JP6628890B2 - アルカノールアミンアルキルアミドと他の湿潤剤との相乗効果 - Google Patents
アルカノールアミンアルキルアミドと他の湿潤剤との相乗効果 Download PDFInfo
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- JP6628890B2 JP6628890B2 JP2018538697A JP2018538697A JP6628890B2 JP 6628890 B2 JP6628890 B2 JP 6628890B2 JP 2018538697 A JP2018538697 A JP 2018538697A JP 2018538697 A JP2018538697 A JP 2018538697A JP 6628890 B2 JP6628890 B2 JP 6628890B2
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- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- SASYSVUEVMOWPL-NXVVXOECSA-N decyl oleate Chemical compound CCCCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC SASYSVUEVMOWPL-NXVVXOECSA-N 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000003398 denaturant Substances 0.000 description 1
- 239000007854 depigmenting agent Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 1
- 229960001083 diazolidinylurea Drugs 0.000 description 1
- TVWTZAGVNBPXHU-NXVVXOECSA-N dioctyl (z)-but-2-enedioate Chemical compound CCCCCCCCOC(=O)\C=C/C(=O)OCCCCCCCC TVWTZAGVNBPXHU-NXVVXOECSA-N 0.000 description 1
- WYHYDRAHICKYDJ-UHFFFAOYSA-L disodium;3-[2-(2-carboxylatoethoxy)ethyl-[2-(decanoylamino)ethyl]amino]propanoate Chemical compound [Na+].[Na+].CCCCCCCCCC(=O)NCCN(CCC([O-])=O)CCOCCC([O-])=O WYHYDRAHICKYDJ-UHFFFAOYSA-L 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000013100 final test Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940074049 glyceryl dilaurate Drugs 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- QAKXLTNAJLFSQC-UHFFFAOYSA-N hexadecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC QAKXLTNAJLFSQC-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical compound OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- XXMIOPMDWAUFGU-UHFFFAOYSA-N hexane-1,6-diol Chemical compound OCCCCCCO XXMIOPMDWAUFGU-UHFFFAOYSA-N 0.000 description 1
- 229940100463 hexyl laurate Drugs 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 239000003752 hydrotrope Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 229940023564 hydroxylated lanolin Drugs 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000011221 initial treatment Methods 0.000 description 1
- 239000000077 insect repellent Substances 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 239000001282 iso-butane Substances 0.000 description 1
- 235000013847 iso-butane Nutrition 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960001375 lactose Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- UVNRLSCOYBEJTM-UHFFFAOYSA-N linolenic alcohol Natural products CCCCCCCCC=C/CC=C/CC=C/CCO UVNRLSCOYBEJTM-UHFFFAOYSA-N 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 229960002160 maltose Drugs 0.000 description 1
