JP6644799B2 - 眼の架橋処置のためのシステム及び方法 - Google Patents
眼の架橋処置のためのシステム及び方法 Download PDFInfo
- Publication number
- JP6644799B2 JP6644799B2 JP2017540986A JP2017540986A JP6644799B2 JP 6644799 B2 JP6644799 B2 JP 6644799B2 JP 2017540986 A JP2017540986 A JP 2017540986A JP 2017540986 A JP2017540986 A JP 2017540986A JP 6644799 B2 JP6644799 B2 JP 6644799B2
- Authority
- JP
- Japan
- Prior art keywords
- light
- oxygen
- cornea
- cross
- crosslinking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000004132 cross linking Methods 0.000 title claims description 94
- 238000011282 treatment Methods 0.000 title claims description 61
- 238000000034 method Methods 0.000 title claims description 38
- 210000004087 cornea Anatomy 0.000 claims description 81
- 238000006243 chemical reaction Methods 0.000 claims description 77
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 66
- 239000001301 oxygen Substances 0.000 claims description 66
- 229910052760 oxygen Inorganic materials 0.000 claims description 66
- 230000000694 effects Effects 0.000 claims description 20
- 239000003431 cross linking reagent Substances 0.000 claims description 19
- 238000009826 distribution Methods 0.000 claims description 15
- 239000003642 reactive oxygen metabolite Substances 0.000 claims description 13
- 230000004044 response Effects 0.000 claims description 12
- 239000004971 Cross linker Substances 0.000 claims description 8
- 150000002978 peroxides Chemical class 0.000 claims description 8
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 7
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 claims description 7
- 230000035876 healing Effects 0.000 claims description 6
- 238000003860 storage Methods 0.000 claims description 5
- 238000007654 immersion Methods 0.000 claims description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 80
- 229960002477 riboflavin Drugs 0.000 description 41
- 239000002151 riboflavin Substances 0.000 description 41
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 40
- 235000019192 riboflavin Nutrition 0.000 description 40
- 238000002474 experimental method Methods 0.000 description 16
- 230000003287 optical effect Effects 0.000 description 13
- 210000001519 tissue Anatomy 0.000 description 13
- 238000001506 fluorescence spectroscopy Methods 0.000 description 9
- 230000006870 function Effects 0.000 description 9
- 238000005286 illumination Methods 0.000 description 9
- 230000007246 mechanism Effects 0.000 description 9
- 230000002186 photoactivation Effects 0.000 description 9
- 230000008859 change Effects 0.000 description 7
- 210000003683 corneal stroma Anatomy 0.000 description 7
- 108090000526 Papain Proteins 0.000 description 6
- 239000004365 Protease Substances 0.000 description 6
- 230000004913 activation Effects 0.000 description 6
- 230000029087 digestion Effects 0.000 description 6
- 229940055729 papain Drugs 0.000 description 6
- 235000019834 papain Nutrition 0.000 description 6
- 150000003254 radicals Chemical class 0.000 description 6
- 201000002287 Keratoconus Diseases 0.000 description 5
- 230000005281 excited state Effects 0.000 description 5
- 230000005283 ground state Effects 0.000 description 5
- -1 hydroxyl radicals Chemical class 0.000 description 5
- 238000012937 correction Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 230000007704 transition Effects 0.000 description 4
- SGSVWAYHEWEQET-SCRDCRAPSA-N 1,5-dihydroriboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2NC2=C1NC(=O)NC2=O SGSVWAYHEWEQET-SCRDCRAPSA-N 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- 206010043189 Telangiectasia Diseases 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000009792 diffusion process Methods 0.000 description 3
- 210000003560 epithelium corneal Anatomy 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000009056 telangiectasis Diseases 0.000 description 3
- 238000012876 topography Methods 0.000 description 3
- 230000003321 amplification Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 201000009310 astigmatism Diseases 0.000 description 2
- 230000003416 augmentation Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000004907 flux Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 230000004379 myopia Effects 0.000 description 2
- 230000007959 normoxia Effects 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 238000012014 optical coherence tomography Methods 0.000 description 2
- 239000003504 photosensitizing agent Substances 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010020675 Hypermetropia Diseases 0.000 description 1
- 208000022873 Ocular disease Diseases 0.000 description 1
- 230000037338 UVA radiation Effects 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004980 dosimetry Methods 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 208000028329 epileptic seizure Diseases 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000012682 free radical photopolymerization Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
- 201000006318 hyperopia Diseases 0.000 description 1
- 230000004305 hyperopia Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000005305 interferometry Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002311 multiphoton fluorescence microscopy Methods 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 231100000434 photosensitization Toxicity 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 201000010041 presbyopia Diseases 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 150000005838 radical anions Chemical group 0.000 description 1
- 150000005839 radical cations Chemical class 0.000 description 1
- 150000005837 radical ions Chemical class 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 150000003287 riboflavins Chemical class 0.000 description 1
- 238000013515 script Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/0079—Methods or devices for eye surgery using non-laser electromagnetic radiation, e.g. non-coherent light or microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F9/00825—Methods or devices for eye surgery using laser for photodisruption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00844—Feedback systems
- A61F2009/00851—Optical coherence topography [OCT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00872—Cornea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00885—Methods or devices for eye surgery using laser for treating a particular disease
- A61F2009/00893—Keratoconus
