JP6813868B2

JP6813868B2 - Bio-adhesive applicator

Info

Publication number: JP6813868B2
Application number: JP2016108315A
Authority: JP
Inventors: 桑名　克之; 克之桑名; 満石月; 雄貴千田
Original assignee: Senko Medical Instrument Manufacturing Co Ltd
Current assignee: Senko Medical Instrument Manufacturing Co Ltd
Priority date: 2016-05-31
Filing date: 2016-05-31
Publication date: 2021-01-13
Anticipated expiration: 2036-05-31
Also published as: JP2017213130A

Description

本発明は、異種の成分を混合することにより生成される生体接着剤を供給するための生体接着剤のアプリケータに関する。 The present invention relates to a bioadhesive applicator for supplying a bioadhesive produced by mixing dissimilar components.

生体接着剤として、例えばフィブリン糊と呼ばれる物が普及しており手術創部の止血等に利用されている。これは、フィブリノゲンとトロンビンとが混合することによりフィブリノゲンに酵素であるトロンビンが反応してフィブリンに変化し、多数のフィブリンが重合することにより生成される。 As a bioadhesive, for example, a substance called fibrin glue is widely used and is used for hemostasis of surgical wounds and the like. This is produced by the mixing of fibrinogen and thrombin, which causes the enzyme thrombin to react with fibrinogen to change it into fibrin, and a large number of fibrins polymerize.

生体接着剤の２つの成分を患者の手術創部付近で混合させる種々の器具が開発されている。例えば、それぞれの開口部が斜め内向きに配置された２つの噴霧ノズルが設けられた分配ヘッドを有し、分配ヘッドの各噴霧ノズルに別々の薬剤をシリンジにて供給するように構成された器具が知られている（特許文献１）。また、２つのパイプ状の薬液吐出ノズルが配置され、各薬液吐出ノズルの外周から無菌ガスを噴出させる先端部を有し、先端部の各薬液吐出ノズルに薬液チューブが接続された器具も知られている（特許文献２）。その他にも関連する先行技術文献として特許文献３〜５が存在する。 Various instruments have been developed that mix the two components of the bioadhesive near the surgical wound of the patient. For example, an instrument configured to have a distribution head provided with two spray nozzles, each opening arranged diagonally inward, and to supply a separate drug to each spray nozzle of the distribution head with a syringe. Is known (Patent Document 1). Further, there is also known an instrument in which two pipe-shaped chemical discharge nozzles are arranged, a tip portion for ejecting sterile gas from the outer periphery of each chemical liquid discharge nozzle is provided, and a chemical liquid tube is connected to each chemical liquid discharge nozzle at the tip portion. (Patent Document 2). In addition, there are Patent Documents 3 to 5 as related prior art documents.

特許第４０５０３２３号公報Japanese Patent No. 40050323 特開２００１−５７９７９号公報Japanese Unexamined Patent Publication No. 2001-57979 特許第３０６１７４１号公報Japanese Patent No. 3061741 特開２００３−１２６２６８号公報Japanese Unexamined Patent Publication No. 2003-126268 特許第５００７０５６号公報Japanese Patent No. 5007056

特許文献１の器具は成型品であるので噴射ノズルの内径は金型のピン外径で決まる。金型のピンは成型時の破損を防止するために太さ及び長さに制約があり、ノズルの出口径を自由に小さくできない。また、特許文献２の器具の場合、薬液吐出ノズルがパイプ状であるのでパイプの強度を確保可能な限度でパイプの肉厚を薄くでき、ノズルの出口間距離を短くできる。しかし、出口間距離を短くした場合は薬液チューブの肉厚があるため、パイプに柔軟性がなければ薬液吐出ノズルへの薬液チューブの接続が困難である。 Since the instrument of Patent Document 1 is a molded product, the inner diameter of the injection nozzle is determined by the outer diameter of the pin of the mold. The mold pin has restrictions on its thickness and length in order to prevent damage during molding, and the outlet diameter of the nozzle cannot be freely reduced. Further, in the case of the instrument of Patent Document 2, since the chemical liquid discharge nozzle has a pipe shape, the wall thickness of the pipe can be reduced to the extent that the strength of the pipe can be secured, and the distance between the nozzle outlets can be shortened. However, when the distance between outlets is shortened, the thickness of the chemical solution tube is thick, and it is difficult to connect the chemical solution tube to the chemical solution discharge nozzle unless the pipe is flexible.

そこで、本発明は、成分吐出部の出口径の小径化が容易で、出口間距離を容易に短縮できる生体接着剤のアプリケータを提供することを目的とする。 Therefore, an object of the present invention is to provide an applicator of a bioadhesive that can easily reduce the outlet diameter of the component discharge portion and easily shorten the distance between outlets.

