JP6565198B2

JP6565198B2 - Medical specimen holding member and medical specimen holding member assembly

Info

Publication number: JP6565198B2
Application number: JP2015020411A
Authority: JP
Inventors: 太一白山; 生雄水野; 芳樹杉村
Original assignee: Mie University NUC; MCC Advanced Moldings Co Ltd
Current assignee: Mie University NUC; MCC Advanced Moldings Co Ltd
Priority date: 2015-02-04
Filing date: 2015-02-04
Publication date: 2019-08-28
Anticipated expiration: 2035-02-04
Also published as: JP2016142686A

Description

本発明は、医療検体を薬品処理する際などに、検体を収容・保持するための医療検体用ケース等の医療検体保持部材に係り、特に、生体組織から採取した検体を容易に該医療検体保持部材側に移し替えることができ、薬品処理時等における検体の保持性にも優れた医療検体保持部材に関する。本発明はまた、この医療検体保持部材をケースに収容してなる医療検体保持部材アッセンブリに関する。 The present invention relates to a medical sample holding member such as a case for medical samples for storing and holding a sample when the medical sample is treated with a medicine, and in particular, a sample collected from a living tissue can be easily held. The present invention relates to a medical specimen holding member that can be transferred to the member side and has excellent specimen holding ability during chemical processing. The present invention also relates to a medical sample holding member assembly in which the medical sample holding member is accommodated in a case.

病変のある臓器から組織を一部取出し、顕微鏡で観察する生検（バイオプシー）は、細胞、血管などの形態学的な組織全体として病変の判断が可能であるという利点を有し、近年、広く採用されるようになってきている。 Biopsy (biopsy), in which a part of tissue is removed from a lesioned organ and observed with a microscope, has the advantage that the lesion can be determined as a whole morphological tissue such as cells and blood vessels. It has been adopted.

一般に、バイオプシーは、次のような手順で行われている。
まず、生体組織に採取針を挿入して採取針の先端側に生体組織の一部を切り取って採取する。この採取針を生体組織から抜き取り、生体組織から採取され、採取針に保持されている検体を濾紙又はスポンジの上に移し置く。その後、ピンセットで濾紙又はスポンジ上の検体を薬品処理用のケースに移し入れ、水洗、アルコール洗浄、キシレン洗浄等の薬品処理を施す。薬品処理後の検体をパラフィンに包埋し、これをスライス加工し、必要に応じて染色、その他の処理を施してサンプル（顕微鏡標本）とし、これを顕微鏡観察する。 In general, biopsy is performed in the following procedure.
First, a sampling needle is inserted into the biological tissue, and a part of the biological tissue is cut out and collected on the distal end side of the sampling needle. The sampling needle is extracted from the biological tissue, and the specimen collected from the biological tissue and held by the sampling needle is transferred onto a filter paper or sponge. Thereafter, the sample on the filter paper or sponge is transferred to the case for chemical treatment with tweezers and subjected to chemical treatment such as water washing, alcohol washing, xylene washing and the like. The specimen after chemical treatment is embedded in paraffin, sliced, and subjected to staining and other treatment as necessary to obtain a sample (microscopic specimen), which is observed with a microscope.

このようなバイオプシー法では、サンプルを作製するまでの工程数が多く、非効率であった。 Such a biopsy method is inefficient because of the large number of steps until a sample is prepared.

そこで、特許文献１には、医療検体を採取針から容易に直接移し替えることができるように、検体収容溝を設けた医療検体用ケースが提案されている。特許文献１の医療検体用ケースでは、検体収容溝の内部に、複数の細孔（例えば、内径が３００μｍ〜５００μｍ程度のもの）を設けたり、複数のトゲを突設させたりするなどして検体収容溝内の摩擦抵抗を大きくし、検体を突起に引っかけるなどして採取針から検体収容溝へ移行させる。この医療検体用ケースでは、採取針から検体を直接ケース内に収容させて、薬品処理を行うことができ、従来の濾紙又はスポンジを経る工程が省略される。 Therefore, Patent Document 1 proposes a medical sample case provided with a sample storage groove so that the medical sample can be easily transferred directly from the collection needle. In the case for medical specimens of Patent Document 1, a specimen is provided by providing a plurality of pores (for example, having an inner diameter of about 300 μm to 500 μm) or projecting a plurality of thorns in the specimen housing groove. The frictional resistance in the accommodation groove is increased, and the specimen is transferred from the collection needle to the specimen accommodation groove by hooking the specimen on the protrusion. In this medical sample case, the sample can be directly stored in the case from the collection needle to perform chemical treatment, and the conventional process of passing through filter paper or sponge is omitted.

また、特許文献２には、薬品処理工程からパラフィン包埋〜スライス工程までを行える医療検査用カセットが提案されており、この医療検査用カセットでは、薬品処理後、検体を包埋したパラフィンブロックをスライスする際に、パラフィンブロックがカセットから剥離することを防止するために、パラフィンブロック形成面が微細な凹凸面とされている。 Further, Patent Document 2 proposes a medical examination cassette capable of performing from a chemical treatment process to a paraffin embedding to slicing process. In this medical examination cassette, a paraffin block in which a specimen is embedded after chemical treatment is provided. In order to prevent the paraffin block from peeling from the cassette when slicing, the paraffin block forming surface is a fine uneven surface.

特開２００８−１２８７４９号公報JP 2008-128749 A 特開２００６−３００６２０号公報JP 2006-300620 A

特許文献１には、医療検体用ケースに設けた検体収容溝内の摩擦抵抗を大きくすることが記載されているが、具体的にどのようにして複数の細孔を設け、どの程度摩擦抵抗を大きくする必要があるのかは明らかにされていない。また、特許文献１で想定している細孔の孔径では、実用上十分ではなく改良の余地を有している。 Patent Document 1 describes that the frictional resistance in the specimen receiving groove provided in the medical specimen case is increased. Specifically, how to provide a plurality of pores and how much frictional resistance is provided. It is not clear if it needs to be larger. Further, the pore diameter assumed in Patent Document 1 is not practically sufficient and has room for improvement.

一方、特許文献２において、微細な凹凸は、波形状、シボ、梨地等と記載されており、これは金型表面加工によるものであるため、既存の金型では対応し得ず、また、凹凸の程度を変更するためにはその都度金型を作製することとなり、工業的な実用化においては不利益が多い。 On the other hand, in Patent Document 2, the fine irregularities are described as a wave shape, a texture, a satin, and the like, and since this is due to the mold surface processing, the existing mold cannot cope with the irregularities. In order to change the degree of the mold, a mold is produced each time, and there are many disadvantages in industrial practical use.

本発明は、生体組織から採取した検体を容易に移し替えることができ、また、薬品処理時等における検体の保持性にも優れ、しかも、工業的生産性にも優れた医療検体保持部材と、この医療検体保持部材を用いた医療検体保持部材アッセンブリを提供することを課題とする。 The present invention can easily transfer a sample collected from a biological tissue, is excellent in the retention of a sample at the time of chemical treatment, and is also excellent in industrial productivity, and a medical sample holding member, It is an object of the present invention to provide a medical specimen holding member assembly using this medical specimen holding member.

本発明者らは、上記課題を解決すべく鋭意検討を重ねた結果、医療検体保持部材の検体保持部に、特定の表面粗さと保留粒子径を有する濾紙や多孔質樹脂シート等の多孔質シートを用いることで、検体の移し替え及び保持に好適な検体保持部を形成することができることを見出した。
本発明はこのような知見に基づいて達成されたものであり、以下を要旨とする。 As a result of intensive studies to solve the above-mentioned problems, the present inventors have determined that a porous sheet such as a filter paper or a porous resin sheet having a specific surface roughness and a reserved particle diameter in the specimen holding part of the medical specimen holding member. It has been found that a sample holding part suitable for transferring and holding a sample can be formed by using.
The present invention has been achieved based on such findings, and the gist thereof is as follows.

［１］検体採取針で採取した検体を移し置くための医療検体保持部材であって、凹形状の検体保持部を有する医療検体保持部材において、該検体保持部の少なくとも一部が、算術平均粗さＲａが１．５μｍ以上３０μｍ以下であり、かつ保留粒子径が０．１μｍ以上２００μｍ以下である多孔質シートで構成されており、該多孔質シート以外の構成部材が耐薬品性の熱可塑性樹脂よりなり、該多孔質シートに前記検体採取針を擦りつけて該検体採取針で採取した検体を該多孔質シートに移し置くものであることを特徴とする医療検体保持部材。 [1] A medical specimen holding member for transferring a specimen collected by a specimen collecting needle, wherein the specimen holding section includes at least a part of the arithmetic average roughness. The thickness Ra is 1.5 μm or more and 30 μm or less, and the retained particle diameter is 0.1 μm or more and 200 μm or less, and the constituent members other than the porous sheet are chemically resistant heat. A medical specimen holding member made of a plastic resin, wherein the specimen collected by rubbing the specimen collecting needle against the porous sheet and transferring the specimen collected by the specimen collecting needle to the porous sheet .

［２］［１］において、前記多孔質シートが、紙、織布、不織布、及び多孔性樹脂フィルムからなる群より選ばれる少なくとも１種よりなることを特徴とする医療検体用保持部材。 [2] The medical specimen holding member according to [1], wherein the porous sheet is made of at least one selected from the group consisting of paper, woven fabric, non-woven fabric, and porous resin film.

［３］［１］又は［２］において、前記医療検体保持部材は、前記多孔質シートと、該多孔質シートの一方の面に重なる板状体と、該多孔質シートを該板状体に重なる状態に支持する支持部材とを有しており、該板状体に、検体採取針の少なくとも側周部が入り込めるスリットが設けられており、該スリットと該スリット内に表出した前記多孔質シートとで前記検体保持部が構成されていることを特徴とする医療検体保持部材。 [3] In [1] or [2], the medical specimen holding member includes the porous sheet, a plate-like body overlapping one surface of the porous sheet, and the porous sheet as the plate-like body. A support member that supports the overlapping state, and the plate-like body is provided with a slit into which at least a side peripheral portion of the sample collection needle can enter, and the porous material that is exposed in the slit and the slit A medical specimen holding member, wherein the specimen holding section is composed of a sheet.

