JP6790135B2 - 光学的な探査及び検知に基づくバイオセンサ - Google Patents
光学的な探査及び検知に基づくバイオセンサ Download PDFInfo
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- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
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- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- G02B6/29331—Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals with wavelength selective means operating by evanescent wave coupling
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Description
本特許文献は、「BIOSENSORS BASED ON OPTICAL PROBING AND SENSING(光学的な探査及び検知に基づくバイオセンサ)」と題された2008年10月27日出願の米国仮出願第61/108,862号の利益及び優先権を主張する。該仮出願は、参照によって本文献の一部として組み込まれるものとする。
本文献は、生物物質及び化学物質を含む物質の光学的検知に関する。
本文献は、センサチップ上の光学センサを使用して物質を光学的に検知するための装置、センサチップ、及び技術を説明する。
る光学センサを識別するための一意のコードを有するように及びプローブ光と光学的に相互作用してそのコードを運ぶ、戻り識別光を生成するように構成される。
ローブ光を受信し、該走査プローブ光をセンサチップ上へ方向付ける対物レンズとを含む。装置は、波長可変レーザの様々な波長にわたって戻りプローブ光の一部分を受信するために及びセンサチップ上の各光学センサの応答を検出するために光学システムと連絡している光学検出器を含む。
スポット位置に作用するように設計された第2のミラーによって走査を完了すること、及びバイオセンサ結合の光学効率が最適化されるまでこの行為を繰り返し実施することによってなされる方法が提供される。
査すること、及びセンサを通って伝播された後の光を捕えることによって得られる。なお、リング共振器センサの場合、光は、共振外のときはセンサに対して主に弱く結合され、共振状態のときはセンサ内を強く通り抜けることに留意せよ。
ら現れ出る光を前進経路の入射角と一致する角度にするように構成することができる。この構成下では、チップから現れ出る光は、逆進経路をたどって自由空間ビーム分割器に到達する。
アによってプログラム可能である。上記のように、エタロンのFSRは、既知で且つ制御状態にあり、一定であると想定される。ソフトウェアは、位置、Q値(Q)、消光比(ER)、左右の壁の傾斜、ピーク透過、並びに線形、***、非線形などのピークの特性を含む、共振線形状の重要な特質を決定する。検出処理ユニットは、また、エタロンスペクトル中に存在する全てのピークの位置を決定するために使用することもできる。センサ共振ピーク位置の正確な測定を行うために、2つのスペクトル(センサ及びエタロン)が重ね合わされる。検出処理ユニットに加えて、コントローラユニットもまた、各種の素子の動作を制御するために及び各種の素子の動作を連係させるために提供することができる。例えば、センサチップ上へのプローブ光の走査と、波長可変レーザの走査及びその他の制御動作との同期化を、コントローラユニットにおいて実施することができる。一部の実装形態では、コントローラユニットは、検出処理ユニットとは別のユニットであってよく、検出処理ユニットからの出力を受信し、このような出力を制御動作の実施に使用する。その他の実装形態では、コントローラユニットは、検出処理ユニットと統合して1つのユニットにすることができる。コントローラユニットの一部として、コンピュータ又はマイクロプロセッサを使用することができる。
とは限らないことに留意せよ。特定のリングは、センサ出力から温度などの影響を排除してシステムを較正する制御のために、稼働バイオセンサとしてではなく参照リング共振器として使用され得るように、手つかずのままで被覆を有することができる。
。リング503内にシリコン導波路502が形成され、薄い二酸化シリコン層510でコーティングされる。この薄い二酸化シリコン層510は、エバネッセント場が、上に配された任意の化学物質と強く反応しつつも、ガラスと共有結合するシランとして知られるクラスの分子を通じた表面結合を開始させるよくあるやり式としても機能することを可能にする。2つの異なるタイプの一般的な導波路が図示されており、図7aには、下方被覆508を露出させた完全にエッチングされた導波路502が、図7bには、下方被覆508が露呈していない部分的にエッチングされた導波路502が、それぞれ示されている。
ンサに一意の識別子を割り振ることによって分離及び識別する必要がある。各センサに一意の識別子を割り振るには、センサから実際の測定値を得るためのセンシングラスタ走査が実施される前に、光学調査器によって、チップに対して登録のための光学ラスタ走査を実施してチップを「登録」すればよい。
、このような動作が、所望の結果を得るために、図示されている特定の順序で又は起こった順番で実施される必要があるとも、又は例示されている全ての動作が実施される必要があるとも理解されるべきでない。
Claims (9)
- バイオセンシングシステムで使用される光学チップであって、
基板と、
前記基板上に設けられた第1光学共振器と、
前記バイオセンシングシステムからの入力光を前記光学チップ内に前記第1光学共振器に向かって結合する第1入力カプラと、
前記第1光学共振器からの出力光を前記光学チップから前記バイオセンシングシステムに向ける第1出力カプラと、
前記第1入力カプラおよび前記第1出力カプラに隣接し、前記第1光学共振器に関連する第1固有パターンに配置される1つまたは複数の再帰反射器の第1グループと、
前記基板上に設けられた第2光学共振器と、
前記バイオセンシングシステムからの入力光を前記光学チップ内に前記第2光学共振器に向かって結合する第2入力カプラと、
前記第2光学共振器からの出力光を前記光学チップから前記バイオセンシングシステムに向ける第2出力カプラと、
前記第2入力カプラおよび前記第2出力カプラに隣接し、前記第2光学共振器に関連する第2固有パターンに配置される1つまたは複数の再帰反射器の第2グループと、
を含む光学チップ。 - 前記第1グループの再帰反射器は、前記第1入力カプラと前記第1出力カプラとの間で前記光学チップ上に設けられる、
請求項1に記載の光学チップ。 - 前記再帰反射器は、光学格子を含む、
請求項1に記載の光学チップ。 - 前記第1固有パターンは、2進数列の形を含む、
請求項1に記載の光学チップ。 - 前記基板上に設けられ、屈折率を有する下方被覆層と、
前記下方被覆層上で、前記第1光学共振器及び前記第2光学共振器の近傍に設けられ、
前記下方被覆層の屈折率よりも高い屈折率を有する光導波路と、
前記光導波路の少なくとも一部の上で、前記第1光学共振器及び前記第2光学共振器の少なくとも一部の上に設けられた流路に隣接して設けられ、前記光導波路の屈折率よりも低い屈折率を有し、フルオロポリマ又はペルフルオロポリマを含む上方被覆層と、をさらに含み、