本発明のアプリケータは、生体接着剤を生成する複数成分（Ｌａ、Ｌｂ）を供給するために使用される生体接着剤のアプリケータ（１Ａ〜１Ｅ）であって、前記複数成分の第１成分（Ｌａ）を第１出口（５ａ）まで導く柔軟な第１軟質管（５）と、前記複数成分の第２成分（Ｌｂ）を第２出口（６ａ）まで導く柔軟な第２軟質管（６）と、前記第１軟質管及び前記第２軟質管を保持する軟質管保持部（７、１７、４０）と、前記第１軟質管、前記第２軟質管、及び前記軟質管保持部にて構成され、前記第１成分及び前記第２成分を吐出させる成分吐出部（３、２０、５０）と、を備え、前記成分吐出部は、前記第１軟質管の前記第１出口と前記第２軟質管の前記第２出口とが近接して並ぶように、前記第１軟質管及び前記第２軟質管が前記軟質管保持部にて保持されることにより構成され、前記第１軟質管及び前記第２軟質管のそれぞれは、軟質管ごとに設けられた供給管（ＴＡ、ＴＢ）を介してシリンジと接続され、前記軟質管保持部に臨む前記供給管の先端部は互いに近付くように傾斜し、前記第１軟質管及び前記第２軟質管のそれぞれの端部は、各軟質管が挿入される前記軟質管保持部の構成部材（８）から外部に引き出されて前記供給管の前記先端部に向かうように曲げられた上で前記供給管と接続されているものである。 The applicator of the present invention is a bioadhesive applicator (1A to 1E) used to supply a plurality of components (La, Lb) for producing a bioadhesive, and is a first component of the plurality of components. A flexible first soft pipe (5) that guides (La) to the first outlet (5a) and a flexible second soft pipe (6) that guides the second component (Lb) of the plurality of components to the second outlet (6a). ), The soft pipe holding portion (7, 17, 40) that holds the first soft pipe and the second soft pipe, and the first soft pipe, the second soft pipe, and the soft pipe holding portion. It is configured and includes a component discharge section (3, 20, 50) for discharging the first component and the second component, and the component discharge section includes the first outlet of the first soft pipe and the second outlet. The first soft pipe and the second soft pipe are held by the soft pipe holding portion so that the second outlet of the soft pipe is lined up in close proximity to the first soft pipe and the second soft pipe. Each of the second soft pipes is connected to a syringe via a supply pipe (TA, TB) provided for each soft pipe, and the tip of the supply pipe facing the soft pipe holding portion is inclined so as to approach each other. the respective ends of the first flexible tube and said second flexible tube, the distal end portion of the supply pipe from the component of the soft tube holder in which each flexible tube is inserted (8) is drawn out It is connected to the supply pipe after being bent toward .

このアプリケータによれば、柔軟な２つの軟質管とこれらの軟質管を各出口が近接するように保持する軟質管保持部とによって成分吐出部が構成されていて、各軟質管が生体接着剤の各成分を導く機能と各成分を吐出する機能とを兼備する。各軟質管はそれらの口径を自由に選択できるし、各軟質管は容易に曲げることができるので、各軟質管に接続される例えば供給管の肉厚を考慮して各軟質管の出口間距離を確保する必要がない。したがって、各軟質管を適宜選択することにより、各成分が適切な混合状態となるように成分吐出部における出口径を容易に小径化でき、かつ出口間距離を容易に短縮できる。 According to this applicator, a component discharge part is composed of two flexible soft tubes and a soft tube holding part that holds these soft tubes so that their outlets are close to each other, and each soft tube is a bioadhesive. It has both the function of guiding each component and the function of discharging each component. Since each soft pipe can freely select their diameter and each soft pipe can be easily bent, the distance between the outlets of each soft pipe is taken into consideration, for example, considering the wall thickness of the supply pipe connected to each soft pipe. There is no need to secure. Therefore, by appropriately selecting each soft tube, the outlet diameter in the component discharge portion can be easily reduced so that each component is in an appropriate mixed state, and the distance between outlets can be easily shortened.

本発明のアプリケータの一態様において、前記軟質管保持部は、前記第１軟質管及び前記第２軟質管を平行に保持する直線区間（Ｓ１）と、前記直線区間に続いていて前記第１軟質管及び前記第２軟質管を同一方向に曲げた状態に保持する曲線区間（Ｓ２）とを有し、前記成分吐出部は、前記曲線区間の終端に設けられていてもよい。生体接着剤のアプリケータは、手術創部を内視鏡で観察しながら使用されることが多い。この態様によれば、曲線区間の終端に成分吐出部が設けられているので、内視鏡を使用しながらアプリケータを使用した場合に成分吐出部で内視鏡の視界が遮られ難くなるためアプリケータの使い勝手が向上する。 In one aspect of the applicator of the present invention, the soft tube holding portion has a straight section (S1) for holding the first soft tube and the second soft tube in parallel, and the first straight section following the straight section. It has a soft pipe and a curved section (S2) that holds the second soft pipe in a bent state in the same direction, and the component discharge portion may be provided at the end of the curved section. Bioadhesive applicators are often used while observing the surgical wound with an endoscope. According to this aspect, since the component discharge portion is provided at the end of the curved section, the view of the endoscope is less likely to be obstructed by the component discharge portion when the applicator is used while using the endoscope. The usability of the applicator is improved.