［４］［３］において、前記支持部材は、前記多孔質シートの他方の面に重なる支持板であり、該支持板と前記板状体とは着脱可能又は開閉可能に連結されていることを特徴とする医療検体保持部材。 [4] In [3], the support member is a support plate that overlaps the other surface of the porous sheet, and the support plate and the plate-like body are detachably or detachably connected. A medical specimen holding member.

［５］［３］において、前記板状体と前記支持部材とは一体成形されており、該板状体と支持部材との間のスペースに前記多孔質シートが設けられていることを特徴とする医療検体保持部材。 [5] In [3], the plate-like body and the support member are integrally formed, and the porous sheet is provided in a space between the plate-like body and the support member. A medical specimen holding member.

［６］［３］ないし［５］のいずれかにおいて、前記板状体及び支持部材は熱可塑性樹脂を成形してなることを特徴とする医療検体保持部材。 [6] The medical specimen holding member according to any one of [3] to [5], wherein the plate-like body and the support member are formed by molding a thermoplastic resin.

［７］［３］ないし［６］のいずれかにおいて、前記支持部材は、通液用の開口部を有することを特徴とする医療検体保持部材。 [7] The medical sample holding member according to any one of [3] to [6], wherein the support member has an opening for liquid passage.

［８］［１］ないし［７］のいずれかに記載の医療検体保持部材と、該医療検体保持部材を収容する通液性のケースとを備えたことを特徴とする医療検体保持部材アッセンブリ。 [8] A medical sample holding member assembly comprising the medical sample holding member according to any one of [1] to [7] and a liquid-permeable case that houses the medical sample holding member.

［９］［８］において、前記ケース内の前記医療検体保持部材を該ケースに係止するための係止手段を有することを特徴とする医療検体保持部材アッセンブリ。 [9] The medical specimen holding member assembly according to [8], further comprising a locking means for locking the medical specimen holding member in the case to the case.

本発明の医療検体保持部材は、検体保持部の少なくとも一部を、所定の算術平均粗さＲａと保留粒子径を有する多孔質シートで構成したものであり、検体採取針からの医療検体の移し替え性、及び保持性に優れる。
即ち、採取針で生体組織から検体を採取し、採取した検体を保持する採取針を本発明の医療検体保持部材の検体保持部の多孔質シートに擦り付けることにより、容易に検体をこの検体保持部に移し置くことができる。また、薬品処理等の検体の取り扱い時においても、検体をこの検体保持部の多孔質シート上に安定して保持することができる。 The medical specimen holding member of the present invention is configured such that at least a part of the specimen holding section is composed of a porous sheet having a predetermined arithmetic average roughness Ra and a reserved particle diameter, and the medical specimen is transferred from the specimen collection needle. Excellent changeability and retention.
That is, a sample is collected from a biological tissue with a collection needle, and the sample is easily rubbed against the porous sheet of the sample holding unit of the medical sample holding member of the present invention. Can be moved to. In addition, the specimen can be stably held on the porous sheet of the specimen holding section even when handling the specimen such as chemical treatment.

本発明の医療検体保持部材は、例えば、通常の熱可塑性樹脂の射出成形品に適当なサイズにカットした濾紙等の多孔質シートを挿入したり挟み込んだりするのみで、或いはカットした多孔質シートを金型内で熱可塑性樹脂と一体化させるインサート成形を行うことで、容易に製造することができ、工業的生産性にも優れる。 The medical specimen holding member of the present invention can be obtained by, for example, inserting or sandwiching a porous sheet such as filter paper cut into an appropriate size into an ordinary thermoplastic resin injection molded product, or by inserting a cut porous sheet. By performing insert molding that is integrated with the thermoplastic resin in the mold, it can be easily manufactured and has excellent industrial productivity.

実施の形態に係る医療検体保持部材の分解斜視図である。It is a disassembled perspective view of the medical sample holding member which concerns on embodiment. 図１の医療検体保持部材の板状体の構成図であり、（ａ）図は平面図、（ｂ）図は右側面図、（ｃ）図は（ａ）図のＣ−Ｃ線断面図、（ｄ）図は（ａ）図のＤ−Ｄ線断面図、（ｅ）図は正面図、（ｆ）図は（ａ）図のＦ−Ｆ線断面図、（ｇ）図は（ａ）図のＧ−Ｇ線断面図である。It is a block diagram of the plate-shaped body of the medical sample holding member of FIG. 1, (a) A figure is a top view, (b) A figure is a right view, (c) A figure is CC sectional view taken on the line of (a). , (D) is a sectional view taken along the line DD of FIG. (A), (e) is a front view, (f) is a sectional view taken along the line FF of (a), and (g) is (a). ) Is a cross-sectional view taken along line GG in FIG. 図１の医療検体保持部材の支持部材の構成図であり、（ａ）図は平面図、（ｂ）図は右側面図、（ｃ）図は（ａ）図のＣ−Ｃ線断面図、（ｄ）図は（ａ）図のＤ−Ｄ線断面図、（ｅ）図は正面図、（ｆ）図は（ａ）図のＦ−Ｆ線断面図、（ｇ）図は（ａ）図のＧ−Ｇ線断面図である。It is a block diagram of the supporting member of the medical sample holding member of FIG. 1, (a) A figure is a top view, (b) A figure is a right view, (c) A figure is CC sectional view taken on the line of (a), (D) The figure is the DD sectional view taken on the line of (a), (e) The figure is a front view, (f) The figure is the sectional view on the FF line of (a), (g) The figure is (a) It is a GG line sectional view of a figure. 実施の形態に係る医療検体保持部材アッセンブリの分解斜視図である。It is a disassembled perspective view of the medical sample holding member assembly which concerns on embodiment. （ａ）図は図１の医療検体保持部材の断面図、（ｂ）図は図４の医療検体保持部材アッセンブリの断面図である。(A) is a cross-sectional view of the medical specimen holding member of FIG. 1, and (b) is a cross-sectional view of the medical specimen holding member assembly of FIG. 別の実施の形態に係る医療検体保持部材の構成図であり、（ａ）図は、蓋部を開放した状態を示す斜視図、（ｂ）図は蓋部を閉止した状態を示す斜視図、（ｃ）図は（ｂ）図のＣ−Ｃ線に沿う断面図である。It is a block diagram of the medical sample holding member which concerns on another embodiment, (a) A figure is a perspective view which shows the state which open | released the cover part, (b) A perspective view which shows the state which closed the cover part, (C) The figure is sectional drawing which follows the CC line of (b) figure.

以下に本発明の実施の形態を詳細に説明する。 Hereinafter, embodiments of the present invention will be described in detail.

本発明の医療検体保持部材は、凹形状の検体保持部を有する医療検体保持部材において、該検体保持部の少なくとも一部が、算術平均粗さＲａが０．５μｍ以上５０μｍ以下であり、かつ保留粒子径が０．１μｍ以上２００μｍ以下である多孔質シートで構成されていることを特徴とするものであり、本発明の医療検体保持部材アッセンブリは、このような本発明の医療検体保持部材が通液性のケースに収容されたものである。 The medical specimen holding member of the present invention is a medical specimen holding member having a concave specimen holding section, wherein at least a part of the specimen holding section has an arithmetic average roughness Ra of 0.5 μm or more and 50 μm or less and is suspended. The medical sample holding member assembly of the present invention is characterized by comprising a porous sheet having a particle size of 0.1 μm or more and 200 μm or less. It is housed in a liquid case.

［構造例］
まず、図１〜５を参照して本発明の医療検体保持部材及び医療検体保持部材アッセンブリの実施の形態の一例について説明する。 [Example of structure]
First, an example of an embodiment of the medical specimen holding member and the medical specimen holding member assembly of the present invention will be described with reference to FIGS.

図１の通り、医療検体保持部材１は、多孔質シート２を板状体１０と支持部材２０としての支持板とで挟持したものである。 As shown in FIG. 1, the medical specimen holding member 1 is obtained by sandwiching a porous sheet 2 between a plate-like body 10 and a support plate as a support member 20.

板状体１０は、方形（この実施の形態では長方形）の主板部１１と、該主板部１１の裏面の周縁から立設された枠状部１２と、該主板部１１を主板部１１の一辺（この実施の形態では短辺）と平行方向に横断するスリット１３と、主板部１１の１つの短辺の辺方向中央部から立設されたフック片１４と、該フック片１４の両側において、該主板部１１の角縁を切り欠くようにして形成された係合口１５，１５と、主板部１１の他方の短辺の辺方向中央部に形成された係合口１６とを有する。この係合口１６も主板部１１の角縁を切り欠くようにして形成されている。 The plate-like body 10 includes a rectangular (in this embodiment, a rectangular) main plate portion 11, a frame-like portion 12 erected from the periphery of the back surface of the main plate portion 11, and the main plate portion 11 on one side of the main plate portion 11. (A short side in this embodiment) a slit 13 that crosses in a parallel direction, a hook piece 14 that is erected from the central part in the side direction of one short side of the main plate portion 11, and both sides of the hook piece 14, The main plate portion 11 has engagement ports 15 and 15 formed so as to cut out the corner edges, and an engagement port 16 formed in the center portion in the side direction of the other short side of the main plate portion 11. This engagement port 16 is also formed so as to cut out the corner edge of the main plate portion 11.