前記第1光学共振器及び前記第2光学共振器は、前記下方被覆層上に設けられ、前記下方被覆層の屈折率よりも高い屈折率を有する、
請求項1に記載の光学チップ。 - 前記光導波路、前記第1光学共振器及び前記第2光学共振器は、シリコンを含む、
請求項5に記載の光学チップ。 - 前記第1光学共振器及び前記第2光学共振器は、リング共振器を含む、
請求項5に記載の光学チップ。 - 前記上方被覆層は、約1.33の屈折率を有する、
請求項5に記載の光学チップ。 - 前記上方被覆層は疎水性であり、前記流路は親水性である、
請求項5に記載の光学チップ。
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US10886208P | 2008-10-27 | 2008-10-27 | |
US61/108,862 | 2008-10-27 |
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Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3561494B1 (en) | 2007-12-06 | 2022-03-02 | Genalyte, Inc. | METHOD FOR IDENTIFYING A SEQUENCE OF NUCLEOTIDES IN AN UNKNOWN SPECIES OF NUCLEIC ACID 
AND DEVICE FOR CARRYING OUT THE METHOD |
EP3572796B8 (en) * | 2008-10-27 | 2023-01-18 | Genalyte, Inc. | Biosensors based on optical probing and sensing |
WO2012061778A2 (en) | 2010-11-05 | 2012-05-10 | Genalyte, Inc. | Optical analyte detection systems and methods of use |
CA2872378C (en) * | 2011-07-20 | 2016-01-12 | University Of Washington Through Its Center For Commercialization | Photonic blood typing |
US10031138B2 (en) | 2012-01-20 | 2018-07-24 | University Of Washington Through Its Center For Commercialization | Hierarchical films having ultra low fouling and high recognition element loading properties |
EP2825885B1 (en) | 2012-03-12 | 2021-05-12 | The Board of Trustees of the University of Illinois | Optical analyte detection systems with magnetic enhancement |
FI125254B (en) | 2012-07-17 | 2015-08-14 | Arm Finland Oy | Method and device in a network service system |
US9983206B2 (en) | 2013-03-15 | 2018-05-29 | The Board Of Trustees Of The University Of Illinois | Methods and compositions for enhancing immunoassays |
JP6030504B2 (ja) * | 2013-05-30 | 2016-11-24 | 日本電信電話株式会社 | リング共振器型センサ |
US9606047B2 (en) * | 2013-06-28 | 2017-03-28 | Gothenburg Sensor Devices Ab | Waveguide structure |
DE102014210980A1 (de) * | 2014-06-10 | 2015-12-17 | Robert Bosch Gmbh | Verfahren zum Betreiben eines Ereigniszählers |
US9995627B2 (en) * | 2014-07-31 | 2018-06-12 | Smiths Detection Inc. | Raster optic device for optical hyper spectral scanning |
JP2017215216A (ja) * | 2016-05-31 | 2017-12-07 | シスメックス株式会社 | 分析方法および分析装置 |
IT201700006640A1 (it) | 2017-01-23 | 2018-07-23 | E Lite S R L | Dispositivo opto-elettronico per la rilevazione di una sostanza dispersa in un fluido |
EP3577437B1 (en) * | 2017-01-31 | 2021-12-08 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Methods and instruments for measuring samples in a well plate |
EP3388816A1 (en) * | 2017-04-11 | 2018-10-17 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Methods and instruments for measuring samples in a well plate |
GB2561238A (en) * | 2017-04-07 | 2018-10-10 | Univ Bath | Apparatus and method for monitoring objects in space |
WO2019018697A1 (en) | 2017-07-19 | 2019-01-24 | Evanostics, Llc | CARTRIDGES FOR ORAL FLUID ANALYSIS AND METHODS OF USE |
WO2019080040A1 (en) * | 2017-10-26 | 2019-05-02 | Shenzhen Genorivision Technology Co. Ltd. | BIOSENSOR |
FI20176101A1 (en) | 2017-12-11 | 2019-06-12 | Teknologian Tutkimuskeskus Vtt Oy | Optical sensor |
EP3724636A4 (en) | 2017-12-15 | 2021-08-18 | Evanostics, LLC | OPTICAL READER FOR ANALYTE TEST |