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Electromagnetism (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Eye Examination Apparatus (AREA)
Description
本出願は、2014年10月27日に出願された米国仮特許出願第62/069,094号の優先権を主張し、その内容全体が参照により本明細書に組み込まれる。
本開示は、眼の障害を処置するシステム及び方法に関し、より詳細には、眼の架橋処置ためのシステム及び方法に関する。
架橋処置は、円錐角膜などの、障害を患った眼を処置するために利用され得る。詳細には、円錐角膜は、角膜内の構造変化が角膜を弱体化及び異常な円錐形状に変化させる眼の変性障害である。架橋処置は、円錐角膜によって弱体化した領域を強化及び安定化させ、望ましくない形状変化を防止することができる。
本開示の態様によれば、角膜処置のためのシステムは、架橋剤で処置された角膜の少なくとも1つの選択された領域において架橋を活性化するように構成された光源を備える。光源は、パラメータのセットに従って光活性化光を角膜の少なくとも1つの選択された領域に送達するように構成される。システムはまた、架橋剤及び光活性化光の送達のためのパラメータのセットに関する入力を受け取るように構成された制御装置を備える。制御装置は、(A)入力から、少なくとも過酸化物、超酸化物、及び水酸ラジカルを含む反応性酸素種(ROS)を伴う反応から生じる架橋を決定する第1のセットのプログラム指令、並びに(B)入力から、酸素を伴わない反応による架橋を決定する第2のセットのプログラム指令を記憶するコンピュータ可読記憶媒体を備える。制御装置は、角膜の少なくとも1つの選択された領域における計算された架橋の量を出力するために第1及び第2のセットのプログラム指令を実行するように構成される。制御装置によって出力される計算された架橋の量に応じて、光源は、光活性化光の送達のためのパラメータのセットの少なくとも1つの値を調節するように構成される。
図1は、眼1の角膜2においてコラーゲンの架橋を生成する例示的な処置システム100を示す。処置システム100は、架橋剤130を角膜2に適用するアプリケータ132を備える。例示的な実施形態では、アプリケータ132は、角膜2に対する液滴として光増感剤130を適用する点眼瓶、シリンジなどであり得る。架橋剤130は、架橋剤130が角膜上皮2aを通過して角膜支質2bの下部の領域へ向かうことを可能にする処方剤に提供され得る。代替的に、角膜上皮2aは、架橋剤130が下部の組織に直接適用され得るように除去又は別途切開され得る。
酸素枯渇実験
非線形光学顕微鏡蛍光実験
パパイン消化方法に基づく蛍光データ実験
角膜支質境界線相関実験
Claims (10)
- 角膜処置のためのシステムであって、
架橋剤で処置された角膜の少なくとも1つの選択された領域において架橋を活性化するように構成された光源であり、パラメータのセットに従って光活性化光を角膜の少なくとも1つの選択された領域に送達するように構成された光源と、
架橋剤及び光活性化光の送達のためのパラメータのセットに関する入力を受け取るように構成された制御装置であり、
(A)入力から、少なくとも過酸化物、超酸化物、及び水酸ラジカルを含む反応性酸素種(ROS)を伴う反応から生じる架橋を決定する第1のセットのプログラム指令と、
(B)入力から、酸素を伴わない反応による架橋を決定する第2のセットのプログラム指令と、
を記憶するコンピュータ可読記憶媒体を備え、
角膜の少なくとも1つの選択された領域における計算された架橋の量を出力するために第1及び第2のセットのプログラム指令を実行するように構成された制御装置と、
を含むシステムであり、
制御装置によって出力される計算された架橋の量に応じて、光源が、光活性化光の送達のためのパラメータのセットの少なくとも1つの値を調節するように構成される、システム。 - 酸素源と、酸素源から角膜の少なくとも1つの選択された領域まで酸素の濃度を提供するように構成された酸素送達デバイスと、を更に含み、制御装置によって受け取られる入力が、更に酸素の濃度に関し、制御装置が、酸素の濃度に追加的に基づいて計算された架橋の量を出力するために第1及び第2のセットのプログラム指令を実行するように構成される、請求項1に記載のシステム。
- 計算された架橋の量が、角膜の少なくとも1つの選択された領域における架橋の三次元分布を指示する、請求項1に記載のシステム。
- 制御装置が、角膜の少なくとも1つの選択された領域における架橋の三次元分布及び反応性酸素種の効果により治癒反応に対応する深さ閾値を計算するように更に構成される、請求項3に記載のシステム。
- 制御装置が、角膜の少なくとも1つの選択された領域における架橋の三次元分布により生体力学的組織反応に対応する生体力学的組織剛度の深さ閾値を計算するように更に構成される、請求項3に記載のシステム。
- 酸素源と、酸素源から角膜の少なくとも1つの選択された領域まで酸素の濃度を提供するように構成された送達デバイスと、を更に含み、酸素の濃度が、架橋の三次元分布を更に決定する、請求項3に記載のシステム。
- 光活性化光の送達のためのパラメータのセットが、波長、放射照度、照射量、パルス化、又は連続波の少なくとも1つを含む、請求項1に記載のシステム。
- 制御装置が、光源に結合され、制御装置が、制御装置によって出力される計算された架橋活動の量に応じて光活性化光を送達するために光源を制御するように構成される、請求項1に記載のシステム。
- 架橋剤に関する入力が、架橋剤の指定された濃度及び架橋剤の処置のための浸漬時間を指示する、請求項1に記載のシステム。
- 第1のセットのプログラム指令が、一重項酸素を含む反応性酸素種(ROS)を伴う反応から生じる架橋を更に決定する、請求項1に記載のシステム。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462069094P | 2014-10-27 | 2014-10-27 | |
US62/069,094 | 2014-10-27 | ||
PCT/US2015/057628 WO2016069628A1 (en) | 2014-10-27 | 2015-10-27 | Systems and methods for cross-linking treatments of an eye |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2017532180A JP2017532180A (ja) | 2017-11-02 |
JP2017532180A5 JP2017532180A5 (ja) | 2018-08-16 |
JP6644799B2 true JP6644799B2 (ja) | 2020-02-12 |
Family
ID=55858266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017540986A Active JP6644799B2 (ja) | 2014-10-27 | 2015-10-27 | 眼の架橋処置のためのシステム及び方法 |
Country Status (6)
Country | Link |
---|---|
US (3) | US10350111B2 (ja) |
EP (3) | EP3212140B1 (ja) |
JP (1) | JP6644799B2 (ja) |
KR (2) | KR102416876B1 (ja) |
CN (1) | CN107205845B (ja) |
WO (2) | WO2016069628A1 (ja) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6377906B2 (ja) | 2010-03-19 | 2018-08-22 | アヴェドロ・インコーポレーテッドAvedro,Inc. | 眼治療を適用およびモニターするためのシステム |
US9622911B2 (en) | 2010-09-30 | 2017-04-18 | Cxl Ophthalmics, Llc | Ophthalmic treatment device, system, and method of use |
WO2012167260A2 (en) | 2011-06-02 | 2012-12-06 | Avedro, Inc. | Systems and methods for monitoring time based photo active agent delivery or photo active marker presence |
WO2013148896A1 (en) | 2012-03-29 | 2013-10-03 | Cxl Ophthalmics, Llc | Ocular treatment solutions, delivery devices and delivery augmentation methods |
EP2830637A4 (en) | 2012-03-29 | 2016-03-16 | Cxl Ophthalmics Llc | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES RELATED TO OXIDATIVE STRESS |
CN107205845B (zh) * | 2014-10-27 | 2020-03-31 | 艾维德洛公司 | 用于眼的交联治疗的***和方法 |
US10114205B2 (en) | 2014-11-13 | 2018-10-30 | Avedro, Inc. | Multipass virtually imaged phased array etalon |
EP3827792A1 (en) | 2015-04-24 | 2021-06-02 | Avedro, Inc. | Systems and methods for photoactivating a photosensitizer applied to an eye |
WO2016191342A1 (en) | 2015-05-22 | 2016-12-01 | Avedro, Inc. | Systems and methods for monitoring cross-linking activity for corneal treatments |
CN108025011A (zh) | 2015-07-21 | 2018-05-11 | 艾维德洛公司 | 用光敏剂治疗眼睛的***和方法 |
BR112018007437A2 (pt) | 2015-10-23 | 2018-10-23 | Univ Columbia | reticulação de colágeno induzida por laser em tecido |
JP6679724B2 (ja) | 2015-12-03 | 2020-04-15 | アヴェドロ・インコーポレーテッドAvedro,Inc. | 眼をマスク装置で処置するためのシステムおよび方法 |
EP3442481B1 (en) | 2016-04-13 | 2023-06-28 | Avedro, Inc. | Systems for delivering drugs to an eye |
US11497403B2 (en) | 2016-06-10 | 2022-11-15 | The Trustees Of Columbia University In The City Of New York | Devices, methods, and systems for detection of collagen tissue features |
EP3496681A4 (en) | 2016-08-08 | 2020-07-22 | Avedro, Inc. | SYSTEMS AND METHODS FOR CROSSLINKING TREATMENT OF DRY EYES |
JP7035081B2 (ja) | 2017-01-11 | 2022-03-14 | アヴェドロ・インコーポレーテッド | 角膜におけるクロスリンキング分布及び/又は角膜の構造的特徴を決定するためのシステム及び方法 |
US9939381B1 (en) * | 2017-04-07 | 2018-04-10 | Vidrio Technologies, Llc | Automated scanning path planner with path calibration for high frame rate multi photon laser scanning microscope with wide field of view |
US11666481B1 (en) | 2017-12-01 | 2023-06-06 | The Trustees Of Columbia University In The City Of New York | Diagnosis and treatment of collagen-containing tissues |
AU2019231257A1 (en) | 2018-03-05 | 2020-10-15 | Avedro, Inc. | System for eye tracking during eye treatment |
US11766356B2 (en) | 2018-03-08 | 2023-09-26 | Avedro, Inc. | Micro-devices for treatment of an eye |
CN108744293B (zh) * | 2018-05-29 | 2019-06-04 | 清华大学深圳研究生院 | 一种用于图像化角膜交联的数字化光学装置 |
CA3112937A1 (en) * | 2018-09-19 | 2020-03-26 | Avedro, Inc. | Systems and methods treating for corneal ectatic disorders |
US12016794B2 (en) | 2018-10-09 | 2024-06-25 | Avedro, Inc. | Photoactivation systems and methods for corneal cross-linking treatments |