- 239000008204 material by function Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- 229940078812 myristyl myristate Drugs 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- DJDAFXBIBNKCBR-UHFFFAOYSA-N n-[2-(2-hydroxyethoxy)ethyl]acetamide Chemical compound CC(=O)NCCOCCO DJDAFXBIBNKCBR-UHFFFAOYSA-N 0.000 description 1
- VAMFXQBUQXONLZ-UHFFFAOYSA-N n-alpha-eicosene Natural products CCCCCCCCCCCCCCCCCCC=C VAMFXQBUQXONLZ-UHFFFAOYSA-N 0.000 description 1
- GQEZCXVZFLOKMC-UHFFFAOYSA-N n-alpha-hexadecene Natural products CCCCCCCCCCCCCCC=C GQEZCXVZFLOKMC-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000005244 neohexyl group Chemical group [H]C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- ZHALDANPYXAMJF-UHFFFAOYSA-N octadecanoate;tris(2-hydroxyethyl)azanium Chemical compound OCC[NH+](CCO)CCO.CCCCCCCCCCCCCCCCCC([O-])=O ZHALDANPYXAMJF-UHFFFAOYSA-N 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- JPMIIZHYYWMHDT-UHFFFAOYSA-N octhilinone Chemical compound CCCCCCCCN1SC=CC1=O JPMIIZHYYWMHDT-UHFFFAOYSA-N 0.000 description 1
- 229940098514 octoxynol-9 Drugs 0.000 description 1
- 229920002114 octoxynol-9 Polymers 0.000 description 1
- BBZAGOMQOSEWBH-UHFFFAOYSA-N octyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCCCCCCC BBZAGOMQOSEWBH-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 229940057874 phenyl trimethicone Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 229940067107 phenylethyl alcohol Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 125000001095 phosphatidyl group Chemical group 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 description 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 229940101027 polysorbate 40 Drugs 0.000 description 1
- 229940113124 polysorbate 60 Drugs 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 229940078492 ppg-17 Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000025508 response to water Effects 0.000 description 1
- 239000006254 rheological additive Substances 0.000 description 1
- WBHHMMIMDMUBKC-QJWNTBNXSA-M ricinoleate Chemical class CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O WBHHMMIMDMUBKC-QJWNTBNXSA-M 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229940045998 sodium isethionate Drugs 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229940006186 sodium polystyrene sulfonate Drugs 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 229940057981 stearalkonium chloride Drugs 0.000 description 1