RU2737056C1 (ru) * | 2018-03-29 | 2020-11-24 | Иллюмина, Инк. | Освещение для флуоресцентной визуализации с помощью линзы объектива |
JP7346555B2 (ja) * | 2018-05-17 | 2023-09-19 | ライトマター インコーポレイテッド | 光学的に接合された積層メモリ、並びに関連する方法及びシステム |
US11573297B2 (en) * | 2018-09-14 | 2023-02-07 | GM Global Technology Operations LLC | Lidar system with integrated circulator |
US11036002B2 (en) | 2019-03-06 | 2021-06-15 | Lightmatter, Inc. | Photonic communication platform |
NL2023275B1 (en) | 2019-06-07 | 2021-01-11 | Delta Diagnostics B V | Alignment and readout of optical chips |
US11409047B2 (en) * | 2019-11-13 | 2022-08-09 | Electronics And Telecommunications Research Institute | Optical coupling method and apparatus |
JP2023505865A (ja) | 2019-12-11 | 2023-02-13 | ロックリー フォトニクス リミテッド | 光検出モジュール |
EP4100773A4 (en) | 2020-02-03 | 2024-03-20 | Lightmatter Inc | PHOTONIC UNIT COMMUNICATION SYSTEMS AND ASSOCIATED PACKAGING |
WO2021207834A1 (en) | 2020-04-13 | 2021-10-21 | The University Of British Columbia | Photonic sensor using a fixed-wavelength laser |
CN111998958B (zh) * | 2020-10-29 | 2021-02-19 | 南京智谱科技有限公司 | 一种探测器非均匀校正方法和*** |
WO2023064337A1 (en) | 2021-10-13 | 2023-04-20 | Lightmatter, Inc. | Multi-tenant isolation on a multi-reticle photonic communication platform |
US11662526B1 (en) * | 2021-12-09 | 2023-05-30 | Visera Technologies Company Ltd. | Optical structure |
US11768153B1 (en) * | 2022-03-08 | 2023-09-26 | Globalfoundries U.S. Inc. | Optical ring resonator-based microfluidic sensor |
Family Cites Families (153)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4078052A (en) | 1976-06-30 | 1978-03-07 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Large unilamellar vesicles (LUV) and method of preparing same |
CH624011A5 (ja) | 1977-08-05 | 1981-07-15 | Battelle Memorial Institute | |
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
IT1111367B (it) | 1978-11-17 | 1986-01-13 | Serono Ist Farm | Processo per la preparazione estemporanea di liposomi e liposomi cosi' ottenuti |
US4310506A (en) | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
US4394372A (en) | 1980-12-22 | 1983-07-19 | The Procter & Gamble Company | Process for making lipid membrane structures |
US4714681A (en) | 1981-07-01 | 1987-12-22 | The Board Of Reagents, The University Of Texas System Cancer Center | Quadroma cells and trioma cells and methods for the production of same |
US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
FR2521565B1 (fr) | 1982-02-17 | 1985-07-05 | Dior Sa Parfums Christian | Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees |
US4522803A (en) | 1983-02-04 | 1985-06-11 | The Liposome Company, Inc. | Stable plurilamellar vesicles, their preparation and use |
US4485054A (en) | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
AU5815886A (en) * | 1985-05-29 | 1986-12-24 | Kurt Tiefenthaler | Optical sensor for selectively determining the presence of substances and the variation of the refraction index in the measured substances |
JPH01287427A (ja) * | 1988-05-16 | 1989-11-20 | Matsushita Electric Ind Co Ltd | レーザー波長検出装置 |
US5478755A (en) | 1988-07-25 | 1995-12-26 | Ares Serono Research & Development Ltd. | Long range surface plasma resonance immunoassay |