US10932864B2 (en) | 2018-11-28 | 2021-03-02 | Rxsight, Inc. | Tracking-based illumination control system |
US11013593B2 (en) | 2018-12-02 | 2021-05-25 | Rxsight, Inc. | Light adjustable lens tracking system and method |
JP2022523211A (ja) * | 2019-02-26 | 2022-04-21 | アヴェドロ・インコーポレーテッド | 眼の架橋処置のためのシステム及び方法 |
IT201900010341A1 (it) | 2019-06-27 | 2020-12-27 | Vision Eng Italy Srl | Dispositivo, sistema e metodo di trattamento di un tessuto corneale |
WO2021026405A1 (en) * | 2019-08-06 | 2021-02-11 | Avedro, Inc. | Photoactivation systems and methods for corneal cross-linking treatments |
CN111493832A (zh) * | 2020-04-24 | 2020-08-07 | 天津恒宇医疗科技有限公司 | 一种基于En face-OCT的内窥成像方法 |
CN117222381A (zh) | 2021-03-08 | 2023-12-12 | 艾维德洛公司 | 用于生成患者特定角膜交联处理图案的***和方法 |
CN114488892B (zh) * | 2022-01-18 | 2023-03-28 | 北京工业大学 | 激光照射控制***、激光照射控制方法、设备及介质 |
Family Cites Families (266)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3169459A (en) | 1963-03-11 | 1965-02-16 | Michael A Friedberg | Method of determining surface contours of an eye |
US4034750A (en) | 1975-04-22 | 1977-07-12 | Maurice Seiderman | Electrochemically linking collagen fibrils to animal tissue |
US4161013A (en) | 1977-05-23 | 1979-07-10 | Massachusetts Institute Of Technology | Electromechanochemical device |
US4326529A (en) | 1978-05-26 | 1982-04-27 | The United States Of America As Represented By The United States Department Of Energy | Corneal-shaping electrode |
US4805616A (en) | 1980-12-08 | 1989-02-21 | Pao David S C | Bipolar probes for ophthalmic surgery and methods of performing anterior capsulotomy |
US4381007A (en) | 1981-04-30 | 1983-04-26 | The United States Of America As Represented By The United States Department Of Energy | Multipolar corneal-shaping electrode with flexible removable skirt |
US4712543A (en) | 1982-01-20 | 1987-12-15 | Baron Neville A | Process for recurving the cornea of an eye |
US4665913A (en) | 1983-11-17 | 1987-05-19 | Lri L.P. | Method for ophthalmological surgery |
US5484432A (en) | 1985-09-27 | 1996-01-16 | Laser Biotech, Inc. | Collagen treatment apparatus |
US4764007A (en) | 1986-02-24 | 1988-08-16 | The United States Of America As Represented By The Secretary Of The Air Force | Glare susceptibility tester |
GB8606821D0 (en) | 1986-03-19 | 1986-04-23 | Pa Consulting Services | Corneal reprofiling |
US5019074A (en) | 1987-03-09 | 1991-05-28 | Summit Technology, Inc. | Laser reprofiling system employing an erodable mask |
US4891043A (en) | 1987-05-28 | 1990-01-02 | Board Of Trustees Of The University Of Illinois | System for selective release of liposome encapsulated material via laser radiation |
US5171318A (en) | 1987-11-09 | 1992-12-15 | Chiron Ophthalmics, Inc. | Treated corneal prosthetic device |
US4969912A (en) | 1988-02-18 | 1990-11-13 | Kelman Charles D | Human collagen processing and autoimplant use |
US4881543A (en) | 1988-06-28 | 1989-11-21 | Massachusetts Institute Of Technology | Combined microwave heating and surface cooling of the cornea |
US5098426A (en) | 1989-02-06 | 1992-03-24 | Phoenix Laser Systems, Inc. | Method and apparatus for precision laser surgery |
US5152759A (en) | 1989-06-07 | 1992-10-06 | University Of Miami, School Of Medicine, Dept. Of Ophthalmology | Noncontact laser microsurgical apparatus |
US5103005A (en) | 1989-07-21 | 1992-04-07 | Coors Biotech, Inc. | Method for recovery of riboflavin |
US5016615A (en) | 1990-02-20 | 1991-05-21 | Riverside Research Institute | Local application of medication with ultrasound |
US5490849A (en) | 1990-07-13 | 1996-02-13 | Smith; Robert F. | Uniform-radiation caustic surface for photoablation |
US6342053B1 (en) | 1990-07-23 | 2002-01-29 | Laser Biotech, Inc. | Apparatus for cornea reshaping |
US5779696A (en) | 1990-07-23 | 1998-07-14 | Sunrise Technologies International, Inc. | Method and apparatus for performing corneal reshaping to correct ocular refractive errors |
US6325792B1 (en) | 1991-11-06 | 2001-12-04 | Casimir A. Swinger | Ophthalmic surgical laser and method |
US5171254A (en) | 1991-11-19 | 1992-12-15 | Sher Neal A | Eye fixation device |
EP0630205A4 (en) | 1992-02-27 | 1995-06-14 | Phoenix Laser Systems Inc | AUTOMATED LASER UNIT FOR HIGH-PRECISION SURGICAL AND INDUSTRIAL INTERVENTIONS. |
RU2086215C1 (ru) | 1992-03-17 | 1997-08-10 | Александр Иосифович Симановский | Способ определения истинного внутриглазного давления, коэффициента легкости оттока и минутного объема продуцирования камерной влаги |
US6450641B2 (en) | 1992-06-02 | 2002-09-17 | Lasersight Technologies, Inc. | Method of corneal analysis using a checkered placido apparatus |
JP2965101B2 (ja) | 1992-07-31 | 1999-10-18 | 株式会社ニデック | 眼科装置 |
WO1994003134A1 (en) | 1992-08-03 | 1994-02-17 | Sunrise Technologies, Inc. | Method and apparatus for exposing a human eye to a controlled pattern of radiation spots |
IL103290A (en) | 1992-09-25 | 1996-06-18 | Ben Nun Joshua | Ophthalmologic examination and/or treatment apparatus |
US5608472A (en) | 1992-11-06 | 1997-03-04 | Research Development Foundation | Eye imaging system |
US5891131A (en) | 1993-02-01 | 1999-04-06 | Arizona Board Of Regents | Method and apparatus for automated simulation and design of corneal refractive procedures |
AU6559394A (en) | 1993-04-15 | 1994-11-08 | Board Of Regents, The University Of Texas System | Raman spectrometer |
US5461212A (en) | 1993-06-04 | 1995-10-24 | Summit Technology, Inc. | Astigmatic laser ablation of surfaces |
AU716040B2 (en) | 1993-06-24 | 2000-02-17 | Bausch & Lomb Incorporated | Ophthalmic pachymeter and method of making ophthalmic determinations |
US20020042612A1 (en) | 1997-10-27 | 2002-04-11 | Hood Larry L. | Method and apparatus for modifications of visual acuity by thermal means |
US5634921A (en) | 1993-08-23 | 1997-06-03 | Hood; Larry | Method and apparatus for modifications of visual acuity by thermal means |
US20020002369A1 (en) | 1993-08-23 | 2002-01-03 | Hood Larry L. | Method and apparatus for modifying visual acuity by moving a focal point of energy within a cornea |
SG52621A1 (en) | 1994-02-09 | 1998-09-28 | Keravision Inc | An electrosurgical procedure recurving the cornea |
JP3263275B2 (ja) | 1994-04-05 | 2002-03-04 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生体組織のレーザー処理のための装置並びに火焔状斑点母斑のレーザー処理装置 |
US6293938B1 (en) | 1994-04-08 | 2001-09-25 | Summit Technology, Inc. | Photo-refractive keratectomy |
US20050187599A1 (en) | 1994-05-06 | 2005-08-25 | Hugh Sharkey | Method and apparatus for controlled contraction of soft tissue |