各軟質管の内径や肉厚は対象となる生体接着剤や使用箇所などを考慮して適宜に設定できる。例えば、本発明のアプリケータの一態様において、前記第１軟質管及び前記第２軟質管は、内径が０．３ｍｍ〜１．０ｍｍで、かつ肉厚が３０μｍ〜０．５ｍｍであってもよい。 The inner diameter and wall thickness of each soft tube can be appropriately set in consideration of the target bioadhesive and the place of use. For example, in one aspect of the applicator of the present invention, the first soft tube and the second soft tube may have an inner diameter of 0.3 mm to 1.0 mm and a wall thickness of 30 μm to 0.5 mm. ..

本発明のアプリケータの一態様は、前記成分吐出部に所定のガスを導くガス供給手段（２７、３３、４７、４８）を更に備えてもよい。ガス供給手段によって成分吐出部にガスを導くことにより、成分吐出部の周囲で生成された生体接着剤や成分吐出部の周囲に残った各成分等の付着物を除去できる。これにより、付着物が残って出口を塞いで吐出不能になったり、各成分の吐出量や方向が変化する吐出不良が発生したりして、各成分の混合状態が悪化する等の諸問題を回避できる。なおガス供給手段が導くガスとして、例えば除菌フィルタを通過した空気を採用できる。 One aspect of the applicator of the present invention may further include gas supply means (27, 33, 47, 48) for guiding a predetermined gas to the component discharge portion. By guiding the gas to the component discharge section by the gas supply means, it is possible to remove the bioadhesive generated around the component discharge section and the deposits of each component remaining around the component discharge section. As a result, there are various problems such as the residue remaining and blocking the outlet, making it impossible to discharge, or causing a discharge failure in which the discharge amount and direction of each component change, resulting in deterioration of the mixed state of each component. It can be avoided. As the gas guided by the gas supply means, for example, air that has passed through a sterilization filter can be adopted.

この態様においては、ガス供給手段がガスを導く態様に制限はない。例えば、前記ガス供給手段として、前記軟質管保持部の外周に設けられていて前記ガスを前記成分吐出部に導くことが可能なガス流路（２７）が設けられていてもよいし、前記第１出口と前記第２出口との間で開口するように前記軟質管保持部に設けられていて前記ガスを前記成分吐出部に導くことが可能な中間流路（４７）が設けられていてもよい。 In this embodiment, there is no limitation on the mode in which the gas supply means guides the gas. For example, the gas supply means may be provided with a gas flow path (27) provided on the outer periphery of the soft pipe holding portion and capable of guiding the gas to the component discharge portion, or the first. Even if the soft pipe holding portion is provided so as to open between the 1 outlet and the 2nd outlet and an intermediate flow path (47) capable of guiding the gas to the component discharge portion is provided. Good.

なお、以上の説明では本発明の理解を容易にするために添付図面の参照符号を括弧書きにて付記したが、それにより本発明が図示の形態に限定されるものではない。 In the above description, reference numerals of the accompanying drawings are added in parentheses to facilitate understanding of the present invention, but the present invention is not limited to the illustrated form.

以上説明したように、本発明のアプリケータによれば、各軟質管が生体接着剤の各成分を導く機能と各成分を吐出する機能とを兼備するので、各軟質管を適宜選択することにより成分吐出部の出口径を容易に小径化でき、かつ出口間距離を容易に短縮できる。 As described above, according to the applicator of the present invention, each soft tube has a function of guiding each component of the bioadhesive and a function of discharging each component. Therefore, by appropriately selecting each soft tube, The outlet diameter of the component discharge portion can be easily reduced, and the distance between outlets can be easily shortened.

本発明の第１の形態に係るアプリケータを示した図。The figure which showed the applicator which concerns on 1st Embodiment of this invention. 図１の矢印II方向から見た状態を示した図。The figure which showed the state seen from the direction of arrow II of FIG. 図１の矢印III方向から見た状態を示した図。The figure which showed the state seen from the direction of arrow III of FIG. 軟質管保持部を示した図。The figure which showed the soft tube holding part. 本発明の第２の形態に係るアプリケータを示した図。The figure which showed the applicator which concerns on the 2nd embodiment of this invention. 図５の矢印VI方向から見た状態を示した図。The figure which showed the state seen from the arrow VI direction of FIG. 図６の矢印VII方向から見た状態を示した図。The figure which showed the state seen from the direction of arrow VII of FIG. 本発明の第３の形態のアプリケータを示した図。The figure which showed the applicator of the 3rd form of this invention. 図８の矢印IX方向から見た状態を示した図。The figure which showed the state seen from the arrow IX direction of FIG. 本発明の第４の形態のアプリケータを示した図。The figure which showed the applicator of the 4th form of this invention. 図１０の矢印XI方向から見た状態を示した図。The figure which showed the state seen from the arrow XI direction of FIG. 本発明の第５の形態のアプリケータを示した図。The figure which showed the applicator of the 5th form of this invention. 図１２の矢印XIII方向から見た状態を示した図。The figure which showed the state seen from the direction of the arrow XIII of FIG. 第５の形態に係る軟質管保持部を示した図。The figure which showed the soft tube holding part which concerns on 5th form.