US4925648A (en) | 1988-07-29 | 1990-05-15 | Immunomedics, Inc. | Detection and treatment of infectious and inflammatory lesions |
US5601819A (en) | 1988-08-11 | 1997-02-11 | The General Hospital Corporation | Bispecific antibodies for selective immune regulation and for selective immune cell binding |
IL91664A (en) | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
JP2814553B2 (ja) | 1989-05-12 | 1998-10-22 | ソニー株式会社 | カード |
ES2096590T3 (es) | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
US5705337A (en) | 1990-06-11 | 1998-01-06 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chemi-SELEX |
JP2763958B2 (ja) | 1990-06-11 | 1998-06-11 | ネクスター ファーマスーティカルズ,インコーポレイテッド | 核酸リガンド |
US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
GB9013984D0 (en) | 1990-06-22 | 1990-08-15 | Nat Res Dev | Spectrometers |
WO1992005793A1 (en) | 1990-10-05 | 1992-04-16 | Medarex, Inc. | Targeted immunostimulation with bispecific reagents |
EP0557300B1 (en) | 1990-10-29 | 1997-11-19 | Chiron Corporation | Bispecific antibodies, method of production, and uses thereof |
JPH04169257A (ja) | 1990-11-02 | 1992-06-17 | Nec Data Terminal Ltd | プリンタ装置 |
AU665758B2 (en) | 1991-04-26 | 1996-01-18 | Surface Active Limited | Novel antibodies, and methods for their use |
US5719262A (en) | 1993-11-22 | 1998-02-17 | Buchardt, Deceased; Ole | Peptide nucleic acids having amino acid side chains |
US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
PT627940E (pt) | 1992-03-05 | 2003-07-31 | Univ Texas | Utilizacao de imunoconjugados para o diagnostico e/ou terapia de tumores vascularizados |
SE501108C2 (sv) * | 1993-04-08 | 1994-11-14 | Pharmacia Lkb Biotech | Sätt och anordning för bestämning av brytningsindex |
US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
JP2924707B2 (ja) | 1995-04-13 | 1999-07-26 | 日本電気株式会社 | 光導波路型蛍光免疫センサとその製造方法 |
GB9508559D0 (en) | 1995-04-27 | 1995-06-14 | Polytech Transfer Ltd | Surface second harmonic and sum-frequency generation immuno and enzyme assays |
GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
EP0932390A1 (en) | 1996-10-11 | 1999-08-04 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method |
ATE232880T1 (de) | 1996-11-18 | 2003-03-15 | Takeshi Imanishi | Neue nucleotidanaloga |
US5939021A (en) | 1997-01-23 | 1999-08-17 | Hansen; W. Peter | Homogeneous binding assay |
JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
DE04020014T1 (de) | 1997-09-12 | 2006-01-26 | Exiqon A/S | Bi-zyklische - Nukleosid,Nnukleotid und Oligonukleotid-Analoga |
US7399589B2 (en) | 1998-02-06 | 2008-07-15 | Digene Corporation | Immunological detection of RNA:DNA hybrids on microarrays |
US20030153023A1 (en) | 1999-05-13 | 2003-08-14 | Starzl Timothy W. | Enumeration method of analyte detection |
FR2784189B3 (fr) * | 1998-10-05 | 2000-11-03 | Commissariat Energie Atomique | Biopuce et dispositif de lecture d'une biopuce comportant une pluralite de zones de reconnaissance moleculaire |
EP1141409B2 (en) | 1998-12-14 | 2009-05-27 | Pacific Biosciences of California, Inc. | A kit and methods for nucleic acid sequencing of single molecules by polymerase synthesis |
ATE465168T1 (de) | 1999-03-18 | 2010-05-15 | Exiqon As | Xylo-lna analoge |
EP1163250B1 (en) | 1999-03-24 | 2006-07-12 | Exiqon A/S | Improved synthesis of ¬2.2.1|bicyclo nucleosides |