AU3496895A (en) | 1994-08-22 | 1996-03-14 | Iomed, Inc. | Iontophoretic delivery device with integral hydrating means |
RU2098057C1 (ru) | 1994-10-20 | 1997-12-10 | Ольга Александровна Киселева | Способ лечения отслойки сетчатки, осложненной субретинальным швартообразованием |
US5624437A (en) | 1995-03-28 | 1997-04-29 | Freeman; Jerre M. | High resolution, high speed, programmable laser beam modulating apparatus for microsurgery |
HU213450B (en) | 1995-04-26 | 1997-06-30 | Ladanyi Jozsef | Gel contains gelatin and process for producing it |
US5910110A (en) | 1995-06-07 | 1999-06-08 | Mentor Ophthalmics, Inc. | Controlling pressure in the eye during surgery |
US6520956B1 (en) | 1995-11-06 | 2003-02-18 | David Huang | Apparatus and method for performing laser thermal keratoplasty with minimized regression |
US6033396A (en) | 1995-11-06 | 2000-03-07 | Huang; David | Apparatus and method for performing laser thermal keratoplasty with minimized regression |
US6441047B2 (en) | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
US7141049B2 (en) | 1999-03-09 | 2006-11-28 | Thermage, Inc. | Handpiece for treatment of tissue |
US7452358B2 (en) | 1996-01-05 | 2008-11-18 | Thermage, Inc. | RF electrode assembly for handpiece |
US20070244496A1 (en) | 1996-02-07 | 2007-10-18 | Hellenkamp Johann F | Automatic surgical device and control assembly for cutting a cornea |
DE19614823A1 (de) | 1996-04-15 | 1997-10-16 | Mann Gerhard Chem Pharm Fab | Ophthalmische Zusammensetzung mit verlängerter Verweilzeit am Auge |
US6726684B1 (en) | 1996-07-16 | 2004-04-27 | Arthrocare Corporation | Methods for electrosurgical spine surgery |
US20060149343A1 (en) | 1996-12-02 | 2006-07-06 | Palomar Medical Technologies, Inc. | Cooling system for a photocosmetic device |
RU2127099C1 (ru) | 1997-04-07 | 1999-03-10 | Борзенок Сергей Анатольевич | Глазные капли "неокератоник" |
RU2127100C1 (ru) | 1997-04-17 | 1999-03-10 | Борзенок Сергей Анатольевич | Глазные капли "пиротоник" |
US6302876B1 (en) | 1997-05-27 | 2001-10-16 | Visx Corporation | Systems and methods for imaging corneal profiles |
RU2121825C1 (ru) | 1997-06-24 | 1998-11-20 | Межотраслевой научно-технический комплекс "Микрохирургия глаза" | Глазные капли "интертоник" |
US6104959A (en) | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
US6007499A (en) | 1997-10-31 | 1999-12-28 | University Of Washington | Method and apparatus for medical procedures using high-intensity focused ultrasound |
RU2130762C1 (ru) | 1997-12-10 | 1999-05-27 | Федоров Святослав Николаевич | Устройство для офтальмохирургических операций |
US20030135122A1 (en) | 1997-12-12 | 2003-07-17 | Spectrx, Inc. | Multi-modal optical tissue diagnostic system |
US20080027328A1 (en) | 1997-12-29 | 2008-01-31 | Julia Therapeutics, Llc | Multi-focal treatment of skin with acoustic energy |
US5885275A (en) | 1998-01-15 | 1999-03-23 | Diomed, Inc. | Medical spacing guide |
US6161544A (en) | 1998-01-28 | 2000-12-19 | Keratoform, Inc. | Methods for accelerated orthokeratology |
US20020013577A1 (en) | 1998-03-06 | 2002-01-31 | Frey Rudolph W. | Laser beam delivery and eye tracking system |
EP1061873B1 (en) | 1998-03-09 | 2005-11-02 | Ista Pharmaceuticals, Inc | Use of glyceraldehyde as corneal hardening agents |
US6398753B2 (en) | 1998-04-03 | 2002-06-04 | Mcdaniel David H. | Ultrasound enhancement of percutaneous drug absorption |
US6188500B1 (en) | 1998-04-03 | 2001-02-13 | Psc Scanning, Inc. | Method for generating multiple scan lines in a thin scanner |
AU3970799A (en) | 1998-05-04 | 1999-11-23 | Board Of Regents | Combined fluorescence and reflectance spectroscopy |
US6099521A (en) | 1998-05-26 | 2000-08-08 | Shadduck; John H. | Semiconductor contact lens cooling system and technique for light-mediated eye therapies |
US6162210A (en) | 1998-08-06 | 2000-12-19 | Shadduck; John H. | Laser mediated treatments for presbyopia and hyperopia |
AU747840B2 (en) | 1998-08-19 | 2002-05-23 | Autonomous Technologies Corporation | Apparatus and method for measuring vision defects of a human eye |
US6101411A (en) | 1998-09-24 | 2000-08-08 | Newsome; David A. | Dilation enhancer |
US6218360B1 (en) | 1998-11-19 | 2001-04-17 | The Schepens Eye Research Institute | Collagen based biomaterials and methods of preparation and use |
US6402739B1 (en) | 1998-12-08 | 2002-06-11 | Y-Beam Technologies, Inc. | Energy application with cooling |
US6617963B1 (en) | 1999-02-26 | 2003-09-09 | Sri International | Event-recording devices with identification codes |
JP4102031B2 (ja) | 1999-03-09 | 2008-06-18 | サーメイジ インコーポレイテッド | 組織を治療するのための装置および方法 |
JP4250721B2 (ja) | 1999-03-15 | 2009-04-08 | カール ツアイス メディテック アクチエンゲゼルシャフト | 眼検査用立体顕微鏡における照明装置及びその方法 |
AU5274000A (en) | 1999-06-04 | 2000-12-28 | Sunrise Technologies International, Inc. | Prevention of regression in refractive keratoplasty |
US6280436B1 (en) | 1999-08-10 | 2001-08-28 | Memphis Eye & Cataract Associates Ambulatory Surgery Center | Eye tracking and positioning system for a refractive laser system |
JP2002058695A (ja) | 1999-09-03 | 2002-02-26 | Carl Zeiss Jena Gmbh | 眼の照射方法及び装置 |
US6946440B1 (en) | 1999-09-15 | 2005-09-20 | Dewoolfson Bruce H | Composition for stabilizing corneal tissue during or after orthokeratology lens wear |
ES2390397T3 (es) | 1999-10-21 | 2012-11-12 | Technolas Perfect Vision Gmbh | Perfil corneal personalizado |
US6319273B1 (en) | 1999-12-16 | 2001-11-20 | Light Sciences Corporation | Illuminating device for treating eye disease |
US6673067B1 (en) | 2000-01-31 | 2004-01-06 | Gholam A. Peyman | System and method for thermally and chemically treating cells at sites of interest in the body to impede cell proliferation |
US8215314B2 (en) | 2000-02-11 | 2012-07-10 | The General Hospital Corporation | Photochemical tissue bonding |
AU2001249984B2 (en) | 2000-02-11 | 2005-05-26 | The General Hospital Corporation | Photochemical tissue bonding |
US7073510B2 (en) | 2000-02-11 | 2006-07-11 | The General Hospital Corporation | Photochemical tissue bonding |
US6394999B1 (en) | 2000-03-13 | 2002-05-28 | Memphis Eye & Cataract Associates Ambulatory Surgery Center | Laser eye surgery system using wavefront sensor analysis to control digital micromirror device (DMD) mirror patterns |
US6949093B1 (en) | 2000-03-21 | 2005-09-27 | Minu, L.L.C. | Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith |
US7867186B2 (en) | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