（第１の形態）
図１〜図３に示したアプリケータ１Ａは生体接着剤を生成する複数成分としてのＡ液Ｌａ及びＢ液Ｌｂを供給するために使用される。例えば、生体接着剤の第１成分であるＡ液Ｌａはフィブリノゲンであり、第２成分であるＢ液Ｌｂはトロンビンである。Ａ液Ｌａ及びＢ液Ｌｂは不図示のシリンジに接続されたＡ液供給管ＴＡとＢ液供給管ＴＢとを介してアプリケータ１Ａに供給される。アプリケータ１Ａは各液Ｌａ、Ｌｂを吐出させる成分吐出部３を備えている。成分吐出部３は第１軟質管５、第２軟質管６及びこれらを保持する軟質管保持部７にて構成される。 (First form)
The applicator 1A shown in FIGS. 1 to 3 is used to supply liquid A La and liquid B Lb as a plurality of components for producing a bioadhesive. For example, liquid A La, which is the first component of the bioadhesive, is fibrinogen, and liquid B Lb, which is the second component, is thrombin. The liquid A La and the liquid B Lb are supplied to the applicator 1A via the liquid A supply pipe TA and the liquid B supply pipe TB connected to a syringe (not shown). The applicator 1A includes a component discharge unit 3 for discharging each of the liquids La and Lb. The component discharge section 3 is composed of a first soft tube 5, a second soft tube 6, and a soft tube holding section 7 that holds them.

第１軟質管５はＡ液Ｌａを第１出口５ａまで導く柔軟な管であり、第２軟質管６はＢ液Ｌｂを第２出口６ａまで導く柔軟な管である。各軟質管５、６の素材は適宜に選択される。例えば、ＰＥＴ等のポリエステル、ＰＰ等のポリオレフィン、ＰＣ、ＰＶＣ（可塑剤入りを含む）、ポリウレタン等の合成樹脂材料が各軟質管５、６の素材として好適である。各軟質管５、６は、内径が０．３ｍｍ〜１．０ｍｍの範囲内で、肉厚が３０μｍ〜０．５ｍｍの範囲内でそれぞれ形成されている。 The first soft pipe 5 is a flexible pipe that guides the liquid A La to the first outlet 5a, and the second soft pipe 6 is a flexible pipe that guides the liquid B Lb to the second outlet 6a. The material of each of the soft tubes 5 and 6 is appropriately selected. For example, polyesters such as PET, polyolefins such as PP, PCs, PVCs (including those containing a plasticizer), and synthetic resin materials such as polyurethane are suitable as materials for the soft tubes 5 and 6. Each of the soft tubes 5 and 6 is formed with an inner diameter in the range of 0.3 mm to 1.0 mm and a wall thickness in the range of 30 μm to 0.5 mm.

図２及び図４に示すように、軟質管保持部７は、例えばプラスチックを素材とし、かつ左右対称に形成された一対の半割状部材８が組み合わされることにより構成される。各半割状部材８には各軟質管５、６の外径に適合しかつ直線的に延びる半円状の保持溝８ａ、８ｂが形成されている。図４に示すように、各保持溝８ａ、８ｂにて各軟質管５、６を保持した状態で各半割状部材８が互いに組み合わされて接合される。図２に示すように、軟質管保持部７は、第１軟質管５の第１出口５ａと、第２軟質管６の第２出口６ａとが近接して並ぶように各軟質管５、６を保持することにより成分吐出部３が構成される。成分吐出部３における各軟質管５、６の出口間距離は、成分吐出部３からＡ液Ｌａ及びＢ液Ｌｂが吐出した場合において、これらの液Ｌａ、Ｌｂが十分に良好な硬化に至る混合状態となるように各軟質管５、６の内径及び肉厚を考慮して適宜に設定されている。 As shown in FIGS. 2 and 4, the soft tube holding portion 7 is formed by combining, for example, a pair of half-split members 8 made of plastic and formed symmetrically. Each semicircular member 8 is formed with semicircular holding grooves 8a and 8b that are compatible with the outer diameters of the soft tubes 5 and 6 and extend linearly. As shown in FIG. 4, the half-split members 8 are combined and joined to each other while the soft pipes 5 and 6 are held by the holding grooves 8a and 8b. As shown in FIG. 2, the soft pipe holding portion 7 has the soft pipes 5 and 6 so that the first outlet 5a of the first soft pipe 5 and the second outlet 6a of the second soft pipe 6 are lined up in close proximity to each other. The component discharge unit 3 is configured by holding the above. The distance between the outlets of the soft pipes 5 and 6 in the component discharge unit 3 is a mixture in which the liquids La and Lb are sufficiently cured when the liquid A La and the liquid B Lb are discharged from the component discharge unit 3. It is appropriately set in consideration of the inner diameter and the wall thickness of each of the soft pipes 5 and 6 so as to be in a state.

図１及び図３に示すように、本形態の場合、成分吐出部３には各軟質管５、６及び軟質管保持部７の長手方向と同一方向に向いた平面状の吐出面１２が形成されていて、各軟質管５、６の各出口５ａ、６ａの開口部は吐出面１２内で一致している（図２も参照）。成分吐出部３の互いに近接する各出口５ａ、６ａからＡ液Ｌａ及びＢ液Ｌｂが吐出されると各液Ｌａ、Ｌｂは混合状態となり生体接着剤が生成される。 As shown in FIGS. 1 and 3, in the case of this embodiment, the component discharge portion 3 is formed with a flat discharge surface 12 facing in the same direction as the longitudinal direction of the soft pipes 5 and 6 and the soft pipe holding portion 7. The openings of the outlets 5a and 6a of the soft pipes 5 and 6 coincide with each other in the discharge surface 12 (see also FIG. 2). When the liquid A La and the liquid B Lb are discharged from the outlets 5a and 6a of the component discharge unit 3 adjacent to each other, the liquids La and Lb are in a mixed state and a bioadhesive is generated.