NZ514348A (en) | 1999-05-04 | 2004-05-28 | Exiqon As | L-ribo-LNA analogues |
WO2001000641A1 (fr) | 1999-06-25 | 2001-01-04 | Sankyo Company, Limited | Nouveaux dérivés de bicyclonucléoside |
DE19929542B4 (de) | 1999-06-28 | 2004-09-23 | Institut für Mikroelektronik Stuttgart Stiftung des öffentlichen Rechts | Flächige Anordnung von Stimulationselektroden auf einem Chip und Herstellungsverfahren dazu und Verwendung als Retina-Implantat |
JP4151751B2 (ja) | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
ATE244883T1 (de) | 1999-09-15 | 2003-07-15 | Suisse Electronique Microtech | Integriert-optischer sensor |
US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
US6583399B1 (en) | 1999-11-22 | 2003-06-24 | California Institute Of Technology | Optical resonator microsphere sensor with altering Q-factor |
US6507684B2 (en) | 2000-06-28 | 2003-01-14 | The Charles Stark Draper Laboratory, Inc. | Optical microcavity resonator system |
JP2002098696A (ja) | 2000-09-26 | 2002-04-05 | Inst Of Physical & Chemical Res | 集積型生体分子センサー |
US6951715B2 (en) | 2000-10-30 | 2005-10-04 | Sru Biosystems, Inc. | Optical detection of label-free biomolecular interactions using microreplicated plastic sensor elements |
US7070987B2 (en) * | 2000-10-30 | 2006-07-04 | Sru Biosystems, Inc. | Guided mode resonant filter biosensor using a linear grating surface structure |
AU2002245537B2 (en) | 2001-02-23 | 2007-12-20 | Genicon Sciences Corporation | Methods for providing extended dynamic range in analyte assays |
CA2442261A1 (en) | 2001-03-26 | 2002-10-03 | Alza Corporation | Liposome composition for improved intracellular delivery of a therapeutic agent |
US7083920B2 (en) | 2001-05-18 | 2006-08-01 | Nagaoka & Co. Ltd. | Surface assembly for immobilizing DNA capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto |
AU2002327220A1 (en) | 2001-07-10 | 2003-01-29 | Wisconsin Alumni Research Foundation | Surface plasmon resonance imaging of micro-arrays |
US6767731B2 (en) | 2001-08-27 | 2004-07-27 | Intel Corporation | Electron induced fluorescent method for nucleic acid sequencing |
US20040023396A1 (en) | 2001-11-14 | 2004-02-05 | Boyd Robert W. | Ring or disk resonator photonic biosensor and its use |
US20050170347A1 (en) | 2001-12-19 | 2005-08-04 | Yuji Miyahara | Potentiometric dna microarray, process for producing the same and method of analyzing nucleic acid |
JP3730652B2 (ja) * | 2002-01-16 | 2006-01-05 | 株式会社東芝 | 光導波路型グルコースセンサ |
US20030224370A1 (en) | 2002-05-31 | 2003-12-04 | William Rassman | Method and apparatus for recognizing molecular compounds |
US20060063178A1 (en) | 2002-06-27 | 2006-03-23 | Trex Enterprises Corporation | Optical sensor and methods for measuring molecular binding interactions |
EP1540590A1 (en) * | 2002-09-12 | 2005-06-15 | Cyvera Corporation | Assay stick comprising coded microbeads |
FR2849196B1 (fr) * | 2002-12-23 | 2006-09-15 | Imstar Image Et Modelisation S | Lecteur de puces de type biopuces, et procedes associes |
US7027163B2 (en) * | 2003-01-24 | 2006-04-11 | General Dynamics Advanced Information Systems, Inc. | Grating sensor |
WO2004067162A2 (en) * | 2003-01-30 | 2004-08-12 | Ciphergen Biosystems Inc. | Apparatus for microfluidic processing and reading of biochip arrays |
