずれかに記載のペットフード組成物。
- 請求項1〜14のいずれかに一項に記載のペットフード組成物を形成する方法であって、
基材を押し出して、前記キブルを生成する工程と、
前記キブルに表面コーティングを施す工程と、を含む、方法。
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CA3121148A1 (en) | 2018-12-20 | 2020-06-25 | Hill's Pet Nutrition, Inc. | Pet food compositions |
WO2020150672A2 (en) * | 2019-01-18 | 2020-07-23 | Mars, Incorporated | Methods and compositions for treating intestinal dysbiosis |
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RU2706953C1 (ru) | 2019-11-21 |
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JP6821682B2 (ja) | 2021-01-27 |
WO2017117091A1 (en) | 2017-07-06 |
CN108471783A (zh) | 2018-08-31 |
BR112018012966B1 (pt) | 2022-07-12 |
CA3009191A1 (en) | 2017-07-06 |
BR112018013011A2 (pt) | 2018-12-04 |
AU2016381433B2 (en) | 2019-02-14 |
WO2017116449A1 (en) | 2017-07-06 |
CN108430230A (zh) | 2018-08-21 |
RU2018123803A (ru) | 2019-12-30 |
RU2740439C2 (ru) | 2021-01-14 |
US20190008186A1 (en) | 2019-01-10 |
EP3397069A1 (en) | 2018-11-07 |
CA3008616A1 (en) | 2017-07-06 |
EP3397068B1 (en) | 2022-09-14 |
BR112018012966A2 (pt) | 2018-12-04 |
JP2019500048A (ja) | 2019-01-10 |
US20190014796A1 (en) | 2019-01-17 |
AU2016381433A1 (en) | 2018-06-28 |
AU2015419243A1 (en) | 2018-06-28 |
MX2018007991A (es) | 2018-11-09 |
US20230067342A1 (en) | 2023-03-02 |
BR112018013011B1 (pt) | 2022-10-11 |
RU2018123803A3 (ja) | 2020-04-08 |
JP2019500047A (ja) | 2019-01-10 |
EP3397068A1 (en) | 2018-11-07 |
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