スリット１３は、その両端部を除いて、主板部１１を厚み方向に貫通している。スリット１３の長手方向の両端側は、スリット１３の端部に向って次第にスリット幅が拡大するテーパ部１３ａ形状となっている。スリット１３の長手方向の中央部は、平面視形状が半円弧形の拡幅部１３ｂとなっている。この拡幅部１３ｂとテーパ部１３ａ以外の箇所におけるスリット１３のスリット幅は、検体採取針の外径よりも大きい。 The slit 13 penetrates the main plate portion 11 in the thickness direction except for both end portions thereof. Both end sides in the longitudinal direction of the slit 13 have a tapered portion 13 a shape in which the slit width gradually increases toward the end of the slit 13. The central portion in the longitudinal direction of the slit 13 is a widened portion 13b having a semicircular arc shape in plan view. The slit width of the slit 13 at a place other than the widened portion 13b and the tapered portion 13a is larger than the outer diameter of the sample collection needle.

フック片１４は、枠状部１２から主板部１１の板面よりも高位まで立ち上がる脚部１４ａと、該脚部１４ａの起立方向先端部から主板部１１の板面と略平行方向かつ主板部１１の板央と反対方向に向って突出した爪部１４ｂとを有する。フック片１４は、主板部１１の板央側に若干傾いている。主板部１１には、脚部１４ａの板央側に貫通部１１ａが形成されており、脚部１４ａが板央側へ弾性的に傾動可能となっている。 The hook piece 14 has a leg portion 14a that rises from the frame-like portion 12 to a position higher than the plate surface of the main plate portion 11, and a main plate portion 11 that is substantially parallel to the plate surface of the main plate portion 11 from the tip end portion of the leg portion 14a. And a claw portion 14b protruding in the opposite direction. The hook piece 14 is slightly inclined toward the center side of the main plate portion 11. The main plate portion 11 has a through portion 11a formed on the center side of the leg portion 14a, and the leg portion 14a can be elastically tilted toward the center of the plate.

図３の通り、支持部材２０は、方形（この実施の形態では長方形）の盤状であり、厚み方向に貫通して、支持部材２０の長辺と平行方向に延在する複数条の第１スリット２１が設けられている。また、支持部材２０の一方の短辺に沿って第２スリット２２が設けられ、他方の短辺に沿って第３スリット２３が設けられている。該一方の短辺の辺方向中央部には、爪部２４が設けられている。他方の短辺にあっては、両端側にそれぞれ爪部２５が設けられている。爪部２４，２５は、支持部材２０の一方の板面（図３（ｅ）〜（ｇ）において上面）と面一状に、且つ該上面の板央と反対方向に突出している。 As shown in FIG. 3, the support member 20 has a square (rectangular in this embodiment) disk shape, and penetrates in the thickness direction and extends in a direction parallel to the long side of the support member 20. A slit 21 is provided. A second slit 22 is provided along one short side of the support member 20, and a third slit 23 is provided along the other short side. A claw portion 24 is provided at the center in the side direction of the one short side. On the other short side, claw portions 25 are provided on both ends. The claw portions 24 and 25 are flush with one plate surface of the support member 20 (upper surface in FIGS. 3E to 3G) and project in the opposite direction to the center of the upper surface.

多孔質シート２は、この支持部材２０よりも一回り小さい大きさを有している。多孔質シート２を板状体１０と支持部材２０とで挟持するには、多孔質シート２を板状体１０の下面（枠状部１２側の面）に重ねるか、又は支持部材２０の上面に重ねておき、板状体１０と支持部材２０とを係合させる。支持部材２０は枠状部１２の内側スペースに挿入される。この際、爪部２５，２５を板状体１０の係合口１５，１５に係合させた後、支持部材２０を枠状部１２内に押し込み、爪部２４を係合口１６に係合させる。なお、先に爪部２４を係合口１６に係合させ、後から爪部２５，２５を係合口１５，１５に係合させてもよい。図５（ａ）は、このように板状体１０と支持部材２０とで多孔質シート２を挟持して一体化した状態を示している。 The porous sheet 2 has a size slightly smaller than the support member 20. In order to sandwich the porous sheet 2 between the plate-like body 10 and the support member 20, the porous sheet 2 is stacked on the lower surface of the plate-like body 10 (the surface on the frame-like portion 12 side), or the upper surface of the support member 20. The plate-like body 10 and the support member 20 are engaged with each other. The support member 20 is inserted into the inner space of the frame-like portion 12. At this time, after the claw portions 25 and 25 are engaged with the engagement ports 15 and 15 of the plate-like body 10, the support member 20 is pushed into the frame-shaped portion 12 and the claw portion 24 is engaged with the engagement port 16. The claw portion 24 may be engaged with the engagement port 16 first, and the claw portions 25 and 25 may be engaged with the engagement ports 15 and 15 later. FIG. 5A shows a state in which the porous sheet 2 is sandwiched and integrated by the plate-like body 10 and the support member 20 as described above.

このように多孔質シート２を板状体１０と支持部材２０とで挟持した医療検体保持部材１のスリット１３に対し、検体採取針を入り込ませ、検体採取針をスリット１３の底部に表出する多孔質シート２に擦り付けると、多孔質シート２は、後述の通り、特定の算術平均粗さＲａと保留粒子径とを有することにより、検体の移し替え性に優れるため、検体採取針に採取した検体を容易に多孔質シート２側へ移し替えることができる。 In this way, the sample collection needle is inserted into the slit 13 of the medical sample holding member 1 holding the porous sheet 2 between the plate-like body 10 and the support member 20, and the sample collection needle is exposed to the bottom of the slit 13. When rubbed against the porous sheet 2, the porous sheet 2 has a specific arithmetic mean roughness Ra and a reserved particle diameter, as described later, and thus is excellent in sample transferability, and thus collected with a sample collection needle. The specimen can be easily transferred to the porous sheet 2 side.

また、このようにして検体を医療検体保持部材１の多孔質シート２上に移し替えた後の薬品処理時にあっては、多孔質シート２は、後述の通り、特定の算術平均粗さＲａと保留粒子径とを有することにより、検体の保持性に優れるため、検体を多孔質シート２上に安定に保持して良好な作業性のもとに薬品処理を行うことができる。また、その際に、多孔質シート２は多孔質で薬液の通過性に優れ、また、多孔質シート２を支持する支持部材２０には、通液可能な第１スリット２１が設けられているため、多孔質シート２上の検体を効率的に薬品処理することができる。 In addition, during the chemical treatment after the specimen is transferred onto the porous sheet 2 of the medical specimen holding member 1 in this way, the porous sheet 2 has a specific arithmetic average roughness Ra as described later. By having the reserved particle diameter, the specimen retainability is excellent, so that the specimen can be stably retained on the porous sheet 2 and the chemical treatment can be performed with good workability. At that time, the porous sheet 2 is porous and excellent in the passage of chemicals, and the support member 20 that supports the porous sheet 2 is provided with a first slit 21 through which liquid can pass. The specimen on the porous sheet 2 can be efficiently treated with chemicals.

このように、検体を多孔質シート２に擦り付けた医療検体保持部材１をケースに収容してもよい。このケースの一例を図４及び図５（ｂ）に示す。 Thus, the medical specimen holding member 1 in which the specimen is rubbed against the porous sheet 2 may be accommodated in the case. An example of this case is shown in FIG. 4 and FIG.

このケース３０は、ケースアッパー４０とケースロワー５０とを有する。ケースアッパー４０は蓋板４１と、該蓋板４１に設けられた多数の小開口４２と、該蓋板４１の長手方向の両辺縁部近傍において、蓋板４１の下面から突設された凸条４３と、短手方向の一方の辺縁部近傍において、蓋板４１の板面から突設された爪部４３と、該蓋板４１の他方の辺縁部近傍に設けられた係合口４４と、蓋板４１の該他方の辺縁部に延設された舌片部４５とを有する。 The case 30 includes a case upper 40 and a case lower 50. The case upper 40 includes a cover plate 41, a large number of small openings 42 provided in the cover plate 41, and ridges protruding from the lower surface of the cover plate 41 in the vicinity of both side edges in the longitudinal direction of the cover plate 41. 43, a claw portion 43 projecting from the plate surface of the cover plate 41 in the vicinity of one edge portion in the short-side direction, and an engagement port 44 provided in the vicinity of the other edge portion of the cover plate 41 , And a tongue piece 45 extending to the other edge of the cover plate 41.

ケースロワー５０は、底面部５１と、該底面部５１に設けられた多数の小開口５２と、該底面部５１の周縁から立設された囲壁部５３と、該囲壁部５３の一辺から延設された傾斜板よりなるスカート部５４と、該スカート部５４の上縁に設けられた透孔５５と、ケースアッパー４０の爪部４３が係合するように囲壁部５３の外面に設けられた段部５６とを有する。 The case lower 50 includes a bottom surface portion 51, a large number of small openings 52 provided in the bottom surface portion 51, a surrounding wall portion 53 erected from the periphery of the bottom surface portion 51, and extending from one side of the surrounding wall portion 53. A step provided on the outer surface of the surrounding wall portion 53 so that the skirt portion 54 made of the inclined plate, the through hole 55 provided on the upper edge of the skirt portion 54, and the claw portion 43 of the case upper 40 are engaged with each other. Part 56.

医療検体保持部材１のフック片１４をケースアッパー４０の係合口４４に係合させて医療検体保持部材１を蓋板４１の下面に沿わせてケースアッパー４０に保持させる。その後、このケースアッパー４０とケースロワー５０とを係合させる。この際、ケースアッパー４０の舌片部４５をケースロワー５０の透孔５５からスカート部５４の裏側に差し込み、該舌片部４５と反対側の爪部４３を段部５６に係合させる。これにより、ケースアッパー４０とケースロワー５０とが係着される。 The hook piece 14 of the medical specimen holding member 1 is engaged with the engagement port 44 of the case upper 40, and the medical specimen holding member 1 is held by the case upper 40 along the lower surface of the lid plate 41. Thereafter, the case upper 40 and the case lower 50 are engaged. At this time, the tongue piece 45 of the case upper 40 is inserted into the back side of the skirt portion 54 through the through hole 55 of the case lower 50, and the claw portion 43 opposite to the tongue piece portion 45 is engaged with the step portion 56. As a result, the case upper 40 and the case lower 50 are engaged.