CA2555962C (en) | 2003-02-26 | 2015-10-06 | Callida Genomics, Inc. | Random array dna analysis by hybridization |
US7695680B2 (en) * | 2003-03-19 | 2010-04-13 | The Trustees Of Boston University | Resonant cavity biosensor |
EP1616169B1 (en) | 2003-03-27 | 2009-06-24 | Corning Incorporated | Label-free evanescent-field detection of biological and chemical agents |
US7184626B1 (en) | 2003-04-07 | 2007-02-27 | Luxtera, Inc | Wafer-level testing of optical and optoelectronic chips |
JP2004354068A (ja) * | 2003-05-27 | 2004-12-16 | Hitachi Ltd | 光導波路を用いた化学物質計測装置 |
JP2004361087A (ja) * | 2003-05-30 | 2004-12-24 | Olympus Corp | 生体分子解析装置 |
US20050250094A1 (en) | 2003-05-30 | 2005-11-10 | Nanosphere, Inc. | Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes |
WO2004109284A1 (en) | 2003-06-06 | 2004-12-16 | Biacore Ab | Method and system for determination of molecular interaction parameters |
US7373255B2 (en) | 2003-06-06 | 2008-05-13 | Biacore Ab | Method and system for determination of molecular interaction parameters |
US7642064B2 (en) | 2003-06-24 | 2010-01-05 | Ventana Medical Systems, Inc. | Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest |
JP4436110B2 (ja) | 2003-11-07 | 2010-03-24 | 積水化学工業株式会社 | 光学的測定装置及びそれを用いた特異的結合物の光学的測定方法 |
US7208174B2 (en) | 2003-12-18 | 2007-04-24 | Hoffmann-La Roche Inc. | Liposome compositions |
US7271896B2 (en) | 2003-12-29 | 2007-09-18 | Intel Corporation | Detection of biomolecules using porous biosensors and raman spectroscopy |
US8815536B2 (en) | 2004-02-04 | 2014-08-26 | The Johns Hopkins University | Methods and systems for sampling, screening, and diagnosis |
JP4511857B2 (ja) | 2004-03-24 | 2010-07-28 | 国立大学法人京都大学 | フォトニック結晶を応用したセンサおよび検出対象物質の検出方法 |
JP2005321244A (ja) | 2004-05-07 | 2005-11-17 | Shimadzu Corp | 光学的測定装置 |
US20080138801A1 (en) | 2004-05-28 | 2008-06-12 | Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Surface Plasmon Resonance Sensor for Detecting Changes in Polynucleotide Mass |
JP2006029883A (ja) | 2004-07-14 | 2006-02-02 | Nmst Giken:Kk | 接触センサー |
US7230714B2 (en) | 2004-10-22 | 2007-06-12 | Agilent Technologies, Inc. | Nonlinear filtering for events in SPR sensing |
JP4558448B2 (ja) * | 2004-11-01 | 2010-10-06 | テルモ株式会社 | 光導波路およびこの光導波路を用いた蛍光センサ |
JP2006153643A (ja) * | 2004-11-29 | 2006-06-15 | Toshiba Corp | 測定装置 |
TWI259290B (en) * | 2004-12-02 | 2006-08-01 | Phalanx Biotech Group Inc | Common-path phase-shift interferometry surface plasmon resonance microscope |
US20060215165A1 (en) | 2004-12-15 | 2006-09-28 | Paul Melman | High sensitivity optical detection by temperature independent differential polarization surface plasmon resonance |
JP4673714B2 (ja) * | 2004-12-27 | 2011-04-20 | 株式会社東芝 | 光導波路型バイオケミカルセンサチップおよびその製造方法 |
US7391936B2 (en) | 2005-01-21 | 2008-06-24 | Lucent Technologies, Inc. | Microfluidic sensors and methods for making the same |
US7663092B2 (en) * | 2005-02-01 | 2010-02-16 | Purdue Research Foundation | Method and apparatus for phase contrast quadrature interferometric detection of an immunoassay |
US7767394B2 (en) | 2005-02-09 | 2010-08-03 | Pacific Biosciences Of California, Inc. | Nucleotide compositions and uses thereof |