JP2001299941A (ja) | 2000-04-27 | 2001-10-30 | Hamamatsu Photonics Kk | レーザ治療装置 |
US6494878B1 (en) | 2000-05-12 | 2002-12-17 | Ceramoptec Industries, Inc. | System and method for accurate optical treatment of an eye's fundus |
US6668190B2 (en) | 2000-06-16 | 2003-12-23 | Wayne State University | Method and apparatus for activating molecules to stimulate neurological tissue |
WO2002000228A1 (fr) | 2000-06-29 | 2002-01-03 | Rohto Pharmaceutical Co., Ltd. | Composition ophtalmique contenant de l'oxygene |
EP1328214A4 (en) | 2000-09-20 | 2009-07-29 | Shahinian Lee Jr | NASAL, INHALABLE AND LOCAL OPHTHALMIC PREPARATIONS AND MEDICATIONS WITH SPONTANEOUS CONSERVATION |
JP2004510825A (ja) | 2000-10-13 | 2004-04-08 | ザ ジョンズ ホプキンズ ユニバーシティ | レーザ視力矯正手術後の角膜と上皮下のもやを防止するためのプラスミノゲンアクチベータ(plasminogenactivator) |
US20020099363A1 (en) | 2001-01-23 | 2002-07-25 | Woodward Benjamin W. | Radiation treatment system and method of using same |
US7753943B2 (en) | 2001-02-06 | 2010-07-13 | Qlt Inc. | Reduced fluence rate PDT |
US7044945B2 (en) | 2001-03-30 | 2006-05-16 | Sand Bruce J | Prevention of regression in thermal ciliary muscle tendinoplasty |
US6766042B2 (en) | 2001-04-26 | 2004-07-20 | Memphis Eye & Contact Associates | System to automatically detect eye corneal striae |
US6918904B1 (en) | 2001-11-07 | 2005-07-19 | Minu, L.L.C. | Method of reshaping the cornea by controlled thermal delivery |
US20030208190A1 (en) | 2001-07-20 | 2003-11-06 | Cynthia Roberts | Methods and instruments for refractive ophthalmic surgery |
US20030030908A1 (en) | 2001-08-13 | 2003-02-13 | Yeou-Yen Cheng | Virtually imaged phased array (VIPA) with machined radiation window boundary |
US9681942B2 (en) | 2001-11-07 | 2017-06-20 | Gholam A. Peyman | Method for prevention of rejection and sever encapsulation of a supportive or functioning implant |
US20050149006A1 (en) | 2001-11-07 | 2005-07-07 | Peyman Gholam A. | Device and method for reshaping the cornea |
US20070142828A1 (en) | 2001-11-07 | 2007-06-21 | Minu, Llc | Method and system for altering the refractive properties of the eye |
US20070135805A1 (en) | 2001-11-07 | 2007-06-14 | Minu Telesystems Llc | Device and method for reshaping the cornea |
US9155652B2 (en) | 2001-11-07 | 2015-10-13 | Gholam A. Peyman | Method for laser correction of refractive errors of an eye with a thin cornea |
US20030167033A1 (en) | 2002-01-23 | 2003-09-04 | James Chen | Systems and methods for photodynamic therapy |
US7130835B2 (en) | 2002-03-28 | 2006-10-31 | Bausch & Lomb Incorporated | System and method for predictive ophthalmic correction |
US7336989B2 (en) | 2002-04-03 | 2008-02-26 | The Regents Of The University Of California | System and method for quantitative or qualitative measurement of exogenous substances in tissue and other materials using laser-induced fluorescence spectroscopy |
DE50202312D1 (de) | 2002-04-05 | 2005-03-31 | Sis Ag Surgical Instr Systems | Vorrichtung und Verfahren zur Bestimmung von geometrischen Messwerten eines Auges |
US6758564B2 (en) | 2002-06-14 | 2004-07-06 | Physical Sciences, Inc. | Line-scan laser ophthalmoscope |
DE10323422B4 (de) | 2002-08-23 | 2022-05-05 | Carl Zeiss Meditec Ag | Vorrichtung und Verfahren zur Messung eines optischen Durchbruchs in einem Gewebe |
ITTO20021007A1 (it) | 2002-11-19 | 2004-05-20 | Franco Bartoli | Apparecchiatura laser ad eccimeri e metodo di pilotaggio |
AU2003297734A1 (en) | 2002-12-09 | 2004-06-30 | The Trustees Of Dartmouth College | Electrically-induced thermokeratoplasty systems and method |
US7377917B2 (en) | 2002-12-09 | 2008-05-27 | The Trustees Of Dartmouth College | Feedback control of thermokeratoplasty treatments |
US20060177430A1 (en) | 2002-12-20 | 2006-08-10 | Chakshu Research Inc | Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer |
US7004902B2 (en) | 2003-03-21 | 2006-02-28 | Reichert, Inc. | Method and apparatus for measuring biomechanical characteristics of corneal tissue |
US20110098790A1 (en) | 2009-10-26 | 2011-04-28 | Albert Daxer | Methods for treating corneal disease |
US7223275B2 (en) | 2003-05-27 | 2007-05-29 | Yichieh Shiuey | System for cutting the cornea of an eye |
JP4152836B2 (ja) | 2003-08-22 | 2008-09-17 | 富士通株式会社 | 分波機能を備えた光部品および波長分散補償器 |
KR20070030158A (ko) | 2003-08-22 | 2007-03-15 | 코세 코퍼레이션 | 일중항산소 소거제 및 그것을 사용한 조성물 |
US20050096515A1 (en) | 2003-10-23 | 2005-05-05 | Geng Z. J. | Three-dimensional surface image guided adaptive therapy system |
ES2322850T3 (es) | 2004-02-03 | 2009-06-30 | Iroc Ag | Dispositivo oftalmologico. |
DE102004021754A1 (de) | 2004-04-30 | 2005-11-24 | Reinhardt Thyzel | Vorrichtung zum Entfernen von Epithelzellen aus einem Linsenkapselsack eines menschlichen oder tierischen Auges |
US8571648B2 (en) | 2004-05-07 | 2013-10-29 | Aesthera | Apparatus and method to apply substances to tissue |
JP2007536272A (ja) | 2004-05-07 | 2007-12-13 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 近視の処置法 |
ITMI20041625A1 (it) | 2004-08-06 | 2004-11-06 | Roberto Pinelli | Apparato per la correzione della presbiopia |
ES2379468T3 (es) | 2004-08-24 | 2012-04-26 | The General Hospital Corporation | Procedimiento, sistema y configuración de software para determinar el módulo de elasticidad |
US20060135957A1 (en) | 2004-12-21 | 2006-06-22 | Dorin Panescu | Method and apparatus to align a probe with a cornea |
US7871378B1 (en) | 2004-12-22 | 2011-01-18 | Achevé Technology, Inc. | Device and method to measure corneal biomechanical properties and its application to intraocular pressure measurement |
US8394084B2 (en) | 2005-01-10 | 2013-03-12 | Optimedica Corporation | Apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation |
US20060276777A1 (en) | 2005-04-08 | 2006-12-07 | Coroneo Minas T | Corneal shaping |
US20060287662A1 (en) | 2005-05-26 | 2006-12-21 | Ntk Enterprises, Inc. | Device, system, and method for epithelium protection during cornea reshaping |
WO2007001926A2 (en) | 2005-06-24 | 2007-01-04 | Hyperbranch Medical Technology, Inc. | Low-swelling hydrogel sealants for wound repair |
US20070027509A1 (en) | 2005-07-29 | 2007-02-01 | Eisenberg Elliot S | Automated panretinal laser photocoagulation |
US7292347B2 (en) | 2005-08-01 | 2007-11-06 | Mitutoyo Corporation | Dual laser high precision interferometer |
US8388668B2 (en) | 2005-08-05 | 2013-03-05 | Gholam A. Peyman | Methods to regulate polarization of excitable cells |
US20070048340A1 (en) | 2005-08-31 | 2007-03-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Multi step patterning of a skin surface |
