JP6450615B2 - Biological sample collector and collection method thereof - Google Patents

Biological sample collector and collection method thereof Download PDF

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JP6450615B2
JP6450615B2 JP2015049745A JP2015049745A JP6450615B2 JP 6450615 B2 JP6450615 B2 JP 6450615B2 JP 2015049745 A JP2015049745 A JP 2015049745A JP 2015049745 A JP2015049745 A JP 2015049745A JP 6450615 B2 JP6450615 B2 JP 6450615B2
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富田　努
努 富田
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New Japan Radio Co Ltd
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Description

本発明は、生体試料採取器及びその採取方法、特に唾液、血液等の生体試料に含まれる成分を分析する分析装置に用いられ、被験者から生体試料を採取するための構成及び方法に関する。   The present invention relates to a biological sample collector and a method for collecting the biological sample, and more particularly to a configuration and method for collecting a biological sample from a subject used in an analyzer that analyzes components contained in a biological sample such as saliva and blood.

従来から、各種の生体試料中の成分を分析・測定するために生体試料採取分析装置が用いられており、その１つとして、唾液採取分析装置があり、この唾液採取分析装置では、被験者の口腔内に脱脂綿を含ませたまましばらく放置することにより、脱脂綿に唾液を十分浸み込ませて唾液の採取を行い、次いでこの脱脂綿を注射器に入れてピストンで絞り出し、濾過した唾液を分析機器に供給する方法や、唾液を含ませた脱脂綿等を遠心分離機に掛け、これで分離した唾液中の成分分析を行う方法等が採用されている。   Conventionally, a biological sample collection and analysis device has been used to analyze and measure components in various biological samples, and one of them is a saliva collection and analysis device. Leave the absorbent cotton inside for a while, so that the saliva is sufficiently soaked in the absorbent cotton, and then collect the saliva. And a method of analyzing components in saliva separated by using a centrifuge with absorbent cotton or the like containing saliva.

特開２０００−９７２８号公報JP 2000-9728 A 国際公開番号ＷＯ２００９／０１７１８８号公報International Publication No. WO2009 / 017188

ところで、近年、自宅で購入するには困難な装置（遠心分離器等）を使用せずに、簡易な構成の機器で、生体試料の分析を行うことが提案されているが、例えば唾液採取分析装置では、唾液の採取に時間がかかるという問題があった。   By the way, in recent years, it has been proposed to analyze a biological sample with a device having a simple configuration without using a device that is difficult to purchase at home (such as a centrifuge). The apparatus has a problem that it takes time to collect saliva.

また、生体試料を正確に分析するためには、センサ・分析部に対し生体試料を適切な量だけ供給することが必要となる。   In addition, in order to accurately analyze a biological sample, it is necessary to supply an appropriate amount of the biological sample to the sensor / analyzer.

本発明は上記問題点に鑑みてなされたものであり、その目的は、短時間かつ簡単に、そして衛生的に生体試料の採取が可能となり、また適切な量の生体試料を分析部に供給することが可能となる生体試料採取器及びその採取方法を提供することにある。   The present invention has been made in view of the above problems, and its purpose is to be able to collect a biological sample in a short time, simply and hygienically, and to supply an appropriate amount of the biological sample to the analyzer. It is an object of the present invention to provide a biological sample collector and a sampling method thereof.

上記目的を達成するために、請求項１の発明に係る生体試料採取器は、吸収体により生体試料を採取する試料採取部と、この試料採取部で得られた生体試料中の成分に応じた電気信号を出力するセンサ部と、上記試料採取部の吸収体の後方部分を被覆し、荷重が掛けられたときの変形により生体試料を上記センサ部へ供給する可撓性被覆部と、上記試料採取部の吸収体を試料採取時に露出し、採取後に覆う状態に移動する可撓性の可動チューブと、を設け、上記吸収体を覆った上記可動チューブを押し潰すことによりこの吸収体の生体試料を上記被覆部側へ送るようにしたことを特徴とする。
請求項２の発明は、上記試料採取部で得られた生体試料を毛細管現象により上記センサ部へ輸送する毛細管部を設け、この毛細管部は、内部に界面活性剤を塗布し乾燥させたことを特徴とする。
請求項３の発明は、上記被覆部と毛細管部を分離して生体試料の溜り部を設け、上記毛細管部に輸送圧力が掛からないようにしたことを特徴とする。
請求項４の発明は、採取器本体の上記センサ部の外装に、分析装置のプローブを挿入するための開口が配設される構成とし、このセンサ部開口を試料採取時に塞ぎ、採取後に開くように移動する可動部材を設けたことを特徴とする。
請求項５の発明の上記センサ部は、試薬を配置したワーク電極、カウンタ電極及びリファレンス電極を有することを特徴とする。 In order to achieve the above object, a biological sample collector according to the invention of claim 1 is responsive to a sample collection unit that collects a biological sample with an absorber and a component in the biological sample obtained by the sample collection unit. A sensor unit that outputs an electrical signal; a flexible covering unit that covers a rear portion of the absorber of the sample collection unit and supplies a biological sample to the sensor unit by deformation when a load is applied; and the sample A flexible movable tube that is exposed at the time of sample collection and moves so as to be covered after collection, and the movable tube covering the absorber is crushed so as to crush the biological sample of the absorber Is sent to the covering portion side.
The invention of claim 2 is provided with a capillary part for transporting the biological sample obtained in the sample collection part to the sensor part by capillary action, and the capillary part is coated with a surfactant and dried. Features.
The invention according to claim 3 is characterized in that the covering portion and the capillary portion are separated to provide a reservoir portion for a biological sample so that no transport pressure is applied to the capillary portion.
A fourth aspect of the present invention, the exterior of the sensor unit of the adoption Toki body, a structure in which an opening for inserting the probe of the analyzer is arranged, closing the sensor opening during sampling, open after harvesting A movable member that moves as described above is provided.
The sensor section of the invention of claim 5 includes a work electrode, a counter electrode, and a reference electrode on which a reagent is arranged.

