JP6491293B2 - 乾癬を治療するためのエアロゾル、ムース、又はフォームの組成物 - Google Patents
乾癬を治療するためのエアロゾル、ムース、又はフォームの組成物 Download PDFInfo
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- JP6491293B2 JP6491293B2 JP2017194544A JP2017194544A JP6491293B2 JP 6491293 B2 JP6491293 B2 JP 6491293B2 JP 2017194544 A JP2017194544 A JP 2017194544A JP 2017194544 A JP2017194544 A JP 2017194544A JP 6491293 B2 JP6491293 B2 JP 6491293B2
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Landscapes
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Description
以下は例示のため提供するものであり、限定を意図するものではない。
男性患者1名において、実施例1で調合した美容液を1回塗布した後日焼け痛が緩和したとの報告があった。患者の報告によると、夜就寝前に本美容液を日焼けした領域に塗布したところ、朝起床時には緩和していた。
本明細書で積極的に特定した全ての特徴又は要素も同様に本発明の実施形態の特徴又は要素として特に除外されてもよいと考えられている点に注意すべきである。
(付記1)
局所投与のための組成物であって、
(a)沸点が150℃以下である、存在し得る全ての溶媒を除外した前記組成物の重量に基づいて25%以上のステロールエステル、
(b)浸透促進剤、及び、
(c)任意に、溶媒、被膜形成/高分子剤、粘度増強剤、乳化剤、抗酸化剤、pH調整剤、保存料、ビタミン類、噴射剤及びこれらの混合物からなる群より選ばれる追加的添加剤、
を含有する、組成物。
前記ステロールエステルを、沸点が150℃以下である、存在し得る全ての溶媒を除外した前記組成物の総重量に基づいて30%以上含有する付記1に記載の組成物。
前記ステロールエステルを、沸点が150℃以下である、存在し得る全ての溶媒を除外した前記組成物の総重量に基づいて40%以上含有する付記1に記載の組成物。
前記ステロールエステルがC10−C30カルボン酸ステロールエステルである付記1に記載の組成物。
前記ステロールエステルがC10−C30カルボン酸コレステロール/ラノステロール混合物である付記4に記載の組成物。
ゲル、クリーム、ローション、膏薬、美容液、エアロゾル、ムース又はフォームであり、被膜形成剤を含有する付記1に記載の組成物。
ゲル、クリーム、ローション、膏薬、美容液、エアロゾル、ムース又はフォームであり、被膜形成剤及び粘度増強剤を含有する付記1に記載の組成物。
ゲル、クリーム、ローション、エアロゾル、ムース又はフォームであり、被膜形成剤、粘度増強剤及び溶媒を含有する付記1に記載の組成物。
エアロゾル、ムース又はフォームであり、被膜形成剤、粘度増強剤、溶媒及び噴射剤を含有する付記1に記載の組成物。
患者の乾癬性領域に少なくとも1日1回組成物を局所投与することを含む乾癬を治療するための方法であって、前記組成物は、
(a)沸点が150℃以下である、存在し得る全ての溶媒を除外した前記組成物の重量に基づいて25%以上のステロールエステル、
(b)浸透促進剤、及び、
(c)任意に、溶媒、被膜形成/高分子剤、粘度増強剤、乳化剤、抗酸化剤、pH調整剤、保存料、ビタミン類、噴射剤及びこれらの混合物からなる群より選ばれる追加的添加剤、
を含有する、方法。
前記ステロールエステルを、沸点が150℃以下である、存在し得る全ての溶媒を除外した前記組成物の総重量に基づいて30%以上含有する付記10に記載の方法。
前記ステロールエステルを、沸点が150℃以下である、存在し得る全ての溶媒を除外した前記組成物の総重量に基づいて40%以上含有する付記10に記載の方法。
前記ステロールエステルはC10−C30カルボン酸ステロールエステルである付記1
0に記載の方法。
前記ステロールエステルはC10−C30カルボン酸コレステロール/ラノステロール
混合物である付記13に記載の方法。
前記組成物は、ゲル、クリーム、ローション、膏薬、美容液、エアロゾル、ムース又はフォームであり、被膜形成剤を含有する付記10に記載の方法。
前記組成物は、ゲル、クリーム、ローション、膏薬、美容液、エアロゾル、ムース又はフォームであり、被膜形成剤及び粘度増強剤を含有する付記10に記載の方法。
前記組成物はゲル、クリーム、ローション、エアロゾル、ムース又はフォームであり、被膜形成剤、粘度増強剤及び溶媒を含有する付記10に記載の方法。
前記組成物は、エアロゾル、ムース又はフォームであり、被膜形成剤、粘度増強剤、溶媒及び噴射剤を含有する付記10に記載の方法。
前記組成物を前記乾癬性領域に1日1回より多く適用する付記10に記載の方法。
前記組成物の適用前に前記乾癬性領域を洗浄及び乾燥する工程をさらに含む付記10に記載の方法。
前記組成物の適用後に前記組成物及び前記乾癬性領域を保護布、包帯、ガーゼ又はラップで覆う工程をさらに含む付記10に記載の方法。
局所投与のための組成物であって、
(a)沸点が150℃以下である、存在し得る全ての溶媒を除外した前記組成物の重量に基づいて25%以上のステロールエステル、