US20070055227A1 (en) | 2005-09-08 | 2007-03-08 | Refractec, Inc. | Probe used for an ocular procedure |
WO2007035913A2 (en) | 2005-09-21 | 2007-03-29 | Kurve Technology, Inc. | Medicament delivery control, monitoring, and reporting system and method |
US8053449B2 (en) | 2005-10-05 | 2011-11-08 | Cell Viable Corporation | Method for inhibiting AGE complex formation |
EP1779891A1 (en) | 2005-10-28 | 2007-05-02 | Abdula Kurkayev | Method of activating a photosensitizer |
CA2621719C (en) | 2005-10-31 | 2014-05-20 | Crs & Associates | Method and apparatus for measuring the deformation characteristics of an object |
DE102005056958A1 (de) | 2005-11-29 | 2007-06-06 | Rowiak Gmbh | Verfahren und Vorrichtung zum Bearbeiten eines Werkstücks |
US20070203547A1 (en) | 2005-12-15 | 2007-08-30 | Costello Benedict J | Medical device identification |
US20090171305A1 (en) | 2006-01-05 | 2009-07-02 | El Hage Sami G | Combination therapy for long-lasting ckr |
WO2007081750A2 (en) | 2006-01-06 | 2007-07-19 | The Curators Of The University Of Missouri | Ultrasound-mediated transcleral drug delivery |
US20070203478A1 (en) | 2006-02-21 | 2007-08-30 | Herekar Satish V | Method and system for elasto-modulation of ocular tissue |
RU2309713C1 (ru) | 2006-03-17 | 2007-11-10 | ЗАО "Екатеринбургский центр МНТК "Микрохирургия глаза" | Способ лечения начальных стадий кератоконуса путем эксимерлазерной хирургии |
US8182471B2 (en) | 2006-03-17 | 2012-05-22 | Amo Manufacturing Usa, Llc. | Intrastromal refractive correction systems and methods |
WO2007112946A1 (en) | 2006-03-30 | 2007-10-11 | Universite De Geneve | Intraocular lens with drug delivery system attached thereto |
EP2004209B1 (en) | 2006-04-13 | 2013-07-24 | Euclid Systems Corporation | Composition and method for stabilizing corneal tissue after refractive surgery |
US8624721B2 (en) | 2006-04-17 | 2014-01-07 | Warsaw Orthopedic, Inc. | Method and apparatus for embedding a transmitter into a tool, and a system for monitoring the tool |
EP2016456A4 (en) | 2006-04-20 | 2010-08-25 | Xceed Imaging Ltd | THROUGH OPTICAL SYSTEM AND METHOD FOR PROVIDING AN ENLARGED SHARPNESS DURING THE FIGURE |
US20100028407A1 (en) | 2006-04-27 | 2010-02-04 | University Of Louisville Research Foundation, Inc. | Layered bio-adhesive compositions and uses thereof |
JP2009535464A (ja) | 2006-05-03 | 2009-10-01 | ビジョン シーアールシー リミティド | 生物系ポリシロキサン |
EP1854438B1 (de) | 2006-05-09 | 2018-07-04 | IROC Services AG | Ophthalmologische Vorrichtung zur Vorbeugung einer Myopie |
WO2007139927A1 (en) | 2006-05-26 | 2007-12-06 | The Cleveland Clinic Foundation | Method for measuring biomechanical properties in an eye |
US20070282313A1 (en) | 2006-06-01 | 2007-12-06 | University Of Southern California | Method and apparatus to guide laser corneal surgery with optical measurement |
US20070291277A1 (en) | 2006-06-20 | 2007-12-20 | Everett Matthew J | Spectral domain optical coherence tomography system |
DE102006030219A1 (de) | 2006-06-30 | 2008-01-03 | Iroc Ag | Bestrahlungssystem für medizinische Anwendungen |
JP3940161B1 (ja) | 2006-07-03 | 2007-07-04 | 朝日インテック株式会社 | 医療用ガイドワイヤ、医療用ガイドワイヤとマイクロカテーテルとの組立体、および医療用ガイドワイヤとバルーンカテーテルとガイディングカテーテルとの組立体 |
US20080015660A1 (en) | 2006-07-13 | 2008-01-17 | Priavision, Inc. | Method And Apparatus For Photo-Chemical Oculoplasty/Keratoplasty |
US10729585B2 (en) | 2006-07-19 | 2020-08-04 | Alcon Inc. | Computer program for ophthalmological surgery |
US20080063627A1 (en) | 2006-09-12 | 2008-03-13 | Surmodics, Inc. | Tissue graft materials containing biocompatible agent and methods of making and using same |
US7535991B2 (en) | 2006-10-16 | 2009-05-19 | Oraya Therapeutics, Inc. | Portable orthovoltage radiotherapy |
US8414911B2 (en) | 2006-10-24 | 2013-04-09 | The Regents Of The University Of California | Photochemical therapy to affect mechanical and/or chemical properties of body tissue |
WO2008070185A2 (en) | 2006-12-06 | 2008-06-12 | The Trustees Of Columbia University In The City Of New York | Method of stabilizing human eye tissue by reaction with nitrite and related agents such as nitro compounds |
WO2008070848A2 (en) | 2006-12-07 | 2008-06-12 | Priavision, Inc. | Method and material for in situ corneal structural augmentation |
WO2008095075A1 (en) | 2007-02-01 | 2008-08-07 | Ls Biopath, Inc. | Optical system for identification and characterization of abnormal tissue and cells |
US8580789B2 (en) | 2007-04-02 | 2013-11-12 | The Cleveland Clinic Foundation | Treating glaucoma |
US8115919B2 (en) | 2007-05-04 | 2012-02-14 | The General Hospital Corporation | Methods, arrangements and systems for obtaining information associated with a sample using optical microscopy |
US8202272B2 (en) | 2007-07-19 | 2012-06-19 | Avedro, Inc. | Eye therapy system |
US8992516B2 (en) | 2007-07-19 | 2015-03-31 | Avedro, Inc. | Eye therapy system |
US10105441B2 (en) | 2007-08-16 | 2018-10-23 | The Schepens Eye Research Institute, Inc. | Method for inhibiting or reducing dry eye disease by IL-1Ra |
US8603081B2 (en) | 2007-08-23 | 2013-12-10 | Ntk Enterprises, Inc. | System and method for defining and controlling LTK and other surgical eye procedures to produce little or no stromal collagen shrinkage |
WO2009042159A1 (en) | 2007-09-24 | 2009-04-02 | The Johns Hopkins University | Wearable photoactivator for ocular therapeutic applications and use thereof |
DE102007052103A1 (de) | 2007-10-31 | 2009-05-07 | Medizinisches Laserzentrum Lübeck GmbH | Vorrichtung zur schonenden Lasertherapie der Retina |
JP2011503232A (ja) | 2007-11-20 | 2011-01-27 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 免疫応答の調節 |
US8431158B2 (en) | 2007-11-26 | 2013-04-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions comprising fibrous polypeptides and polysaccharides |
WO2009073213A1 (en) | 2007-12-05 | 2009-06-11 | Avedro, Inc. | Eye therapy system |
US20100057060A1 (en) | 2007-12-07 | 2010-03-04 | Seros Medical, Llc | In Situ UV/Riboflavin Ocular Treatment System |
US20090149923A1 (en) * | 2007-12-07 | 2009-06-11 | 21X Corporation Dba Priavision, Inc. | Method for equi-dosed time fractionated pulsed uva irradiation of collagen/riboflavin mixtures for ocular structural augmentation |
US8348935B2 (en) | 2008-01-23 | 2013-01-08 | Avedro, Inc. | System and method for reshaping an eye feature |
AU2009223641A1 (en) | 2008-03-14 | 2009-09-17 | Euclid Systems Corporation | Ultraviolet irradiation to treat corneal weakness disorders |