請求項６の発明に係る生体試料採取方法は、吸収体を有する試料採取部と、この試料採取部の吸収体の後方部分を被覆する可撓性の被覆部と、上記試料採取部で得られた生体試料中の成分に応じた電気信号を出力するセンサ部と、上記試料採取部の吸収体及び被覆部を覆うための可撓性の可動チューブと、を設けた生体試料採取器を用い、上記試料採取部の吸収体に生体試料を吸収させた後、上記試料採取部の吸収体及び被覆部を上記可動チューブで覆う状態とし、この可動チューブに外部から荷重を掛け、この可動チューブを変形させることにより生体試料を上記センサ部側へ送るようにしたことを特徴とする。 A biological sample collection method according to the invention of claim 6 is obtained by a sample collection unit having an absorber, a flexible coating unit covering a rear part of the absorber of the sample collection unit, and the sample collection unit. Using a biological sample collector provided with a sensor unit that outputs an electrical signal corresponding to a component in the biological sample, and a flexible movable tube for covering the absorber and the covering unit of the sample sampling unit, After the biological sample is absorbed by the absorber of the sample collection unit, the absorber and the covering unit of the sample collection unit are covered with the movable tube, a load is applied to the movable tube from the outside, and the movable tube is deformed. By doing so, the biological sample is sent to the sensor unit side.

上記の構成によれば、脱脂綿等の吸収体に生体試料（例えば唾液）を吸収させた後、この吸収体とこの吸収体を部分的に被覆する可撓性被覆部とを可動チューブで覆い（包み）、この可動チューブに先端側からローラー等で荷重を掛けて変形させれば、吸収体に吸着した生体試料が絞られて被覆部へ集められ、かつこの被覆部も変形することにより、生体試料は例えば毛細管部へ効率よく送られ、この毛細管部を介してセンサ部へ輸送される。   According to said structure, after making a biological sample (for example, saliva) absorb in absorbent bodies, such as absorbent cotton, this absorbent body and the flexible coating part which coat | covers this absorber partially are covered with a movable tube ( If the movable tube is deformed by applying a load to the movable tube with a roller or the like from the distal end side, the biological sample adsorbed on the absorber is squeezed and collected in the covering part, and the covering part is also deformed, For example, the sample is efficiently sent to the capillary part, and is transported to the sensor part via the capillary part.

また、上記の可動チューブに、本体のセンサ部開口を塞ぐ可動部材としての役目もさせることもでき、この場合は、試料採取時に、可動チューブを後端側へ移動させることで、センサ部開口を塞ぎながら試料採取部吸収体を露出し、検出・分析時に、可動チューブを先端側へ移動させることで、センサ部開口を開けながら試料採取部吸収体を覆う状態にすることができる。   In addition, the movable tube can also serve as a movable member that closes the sensor unit opening of the main body.In this case, when the sample is collected, the movable tube is moved to the rear end side, thereby opening the sensor unit opening. By exposing the sample collection part absorber while closing and moving the movable tube to the tip side during detection and analysis, the sample collection part absorber can be covered while opening the sensor part opening.

本発明の生体試料採取器及びその採取方法によれば、短時間かつ簡単に、そして衛生的に生体試料の採取が可能となり、また適切な量の生体試料をセンサ部に供給することが可能となる。
上記毛細管部は、界面活性剤を塗布し乾燥することで、安定した動作ができる毛細管となり、効率よく唾液等の生体試料をセンサ部へ輸送することができる。 According to the biological sample collector and the sampling method of the present invention, it is possible to collect a biological sample in a short time, easily and hygienically, and to supply an appropriate amount of the biological sample to the sensor unit. Become.
The capillary section becomes a capillary capable of stable operation by applying a surfactant and drying, and can efficiently transport a biological sample such as saliva to the sensor section.

また、上記被覆部と毛細管部との間に溜り部を設けることで、毛細管部側へ輸送圧力（動圧）が直接かかることが防止され、必要以上の生体試料をセンサ部へ送ることなく、生体試料を適正な量とすることが可能になる。   Moreover, by providing a reservoir between the covering portion and the capillary portion, it is prevented that the transport pressure (dynamic pressure) is directly applied to the capillary portion side, without sending a biological sample more than necessary to the sensor portion, A biological sample can be made into an appropriate amount.

更に、可動部材（可撓性チューブ等）で、センサ部開口を試料採取時に塞ぎ、検出・分析時に開くようにすることで、センサ部が直接口腔内（唾液採取の場合）や生体に触れることが防止され、また可撓性チューブにて試料採取部の吸収体を覆うため、生体試料が周囲に付着したり、他の検体と混ざったりすることもなく、安全かつ衛生的な採取が可能となる。   Furthermore, the sensor part can be directly touched in the oral cavity (for saliva collection) or a living body by closing the sensor part opening at the time of sample collection with a movable member (flexible tube etc.) and opening it at the time of detection / analysis. In addition, the flexible sample tube covers the absorber of the sample collection unit, so that biological samples can be collected safely and hygienicly without adhering to the surroundings or mixing with other samples. Become.

本発明の第１実施例に係る唾液採取器の構成を示し、図（Ａ）は内部透視状態の側面図、図（Ｂ）は先端側内部透視状態の上面図である。BRIEF DESCRIPTION OF THE DRAWINGS The structure of the saliva collector which concerns on 1st Example of this invention is shown, A figure (A) is a side view of an internal see-through state, and a figure (B) is a top view of a front end side see-through state. 第１実施例の唾液採取器の構成で、図（Ａ）は採取前及び分析時の状態を示す斜視図、図（Ｂ）は採取時の状態を示す斜視図である。FIG. 1A is a perspective view showing a state before collection and during analysis, and FIG. 2B is a perspective view showing a state during collection, with the configuration of the saliva collector of the first embodiment. 第１実施例の唾液採取器を分析器本体にて分析するときの状態を示す図である。It is a figure which shows a state when analyzing the saliva collector of 1st Example in an analyzer main body. 第２実施例に係る唾液採取器の構成を示し、図（Ａ）は採取時位置よりもホルダを後へずらしたときの状態を示す斜視図、図（Ｂ）は分析時の状態を示す斜視図である。The structure of the saliva collector which concerns on 2nd Example is shown, A figure (A) is a perspective view which shows the state when shifting a holder back rather than the position at the time of collection, FIG. (B) is a perspective view which shows the state at the time of analysis. FIG. 第２実施例の唾液採取器を分析器本体にて分析するときの状態を示す図である。It is a figure which shows a state when analyzing the saliva collector of 2nd Example in an analyzer main body. 第３実施例に係る唾液採取器の構成を示す斜視図である。It is a perspective view which shows the structure of the saliva collector based on 3rd Example. 第４実施例に係る唾液採取器の構成を示し、図（Ａ）は内部透視状態の側面図、図（Ｂ）は先端側内部透視状態の上面図である。The structure of the saliva collector which concerns on 4th Example is shown, A figure (A) is a side view of an internal see-through state, and a figure (B) is a top view of a front end side see-through state.

図１〜図３に、唾液分析装置に適用される第１実施例の唾液採取器の構成が示されており、図１及び図２に示されるように、採取器の本体１は、円筒外装体を持つスティック状からなり、この本体１には、図３の分析装置３０の所定位置にセットして固定するためのロック部材２が設けられると共に、この分析装置３０内の分析部３１からのプローブ３２を内部に挿入するための開口１ａが形成される。   1 to 3 show the configuration of the saliva collector of the first embodiment applied to the saliva analyzer. As shown in FIGS. 1 and 2, the main body 1 of the collector is a cylindrical exterior. The main body 1 is provided with a lock member 2 for setting and fixing at a predetermined position of the analyzer 30 in FIG. 3 and also from the analysis unit 31 in the analyzer 30. An opening 1a for inserting the probe 32 therein is formed.