(b)溶媒、
(c)噴射剤、
(d)浸透促進剤、
(e)粘度増強剤、及び、
(f)任意に、共溶媒、被膜形成/高分子剤、乳化剤、抗酸化剤、pH調整剤、保存料、ビタミン類及びこれらの混合物からなる群より選ばれる追加的添加剤、
を含有し、
エアロゾル、ムース又はフォームである、組成物。
前記ステロールエステルを、沸点が150℃以下である、存在し得る全ての溶媒を除外した前記組成物の総重量に基づいて30%以上含有する付記22に記載の組成物。
前記ステロールエステルを、沸点が150℃以下である、存在し得る全ての溶媒を除外した前記組成物の総重量に基づいて40%以上含有する付記22に記載の組成物。
前記ステロールエステルがC10−C30カルボン酸ステロールエステルである付記22に記載の組成物。
前記ステロールエステルがC10−C30カルボン酸コレステロール/ラノステロール混合物である付記22に記載の組成物。
Claims (11)
- 一日に少なくとも一回患者の乾癬性領域に局所投与される乾癬治療のためのエアロゾル、ムース、又はフォームの組成物であって、
(a)30重量%−75重量%のC10−C30カルボン酸コレステロール/ラノステロール混合物、
(b)0.001重量%−10重量%の浸透促進剤、
(c)50重量%−95重量%の溶媒、
(d)0.5重量%−25重量%の噴射剤、
(e)0重量%−10重量%の抗酸化剤、
(f)0重量%−10重量%の保存料、
(但し、前記C 10 −C 30 カルボン酸コレステロール/ラノステロール混合物の量は前記溶媒を除外した前記組成物の重量に基づき、その他の成分の量は前記溶媒を含む前記組成物の重量に基づく)
を含む、エアロゾル、ムース、又はフォームの組成物。 - (a)35重量%−60重量%の前記C10−C30カルボン酸コレステロール/ラノステロール混合物、
(b)0.002重量%−5重量%の前記浸透促進剤、
(c)60重量%−90重量%の前記溶媒、
(d)1重量%−10重量%の前記噴射剤、
(e)0.001重量%−5重量%の前記抗酸化剤、
(但し、前記C 10 −C 30 カルボン酸コレステロール/ラノステロール混合物の量は前記溶媒を除外した前記組成物の重量に基づき、その他の成分の量は前記溶媒を含む前記組成物の重量に基づく)
を含む、請求項1に記載のエアロゾル、ムース、又はフォームの組成物。 - 0.001重量%−10重量%の被膜形成高分子剤をさらに含む、請求項1又は2に記載のエアロゾル、ムース、又はフォームの組成物。
- 0.005重量%−5重量%の被膜形成高分子剤をさらに含む、請求項3に記載のエアロゾル、ムース、又はフォームの組成物。
- 前記被膜形成高分子剤は水溶性である、請求項3又は4に記載のエアロゾル、ムース、又はフォームの組成物。
- 前記被膜形成高分子剤は非水溶性である、請求項3又は4に記載のエアロゾル、ムース、又はフォームの組成物。
- 前記浸透促進剤は、オレイルアルコール、ラウリルアルコール、イソプロピルミリステート、オレイルオレート、レブリン酸、グリセロールモノオレート、メチルラウレート、ソルビタンモノオレート、トリアセチン、セチルアルコール、セチルラクテート、ジメチルイソソルビド、ジプロピレングリコール、エチルヘキシルラクテート、グリコール酸、ラウラミンオキシド、ラウリルベタイン、ラウリルラクテート、ラウリルラウレート、イソプロピルパルミテート、ミリスチルアルコール、ミリスタルラクテート(myristal lactate)、オクチルサリチレート、オレアミンオキシド、オレイン酸、オレイルベタイン、サリチル酸、ステアリルアルコール、ステアリルラクテート、トリエタノールアミントリアセテート及びこれらの混合物からなる群より選択される、請求項1から6のいずれか1項に記載のエアロゾル、ムース、又はフォームの組成物。
- 前記保存料は、プロピルパラベン、メチルパラベン、ベンジルアルコール、塩化ベンザルコニウム、第三リン酸カルシウム、及びフェノキシエタノールからなる群より選択される、請求項1から7のいずれか1項に記載のエアロゾル、ムース、又はフォームの組成物。
- 天然蝋類、合成蝋類、C12−C60アルコール類、C12−C60酸類、アルファ−ヒドロキシ脂肪酸類、ポリヒドロキシ脂肪酸エステル類、ポリヒドロキシ脂肪酸アミド類、金属エステル錯体、ヒュームドシリカ、有機粘土、ポリオールポリエステル類、グリセリルエステル類、ポリグリセリルエステル類、ポリシロキサン類、ゲル化剤、水素添加植物油、C10〜C100の鎖長を持つ石油系皮膚軟化剤、及びこれらの混合物からなる群より選択される粘度増強剤をさらに含む、請求項1から8のいずれか1項に記載のエアロゾル、ムース、又はフォームの組成物。
- 前記粘度増強剤は、天然蝋類、合成蝋類、ゲル化剤、ヒュームドシリカ、粘土、水素添加植物油、及びこれらの混合物からなる群より選択される、請求項9に記載のエアロゾル、ムース、又はフォームの組成物。
- 前記溶媒は、水、C1−C6アルコール、芳香族アルコール、多価アルコール、メタノール、エタノール、イソプロパノール、1,3−ブチレングリコール、プロピレングリコール、ポリエチレングリコール400、ヘキシレングリコール、ジプロピレングリコール、ジプロプレングリセロール、及びこれらの混合物からなる群より選択される、請求項1から10のいずれか1項に記載のエアロゾル、ムース、又はフォームの組成物。
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