US9125735B2 (en) | 2008-04-04 | 2015-09-08 | Forsight Labs, Llc | Method of correcting vision using corneal onlays |
EP2276420B1 (en) | 2008-04-04 | 2021-10-06 | Journey1, Inc. | Device to treat an eye having an epithelium with a defect |
EP2296580A2 (en) | 2008-04-04 | 2011-03-23 | Forsight Labs, Llc | Corneal onlay devices and methods |
WO2009132221A1 (en) | 2008-04-23 | 2009-10-29 | The Cleveland Clinic Foundation | Method for modeling biomechanical properties of an eye |
US20090275929A1 (en) | 2008-04-30 | 2009-11-05 | Amo Development, Llc | System and method for controlling measurement in an eye during ophthalmic procedure |
US7898656B2 (en) | 2008-04-30 | 2011-03-01 | The General Hospital Corporation | Apparatus and method for cross axis parallel spectroscopy |
WO2010011119A1 (es) | 2008-07-22 | 2010-01-28 | Choza Remero Andres Abelino | Solución oftálmica para engrosar córneas |
US20110202114A1 (en) | 2008-08-08 | 2011-08-18 | Line Kessel | System and method for treatment of lens related disorders |
RU2391078C2 (ru) | 2008-08-14 | 2010-06-10 | Сергей Игоревич Анисимов | Способ лечения кератоконуса воздействием ультрафиолетового излучения и устройство для его осуществления (варианты) |
IT1393402B1 (it) | 2008-08-28 | 2012-04-20 | Sooft Italia Spa | Uso di enhancer eventualmente con riboflavina, nonche' relative composizioni oftalmiche per cross-linking corneale del cheratocono o di altre patologie ectasiche corneali |
DE102008046834A1 (de) | 2008-09-11 | 2010-03-18 | Iroc Ag | Steuerprogramm zum Steuern elektromagnetischer Strahlung für eine Quervernetzung von Augengewebe |
US20100082018A1 (en) | 2008-09-26 | 2010-04-01 | Daryus Panthakey | Method and system for reshaping the cornea |
WO2010039854A1 (en) | 2008-09-30 | 2010-04-08 | Neal Marshall | Eye therapy system |
US8226232B2 (en) | 2008-12-17 | 2012-07-24 | Technion Research And Development Foundation, Ltd. | System and method for fast retinal imaging |
US8496651B2 (en) | 2009-01-27 | 2013-07-30 | Technolas Perfect Vision Gmbh | System and method for refractive surgery with augmentation by intrastromal corrective procedure |
US20120059439A1 (en) | 2009-02-12 | 2012-03-08 | University Of Rochester | Aberration control by corneal collagen crosslinking combined with beam-shaping technique |
JP5628839B2 (ja) | 2009-02-12 | 2014-11-19 | アルコン リサーチ, リミテッド | 眼球表面疾患を検出するシステムおよび眼球表面検査装置 |
US7883210B2 (en) | 2009-04-24 | 2011-02-08 | Filar Paul A | Apparatus for photographing the anterior segment and retina of the eye through the use of a camera attachment |
EP2253321A1 (en) | 2009-05-06 | 2010-11-24 | Roberto Pinelli | Collyrium for the treatment of conial cornea with "cross-linking" trans-epithelial technique |
US20100286156A1 (en) | 2009-05-06 | 2010-11-11 | Roberto Pinelli | Collyrium For The Treatment Of Conical Cornea With Cross-Linking Trans-Epithelial Technique |
US20100318017A1 (en) | 2009-06-11 | 2010-12-16 | Lewis Scott E | Method of improving vision using contact lenses and corneal collagen crosslinking |
US20120203161A1 (en) | 2009-08-12 | 2012-08-09 | Seros Medical, Llc | Deuterated water and riboflavin solution for extending singlet oxygen lifetimes in treatment of ocular tissue and method of use |
US8710099B2 (en) | 2009-09-10 | 2014-04-29 | New York University | Treatment of cancer using the sodium salt of a benzoic acid derivative |
US8518028B2 (en) | 2009-09-30 | 2013-08-27 | Abbott Medical Optics Inc. | Methods for enhancing accommodation of a natural lens of an eye |
US8948863B2 (en) | 2009-10-09 | 2015-02-03 | Board Of Regents, The University Of Texas System | Photokinetic ocular drug delivery methods and apparatus |
WO2011050164A1 (en) * | 2009-10-21 | 2011-04-28 | Avedro, Inc. | Eye therapy |
US20130245536A1 (en) * | 2009-10-21 | 2013-09-19 | Avedro, Inc. | Systems and methods for corneal cross-linking with pulsed light |
US9707126B2 (en) | 2009-10-21 | 2017-07-18 | Avedro, Inc. | Systems and methods for corneal cross-linking with pulsed light |
US20110098809A1 (en) | 2009-10-23 | 2011-04-28 | John Wardle | Ocular Implant System and Method |
JP6377906B2 (ja) | 2010-03-19 | 2018-08-22 | アヴェドロ・インコーポレーテッドAvedro,Inc. | 眼治療を適用およびモニターするためのシステム |
US20120215155A1 (en) | 2010-03-19 | 2012-08-23 | Avedro Inc. | Controlled cross-linking initiation and corneal topography feedback systems for directing cross-linking |
US20120283621A1 (en) | 2010-03-19 | 2012-11-08 | Avedro, Inc. | Sterilizing application of cross-linking agent |
US20120289886A1 (en) | 2010-04-13 | 2012-11-15 | Avedro, Inc. | Controlled application of cross-linking agent |
US20110288466A1 (en) | 2010-04-13 | 2011-11-24 | Avedro, Inc. | Systems and methods for activating cross-linking in an eye |
RU2428152C1 (ru) | 2010-04-19 | 2011-09-10 | Сергей Васильевич Безик | Способ мобилизации интраокулярной линзы для удаления вторичной катаракты с использованием бимануальной автоматизированной системы аспирации-ирригации при наличии фимоза переднего капсулорексиса |
EP2907490A1 (de) | 2010-04-21 | 2015-08-19 | IROC Innocross AG | Vorrichtung für die vernetzung von okulärem gewebe mit elektromagnetischer strahlung |
CN102917676A (zh) * | 2010-04-30 | 2013-02-06 | 塞罗斯医学有限责任公司 | 使用组合的方式治疗眼组织的方法和装置 |
DE102010020194B4 (de) | 2010-05-07 | 2022-09-08 | Carl Zeiss Meditec Ag | Vorrichtung zur Stabilisierung der Augenhornhaut |
KG1376C1 (en) | 2010-05-31 | 2011-08-30 | M A Medvedev | Method for keratoconus treatment |
IT1400982B1 (it) | 2010-07-05 | 2013-07-05 | Pinelli | Collirio osmotico trans-epiteliale per la cura del cheratocono. |
US9622911B2 (en) | 2010-09-30 | 2017-04-18 | Cxl Ophthalmics, Llc | Ophthalmic treatment device, system, and method of use |
US20120083772A1 (en) | 2010-09-30 | 2012-04-05 | Curveright Llc | Corneal treatment system and method |
US10456209B2 (en) * | 2010-10-13 | 2019-10-29 | Gholam A. Peyman | Remote laser treatment system with dynamic imaging |
MX2013008042A (es) | 2011-01-12 | 2013-09-16 | Sooft Italia Spa | Suministro a la cornea de agentes de reticulacion mediante iontoforesis, para el tratamiento del queratocono y composiciones oftalmicas relacionadas. |
WO2012112543A2 (en) | 2011-02-15 | 2012-08-23 | Seros Medical, Llc | Method and apparatus for the delivery of photo-chemical (cross-linking) treatment to scleral tissue |