医療検体保持部材１及びケース３０よりなる本発明の医療検体保持部材アッセンブリを用いるバイオプシーは、次のようにして行われる。 The biopsy using the medical sample holding member assembly of the present invention comprising the medical sample holding member 1 and the case 30 is performed as follows.

まず、前述のように、検体を採取した検体採取針を医療検体保持部材１のスリット１３内に押し当てて、医療検体保持部材１の板状体１０のスリット１３内に表出する多孔質シート２に擦り付けて検体を移し置いて付着させる。この操作を繰り返して、必要な数の検体をスリット１３内の多孔質シート２上に付着させた後、医療検体保持部材１を上記のように、ケース３０のケースアッパー４０に取り付ける。その後、ケースアッパー４０ごと、或いは、ケースアッパー４０を更に薬品処理箱等にセットし、薬品処理を行なった後、ケース３０のケースロワー５０に係着する。その際、必要に応じてスカート部５４の表側に検体の情報を記載する。 First, as described above, a porous sheet that is exposed in the slit 13 of the plate-like body 10 of the medical specimen holding member 1 by pressing the specimen collecting needle that has collected the specimen into the slit 13 of the medical specimen holding member 1. Rub on 2 and transfer specimen to attach. This operation is repeated to attach a required number of specimens on the porous sheet 2 in the slit 13, and then the medical specimen holding member 1 is attached to the case upper 40 of the case 30 as described above. Thereafter, the case upper 40 or the case upper 40 is further set in a chemical processing box or the like, and after chemical processing, the case upper 40 is engaged with the case lower 50 of the case 30. At that time, specimen information is written on the front side of the skirt portion 54 as necessary.

このように検体を保持させた医療検体保持部材１をケース３０に収容した後、ケース３０ごと、或いは、ケース３０を更に薬品処理箱等にセットし、再度薬品処理を行う。その後、ケース３０から医療検体保持部材１を取り出し、医療検体保持部材１から検体を取り出して包埋処理した後、スライスしてサンプルを切り出し、顕微鏡観察する。 After the medical sample holding member 1 holding the sample in this way is accommodated in the case 30, the case 30 or the case 30 is further set in a chemical processing box or the like, and chemical processing is performed again. Thereafter, the medical specimen holding member 1 is taken out from the case 30, and the specimen is taken out from the medical specimen holding member 1 and embedded, and then sliced to cut out the sample and observed with a microscope.

この薬品処理時において、検体は、医療検体保持部材１の多孔質シート２上に安定に保持される。また、ケース３０は、ケースアッパー４０の蓋板４１に多数の開口４２を有すると共に、ケースロワー５０の底面部５１にも多数の開口５２を有することにより、通液性であり、このケース３０内に検体を保持した医療検体保持部材１を収容した状態で、薬品処理することができ、その際、ケース３０のケースアッパー４０及びケースロワー５０は薬液の通液性に優れるため、ケース３０内の医療検体保持部材１に保持された検体を十分に薬品処理することができる。 During the chemical treatment, the specimen is stably held on the porous sheet 2 of the medical specimen holding member 1. In addition, the case 30 has a large number of openings 42 in the cover plate 41 of the case upper 40 and a plurality of openings 52 in the bottom surface portion 51 of the case lower 50. In the state where the medical sample holding member 1 holding the sample is accommodated, the chemical treatment can be performed. At this time, the case upper 40 and the case lower 50 of the case 30 are excellent in the liquid permeability of the chemical solution. The specimen held on the medical specimen holding member 1 can be sufficiently treated with chemicals.

図１〜５は、本発明の医療検体保持部材及び医療検体保持部材アッセンブリの一例を示すものであって、何ら本発明は図示のものに限定されるものではない。
例えば、医療検体保持部材は板状体と支持部材とに分割可能なものに限定されず、後掲の図６に示すように、一端側で開閉（回動）可能に連結されたものであってもよい。また、板状体と支持部材とは両者の間に多孔質シートを出し入れ可能な開口部を設けて一体化されたものであってもよい。医療検体保持部材を収容するケースについても同様に、ケースアッパーとケースロワーとが別体に設けられたものに限らず、一端側でこれらが開閉（回動）可能に連結されたものであってもよく、また、これらの間に医療検体保持部材を出し入れ可能な開口部を設けて一体化されたものであってもよい。更に、医療検体保持部材は、ケースのケースアッパーではなく、ケースロワー側に係止されてもよい。 1 to 5 show an example of the medical specimen holding member and the medical specimen holding member assembly of the present invention, and the present invention is not limited to the illustrated one.
For example, the medical specimen holding member is not limited to a member that can be divided into a plate-like body and a supporting member, and is connected to be openable and closable (rotatable) on one end side as shown in FIG. May be. Further, the plate-like body and the support member may be integrated by providing an opening through which a porous sheet can be taken in and out. Similarly, the case housing the medical specimen holding member is not limited to the case upper and the case lower provided separately, but is connected to be openable and closable (turnable) at one end side. Alternatively, it may be integrated by providing an opening through which a medical specimen holding member can be taken in and out. Furthermore, the medical specimen holding member may be locked to the case lower side instead of the case upper of the case.

板状体１０に形成するスリット１３の幅及び深さ（この深さは、板状体１０の厚みに相当する。）は、検体採取針の少なくとも側周部がスリット１３に入り込むことで、検体採取針に採取された検体を多孔質シート２に擦り付けることができるような大きさであることが必要とされ、通常、スリット１３の幅は、検体採取針の外径よりも０．１〜１．０ｍｍ程度大きく、例えば１．１〜２．０ｍｍ程度に形成され、スリットの深さ、即ち板状体１０の厚みは、スリット１３の幅にもよるが、検体採取針の外径に対して０．１〜１．０ｍｍ程度大きく、例えば１．１〜２．０ｍｍ程度に形成される。また、スリット１３の長さについては、多孔質シート２の表出長さが１０〜２５ｍｍ程度となるように設けられることが好ましい。 The width and depth of the slit 13 formed in the plate-like body 10 (this depth corresponds to the thickness of the plate-like body 10) is such that at least the side peripheral portion of the specimen collection needle enters the slit 13 so that the specimen It is necessary that the sample collected by the collection needle be sized so that the sample can be rubbed against the porous sheet 2. Usually, the width of the slit 13 is 0.1 to 1 than the outer diameter of the sample collection needle. The slit depth, that is, the thickness of the plate-like body 10 depends on the outer diameter of the sample collection needle, although it depends on the width of the slit 13. It is about 0.1 to 1.0 mm larger, for example, about 1.1 to 2.0 mm. The length of the slit 13 is preferably provided so that the exposed length of the porous sheet 2 is about 10 to 25 mm.

支持部材２０は、透液性であればよく、図１，３に示すように板面にスリットを貫通させて設けたものの他、多数の開口を設けたものであってもよい。また、多孔質シート２にある程度の自立性があれば、枠部材であってもよい。 The support member 20 only needs to be liquid permeable, and may be provided with a large number of openings in addition to the plate surface provided with slits as shown in FIGS. Further, if the porous sheet 2 has a certain degree of self-supporting property, it may be a frame member.

同様に、ケース３０のケースアッパー４０の蓋板４１及びケースロワー５０の底面部５１についても通液性を確保できれば、小開口に限らず、スリットを設けてもよく、また、メッシュ素材で全体を構成してもよい。
支持部材やケースに設ける通液のための開口の大きさやスリットの幅については、薬液が円滑に透過するように適宜設計される。ただし、ケースアッパー４０については、薬品処理時に多孔質シート２からの検体の浮き上がりが発生した場合であっても、検体がケース３０外に脱落することを防止するために、検体の大きさよりも小さい径の小開口又は検体の大きさよりも小さい幅のスリットとすることが好ましい。 Similarly, the lid plate 41 of the case upper 40 of the case 30 and the bottom surface portion 51 of the case lower 50 can be provided with slits as well as small openings as long as liquid permeability can be ensured, and the mesh material can be used as a whole. It may be configured.
About the magnitude | size of the opening for liquid passing provided in a support member or a case, and the width | variety of a slit, it designs suitably so that a chemical | medical solution may permeate | transmit smoothly. However, the case upper 40 is smaller than the size of the specimen in order to prevent the specimen from dropping out of the case 30 even when the specimen is lifted from the porous sheet 2 during chemical treatment. A slit having a small diameter or a width smaller than the size of the specimen is preferable.

図１〜５に示す医療検体保持部材の板状体１０及び支持部材２０や、ケース３０のケースアッパー４０及びケースロワー５０は、後述の熱可塑性樹脂を用いて、射出成形等により容易に製造することができる。多孔質シートは、図１〜５に示すように、成形された板状体１０と支持部材２０との間に挟み込んだり挿入したりして固定することもできるし、板状体又は支持部材の成形時に金型に予め多孔質シートを設けておくインサート成形により一体成形することもできる。 The plate 10 and the support member 20 of the medical specimen holding member shown in FIGS. 1 to 5 and the case upper 40 and the case lower 50 of the case 30 are easily manufactured by injection molding or the like using a thermoplastic resin described later. be able to. As shown in FIGS. 1 to 5, the porous sheet can be fixed by being sandwiched or inserted between the molded plate-like body 10 and the support member 20, or of the plate-like body or the support member. It can also be integrally formed by insert molding in which a porous sheet is provided in advance in the mold during molding.

次に、図６を参照して本発明の医療検体保持部材の別の実施の形態について説明する。 Next, another embodiment of the medical specimen holding member of the present invention will be described with reference to FIG.