- 229940098760 steareth-2 Drugs 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 238000004441 surface measurement Methods 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229940029614 triethanolamine stearate Drugs 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- 229940124543 ultraviolet light absorber Drugs 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 229940045136 urea Drugs 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Description
(a)式(I)
nは、2〜5までの整数であり、
R1は、独立して、HまたはC1〜C3アルキルであり、
R2は、非置換の直鎖状または分岐状C1〜C6アルキルである。)
の化合物を含む、第1の湿潤剤
(b)少なくとも1種のさらなる湿潤剤、
および
(c)化粧品用に許容されるビヒクル
を含む、パーソナルケア配合物を提供する。
(a)式(I)
nは、2〜5までの整数であり、
R1は、独立して、HまたはC1〜C3アルキルであり、
R2は、非置換の直鎖状または分岐状C1〜C6アルキルである。)
の化合物を含む、第1の湿潤剤、
(b)少なくとも1種のさらなる湿潤剤および
(c)化粧品用に許容されるビヒクル
を含む。
下記において使用されている用語および表現は、提示された意味を有する。
ジグリコールアミン(DGA)アセトアミド/グリセロール配合品の調製
94.63g(0.9mol)の2−(2−アミノエトキシ)エタノール、65.46g(0.3mol)の1,2,3−トリアセトキシプロパン(トリアセチン)および1.24gの炭酸カリウムの混合物を混合し、油浴中に浸漬された250ml丸底フラスコ内で、N2雰囲気下において約120〜125℃で加熱した。1739cm−1におけるトリアセチンのエステルカルボニルピークの消失と1646cm−1の波数における生成物のアミドカルボニルピークの出現とをIRによってモニタリングして、反応がトリアセチンから生成物への完全な変換を示すまで、混合物を撹拌したが、エステルカルボニルピークの消失とアミドカルボニルピークの出現は両方とも、(ZnSe結晶を用いる一回反射型ATR用付属装置および分光計Nicolet iS10を用いるDTGS検出器を使用して)FTIRによってモニタリングした。このようにして得られた液体生成物(161.33g)は、3:1のモル比のDGAアセトアミドとグリセロールとの混合物であり、この3:1のモル比は、83wt%のDGAアセトアミドおよび17wt%のグリセロールに対応する。
ジグリコールアミン(DGA)アセトアミドの調製
油浴中に浸漬された250ml丸底フラスコ内で、N2雰囲気下において、42.06g(0.4mol)の2−(2−アミノエトキシ)エタノール、70.49g(0.8mol)の酢酸エチルおよび0.33gの亜リン酸の混合物を還流した。(ZnSe結晶を用いる一回反射型ATR用付属装置および分光計Nicolet iS10を用いるDTGS検出器を使用して)FTIRによってモニタリングする反応が、1646cm−1の波数における(生成物に起因する)アミドカルボニルピークの比のさらなる増大を示さなくなるまで、混合物を還流した。次いで、過剰な酢酸エチルおよびエタノール副生成物を、下流側における蒸留によって留去した。次いで、新たな酢酸エチル(35.24g、0.4mol)を反応混合物に加えたら、FTIRによってモニタリングされる1646cm−1におけるアミドカルボニルピークにより、生成物の形成のさらなる増大が見受けられなくなるまで、還流を継続した。過剰な酢酸エチル/エタノールをストリッピングし、新たな酢酸エチルを加えるこのステップは、FTIRが、所望の生成物であるとされる1646cm−1におけるアミドカルボニルピークのさらなる増大を示さなくなり、2−(2−アミノエトキシ)エタノールの反応が完了したことが示されるまで、繰り返した。
動的蒸気収着分析
動的蒸気収着(DVS)法を使用して、特定の湿度レベルにおける特定の化合物の水分の取込みを測定した。Surface Measurement Systems UK Ltd.(London、United Kingdom)によって製造されたDVS Intrinsicという機器を使用して、DVSを測定した。次の測定手順を使用して、特定の組成物の水蒸気の吸収を測定した。
Corneometer分析
ゲル配合物
ゲル配合物を調製するために、オーバーヘッドミキサーおよびジフィーブレード(jiffy blade)を使用した混合のために構築された4oz容量の丈が高いジャーに脱イオン水を加えた。次いで、ジャーの底部にほぼ到達する良好な渦巻きを発生させる速度(例えば、約700rpm)で、水を混合した。これに、Carbopol(登録商標)940(Lubrizol、Wickliffe、Ohioから入手可能な架橋ポリアクリレートポリマー)をゆっくり加え、均一になるまで少なくとも15分混合した。次いで、トリエタノールアミン(TEA)を加え、混合速度を約200rpmにオーバーヘッド調整し、混合を(例えば、生成物の粘度上昇のために)約10分継続した。この混合物に、単一の作用物質または作用物質の組合せの状態である5wt%の湿潤剤を加え、続いて、0.5wt%のGlydant(商標)Plus(商標)(Lonza、Basel、Switzerlandから入手可能な保存料)と、残部としての水とを加えた。混合を200rpmで約15〜20分継続した。次いで、混合物をミキサーから取り出し、最終的なpHを測定した。分析前に、試料を2000rpmで15分遠心分離して、ゲル配合物から懸濁している空気ポケットを除去した。最終的な試験ゲル配合物の濃度は、表3に提示されている。
約30μlの各試験ゲル配合物を、約3cmの直径の円になるように、各パネリストの内側前腕に一度に(例えば、さらに再塗布することがない1回の塗布で)塗布した。水分レベルは、Corneometer(登録商標)CM825(CK Industriesから入手可能)を使用し、試験ゲル配合物の塗布前、および22℃の温度および50%の相対湿度で、塗布後6時間および30時間に測定した。
図2は、ゲルを塗布してから6時間後に得た、有効成分がそれぞれグリセロールおよび水である2種のゲル試験配合物に関する8人のパネリストによるcorneometer読取値を示している。8人の各パネリストについての水とグリセロールの両方に関する実際の読取値は異なっており、ゲル試験配合物に対する反応の個人差と、各パネリストに固有の水分レベルの差とを示していた。これらの個人差の結果として、8人のパネリストのcorneometer読取値の平均は、大きな標準偏差を与えた。
本願発明には以下の態様が含まれる。
[1]
(a)式(I)
nは、2〜5までの整数であり、
R 1 は、独立して、HまたはC 1 〜C 3 アルキルであり、
R 2 は、非置換の直鎖状または分岐状C 1 〜C 6 アルキルである。)の化合物を含む第1の湿潤剤、
(b)少なくとも1種のさらなる湿潤剤、および
(c)化粧品用に許容されるビヒクル
を含む、パーソナルケア配合物。
[2]
前記成分(b)の少なくとも1種のさらなる湿潤剤が、ペトロラタム、鉱物油および植物油、ラノリン、グリセロール、ソルビトール、ポリオール、尿素、ヒドロキシアルキル尿素、乳酸、乳酸塩、ショ糖、αヒドロキシ酸、βヒドロキシ酸、ヒアルロン酸ナトリウム、ヒアルロン酸、ピロリドンカルボン酸ならびにピロリドンカルボキシレートまたはこれらの組合せから選択される、上記[1]に記載のパーソナルケア配合物。
[3]
前記成分(b)の少なくとも1種のさらなる湿潤剤が、グリセロール、ポリオール、ヒドロキシアルキル尿素、ピロリドンカルボン酸およびこの塩、乳酸およびこの塩またはこれらの組合せから選択される、上記[1]または[2]に記載のパーソナルケア配合物。
[4]
前記成分(b)の少なくとも1種のさらなる湿潤剤に対する、前記成分(a)の式(I)の化合物の重量比が、重量により約10:1〜約1:10であり、または約5:1〜約1:5であり、約3:5もしくは約3:4であり、または約1:1.2〜約1:1.3である、上記[3]に記載のパーソナルケア配合物。
[5]
nが、2である、上記[1]から[4]のいずれか一項に記載のパーソナルケア配合物。
[6]
R 2 が、非置換の直鎖状または分岐状C 1 〜C 4 アルキルである、上記[1]から[5]のいずれか一項に記載のパーソナルケア配合物。
[7]
R 2 が、メチルである、上記[6]に記載のパーソナルケア配合物。
[8]
R 1 が、Hである、上記[1]から[7]のいずれか一項に記載のパーソナルケア配合物。
[9]
化合物(I)が、
である、上記[1]から[3]のいずれか一項に記載のパーソナルケア配合物。
[10]
化合物(I)が、前記パーソナルケア配合物に対して約0.5重量%〜約15重量%で存在する、上記[1]から[9]のいずれか一項に記載のパーソナルケア配合物。
[11]
前記成分(b)の少なくとも1種のさらなる湿潤剤が、前記パーソナルケア配合物に対して約0.5重量%〜約15重量%で存在する、上記[1]から[10]のいずれか一項に記載のパーソナルケア配合物。
[12]
増粘剤、懸濁剤、乳化剤、pH調整剤、保水剤、湿潤剤、皮膚軟化薬、油、ワックス、溶媒、キレート化剤、ビタミン、酸化防止剤、植物抽出物、シリコーン、中和剤、保存料、香料、染料、顔料、コンディショナー、ポリマー、発汗抑制作用のある有効成分、抗座瘡剤、ふけ防止用活性物質、界面活性剤、角質除去剤、成膜剤、噴射剤、UVフィルター、日焼け止め用活性物質、日焼け促進剤、毛髪固定剤および染毛剤ならびにこれらの組合せからなる群から選択される1種または複数の添加剤をさらに含む、上記[1]から[11]のいずれか一項に記載のパーソナルケア配合物。
[13]
スキンケア配合物またはヘアケア配合物として用いられる、上記[1]から[12]のいずれか一項に記載のパーソナルケア配合物。
[14]
配合物が、ローション、クリーム、リンスオフ型ボディローション、湿潤作用のあるクレンザー、石けん、アンチエージング製品、ナリシング用クリームおよびローション、ファーミング用およびトーニング用製品、ひげ剃り用クリーム、脱毛剤、デオドラント、化粧品用カラーファンデーション、化粧品、口紅、日焼け止め、日焼けローション、日焼け手入れ用製品、パーソナルケア用ふき取り用具、乳児用ケア製品ならびに入浴用およびシャワー用製品、シャンプー、リーブイン型コンディショナー、リンスオフ型コンディショナー、ヘアジェル、ヘアローション、ヘアクリーム、ムースならびにヘアスプレーからなる群から選択される、上記[1]から[12]のいずれか一項に記載のパーソナルケア配合物。
[15]
湿潤用に効果的な量の上記[1]から[14]のいずれか一項に記載のパーソナルケア配合物を、対象の皮膚または毛髪に塗布することを含む、対象の皮膚または毛髪を湿潤する方法。
Claims (14)
- (a)式(I)
nは、2〜5までの整数であり、
R1は、独立して、HまたはC1〜C3アルキルであり、
R2は、非置換の直鎖状または分岐状C1〜C4アルキルである。)の湿潤剤、
(b)少なくとも1種のさらなる湿潤剤、および
(c)化粧品用に許容されるビヒクル
を含む、パーソナルケア配合物。 - 前記成分(b)の少なくとも1種のさらなる湿潤剤が、ペトロラタム、鉱物油および植物油、ラノリン、グリセロール、ソルビトール、ポリオール、尿素、ヒドロキシアルキル尿素、乳酸、乳酸塩、ショ糖、αヒドロキシ酸、βヒドロキシ酸、ヒアルロン酸ナトリウム、ヒアルロン酸、ピロリドンカルボン酸ならびにピロリドンカルボキシレートまたはこれらの組合せから選択される、請求項1に記載のパーソナルケア配合物。
- 前記成分(b)の少なくとも1種のさらなる湿潤剤が、グリセロール、ポリオール、ヒドロキシアルキル尿素、ピロリドンカルボン酸およびこの塩、乳酸およびこの塩またはこれらの組合せから選択される、請求項1または2に記載のパーソナルケア配合物。
- 前記成分(b)の少なくとも1種のさらなる湿潤剤に対する、前記成分(a)の式(I)の前記湿潤剤の重量比が、重量により10:1〜1:10である、請求項3に記載のパーソナルケア配合物。
- nが、2である、請求項1から4のいずれか一項に記載のパーソナルケア配合物。
- R2が、メチルである、請求項1から5のいずれか一項に記載のパーソナルケア配合物。
- R1が、Hである、請求項1から6のいずれか一項に記載のパーソナルケア配合物。
- 式(I)の前記湿潤剤が、
である、請求項1から3のいずれか一項に記載のパーソナルケア配合物。 - 式(I)の前記湿潤剤が、前記パーソナルケア配合物に対して0.5重量%〜15重量%で存在する、請求項1から8のいずれか一項に記載のパーソナルケア配合物。
- 前記成分(b)の少なくとも1種のさらなる湿潤剤が、前記パーソナルケア配合物に対して0.5重量%〜15重量%で存在する、請求項1から9のいずれか一項に記載のパーソナルケア配合物。
- 増粘剤、懸濁剤、乳化剤、pH調整剤、保水剤、皮膚軟化薬、油、ワックス、溶媒、キレート化剤、ビタミン、酸化防止剤、植物抽出物、シリコーン、中和剤、保存料、香料、染料、顔料、コンディショナー、ポリマー、発汗抑制作用のある有効成分、抗座瘡剤、ふけ防止用活性物質、界面活性剤、角質除去剤、成膜剤、噴射剤、UVフィルター、日焼け止め用活性物質、日焼け促進剤、毛髪固定剤および染毛剤ならびにこれらの組合せからなる群から選択される1種または複数の添加剤をさらに含む、請求項1から10のいずれか一項に記載のパーソナルケア配合物。
- スキンケア組成物またはヘアケア組成物として用いられる、請求項1から11のいずれか一項に記載のパーソナルケア配合物。
- 配合物が、ローション、クリーム、リンスオフ型ボディローション、湿潤作用のあるクレンザー、石けん、アンチエージング製品、ナリシング用クリームおよびローション、ファーミング用およびトーニング用製品、ひげ剃り用クリーム、脱毛剤、デオドラント、化粧品用カラーファンデーション、化粧品、口紅、日焼け止め、日焼けローション、日焼け手入れ用製品、パーソナルケア用ふき取り用具、乳児用ケア製品ならびに入浴用およびシャワー用製品、シャンプー、リーブイン型コンディショナー、リンスオフ型コンディショナー、ヘアジェル、ヘアローション、ヘアクリーム、ムースならびにヘアスプレーからなる群から選択される、請求項1から11のいずれか一項に記載のパーソナルケア配合物。
- 湿潤用に効果的な量の請求項1から13のいずれか一項に記載のパーソナルケア配合物を、対象の皮膚または毛髪に塗布することを含む、対象の皮膚または毛髪を湿潤する方法。
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JP4681425B2 (ja) * | 2005-11-15 | 2011-05-11 | 花王株式会社 | 毛髪弾性改善剤 |
JP5334511B2 (ja) | 2008-09-22 | 2013-11-06 | 日本精化株式会社 | 化粧料 |
US20120277444A1 (en) | 2011-04-27 | 2012-11-01 | Shivkumar Mahadevan | Synthesis of hydroxyalkyl amides from esters |
JP6222636B2 (ja) * | 2014-02-20 | 2017-11-01 | 富士フイルム株式会社 | インク組成物、インクセット及びインクジェット記録方法 |
JP6536796B2 (ja) | 2015-04-01 | 2019-07-03 | セイコーエプソン株式会社 | インクジェット記録用水系インク組成物 |
SG11201805824TA (en) | 2016-01-29 | 2018-08-30 | Akzo Nobel Chemicals Int Bv | Use of alkanolamine alkylamides as humectants |
CN108602759B (zh) | 2016-01-29 | 2023-10-27 | 阿克苏诺贝尔化学品国际有限公司 | 制备烷醇胺烷基酰胺和多元醇的组合物的方法 |
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TW201728320A (zh) | 2017-08-16 |
JP2019507123A (ja) | 2019-03-14 |
CN108495614A (zh) | 2018-09-04 |
SG11201805822XA (en) | 2018-08-30 |
CN108495614B (zh) | 2021-04-16 |
EP3407863B1 (en) | 2019-11-27 |
WO2017129273A1 (en) | 2017-08-03 |
BR112018015044B1 (pt) | 2021-08-10 |
US11154476B2 (en) | 2021-10-26 |
EP3407863A1 (en) | 2018-12-05 |
CA3012025A1 (en) | 2017-08-03 |
US20190021969A1 (en) | 2019-01-24 |
BR112018015044A2 (pt) | 2018-12-18 |
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