US8111394B1 (en) | 2011-04-01 | 2012-02-07 | IsoSpec Technologies, LP | Raman spectrometer for monitoring traces of dissolved organic and inorganic substances |
RU2456971C1 (ru) * | 2011-04-19 | 2012-07-27 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Способ лечения прогрессирующего кератоконуса |
US10182941B2 (en) | 2011-04-29 | 2019-01-22 | Farhad Hafezi | Apparatus for the treatment and/or prevention of corneal diseases |
EP2712299A4 (en) | 2011-04-29 | 2014-12-10 | Gen Hospital Corp | METHODS AND ARRANGEMENTS FOR OBTAINING INFORMATION AND PROVIDING ANALYSIS FOR BIOLOGICAL TISSUES |
US20140066835A1 (en) | 2011-05-24 | 2014-03-06 | Avedro, Inc. | Systems and methods for corneal cross-linking with pulsed light |
US9044308B2 (en) | 2011-05-24 | 2015-06-02 | Avedro, Inc. | Systems and methods for reshaping an eye feature |
WO2012167260A2 (en) | 2011-06-02 | 2012-12-06 | Avedro, Inc. | Systems and methods for monitoring time based photo active agent delivery or photo active marker presence |
US10813791B2 (en) | 2011-06-02 | 2020-10-27 | University Of Rochester | Method for modifying the refractive index of ocular tissues and applications thereof |
WO2012174453A2 (en) | 2011-06-15 | 2012-12-20 | Sybotics, Llc | Systems and methods for binocular iris imaging |
JP2015500670A (ja) | 2011-10-02 | 2015-01-08 | アヴェドロ・インコーポレーテッドAvedro,Inc. | 眼治療を適用及びモニタするシステム及び方法 |
US20130110091A1 (en) * | 2011-10-26 | 2013-05-02 | Ntk Enterprises, Inc. | Apparatus and method for performing surgical eye procedures including ltk and cxl procedures |
WO2013148713A1 (en) | 2012-03-28 | 2013-10-03 | Cxl Ophthalmics, Llc | Ocular treatment system and method using red and gold phototherapy |
EP2830637A4 (en) | 2012-03-29 | 2016-03-16 | Cxl Ophthalmics Llc | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING DISEASES RELATED TO OXIDATIVE STRESS |
WO2013148896A1 (en) | 2012-03-29 | 2013-10-03 | Cxl Ophthalmics, Llc | Ocular treatment solutions, delivery devices and delivery augmentation methods |
WO2013148895A1 (en) * | 2012-03-29 | 2013-10-03 | Cxl Ophthalmics, Llc | Ocular cross-linking system and method for sealing corneal wounds |
JP5989523B2 (ja) | 2012-05-01 | 2016-09-07 | 株式会社トプコン | 眼科装置 |
WO2014081875A1 (en) | 2012-11-20 | 2014-05-30 | David Muller | Systems and methods for treating glaucoma |
US20140276361A1 (en) | 2012-11-20 | 2014-09-18 | Avedro, Inc. | Systems and methods for treating glaucoma |
WO2014145666A2 (en) | 2013-03-15 | 2014-09-18 | Avedro, Inc. | Treatments of extracellular matrices of the eye |
US20140277431A1 (en) | 2013-03-15 | 2014-09-18 | Avedro, Inc. | Treatments of extracellular matrices of the eye |
EP3858356A3 (en) | 2013-05-19 | 2021-12-01 | Avedro, Inc. | Systems, methods, and compositions for cross-linking |
US9498114B2 (en) | 2013-06-18 | 2016-11-22 | Avedro, Inc. | Systems and methods for determining biomechanical properties of the eye for applying treatment |
DE102013211854B4 (de) | 2013-06-21 | 2017-01-05 | Universität Rostock | Verfahren und Vorrichtung zur Bestimmung einer spektralen Änderung von gestreutem Licht |
CN107205845B (zh) * | 2014-10-27 | 2020-03-31 | 艾维德洛公司 | 用于眼的交联治疗的***和方法 |
US10114205B2 (en) | 2014-11-13 | 2018-10-30 | Avedro, Inc. | Multipass virtually imaged phased array etalon |
EP4082547A1 (en) | 2014-12-02 | 2022-11-02 | Avedro, INC. | Systems, methods, and compositions for cross-linking treatments of an eye |
CA3112937A1 (en) * | 2018-09-19 | 2020-03-26 | Avedro, Inc. | Systems and methods treating for corneal ectatic disorders |
AU2019345058A1 (en) * | 2018-09-19 | 2021-04-15 | Avedro, Inc. | Systems and methods for eye tracking during eye treatment |
US12016794B2 (en) * | 2018-10-09 | 2024-06-25 | Avedro, Inc. | Photoactivation systems and methods for corneal cross-linking treatments |
-
2015
- 2015-10-27 CN CN201580071255.XA patent/CN107205845B/zh active Active
- 2015-10-27 KR KR1020177014080A patent/KR102416876B1/ko active IP Right Grant
- 2015-10-27 JP JP2017540986A patent/JP6644799B2/ja active Active
- 2015-10-27 WO PCT/US2015/057628 patent/WO2016069628A1/en active Application Filing
- 2015-10-27 KR KR1020227022431A patent/KR102545628B1/ko active IP Right Grant
- 2015-10-27 EP EP15855328.9A patent/EP3212140B1/en active Active
-
2016
- 2016-04-27 EP EP22204234.3A patent/EP4241748A3/en active Pending
- 2016-04-27 US US15/140,184 patent/US10350111B2/en active Active
- 2016-04-27 WO PCT/US2016/029559 patent/WO2017074500A1/en active Application Filing
- 2016-04-27 EP EP16860413.0A patent/EP3367983B1/en active Active
-
2019
- 2019-07-15 US US16/511,500 patent/US11219553B2/en active Active
-
2021
- 2021-10-25 US US17/509,337 patent/US20220151830A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3367983A1 (en) | 2018-09-05 |
US20190336336A1 (en) | 2019-11-07 |
WO2017074500A1 (en) | 2017-05-04 |
EP3367983B1 (en) | 2022-12-07 |
US10350111B2 (en) | 2019-07-16 |
JP2017532180A (ja) | 2017-11-02 |
CN107205845A (zh) | 2017-09-26 |
CN107205845B (zh) | 2020-03-31 |
US20220151830A1 (en) | 2022-05-19 |
EP4241748A2 (en) | 2023-09-13 |
EP3367983A4 (en) | 2019-07-31 |
EP3212140A4 (en) | 2018-08-01 |
WO2016069628A1 (en) | 2016-05-06 |
EP3212140A1 (en) | 2017-09-06 |
US20160310319A1 (en) | 2016-10-27 |
EP3212140B1 (en) | 2021-12-01 |
KR20220098291A (ko) | 2022-07-11 |
US11219553B2 (en) | 2022-01-11 |
EP4241748A3 (en) | 2023-10-11 |
KR102545628B1 (ko) | 2023-06-20 |
KR20170074967A (ko) | 2017-06-30 |
KR102416876B1 (ko) | 2022-07-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6644799B2 (ja) | 眼の架橋処置のためのシステム及び方法 | |
CN108601668B (zh) | 利用面罩装置处理眼睛的***和方法 | |
US10028657B2 (en) | Systems and methods for monitoring cross-linking activity for corneal treatments | |
JP6933377B2 (ja) | 光増感剤を用いた眼の処置用システム及び方法 | |
JP7504083B2 (ja) | 角膜拡張障害を治療するシステム及び方法 | |
US20220133533A1 (en) | Systems and Methods for Cross-Linking Treatments of an Eye | |
JPWO2020061278A5 (ja) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20180704 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20180704 |
|
A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20190510 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20190514 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20190802 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20191001 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20191210 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20200108 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6644799 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |