JP6703492B2 - 薬物送達デバイス用の用量標示機構および薬物送達デバイス - Google Patents
薬物送達デバイス用の用量標示機構および薬物送達デバイス Download PDFInfo
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- 229960004666 glucagon Drugs 0.000 description 1
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- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
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- GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 1
- 229960004338 leuprorelin Drugs 0.000 description 1
- XVVOERDUTLJJHN-IAEQDCLQSA-N lixisenatide Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 XVVOERDUTLJJHN-IAEQDCLQSA-N 0.000 description 1
- 108010004367 lixisenatide Proteins 0.000 description 1
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- RWHUEXWOYVBUCI-ITQXDASVSA-N nafarelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 RWHUEXWOYVBUCI-ITQXDASVSA-N 0.000 description 1
- 229960002333 nafarelin Drugs 0.000 description 1
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- 229940111202 pepsin Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
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- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 1
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
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- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 1
- 229960004824 triptorelin Drugs 0.000 description 1
- VXKHXGOKWPXYNA-PGBVPBMZSA-N triptorelin Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 VXKHXGOKWPXYNA-PGBVPBMZSA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Images
Classifications
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- A61M5/178—Syringes
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- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
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- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
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- A61M2005/2403—Ampoule inserted into the ampoule holder
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
Landscapes
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- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
2 カートリッジ
3 本体(ハウジング)
4 近位端
5 遠位端
6 ダイヤルグリップ
7 用量ダイヤル部材(数字スリーブ)
8 投薬数
9 螺旋溝
10 第1の用量インジケータ手段
11 第1の用量窓
12 カートリッジホルダ
13 第1の用量スケール
14 第2の用量スケール
15 第2の用量インジケータ手段
16 第2の用量窓
17 穴
18 投薬数
19 色付きマーキング(インジケータ)
20 細長いアパーチャ
21 可動の要素
22 ポインタ(インジケータ)
23 溝
24 内側表面
25 ねじ山要素
26 透明なカバー
Claims (14)
- 単一の薬剤カートリッジ(2)内に含まれた薬剤を送達するように構成された薬物送達デバイス(1)用の用量標示機構であって、薬剤は、少なくとも1つの第1の薬物および1つの第2の薬物を含み、ここで、該用量標示機構は、
本体(3)と、
用量設定中に本体(3)に対して動くように構成された用量ダイヤル部材(7)と、
用量設定中に用量ダイヤル部材(7)の変位に応じて第1の薬物の設定された用量を表示するように構成された第1の用量インジケータ手段(10)とを含み、
該用量標示機構は、用量設定中、第2の薬物の設定された用量を表示するように構成される第2の用量インジケータ手段(15)であって、表示される設定された用量が用量ダイヤル部材(7)の変位に応じて変化するように用量ダイヤル部材(7)に連結される前記第2の用量インジケータ手段(15)をさらに含むことを特徴とする、前記用量標示機構。 - 第1の用量インジケータ手段(10)および/または第2の用量インジケータ手段(15)は、用量値を表示するように構成されることを特徴とする、請求項1に記載の用量標示機構。
- 第2の薬物の表示される設定された用量は、第1の薬物の表示される用量に対して一定の比率にあることを特徴とする、請求項1または2に記載の用量標示機構。
- 第1の用量インジケータ手段(10)は、第1の用量スケール(13)を含むこと、および/または第2の用量インジケータ手段(15)は、第2の用量スケール(14)を含むことを特徴とする、請求項1〜3のいずれか1項に記載の用量標示機構。
- 第1の用量スケール(13)は、第2の用量スケール(14)に対して異なることを特徴とする、請求項4に記載の用量標示機構。
- 用量ダイヤル部材(7)は、外側周囲表面上に用量関連の情報(19)を備えることを
特徴とする、請求項1〜5のいずれか1項に記載の用量標示機構。 - 第1および/または第2の用量インジケータ手段(10、15)は、用量関連の情報(19、13、14)を含み、かつ、用量ダイヤル部材の変位が用量関連の情報の変位を引き起こすように用量ダイヤル部材(7)に連結される、少なくとも1つの可動の要素(21)を含むことを特徴とする、請求項1〜6のいずれか1項に記載の用量標示機構。
- 可動の要素(21)は、本体(3)に対して軸方向に動くように構成されることを特徴とする、請求項7に記載の用量標示機構。
- 可動の要素(21)は、本体(3)内で軸方向に案内されることを特徴とする、請求項8に記載の用量標示機構。
- 本体(3)は、用量設定中、可動の要素(21)上の用量関連の情報(19)と相互作用するように構成された用量関連の情報(13、14、17)を備えることを特徴とする、請求項7〜9のいずれか1項に記載の用量標示機構。