US7259856B2 (en) * | 2005-02-16 | 2007-08-21 | Picarro, Inc. | Method for the precise measurement of the wavelength of light |
JP2006267052A (ja) * | 2005-03-25 | 2006-10-05 | Toshiba Corp | 免疫反応測定用検査装置 |
US7528403B1 (en) | 2005-04-25 | 2009-05-05 | California Institute Of Technology | Hybrid silicon-on-insulator waveguide devices |
US20070081163A1 (en) * | 2005-06-03 | 2007-04-12 | Minhua Liang | Method and apparatus for scanned beam microarray assay |
DE102005054495A1 (de) | 2005-11-16 | 2007-05-24 | Mivitec Gmbh | Verteilte Sensor- und Referenzspots für Chemo- und Biosensoren |
US7336859B2 (en) | 2005-12-28 | 2008-02-26 | Honeywell International, Inc. | Sensor using ultra thin waveguides and optical fibers |
EP1972122B1 (en) | 2006-01-11 | 2020-03-04 | Samsung Electronics Co., Ltd. | Security management method and apparatus in multimedia middleware, and storage medium therefor |
JP4557907B2 (ja) * | 2006-02-16 | 2010-10-06 | アンリツ株式会社 | Mems波長掃引光源の波長校正装置及び方法 |
US7693369B2 (en) | 2006-04-07 | 2010-04-06 | The Curators Of The University Of Missouri | Hollow core optical ring resonator sensor, sensing methods, and methods of fabrication |
EP2021491A4 (en) * | 2006-05-10 | 2010-02-24 | Univ Texas | DETECTION OF TUMOR BIOMARKERS IN MOUTH CANCER |
CN101438142B (zh) | 2006-05-10 | 2013-10-30 | 皇家飞利浦电子股份有限公司 | 快速磁生物传感器 |
JP2007309886A (ja) * | 2006-05-22 | 2007-11-29 | Olympus Corp | 分析装置 |
US7998672B2 (en) | 2006-05-30 | 2011-08-16 | The University Of Utah Research Foundation | Simultaneous amplification and detection of ribonucleic acid be an optical method using surface plasmon resonance |
US20080026394A1 (en) | 2006-07-11 | 2008-01-31 | Antara Biosciences Inc. | Methods of detecting one or more cancer markers |
US8120002B2 (en) * | 2006-07-20 | 2012-02-21 | Koninklijke Philips Electronics N.V. | Multi-color biosensor for detecting luminescence sites on a substrate having a refractive optical element for adjusting and focusing at least two incident irradiation beams of different wavelengths |
JP5030059B2 (ja) * | 2006-08-28 | 2012-09-19 | 日立化成工業株式会社 | センサ基板およびこれを用いた複合センサ |
JP2008057997A (ja) * | 2006-08-29 | 2008-03-13 | Olympus Corp | 化学発光試料の観察方法および顕微鏡 |
JP5221549B2 (ja) | 2006-10-12 | 2013-06-26 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 試薬層を有した高速バイオセンサ |
KR100839969B1 (ko) * | 2006-11-03 | 2008-06-19 | 중앙대학교 산학협력단 | 마이크로 공진기 센서 |
US7933022B2 (en) * | 2006-12-01 | 2011-04-26 | 3M Innovative Properties Company | Integrated optical disk resonator |
US7512298B2 (en) | 2006-12-01 | 2009-03-31 | 3M Innovative Properties Company | Optical sensing methods |
US7903240B2 (en) * | 2006-12-01 | 2011-03-08 | 3M Innovative Properties Company | Optical sensing device |
CN101573593A (zh) * | 2006-12-28 | 2009-11-04 | 住友电气工业株式会社 | 对象物的物理量测定方法及控制方法 |
US7993525B2 (en) | 2006-12-29 | 2011-08-09 | Intel Corporation | Device and method for particle complex handling |
JP4855960B2 (ja) | 2007-01-30 | 2012-01-18 | 株式会社リコー | タンデム印刷システムのウェブ搬送方法および装置 |
WO2008097199A1 (en) * | 2007-02-06 | 2008-08-14 | Nanyang Technological University | Apparatus and method for analysing a fluorescent sample disposed on a substrate |
US7599055B2 (en) | 2007-02-27 | 2009-10-06 | Corning Incorporated | Swept wavelength imaging optical interrogation system and method for using same |
EP2461163A3 (en) | 2007-03-20 | 2012-09-26 | Becton, Dickinson and Company | Assays using surface-enhanced raman spectroscopy (sers)-active particles |
US7778499B2 (en) | 2007-05-21 | 2010-08-17 | National Research Council Of Canada | Silicon photonic wire waveguide biosensor |
US7796262B1 (en) | 2007-05-31 | 2010-09-14 | Nomadics, Inc. | Integrated optical resonator device for measuring chemical and biological analyte concentrations |
WO2009069009A1 (en) | 2007-11-26 | 2009-06-04 | Koninklijke Philips Electronics N.V. | Optical detection of particles in a magnetic biosensor using a waveguide |
EP3561494B1 (en) | 2007-12-06 | 2022-03-02 | Genalyte, Inc. | METHOD FOR IDENTIFYING A SEQUENCE OF NUCLEOTIDES IN AN UNKNOWN SPECIES OF NUCLEIC ACID 
AND DEVICE FOR CARRYING OUT THE METHOD |
KR100927603B1 (ko) | 2007-12-11 | 2009-11-23 | 한국전자통신연구원 | 표적 바이오 물질 검출 키트 및 표적 바이오 물질 검출방법 |
EP3572796B8 (en) * | 2008-10-27 | 2023-01-18 | Genalyte, Inc. | Biosensors based on optical probing and sensing |
US8992836B2 (en) | 2008-11-14 | 2015-03-31 | Cornell University | Cavity-enhanced on-chip absorption spectroscopy |
US8642111B2 (en) | 2009-05-19 | 2014-02-04 | Polytechnic Institute Of New York University | Functionalizing a sensing ribbon on a whispering gallery mode microresonator using light force to fabricate a whispering gallery mode sensor |
SI2494356T1 (sl) | 2009-10-26 | 2017-07-31 | Genentech, Inc. | Preizkusi za detektiranje protiteles, specifičnih za terapevtska protitelesa proti IgE, in njihova uporaba pri anafilaksi |
WO2011091037A2 (en) | 2010-01-19 | 2011-07-28 | President And Fellows Of Harvard College | Rapid pathogen diagnostic device and method |
WO2011133670A2 (en) * | 2010-04-20 | 2011-10-27 | President And Fellows Of Harvard College | Biomedical and chemical sensing with nanobeam photonic crystal cavities using optical bistability |
US20120045748A1 (en) | 2010-06-30 | 2012-02-23 | Willson Richard C | Particulate labels |
WO2012061778A2 (en) | 2010-11-05 | 2012-05-10 | Genalyte, Inc. | Optical analyte detection systems and methods of use |
ME02506B (me) | 2010-11-11 | 2017-02-20 | Abbvie Biotechnology Ltd | VISOKA KONCETRACIJA TEČNIH FORMULACIJA ANTI TNF alfa ANTITIJELA |
JP6181646B2 (ja) | 2011-07-06 | 2017-08-16 | ネステク ソシエテ アノニム | Tnfアルファによる生物学的治療に対する中和自己抗体の検出のためのアッセイ |
EP2825885B1 (en) | 2012-03-12 | 2021-05-12 | The Board of Trustees of the University of Illinois | Optical analyte detection systems with magnetic enhancement |
US9157856B2 (en) | 2012-09-10 | 2015-10-13 | Yunbo Guo | Integrated photonic crystal structures and their applications |
US9983206B2 (en) | 2013-03-15 | 2018-05-29 | The Board Of Trustees Of The University Of Illinois | Methods and compositions for enhancing immunoassays |
CA2972052A1 (en) | 2016-06-30 | 2017-12-30 | Sightline Innovation Inc. | System, method, and module for biomarker detection |
DE102016212844A1 (de) | 2016-07-14 | 2018-01-18 | Robert Bosch Gmbh | Verfahren und System zum Nachweis von biologischen Zielstrukturen |
US10886208B2 (en) | 2018-10-12 | 2021-01-05 | Advanced Semiconductor Engineering, Inc. | Semiconductor device package, electronic assembly and method for manufacturing the same |
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