本形態のアプリケータ１Ａによれば、柔軟な２つの軟質管５、６と、これらの各出口５ａ、６ａが近接するように保持する軟質管保持部７とによって成分吐出部３が構成されていて、各軟質管５、６が生体接着剤の各液Ｌａ、Ｌｂを導く機能と各液Ｌａ、Ｌｂを吐出する機能とを兼備する。各軟質管５、６はそれらの内径を自由に選択できるし、容易に曲げることもできる。したがって、図１に示すように、Ａ液Ｌａ及びＢ液Ｌｂを供給する各供給管ＴＡ、ＴＢを、それらの肉厚を考慮せずに各軟質管５、６に接続できる。そのため、各軟質管５、６の出口間距離を各液Ｌａ、Ｌｂの混合状態が適切になるように自由に設定できる。 According to the applicator 1A of the present embodiment, the component discharge portion 3 is composed of two flexible soft pipes 5 and 6 and a soft pipe holding portion 7 that holds the outlets 5a and 6a so as to be close to each other. Each of the soft tubes 5 and 6 has a function of guiding each liquid La and Lb of the bioadhesive and a function of discharging each liquid La and Lb. The inner diameters of the soft tubes 5 and 6 can be freely selected and can be easily bent. Therefore, as shown in FIG. 1, the supply pipes TA and TB for supplying the liquid A La and the liquid B Lb can be connected to the soft pipes 5 and 6 without considering their wall thickness. Therefore, the distance between the outlets of the soft tubes 5 and 6 can be freely set so that the mixed state of the liquids La and Lb is appropriate.

（第２の形態）
次に、図５〜図７を参照しながら、本発明の第２の形態を説明する。アプリケータ１Ｂは軟質管保持部１７の構成を除いて第１の形態のアプリケータ１Ａと共通する。以下、第１の形態と共通する構成には同一の参照符号を付して説明を省略する。 (Second form)
Next, the second embodiment of the present invention will be described with reference to FIGS. 5 to 7. The applicator 1B is common to the applicator 1A of the first form except for the configuration of the soft tube holding portion 17. Hereinafter, the same reference numerals will be given to the configurations common to the first embodiment, and the description thereof will be omitted.

図６に示すように、アプリケータ１Ｂの軟質管保持部１７は各軟質管６、５を平行に保持する直線区間Ｓ１と、直線区間Ｓ１に続いていて各軟質管５、６を同一方向に曲げた状態に保持する曲線区間Ｓ２とを有している。軟質保持部１７もまた左右対称の一対の半割状部材１８が組み合わされることにより構成されている。各半割状部材１８には一部が直線状に延びていて残りが曲線状に延びる半円状の保持溝１８ａ、１８ｂが形成されている。曲線区間Ｓ２の終端には成分吐出部２０が設けられている。そのため、成分吐出部２０の吐出面２１は、各軟質管５、６及び軟質管保持部１７の長手方向に対して４５度程度の傾斜角θで傾いている。本形態においては、軟質管保持部１７の外径の範囲内で曲がっているので、径方向の拡大を伴わずに吐出面２１を長手方向に対して曲げることができる。 As shown in FIG. 6, the soft pipe holding portion 17 of the applicator 1B has a straight section S1 that holds the soft pipes 6 and 5 in parallel, and a straight section S1 that is followed by the soft pipes 5 and 6 in the same direction. It has a curved section S2 that is held in a bent state. The soft holding portion 17 is also configured by combining a pair of symmetrical half-split members 18. Each semicircular member 18 is formed with semicircular holding grooves 18a and 18b, one of which extends linearly and the other of which extends in a curved shape. A component discharge unit 20 is provided at the end of the curved section S2. Therefore, the discharge surface 21 of the component discharge portion 20 is tilted at an inclination angle θ of about 45 degrees with respect to the longitudinal direction of each of the soft pipes 5 and 6 and the soft pipe holding portion 17. In this embodiment, since the soft pipe holding portion 17 is bent within the range of the outer diameter, the discharge surface 21 can be bent in the longitudinal direction without expanding in the radial direction.

アプリケータ１Ｂによれば、第１の形態と同様の効果を得ることができる。更に、曲線区間Ｓ２の終端に成分吐出部２０が設けられているので、内視鏡を使用しながらアプリケータ１Ｂを使用した場合に成分吐出部２０で内視鏡の視界が遮られ難くなるためアプリケータ１Ｂの使い勝手が向上する。 According to the applicator 1B, the same effect as that of the first embodiment can be obtained. Further, since the component discharge unit 20 is provided at the end of the curved section S2, when the applicator 1B is used while using the endoscope, the component discharge unit 20 does not easily block the field of view of the endoscope. The usability of the applicator 1B is improved.

（第３の形態）
次に、図８及び図９を参照しながら、本発明の第３の形態を説明する。第３の形態のアプリケータ１Ｃは第１の形態のアプリケータ１Ａの改良に相当し、所定のガスとしての除菌フィルタを通過した空気を成分吐出部３に供給する機能が付与されている。以下、第１の形態と共通する構成には同一の参照符号を付して説明を省略する。 (Third form)
Next, a third embodiment of the present invention will be described with reference to FIGS. 8 and 9. The applicator 1C of the third form corresponds to an improvement of the applicator 1A of the first form, and is provided with a function of supplying air that has passed through a sterilization filter as a predetermined gas to the component discharge unit 3. Hereinafter, the same reference numerals will be given to the configurations common to the first embodiment, and the description thereof will be omitted.

アプリケータ１Ｃは各軟質管５、６を保持する軟質管保持部７の外周を囲むスリーブ２５と、スリーブ２５を軟質管保持部７に対して固定する４つの支持部２６とを備えている。これにより、スリーブ２５の内周と軟質管保持部７の外周との間にガス供給手段としてのガス流路２７が形成される。ガス流路２７には、不図示のガス供給源から所定のガスとしての除菌フィルタを通過した空気Ａｒが供給される。 The applicator 1C includes a sleeve 25 that surrounds the outer circumference of the soft pipe holding portion 7 that holds the soft pipes 5 and 6, and four support portions 26 that fix the sleeve 25 to the soft pipe holding portion 7. As a result, a gas flow path 27 as a gas supply means is formed between the inner circumference of the sleeve 25 and the outer circumference of the soft pipe holding portion 7. Air Ar that has passed through a sterilization filter as a predetermined gas is supplied to the gas flow path 27 from a gas supply source (not shown).

アプリケータ１Ｃによれば、第１の形態と同様の効果を得ることができる。更に、ガス流路２７によって成分吐出部３に空気を導くことができるので、成分吐出部３の周囲で生成された生体接着剤や成分吐出部３の周囲に残った各液Ｌａ、Ｌｂ等の付着物を除去できる。これにより、付着物が残って各軟質管５、６の各出口５ａ、６ａを塞いで吐出不能になったり、各液Ｌａ、Ｌｂの吐出量や方向が変化する吐出不良が発生したりして、各液Ｌａ、Ｌｂの混合状態が悪化する等の諸問題を回避できる。 According to the applicator 1C, the same effect as that of the first embodiment can be obtained. Further, since air can be guided to the component discharge unit 3 by the gas flow path 27, the bioadhesive generated around the component discharge unit 3 and the liquids La, Lb, etc. remaining around the component discharge unit 3 can be used. Adhesives can be removed. As a result, deposits may remain and block the outlets 5a and 6a of the soft tubes 5 and 6 to make it impossible to discharge, or discharge defects that change the discharge amount and direction of each liquid La and Lb may occur. , Problems such as deterioration of the mixed state of each liquid La and Lb can be avoided.

（第４の形態）
次に、図１０及び図１１を参照しながら、本発明の第４の形態を説明する。第４の形態のアプリケータ１Ｄは第３の形態のアプリケータ１Ｃの変形例に相当し、ガス供給手段の形態が異なる。以下、第１の形態と共通する構成には同一の参照符号を付して説明を省略する。 (Fourth form)
Next, a fourth embodiment of the present invention will be described with reference to FIGS. 10 and 11. The applicator 1D of the fourth form corresponds to a modification of the applicator 1C of the third form, and the form of the gas supply means is different. Hereinafter, the same reference numerals will be given to the configurations common to the first embodiment, and the description thereof will be omitted.

アプリケータ１Ｄは各軟質管５、６を保持する軟質管保持部７の外周を囲み、かつ成分吐出部３の側で一部が開口し残りが閉鎖されているスリーブ３０と、スリーブ３０を軟質管保持部７に対して固定する４つの支持部３１とを備えている。これにより、スリーブ３０の内周と軟質管保持部７の外周との間にガス供給手段としてのガス流路３３が形成される。ガス流路３３はスリーブ３０の開口部３０ａにて開口する。ガス流路３３には不図示のガス供給源から所定のガスとしての除菌フィルタを通過した空気Ａｒが供給される。ガス流路３３から流出した空気Ａｒは吐出面１２と平行な方向に延びるフラップ３０ｂにて吐出面１２に沿う方向に誘導される（図１０参照）。 The applicator 1D surrounds the outer circumference of the soft pipe holding portion 7 that holds the soft pipes 5 and 6, and softens the sleeve 30 and the sleeve 30 in which a part is opened on the side of the component discharging portion 3 and the rest is closed. It is provided with four support portions 31 that are fixed to the pipe holding portion 7. As a result, a gas flow path 33 as a gas supply means is formed between the inner circumference of the sleeve 30 and the outer circumference of the soft pipe holding portion 7. The gas flow path 33 opens at the opening 30a of the sleeve 30. Air Ar that has passed through a sterilization filter as a predetermined gas is supplied to the gas flow path 33 from a gas supply source (not shown). The air Ar flowing out of the gas flow path 33 is guided in the direction along the discharge surface 12 by the flap 30b extending in the direction parallel to the discharge surface 12 (see FIG. 10).

アプリケータ１Ｄによれば、第１の形態と同様の効果を得ることができ、更にガス流路３３によって成分吐出部３に空気を導くことができるので第３の形態と同一の効果を得ることができる。 According to the applicator 1D, the same effect as that of the first embodiment can be obtained, and since air can be guided to the component discharge portion 3 by the gas flow path 33, the same effect as that of the third embodiment can be obtained. Can be done.

（第５の形態）
次に、図１２〜図１４を参照しながら、本発明の第５の形態を説明する。第５の形態のアプリケータ１Ｅは第３の形態の改良に相当する。以下、第１の形態と共通する構成には同一の参照符号を付して説明を省略する。 (Fifth form)
Next, a fifth embodiment of the present invention will be described with reference to FIGS. 12 to 14. The applicator 1E of the fifth form corresponds to the improvement of the third form. Hereinafter, the same reference numerals will be given to the configurations common to the first embodiment, and the description thereof will be omitted.

アプリケータ１Ｅは、各軟質管５、６を保持する軟質管保持部４０と、軟質管保持部４０の外周を囲むスリーブ４１と、スリーブ４１を軟質管保持部４０に対して固定する４つの支持部４２とを備えている。図１４にも示すように、軟質保持部４０は第１の形態と同様に左右対称の一対の半割部材４５が組み合わせて構成されている。各半割部材４５には各軟質管５、６を保持する保持溝４５ａ、４５ｂが形成されている。各保持溝４５ａ、４５ｂの間には長手方向に延びる欠落部４６が設けられ、これらの欠落部４６によって一対の半割部材４５が組み合わされた時に長手方向に延びる隙間が生じる。これにより、図１３に示すように、各軟質管５、６と欠落部４６とによって第１出口５ａと第２出口６ａとの間に開口するガス供給手段としての中間流路４７が形成され、第１出口５ａ、第２出口６ａ及び中間流路４７が成分吐出部５０の吐出面５１で開口する。また、第３の形態と同様に、スリーブ４１の内周と軟質管保持部４０の外周との間にガス流路４８が形成される。中間流路４７及びガス流路４８には不図示のガス供給源から所定のガスとしての除菌フィルタを通過した空気Ａｒが供給される。 The applicator 1E has a soft pipe holding portion 40 that holds the soft pipes 5 and 6, a sleeve 41 that surrounds the outer circumference of the soft pipe holding portion 40, and four supports that fix the sleeve 41 to the soft pipe holding portion 40. It is provided with a unit 42. As shown in FIG. 14, the soft holding portion 40 is formed by combining a pair of symmetrical half-split members 45 as in the first embodiment. Holding grooves 45a and 45b for holding the soft pipes 5 and 6 are formed in each half member 45. A missing portion 46 extending in the longitudinal direction is provided between the holding grooves 45a and 45b, and a gap extending in the longitudinal direction is created by these missing portions 46 when the pair of half-split members 45 are combined. As a result, as shown in FIG. 13, an intermediate flow path 47 as a gas supply means opened between the first outlet 5a and the second outlet 6a is formed by the soft pipes 5 and 6 and the missing portion 46. The first outlet 5a, the second outlet 6a, and the intermediate flow path 47 open at the discharge surface 51 of the component discharge portion 50. Further, as in the third embodiment, the gas flow path 48 is formed between the inner circumference of the sleeve 41 and the outer circumference of the soft pipe holding portion 40. Air Ar that has passed through a sterilization filter as a predetermined gas is supplied to the intermediate flow path 47 and the gas flow path 48 from a gas supply source (not shown).

アプリケータ１Ｅによれば、第１の形態及び第３の形態と同様の効果を得ることができ、更に中間流路４７によって、互いに近接する各出口５ａ、６ａの間に空気を導くことができるので付着物をより確実に除去することが可能となる。 According to the applicator 1E, the same effect as that of the first form and the third form can be obtained, and air can be guided between the outlets 5a and 6a adjacent to each other by the intermediate flow path 47. Therefore, it is possible to remove the deposits more reliably.

本発明は上記各形態に限定されず、種々の形態にて実施できる。上記各形態の軟質管は合成樹脂製であるが柔軟な素材であれば必ずしも合成樹脂製でなくてもよく、例えば合成ゴムやその他の柔軟な素材を採用することもできる。軟質管保持部の構成にも制限はなく一対の半割部材による構成は一例にすぎない。例えば、各軟質管を挿入可能な貫通孔が形成された部材によって軟質管保持部を構成することも可能である。 The present invention is not limited to each of the above forms, and can be carried out in various forms. The soft tube of each of the above forms is made of synthetic resin, but it does not necessarily have to be made of synthetic resin as long as it is a flexible material, and for example, synthetic rubber or other flexible material can be adopted. There are no restrictions on the configuration of the soft pipe holding portion, and the configuration of a pair of half-split members is only an example. For example, it is also possible to form the soft pipe holding portion by a member having a through hole into which each soft pipe can be inserted.

第３〜第５の各形態は、第１の形態のように曲線区間を含まないアプリケータにガス供給手段を加えたものであるが、第２の形態のように曲線区間を含むアプリケータに適用するように変更することも可能である。 Each of the third to fifth forms is an applicator that does not include a curved section as in the first form, to which a gas supply means is added, but the applicator that includes a curved section as in the second form. It can be changed to apply.