- 本体(3)は、第1の薬物の設定された用量および/または第2の薬物の設定された用量がアパーチャ(11、16、17)を通じて示されるように配置される少なくとも1つのアパーチャ(11、16、17)を備えることを特徴とする、請求項1〜10のいずれか1項に記載の用量標示機構。
- 可動の要素(21)および/または用量ダイヤル部材(7)は、色付きインジケータ(19)を含むことを特徴とする、請求項1〜11のいずれか1項に記載の用量標示機構。
- 単一の薬剤カートリッジ(2)内に含まれた薬剤を送達するように構成された薬物送達デバイスであって、請求項1〜12のいずれか1項に記載の用量標示機構を含む、前記薬物送達デバイス。
- プレミックス薬剤を有する薬剤カートリッジ(2)を含み、該薬剤は、第1の薬物および第2の薬物を含み、第1の薬物と第2の薬物の間の比率は、第1の用量インジケータ手段(10)と第2の用量インジケータ手段(15)の表示される用量値間の比率に対応することを特徴とする、請求項13に記載の薬物送達デバイス。
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EP14170332 | 2014-05-28 | ||
EP14170332.2 | 2014-05-28 | ||
PCT/EP2015/061619 WO2015181187A1 (en) | 2014-05-28 | 2015-05-27 | Dose indicating mechanism for a drug delivery device and drug delivery device |
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US (1) | US10973980B2 (ja) |
EP (1) | EP3148612A1 (ja) |
JP (1) | JP6703492B2 (ja) |
CN (1) | CN106413780B (ja) |
HK (1) | HK1232166A1 (ja) |
WO (1) | WO2015181187A1 (ja) |
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US5240146A (en) | 1990-12-14 | 1993-08-31 | Smedley William H | Variable proportion dispenser |
US5253785A (en) * | 1992-04-02 | 1993-10-19 | Habley Medical Technology Corp. | Variable proportion dispenser |
US5423752A (en) | 1992-07-31 | 1995-06-13 | Habley Medical Technology Corporation | Variable proportion dispenser with cartridge replacement assembly |
ZA941881B (en) * | 1993-04-02 | 1995-09-18 | Lilly Co Eli | Manifold medication injection apparatus and method |
JP2000070368A (ja) | 1998-08-27 | 2000-03-07 | Shimadzu Corp | 針無注射器 |
JP2003010327A (ja) | 2001-07-03 | 2003-01-14 | Eisuke Fujimoto | 無針注射器 |
GB0304822D0 (en) | 2003-03-03 | 2003-04-09 | Dca Internat Ltd | Improvements in and relating to a pen-type injector |
US20080269688A1 (en) | 2005-12-08 | 2008-10-30 | Jose Colucci | Dose Indicating Assembly of a Pharmaceutical Injection Device |
EP2007451B1 (en) | 2006-03-21 | 2018-11-07 | SHL Group AB | Dose information device |
DK2401010T3 (en) | 2009-02-26 | 2018-07-23 | Shl Group Ab | DOSE ADJUSTMENT MECHANISM |
US8672896B2 (en) | 2009-06-01 | 2014-03-18 | Sanofi-Aventis Deutschland Gmbh | Inner housing for a drug delivery device |
EP2335755A1 (en) | 2009-12-17 | 2011-06-22 | Sanofi-Aventis Deutschland GmbH | Device and method for delivery of two or more drug agents |
US9463284B2 (en) | 2009-12-02 | 2016-10-11 | Sanofi-Aventis Deutschland Gmbh | Dose display mechanism for drug delivery device with first and second windows and scales |
AR083378A1 (es) * | 2010-10-13 | 2013-02-21 | Sanofi Aventis Deutschland | Mecanismo de establecimiento de dosis y metodo para establecer una dosis |
WO2012072533A1 (en) * | 2010-11-29 | 2012-06-07 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device having a trigger |
US9492648B2 (en) | 2011-05-06 | 2016-11-15 | Sanofi-Aventis Deutschland Gmbh | Valve element |
DK2709697T3 (da) | 2011-05-19 | 2019-05-06 | Becton Dickinson Co | Injektionsindretning med flere vinduer til indstilling af dosis |
EP2806924A1 (en) | 2012-01-27 | 2014-12-03 | Michael A. Creaturo | Safety syringe and safety dose combination kit |
-
2015
- 2015-05-27 US US15/313,431 patent/US10973980B2/en active Active
- 2015-05-27 CN CN201580027367.5A patent/CN106413780B/zh not_active Expired - Fee Related
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- 2015-05-27 WO PCT/EP2015/061619 patent/WO2015181187A1/en active Application Filing
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WO2015181187A1 (en) | 2015-12-03 |
US20170182257A1 (en) | 2017-06-29 |
JP2017516561A (ja) | 2017-06-22 |
HK1232166A1 (zh) | 2018-01-05 |
CN106413780B (zh) | 2020-07-10 |
US10973980B2 (en) | 2021-04-13 |
EP3148612A1 (en) | 2017-04-05 |
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