図６の医療検体保持部材６０は、本体部７０と、基端側が該本体部７０にヒンジ部９０によって回動可能に連結された蓋部８０とを備えている。 The medical sample holding member 60 of FIG. 6 includes a main body portion 70 and a lid portion 80 whose base end is rotatably connected to the main body portion 70 by a hinge portion 90.

本体部７０は、略長方形状の平盤状の板状部（板状体に相当する）７１と、この板状部７１に多孔質シート２の挿入スペースを設けて一体成形された支持部（支持部材に相当する）７３とを有し、板状部７１には短手方向に互いに平行に延在するように複数のスリット７２が設けられている。このスリット７２の寸法については、図１〜５に示す医療検体保持部材１の板状体１０のスリット１３と同等に設計される。 The main body 70 includes a substantially rectangular flat plate-like plate-like portion (corresponding to a plate-like body) 71 and a support portion (in which the porous sheet 2 is inserted in the plate-like portion 71 and integrally formed). The plate-like portion 71 is provided with a plurality of slits 72 so as to extend in parallel with each other in the lateral direction. About the dimension of this slit 72, it designs similarly to the slit 13 of the plate-shaped body 10 of the medical specimen holding member 1 shown to FIGS.

支持部７３は、多孔質シート２を支持する枠状のものである。 The support portion 73 has a frame shape that supports the porous sheet 2.

この支持部７３と板状部７１とを有する本体部７０は、後述の熱可塑性樹脂の射出成形等により一体成形にて製造することができる。多孔質シート２はこの成形時にインサート成形して設けてもよいし、板状部７１と支持部７３の間に多孔質シートの出し入れ用の開口部を設けて本体部を成形した後、この開口から多孔質シートを挿入するようにしてもよい。 The main body portion 70 having the support portion 73 and the plate-like portion 71 can be manufactured by integral molding by injection molding of a thermoplastic resin described later. The porous sheet 2 may be provided by insert molding at the time of molding, or after the body portion is molded by providing an opening for taking in and out the porous sheet between the plate-like portion 71 and the support portion 73, Alternatively, a porous sheet may be inserted.

蓋部８０は、本体部７０に被さった図６（ｂ）の閉止状態と、それから１８０°回転した図６（ａ）の開放状態とをとりうるようにヒンジ部９０によって本体部７０に回動自在に連結されている。蓋部８０は、略長方形状の主板部８１と、該主板部８１の１対の長側辺から起立する側壁部８２と、主板部８１の先端側（ヒンジ部９０と反対側）に連なる平板状の端板部８３とを有している。端板部８３は、主板部８１と面一状となっており、閉止状態では主板部８１が本体部７０の板状部７１に密着状に重なるように構成されている。なお、本体部７０の長手方向の側面部には、蓋部８０を閉止したときに側壁部８２と当接する段部７０ａが設けられている。 The lid portion 80 is rotated to the main body portion 70 by the hinge portion 90 so as to be able to take the closed state shown in FIG. 6B covering the main body portion 70 and the opened state shown in FIG. It is connected freely. The lid portion 80 includes a substantially rectangular main plate portion 81, a side wall portion 82 rising from a pair of long sides of the main plate portion 81, and a flat plate connected to the distal end side of the main plate portion 81 (the side opposite to the hinge portion 90). Shaped end plate portion 83. The end plate portion 83 is flush with the main plate portion 81, and is configured such that the main plate portion 81 overlaps the plate-like portion 71 of the main body portion 70 in a closed state in the closed state. In addition, a stepped portion 70 a that comes into contact with the side wall portion 82 when the lid portion 80 is closed is provided on the side surface portion in the longitudinal direction of the main body portion 70.

主板部８１には、該主板部８１を厚さ方向に貫通する複数の孔部８０ａが設けられている。孔部８０ａの孔径は、検体の大きさよりも小さい。端板部８３からは、閉止状態（図６（ｂ））にある蓋部８０を開放方向に回動させる際に指を掛けるための操作片８４が突設されている。また、端板部８３には、閉止状態において本体部７０側へ起立する爪部８５が突設されており、本体部７０にはこの爪部８５が差し込まれる小開口７０ｂが設けられている。爪部８５が小開口７０ｂに係合することにより、蓋部８０の開き出しが阻止される。爪部８５の小開口７０ｂへの係合を解消し、操作片８４を引き上げることにより、蓋部８０が開放方向に回動する。
蓋部８０も、後述の熱可塑性樹脂の射出成形等により製造される。 The main plate portion 81 is provided with a plurality of holes 80a that penetrate the main plate portion 81 in the thickness direction. The hole diameter of the hole 80a is smaller than the size of the specimen. From the end plate portion 83, an operation piece 84 is provided for hooking a finger when the lid portion 80 in the closed state (FIG. 6B) is rotated in the opening direction. Further, the end plate portion 83 is provided with a claw portion 85 that stands up toward the main body portion 70 in the closed state, and the main body portion 70 is provided with a small opening 70b into which the claw portion 85 is inserted. When the claw portion 85 is engaged with the small opening 70b, the opening of the lid portion 80 is prevented. By releasing the engagement of the claw portion 85 with the small opening 70b and pulling up the operation piece 84, the lid portion 80 rotates in the opening direction.
The lid 80 is also manufactured by injection molding of a thermoplastic resin described later.

この医療検体保持部材６０を用いる場合は、蓋部８０を開放状態としておき、検体を採取した検体採取針を本体部７０のスリット７２内に押し当てて、スリット７２内に表出する多孔質シート２に擦り付けて検体を移し置いて付着させる。この操作を繰り返して、必要な数の検体を本体部７０のスリット７２内の多孔質シート２上に付着させた後、蓋部８０を閉止し、爪部８５を小開口７０ｂに係合させる。
こうして、全ての検体を医療検体保持部材６０に収容した後に、医療検体保持部材６０ごと検体を薬品処理し、その後、検体をケースから取り出して包埋処理した後、スライスしてサンプルを切り出し、顕微鏡観察する。 When this medical sample holding member 60 is used, a porous sheet that is exposed in the slit 72 by keeping the lid 80 open and pressing the sample collection needle that collects the sample into the slit 72 of the main body 70. Rub on 2 and transfer specimen to attach. This operation is repeated to attach a necessary number of specimens on the porous sheet 2 in the slit 72 of the main body 70, and then the lid 80 is closed and the claw 85 is engaged with the small opening 70b.
In this way, after all the specimens are accommodated in the medical specimen holding member 60, the specimen is treated with the medicine together with the medical specimen holding member 60, and then the specimen is taken out from the case and embedded, and then sliced to cut out the sample. Observe.

図６の医療検体保持部材６０であっても、図１〜５に示す医療検体保持部材１と同様に、検体採取針で採取した検体を容易に多孔質シート２上に移し置き、その後の薬品処理時には、検体を多孔質シート２上に安定に保持することができる。また、薬品処理時には、多孔質シート２が通液性に優れると共に、蓋部８０に孔部８０ａが設けられていることにより、薬液を円滑に通液して、医療検体保持部材６０内の検体を効率的に薬品処理することができる。 Even in the case of the medical sample holding member 60 of FIG. 6, the sample collected by the sample collection needle can be easily transferred onto the porous sheet 2 in the same manner as the medical sample holding member 1 shown in FIGS. At the time of processing, the specimen can be stably held on the porous sheet 2. In addition, when the chemical treatment is performed, the porous sheet 2 is excellent in liquid permeability, and the hole 80a is provided in the lid 80, so that the chemical liquid can be smoothly passed and the specimen in the medical specimen holding member 60 can be passed. Can be efficiently treated with chemicals.

［多孔質シート］
本発明で用いる多孔質シート２について、以下に説明する。
本発明に用いられる多孔質シートとしては、アルコール、キシレン、ホルマリン、パラフィン等に対する耐薬品性を有するものであれば特に制限されず、以下のようなものが挙げられるが、アルコール、キシレン等の薬液や液状パラフィンを透過させ、また、検体採取針から該多孔質シート上に検体を安定的に移し替えて保持させるために、所定の算術平均粗さＲａと保留粒子径を有することが重要となる。 [Porous sheet]
The porous sheet 2 used in the present invention will be described below.
The porous sheet used in the present invention is not particularly limited as long as it has chemical resistance to alcohol, xylene, formalin, paraffin and the like, and examples thereof include the following, but chemicals such as alcohol and xylene In addition, it is important to have a predetermined arithmetic average roughness Ra and a reserved particle diameter in order to permeate liquid paraffin and to stably transfer and hold the specimen from the specimen collection needle onto the porous sheet. .

多孔質シートとしては、濾紙等の紙、織布、不織布、多孔性樹脂フィルムが挙げられ、必要に応じ、これらの積層体（ラミネート）でも良い。
また、多孔性樹脂フィルムは、例えば、機械的に多数の細孔を開けて多孔化したものや、無孔性樹脂フィルムを延伸によって多孔化したもの、無孔性樹脂フィルムに可塑剤等を分散させ、これを溶媒抽出して多孔化したもの、無孔性樹脂フィルムを発泡によって多孔化したもの、などを、適宜用いることができる。
また、多孔質シートにはプラズマ処理等の親水化処理を施しても良い。このような親水化処理を施すことで、多孔質シートの薬液透過性を向上させることができる。
これらの中でも、本発明においては、製品コスト低減および薬液透過性の観点から紙を用いることが特に好ましく、とりわけ濾紙が好ましい。 Examples of the porous sheet include paper such as filter paper, woven fabric, non-woven fabric, and porous resin film, and a laminate (laminate) of these may be used as necessary.
In addition, the porous resin film is, for example, a material obtained by mechanically opening a large number of pores to make it porous, a nonporous resin film made porous by stretching, or a plasticizer or the like dispersed in a nonporous resin film. In addition, what is made porous by solvent extraction, what is made nonporous resin film porous by foaming, and the like can be appropriately used.
Further, the porous sheet may be subjected to hydrophilic treatment such as plasma treatment. By performing such a hydrophilic treatment, the chemical liquid permeability of the porous sheet can be improved.
Among these, in the present invention, it is particularly preferable to use paper from the viewpoint of product cost reduction and chemical liquid permeability, and filter paper is particularly preferable.

多孔質シートとして、織布、不織布、又は多孔性樹脂フィルムを用いる場合、これらに使用する樹脂は特に制限されず、天然樹脂、合成樹脂、半合成樹脂が用いられ、また生分解性樹脂も使用可能である。
これらの中でも、耐薬品性の観点からポリエチレン、ポリプロピレン、シクロオレフィンポリマー、共重合ポリオレフィンなどのポリオレフィン樹脂；ポリエチレンテレフタレート、ポリブチレンテレフタレートなどのポリエステル樹脂；ポリアミド６、ポリアミド６６、ポリアミド１２などのポリアミド樹脂；ポリオキシメチレン、ポリフェニレンサルファイド、ポリエーテルイミド、液晶性ポリエステル、ポリフェニレンエーテル、ポリサルフォン、ポリエーテルサルフォン、ポリエーテルエーテルケトン、熱可塑性ポリイミド、エチレン−テトラフルオロエチレン共重合体などの熱可塑性フッ素樹脂が挙げられる。 When a woven fabric, a nonwoven fabric, or a porous resin film is used as the porous sheet, the resin used for these is not particularly limited, and natural resins, synthetic resins, semi-synthetic resins are used, and biodegradable resins are also used. Is possible.
Among these, from the viewpoint of chemical resistance, polyolefin resins such as polyethylene, polypropylene, cycloolefin polymer and copolymer polyolefin; polyester resins such as polyethylene terephthalate and polybutylene terephthalate; polyamide resins such as polyamide 6, polyamide 66 and polyamide 12; Thermoplastic fluororesins such as polyoxymethylene, polyphenylene sulfide, polyetherimide, liquid crystalline polyester, polyphenylene ether, polysulfone, polyether sulfone, polyether ether ketone, thermoplastic polyimide, ethylene-tetrafluoroethylene copolymer It is done.

本発明で用いる多孔質シートの算術平均粗さＲａは、０．５μｍ以上５０μｍ以下である。多孔質シートの算術平均粗さＲａの下限は、好ましくは１．０μｍ以上、より好ましくは１．５μｍ以上である。一方、多孔質シートの算術平均粗さＲａの上限は、好ましくは４０μｍ以下、より好ましくは３０μｍ以下である。 The arithmetic average roughness Ra of the porous sheet used in the present invention is 0.5 μm or more and 50 μm or less. The lower limit of the arithmetic average roughness Ra of the porous sheet is preferably 1.0 μm or more, more preferably 1.5 μm or more. On the other hand, the upper limit of the arithmetic average roughness Ra of the porous sheet is preferably 40 μm or less, more preferably 30 μm or less.

多孔質シートの算術平均粗さＲａが０．５μｍ未満では、検体採取針からの検体の移し替えが困難になるだけでなく、薬品処理時の検体の保持性能が不十分となり好ましくない。また、多孔質シートの算術平均粗さＲａが５０μｍより大きいと、検体の移し替え時に凹凸が障害となって作業が困難になるおそれがあり好ましくない。 When the arithmetic average roughness Ra of the porous sheet is less than 0.5 μm, not only is it difficult to transfer the specimen from the specimen collection needle, but also the specimen holding performance during chemical treatment is insufficient, which is not preferable. Further, if the arithmetic average roughness Ra of the porous sheet is larger than 50 μm, it is not preferable because the unevenness becomes an obstacle during the transfer of the specimen and the operation becomes difficult.

多孔質シートの算術平均粗さＲａは、後述する多孔質シートの保留粒子径のみならず、例えば多孔質シートが紙や不織布、織布等であれば表面の繊維の材質や寸法（繊維径、アスペクト比等）、繊維の状態などが影響する。多孔質シートが多孔性樹脂フィルムや発泡樹脂フィルムの場合には、樹脂の結晶状態や分子の絡み合いの状態、孔の分布、延伸前の原反の表面粗さ等、様々な要因が複雑に影響するものであり、一概に保留粒子径の大小のみで決定されるものではなく、保留粒子径とは別異の物性である。
多孔質シートの算術平均粗さＲａは、具体的には後述の実施例の項に示される方法で、ＪＩＳＢ０６０１（２０１３年）に従って測定される。 The arithmetic average roughness Ra of the porous sheet is not limited to the retained particle diameter of the porous sheet, which will be described later. Aspect ratio, etc.), fiber condition, etc. When the porous sheet is a porous resin film or foamed resin film, various factors such as the crystalline state of the resin, the state of entanglement of the molecules, the distribution of pores, and the surface roughness of the original fabric before stretching have a complex effect. Therefore, it is not generally determined only by the size of the retained particle diameter, but is a physical property different from the retained particle diameter.
The arithmetic average roughness Ra of the porous sheet is specifically measured according to JIS B0601 (2013) by the method shown in the section of the examples described later.

本発明で用いる多孔質シートの保留粒子径は、０．１μｍ以上２００μｍ以下である。多孔質シートの保留粒子径とは、該多孔質シートを用いて比較的一定の粒子径分布である粒子を混合した液の濾過を行った時に、濾過効率が９０％以上となる粒子径の最小値を言う。より具体的には、ＪＩＳＺ８９０１（２００６年）に記載の「試験用粉体１の７種」として規定された粒子径分布を有する粉体を水１００質量部に対して２質量部分散させた分散液５０ｍＬについて、該多孔質シートを用いて大気圧で濾過を行った時に、濾過効率が９０％以上となる粒子径の最小値を、本発明の多孔質シートの保留粒子径と定める。
多孔質シートの保留粒子径の下限は、好ましくは０．５μｍ以上、より好ましくは１．０μｍ以上である。一方、多孔質シートの保留粒子径の上限は、好ましくは１５０μｍ以下、より好ましくは１００μｍ以下である。 The reserved particle diameter of the porous sheet used in the present invention is 0.1 μm or more and 200 μm or less. The reserved particle diameter of the porous sheet is the minimum particle diameter at which the filtration efficiency is 90% or more when a liquid mixed with particles having a relatively constant particle size distribution is filtered using the porous sheet. Say the value. More specifically, a powder having a particle size distribution defined as “7 types of test powder 1” described in JIS Z8901 (2006) was dispersed in an amount of 2 parts by mass with respect to 100 parts by mass of water. When 50 mL of the dispersion is filtered at atmospheric pressure using the porous sheet, the minimum value of the particle diameter at which the filtration efficiency is 90% or more is determined as the retained particle diameter of the porous sheet of the present invention.
The lower limit of the retained particle diameter of the porous sheet is preferably 0.5 μm or more, more preferably 1.0 μm or more. On the other hand, the upper limit of the retained particle diameter of the porous sheet is preferably 150 μm or less, more preferably 100 μm or less.

多孔質シートの保留粒子径が０．１μｍ未満では、表面の凹凸が小さく検体採取針からの検体の移し替えが困難になるだけでなく、薬液の透過性が低くなり検体の薬品処理が不十分となる。一方、多孔質シートの保留粒子径が２００μｍより大きいと処理中に検体の一部が孔から脱落するおそれがあるだけでなく、検体採取針からの検体の移し替えの際、検体採取針の先端が孔に引っかかり検体を損傷するおそれがあるため好ましくない。 If the retained particle diameter of the porous sheet is less than 0.1 μm, the surface unevenness is small and not only the transfer of the sample from the sample collection needle is difficult, but also the chemical treatment of the sample is insufficient due to the low permeability of the chemical solution. It becomes. On the other hand, if the retained particle diameter of the porous sheet is larger than 200 μm, not only a part of the specimen may fall out of the hole during processing, but also the tip of the specimen collecting needle may be transferred when the specimen is transferred from the specimen collecting needle. Is not preferable because it may get caught in the hole and damage the specimen.

多孔質シートの厚みは、０．１ｍｍ以上３．０ｍｍ以下が好ましい。多孔質シートの厚みの下限は、より好ましくは０．１５ｍｍ以上、更に好ましくは０．２ｍｍ以上である。また、多孔質シートの厚みの上限は、より好ましくは２．５ｍｍ以下、さらに好ましくは２．０ｍｍ以下である。 The thickness of the porous sheet is preferably from 0.1 mm to 3.0 mm. The lower limit of the thickness of the porous sheet is more preferably 0.15 mm or more, and still more preferably 0.2 mm or more. Moreover, the upper limit of the thickness of a porous sheet becomes like this. More preferably, it is 2.5 mm or less, More preferably, it is 2.0 mm or less.

多孔質シートの厚みが０．１ｍｍ以上であれば、多孔質シートが機械強度に優れ、容易に変形するおそれがないため、本発明の医療検体保持部材の作製時のハンドリング性や、検体の移し替え時の作業性が良好となる。一方、多孔質シートの厚みが３．０ｍｍ以下であれば、本発明の医療検体保持部材の作製時に多孔質シートを加工することが容易となり、また薬品処理時に薬液の透過性が良好となる。 If the thickness of the porous sheet is 0.1 mm or more, the porous sheet has excellent mechanical strength and is not likely to be easily deformed. Workability at the time of replacement is improved. On the other hand, if the thickness of the porous sheet is 3.0 mm or less, it becomes easy to process the porous sheet when producing the medical specimen holding member of the present invention, and the permeability of the chemical solution is improved during chemical treatment.

［熱可塑性樹脂］
以下に、前述の医療検体保持部材の板状体、支持部材及びケースや、医療検体保持部材の本体部及び蓋部の構成材料として好適な熱可塑性樹脂について説明する。 [Thermoplastic resin]
Hereinafter, a thermoplastic resin suitable as a constituent material of the plate-like body, the support member, and the case of the medical specimen holding member, and the main body portion and the lid portion of the medical specimen holding member will be described.

本発明で用いる熱可塑性樹脂は限定されないが、具体的には、ポリエチレン、ポリプロピレン、シクロオレフィンポリマー、共重合ポリオレフィンなどのポリオレフィン樹脂；ポリスチレン、ＡＢＳ樹脂、ＡＳ樹脂等のスチレン樹脂；ポリブチレンテレフタレート、ポリエチレンテレフタレートなどのポリエステル樹脂；ポリアミド６、ポリアミド６６、ポリアミド１２などのポリアミド樹脂；ポリオキシメチレン、ポリカーボネート、ポリアリレート、ポリフェニレンサルファイド、ポリエーテルイミド、液晶性ポリエステル、ポリフェニレンエーテル、ポリサルフォン、ポリエーテルサルフォン、ポリエーテルエーテルケトン、熱可塑性ポリイミド、エチレン−テトラフルオロエチレン共重合体などの熱可塑性フッ素樹脂、ＥＰＲなどのオレフィン系エラストマー、ＳＥＢＳなどのスチレン系エラストマー、ポリエステル系エラストマー、ポリウレタンエラストマー、ポリアミドエラストマー、シリコーンエラストマー、アクリルエラストマー等の熱可塑性エラストマーなどを使用することができる。前記の熱可塑性樹脂は、１種を単独で使用してもよいし、２種以上を併用してもよい。 The thermoplastic resin used in the present invention is not limited, but specifically, polyolefin resins such as polyethylene, polypropylene, cycloolefin polymer and copolymer polyolefin; styrene resins such as polystyrene, ABS resin and AS resin; polybutylene terephthalate, polyethylene Polyester resins such as terephthalate; Polyamide resins such as polyamide 6, polyamide 66, polyamide 12; polyoxymethylene, polycarbonate, polyarylate, polyphenylene sulfide, polyetherimide, liquid crystalline polyester, polyphenylene ether, polysulfone, polyethersulfone, poly Thermoplastic fluororesins such as ether ether ketone, thermoplastic polyimide, ethylene-tetrafluoroethylene copolymer, EPR, etc. Olefin elastomers, styrene elastomers such as SEBS, polyester elastomer, polyurethane elastomer, polyamide elastomer, silicone elastomer, or the like can be used a thermoplastic elastomer such as an acrylic elastomer. The said thermoplastic resin may be used individually by 1 type, and may use 2 or more types together.

なお、医療検体は保持部材上にて、様々な処理薬品で処理されることが多いため、本発明で用いる熱可塑性樹脂は、耐薬品性に優れていることが好ましい。
従って、上記の熱可塑性樹脂の中でも、ポリエチレン、ポリプロピレン、シクロオレフィンポリマー、共重合ポリオレフィンなどのポリオレフィン樹脂；ポリエチレンテレフタレート、ポリブチレンテレフタレートなどのポリエステル樹脂；ポリアミド６、ポリアミド６６、ポリアミド１２などのポリアミド樹脂；ポリオキシメチレン、ポリフェニレンサルファイド、ポリエーテルイミド、液晶性ポリエステル、ポリフェニレンエーテル、ポリサルフォン、ポリエーテルサルフォン、ポリエーテルエーテルケトン、熱可塑性ポリイミド、エチレン−テトラフルオロエチレン共重合体などの熱可塑性フッ素樹脂が、耐薬品性に優れる点で好ましい。
これらの中でも、ポリオキシメチレンがコストの点でとりわけ好ましい。 Since the medical specimen is often treated with various treatment chemicals on the holding member, the thermoplastic resin used in the present invention is preferably excellent in chemical resistance.
Therefore, among the thermoplastic resins described above, polyolefin resins such as polyethylene, polypropylene, cycloolefin polymer, copolymer polyolefin, etc .; polyester resins such as polyethylene terephthalate and polybutylene terephthalate; polyamide resins such as polyamide 6, polyamide 66, and polyamide 12; Thermoplastic fluororesins such as polyoxymethylene, polyphenylene sulfide, polyetherimide, liquid crystalline polyester, polyphenylene ether, polysulfone, polyether sulfone, polyether ether ketone, thermoplastic polyimide, ethylene-tetrafluoroethylene copolymer, It is preferable in terms of excellent chemical resistance.
Among these, polyoxymethylene is particularly preferable from the viewpoint of cost.

本発明で用いる熱可塑性樹脂には、発明の効果を損なわない範囲で付加成分を添加することができる。
このような付加成分としては、例えば、ヒンダードフェノールやリン酸エステル等の熱安定剤、酸化防止剤、離型剤、パラフィンオイル等の可塑剤、ハロゲン系、リン系等の難燃剤、光安定剤、紫外線吸収剤、中和剤、滑剤、シランカップリング相溶化剤、防曇剤、アンチブロッキング剤、スリップ剤、分散剤、酸化チタン等の着色剤、防菌剤、蛍光増白剤、結晶核剤等といった各種添加剤を挙げることができる。
また、タルク、マイカ、炭酸カルシウム、ガラスビーズ等のフィラーを添加してもよい。 An additional component can be added to the thermoplastic resin used in the present invention as long as the effects of the invention are not impaired.
Examples of such additional components include heat stabilizers such as hindered phenols and phosphate esters, antioxidants, mold release agents, plasticizers such as paraffin oil, halogen-based and phosphorus-based flame retardants, and light stability. Agents, UV absorbers, neutralizers, lubricants, silane coupling compatibilizers, antifogging agents, antiblocking agents, slip agents, dispersants, coloring agents such as titanium oxide, antibacterial agents, fluorescent whitening agents, crystals Various additives such as a nucleating agent can be mentioned.
Further, fillers such as talc, mica, calcium carbonate, glass beads may be added.

以下に実施例を挙げて本発明をより具体的に説明する。 Hereinafter, the present invention will be described more specifically with reference to examples.

以下の実施例及び比較例において、多孔質シートとして用いた濾紙の算術平均粗さＲａ及び保留粒子径は以下の方法で測定した。 In the following examples and comparative examples, the arithmetic average roughness Ra and the retained particle diameter of the filter paper used as the porous sheet were measured by the following methods.

＜算術平均粗さＲａ＞
多孔質シートの表面を、ミツトヨ社製表面粗さ計「サーフテストＳＪ−４００」を使用し、ＪＩＳＢ０６０１（２０１３年）の条件（評価長さ：４ｍｍ、測定速度：０．５ｍｍ／ｓ）にて、算術表面粗さＲａを測定した。 <Arithmetic mean roughness Ra>
The surface of the porous sheet was subjected to the conditions of JIS B0601 (2013) (evaluation length: 4 mm, measurement speed: 0.5 mm / s) using a surface roughness meter “Surf Test SJ-400” manufactured by Mitutoyo Corporation. Then, the arithmetic surface roughness Ra was measured.

＜保留粒子径＞
ＪＩＳＺ８９０１（２００６年）に記載の「試験用粉体１の７種」として規定された粒子径分布を有する粉体を水１００質量部に対して２質量部分散させた分散液５０ｍＬについて、実施例及び比較例で使用したシートを用いて大気圧で濾過を行った。得られた濾液中の粒子と残渣中の粒子について、それぞれの粒子径分布をレーザー回折／散乱式粒度分布計で測定し、濾過効率が９０％以上となる粒子径の最小値を、シートの保留粒子径とした。 <Retained particle size>
Conducted on 50 mL of dispersion in which 2 parts by mass of a powder having a particle size distribution defined as “7 types of test powder 1” described in JIS Z8901 (2006) was dispersed in 100 parts by mass of water Filtration was performed at atmospheric pressure using the sheets used in the examples and comparative examples. For the particles in the obtained filtrate and the particles in the residue, the particle size distribution is measured with a laser diffraction / scattering particle size distribution meter, and the minimum particle size at which the filtration efficiency is 90% or more is determined. The particle diameter was taken.

［実施例１〜３、比較例１、２］
多孔質シート２として、以下及び表１に示す算術平均粗さＲａ、保留粒子径及び厚みの多孔質シートを用い、図１に示す医療検体保持部材１を作製した。
板状体１０及び支持部材２０は、光硬化性樹脂（Ｓｔｒａｔａｓｙｓ社製「ＦｕｌｌＣｕｒｅＲＧＤ７２０」）を用いて、３Ｄプリンター（Ｓｔｒａｔａｓｙｓ社製「ＥＤＥＮ２６０Ｖ」）にて作製した（なお、実施例では、３Ｄプリンターを用いて成形を行ったが、実際の工業的な医療検体保持部材の生産においては射出成形が好ましい。）。 [Examples 1 to 3, Comparative Examples 1 and 2]
As the porous sheet 2, a medical sample holding member 1 shown in FIG. 1 was prepared using the porous sheet having the arithmetic average roughness Ra, the reserved particle diameter, and the thickness shown below and in Table 1.
The plate-like body 10 and the support member 20 were prepared with a 3D printer (“EDEN260V” manufactured by Stratasys) using a photocurable resin (“FullCure RGD720” manufactured by Stratasys) (in the examples, a 3D printer). However, injection molding is preferable in the production of an actual industrial medical specimen holding member.

スリット１３の寸法は以下の通りである。
幅：１．５ｍｍ
深さ：１．５ｍｍ（板状体１０の厚み）
多孔質シート２の表出長さ：１６ｍｍ The dimensions of the slit 13 are as follows.
Width: 1.5mm
Depth: 1.5 mm (thickness of plate-like body 10)
The exposed length of the porous sheet 2: 16 mm

作製された各医療検体保持部材を用い、以下の検体移し替え試験を行い、結果を表１に示した。 Using the produced medical specimen holding members, the following specimen transfer test was conducted, and the results are shown in Table 1.

＜実施例１＞
光硬化性樹脂を用いて、３Ｄプリンターにて板状体１０、支持部材２０、ケースアッパー４０を成形し、板状体１０と支持部材２０で多孔質シート２として濾紙（安積濾紙製Ｎｏ．ＬＳ１００、保留粒子径：０．５μｍ）を挟持することで医療検体保持部材を作製した。 <Example 1>
A plate-like body 10, a support member 20, and a case upper 40 are formed by a 3D printer using a photocurable resin, and a filter paper (No. LS100 made by Azumi filter paper) is formed as a porous sheet 2 with the plate-like body 10 and the support member 20. The retained specimen diameter: 0.5 μm) was used to produce a medical specimen holding member.

＜検体移し替え試験＞
医療検体用採取針（メディコン社製「バードモノプティ」、外径１．０ｍｍ）を用いて、鳥の生肉より組織検体を採取した後、医療検体保持部材１の検体保持部であるスリット１３内の多孔質シート２に、検体を保持した採取針を擦りつけて、検体の移し替えを行い、このときの移し替え性及び検体保持性を下記基準で評価した。
○：検体をスムーズに検体保持部に移し替えることができ、さらに振動等で容易に落下することなく良好な検体保持性が得られた。
△：検体をスムーズに検体保持部に移し替えることができたが、振動等により検体が保持部より脱落した。
×：検体を検体保持部へ移し替えることができなかった。 <Sample transfer test>
After a tissue sample is collected from raw chicken meat using a medical sample collection needle (Medibird's “Bird Monoputi”, outer diameter 1.0 mm), inside the slit 13 which is a sample holding portion of the medical sample holding member 1 The porous needle 2 was rubbed with a sampling needle holding the specimen to transfer the specimen, and the transferability and specimen retention at this time were evaluated according to the following criteria.
○: The specimen could be smoothly transferred to the specimen holder, and good specimen retention was obtained without being easily dropped by vibration or the like.
Δ: The sample could be smoothly transferred to the sample holding unit, but the sample dropped out of the holding unit due to vibration or the like.
X: The sample could not be transferred to the sample holding unit.

＜実施例２＞
実施例１で使用した濾紙を安積濾紙製Ｎｏ．１（保留粒子径：６μｍ）に変更した他は実施例１と同様にして医療検体保持部材を製作し、検体移し替え試験を実施した。 <Example 2>
The filter paper used in Example 1 was Azumi filter paper No. A medical specimen holding member was produced in the same manner as in Example 1 except that it was changed to 1 (retained particle diameter: 6 μm), and a specimen transfer test was performed.

＜実施例３＞
実施例１で使用した濾紙を安積濾紙製Ｎｏ．５００（保留粒子径：１４μｍ）に変更した他は実施例１と同様にして医療検体保持部材を製作し、検体移し替え試験を実施した。 <Example 3>
The filter paper used in Example 1 was Azumi filter paper No. A medical sample holding member was produced in the same manner as in Example 1 except that the particle size was changed to 500 (retained particle size: 14 μm), and a sample transfer test was performed.

＜比較例１＞
実施例１で使用した濾紙をポリエチレンメッシュ（保留粒子径：２５０μｍ）に変更した他は実施例１と同様にして医療検体保持部材を製作し、検体移し替え試験を実施した。 <Comparative Example 1>
A medical specimen holding member was produced in the same manner as in Example 1 except that the filter paper used in Example 1 was changed to a polyethylene mesh (retained particle diameter: 250 μm), and a specimen transfer test was performed.

＜比較例２＞
実施例１で使用した濾紙をポリエチレンフィルム（貫通孔無し）に変更した他は実施例１と同様にして医療検体保持部材を製作し、検体移し替え試験を実施した。 <Comparative Example 2>
A medical specimen holding member was produced in the same manner as in Example 1 except that the filter paper used in Example 1 was changed to a polyethylene film (no through-hole), and a specimen transfer test was performed.

表１より明らかなように、算術平均粗さＲａが５０μｍより大きく、保留粒子径が２００μｍより大きいポリエチレンメッシュを用いた比較例１および、算術平均粗さＲａが０．５μｍ未満であり、かつ細孔を有さないポリエチレンフィルムを用いた比較例２では、検体移し替え性が悪いが、算術平均粗さＲａ及び保留粒子径が本発明の規定範囲内の濾紙を用いた実施例１〜３では、いずれも良好な検体移し替え性及び保持性が得られた。 As is clear from Table 1, Comparative Example 1 using a polyethylene mesh having an arithmetic average roughness Ra of greater than 50 μm and a retained particle diameter of greater than 200 μm, and the arithmetic average roughness Ra of less than 0.5 μm, In Comparative Example 2 using a polyethylene film having no holes, sample transferability is poor, but in Examples 1 to 3 using filter paper whose arithmetic average roughness Ra and retention particle diameter are within the specified range of the present invention. In both cases, good sample transferability and retention were obtained.

１医療検体保持部材
２多孔質シート
１０板状体
１３スリット
１４フック片
２０支持部材
２１第１スリット
２２第２スリット
２３第３スリット
３０ケース
４０ケースアッパー
５０ケースロワー
６０医療検体保持部材
７０本体部
７１板状部
７２スリット
７３支持部
８０蓋部
８０ａ孔部
９０ヒンジ部 DESCRIPTION OF SYMBOLS 1 Medical sample holding member 2 Porous sheet 10 Plate-shaped body 13 Slit 14 Hook piece 20 Support member 21 1st slit 22 2nd slit 23 3rd slit 30 Case 40 Case upper 50 Case lower 60 Medical sample holding member 70 Main body part 71 Plate-like part 72 Slit 73 Support part 80 Lid part 80a Hole part 90 Hinge part

Claims

検体採取針で採取した検体を移し置くための医療検体保持部材であって、凹形状の検体保持部を有する医療検体保持部材において、
該検体保持部の少なくとも一部が、算術平均粗さＲａが１．５μｍ以上３０μｍ以下であり、かつ保留粒子径が０．１μｍ以上２００μｍ以下である多孔質シートで構成されており、
該多孔質シート以外の構成部材が耐薬品性の熱可塑性樹脂よりなり、
該多孔質シートに前記検体採取針を擦りつけて該検体採取針で採取した検体を該多孔質シートに移し置くものであり、
該医療検体保持部材は、前記多孔質シートと、該多孔質シートの一方の面に重なる板状体と、該多孔質シートを該板状体に重なる状態に支持する支持部材とを有しており、該板状体に、検体採取針の少なくとも側周部が入り込めるスリットが設けられており、該スリットの幅は１．１〜２．０ｍｍであり、該スリットの深さは１．１〜２．０ｍｍであり、該スリットと該スリット内に表出した前記多孔質シートとで前記検体保持部が構成されていることを特徴とする医療検体保持部材。 A medical sample holding member for transferring and collecting a sample collected by a sample collecting needle, wherein the medical sample holding member has a concave sample holding portion,
At least a part of the specimen holding part is composed of a porous sheet having an arithmetic average roughness Ra of 1.5 μm or more and 30 μm or less and a retained particle diameter of 0.1 μm or more and 200 μm or less,
Components other than the porous sheet are made of a chemical-resistant thermoplastic resin,
Rubbing the sample collection needle against the porous sheet and transferring the sample collected with the sample collection needle to the porous sheet;
The medical specimen holding member includes the porous sheet, a plate-like body that overlaps one surface of the porous sheet, and a support member that supports the porous sheet so as to overlap the plate-like body. The plate-like body is provided with a slit through which at least the side periphery of the sample collection needle can enter, the width of the slit is 1.1 to 2.0 mm, and the depth of the slit is 1.1 to A medical specimen holding member having a thickness of 2.0 mm, wherein the specimen holding section is composed of the slit and the porous sheet exposed in the slit .

請求項１において、前記多孔質シートが、紙、織布、不織布、及び多孔性樹脂フィルムからなる群より選ばれる少なくとも１種よりなることを特徴とする医療検体用保持部材。 The medical specimen holding member according to claim 1, wherein the porous sheet is made of at least one selected from the group consisting of paper, woven fabric, non-woven fabric, and porous resin film.

請求項１において、前記支持部材は、前記多孔質シートの他方の面に重なる支持板であり、該支持板と前記板状体とは着脱可能又は開閉可能に連結されていることを特徴とする医療検体保持部材。 2. The support member according to claim 1 , wherein the support member is a support plate that overlaps the other surface of the porous sheet, and the support plate and the plate-like body are detachably or detachably connected. Medical specimen holding member.

請求項１において、前記板状体と前記支持部材とは一体成形されており、該板状体と支持部材との間のスペースに前記多孔質シートが設けられていることを特徴とする医療検体保持部材。 The medical specimen according to claim 1 , wherein the plate-like body and the support member are integrally formed, and the porous sheet is provided in a space between the plate-like body and the support member. Holding member.

請求項１ないし４のいずれか１項において、前記板状体及び支持部材は熱可塑性樹脂を成形してなることを特徴とする医療検体保持部材。 In any one of claims 1 to 4, the plate-like member and the support member is characterized by being obtained by molding the thermoplastic resin medical object holding member.

請求項１ないし５のいずれか１項において、前記支持部材は、通液用の開口部を有することを特徴とする医療検体保持部材。 In any one of claims 1 to 5, wherein the support member is a medical specimen holding member and having an opening for passing fluid.

請求項１ないし６のいずれか１項に記載の医療検体保持部材と、
該医療検体保持部材を収容する通液性のケースと
を備えたことを特徴とする医療検体保持部材アッセンブリ。 The medical specimen holding member according to any one of claims 1 to 6 ,
A medical specimen holding member assembly, comprising: a liquid-permeable case that houses the medical specimen holding member.

請求項７において、前記ケース内の前記医療検体保持部材を該ケースに係止するための係止手段を有することを特徴とする医療検体保持部材アッセンブリ。 8. The medical sample holding member assembly according to claim 7 , further comprising locking means for locking the medical sample holding member in the case to the case.