１Ａ〜１Ｅアプリケータ
３、２０、５０成分吐出部
５第１軟質管
５ａ第１出口
６第２軟質管
６ａ第２出口
７、１７、４０軟質管保持部
２７ガス流路（ガス供給手段）
４７中間流路（ガス供給手段）
Ｓ１直線区間
Ｓ２曲線区間 1A to 1E Applicator 3, 20, 50 Component discharge part 5 First soft pipe 5a First outlet 6 Second soft pipe 6a Second outlet 7, 17, 40 Soft pipe holding part 27 Gas flow path (gas supply means)
47 Intermediate flow path (gas supply means)
S1 straight section S2 curved section

Claims

生体接着剤を生成する複数成分を供給するために使用される生体接着剤のアプリケータであって、
前記複数成分の第１成分を第１出口まで導く柔軟な第１軟質管と、
前記複数成分の第２成分を第２出口まで導く柔軟な第２軟質管と、
前記第１軟質管及び前記第２軟質管を保持する軟質管保持部と、
前記第１軟質管、前記第２軟質管、及び前記軟質管保持部にて構成され、前記第１成分及び前記第２成分を吐出させる成分吐出部と、を備え、
前記成分吐出部は、前記第１軟質管の前記第１出口と前記第２軟質管の前記第２出口とが近接して並ぶように、前記第１軟質管及び前記第２軟質管が前記軟質管保持部にて保持されることにより構成され、
前記第１軟質管及び前記第２軟質管のそれぞれは、軟質管ごとに設けられた供給管を介してシリンジと接続され、
前記軟質管保持部に臨む前記供給管の先端部は互いに近付くように傾斜し、
前記第１軟質管及び前記第２軟質管のそれぞれの端部は、各軟質管が挿入される前記軟質管保持部の構成部材から外部に引き出されて前記供給管の前記先端部に向かうように曲げられた上で前記供給管と接続されている生体接着剤のアプリケータ。 A bioadhesive applicator used to supply multiple components that produce bioadhesives.
A flexible first soft tube that guides the first component of the plurality of components to the first outlet,
A flexible second soft tube that guides the second component of the plurality of components to the second outlet,
A soft pipe holding portion for holding the first soft pipe and the second soft pipe,
It is composed of the first soft pipe, the second soft pipe, and the soft pipe holding portion, and includes a component discharging portion for discharging the first component and the second component.
In the component discharge portion, the first soft pipe and the second soft pipe are said to be soft so that the first outlet of the first soft pipe and the second outlet of the second soft pipe are lined up in close proximity to each other. It is configured by being held by the pipe holding part,
Each of the first soft tube and the second soft tube is connected to the syringe via a supply tube provided for each soft tube .
The tips of the supply pipes facing the soft pipe holding portion are inclined so as to approach each other.
Each end of the first soft pipe and the second soft pipe is pulled out from the constituent member of the soft pipe holding portion into which each soft pipe is inserted so as to be directed toward the tip of the supply pipe. A bioadhesive applicator that is bent and then connected to the supply tube.

前記軟質管保持部は、前記第１軟質管及び前記第２軟質管を平行に保持する直線区間と、前記直線区間に続いていて前記第１軟質管及び前記第２軟質管を同一方向に曲げた状態に保持する曲線区間とを有し、
前記成分吐出部は、前記曲線区間の終端に設けられている請求項１に記載のアプリケータ。 The soft pipe holding portion bends the first soft pipe and the second soft pipe in the same direction following the straight section and the straight section for holding the first soft pipe and the second soft pipe in parallel. It has a curved section that holds it in a closed state
The applicator according to claim 1, wherein the component discharge unit is provided at the end of the curved section.

前記第１軟質管及び前記第２軟質管は、内径が０．３ｍｍ〜１．０ｍｍで、かつ肉厚が３０μｍ〜０．５ｍｍである請求項１又は２に記載のアプリケータ。 The applicator according to claim 1 or 2, wherein the first soft tube and the second soft tube have an inner diameter of 0.3 mm to 1.0 mm and a wall thickness of 30 μm to 0.5 mm.

前記成分吐出部に所定のガスを導くガス供給手段を更に備える請求項１〜３のいずれか一項に記載のアプリケータ。 The applicator according to any one of claims 1 to 3, further comprising a gas supply means for guiding a predetermined gas to the component discharge unit.

前記ガス供給手段として、前記軟質管保持部の外周に設けられていて前記ガスを前記成分吐出部に導くことが可能なガス流路が設けられている請求項４に記載のアプリケータ。 The applicator according to claim 4, wherein as the gas supply means, a gas flow path provided on the outer periphery of the soft pipe holding portion and capable of guiding the gas to the component discharging portion is provided.

前記ガス供給手段として、前記第１出口と前記第２出口との間で開口するように前記軟質管保持部に設けられていて前記ガスを前記成分吐出部に導くことが可能な中間流路が設けられている請求項４に記載のアプリケータ。 As the gas supply means, an intermediate flow path provided in the soft pipe holding portion so as to open between the first outlet and the second outlet and capable of guiding the gas to the component discharge portion is provided. The applicator according to claim 4, which is provided.