上記本体１の先端側に、唾液採取部を構成するものとして、脱脂綿等を用いた吸収体３と、この吸収体３の少なくとも１／３を被覆し、後端へ向けて細くなる（管径が小さくなるラッパ状）唾液通路を持つ可撓性被覆部４が設けられる。この被覆部４は、吸収体３から絞り出される唾液を集める役目と、それ自体が潰されることで、後端側の唾液通路へ唾液を送る役目をしている。   Covering at least 1/3 of the absorbent body 3 using absorbent cotton and the absorbent body 3 as a constituent of the saliva collection part on the front end side of the main body 1, and narrowing toward the rear end (tube diameter) A flexible covering portion 4 having a saliva passage is provided. The covering 4 serves to collect saliva squeezed out from the absorber 3 and to serve to send saliva to the saliva passage on the rear end side by being crushed.

また、上記被覆部４の後方に、図１（Ｂ）に示されるように、毛細管部６とセンサ部７を有する基板８が配置されており、上記毛細管部６は、界面活性剤を塗布して乾燥させており、この状態の毛細管現象により唾液を効率よく輸送できるようになる。上記センサ部７には、試薬等と共に電極７ｅが設けられており、この電極７ｅに図３の分析部３１のプローブ３２が接触するようになっている。   Further, as shown in FIG. 1B, a substrate 8 having a capillary tube portion 6 and a sensor portion 7 is disposed behind the covering portion 4, and the capillary tube portion 6 is coated with a surfactant. The saliva can be efficiently transported by the capillary phenomenon in this state. The sensor unit 7 is provided with an electrode 7e together with a reagent and the like, and the probe 32 of the analysis unit 31 of FIG. 3 is in contact with the electrode 7e.

また、実施例では、被覆部４と毛細管部６との間に溜り部（分離部）１Ｆが設けられており、この溜り部１Ｆによって、動圧（輸送圧力）が毛細管部６へ掛からないようにしている。なお、被覆部４は本体１に対し例えば固定部１ｂで固定され、毛細管部６とセンサ部７を有する基板８は、本体１の内壁にて固定される。   Further, in the embodiment, a reservoir (separation unit) 1F is provided between the covering unit 4 and the capillary unit 6 so that dynamic pressure (transport pressure) is not applied to the capillary unit 6 by the reservoir 1F. I have to. The covering portion 4 is fixed to the main body 1 by, for example, a fixing portion 1 b, and the substrate 8 having the capillary portion 6 and the sensor portion 7 is fixed on the inner wall of the main body 1.

更に、円形スティック状の本体１の外側には、この本体１の外径よりも僅かに大きい内径とされ、かつ可撓性を有する薄厚の可動チューブ（管）１０が設けられ、この可動チューブ１０は、本体１上をその軸方向にスライド（移動）するように取り付けられる。また、図２に示されるように、本体１の外側に、突起状の前側ストッパ１２と後側ストッパ１３が設けられており、可動チューブ１０が吸収体３を覆いかつ開口１ａを開けるとき、この可動チューブ１０は、そのチューブ壁に設けられた係合孔が前側ストッパ１２に係止することにより前側位置にセットされ、一方、可動チューブ１０が吸収体３を露出しかつ開口１ａを塞ぐとき、この可動チューブ１０は後側ストッパ１３で停止することにより後側位置にセットされる。   Further, a thin movable tube (tube) 10 having an inner diameter slightly larger than the outer diameter of the main body 1 and having flexibility is provided on the outer side of the circular stick-shaped main body 1. Is attached so as to slide (move) in the axial direction on the main body 1. Further, as shown in FIG. 2, a protruding front stopper 12 and a rear stopper 13 are provided outside the main body 1, and when the movable tube 10 covers the absorber 3 and opens the opening 1a, The movable tube 10 is set at the front position by engaging the engagement hole provided in the tube wall with the front stopper 12, while the movable tube 10 exposes the absorber 3 and closes the opening 1a. The movable tube 10 is set at the rear position by stopping at the rear stopper 13.

次に、唾液採取の方法について説明する。
まず、採取時は、図２（Ｂ）のように、可動チューブ１０を後側位置へスライドさせることにより、吸収体３を露出（暴露）すると共に開口１ａを塞ぎ、この状態で吸収体３を舌下に入れ唾液を採取する。 Next, a method for collecting saliva will be described.
First, at the time of collection, as shown in FIG. 2 (B), the movable tube 10 is slid to the rear side position to expose (expose) the absorber 3 and close the opening 1a. Put saliva under the tongue.

この唾液採取の後、図２（Ａ）のように、可動チューブ１０を前側位置へスライドさせ、可動チューブ１０にて吸収体３が包まれる状態とし、この採取器を分析装置３０の所定位置に挿入すると共に、図３に示されるように、プローブ３２をセンサ部７の電極７ｅにセットする。そして、実施例では、ローラー３３を可動チューブ１０の上に転がして荷重を掛けることにより、可動チューブ１０、吸収体３、そして被覆部４を順に押し潰すようにすれば、その結果、吸収体３に採取された唾液は、被覆部４に集められ、溜り部１Ｆと毛細管部６を介して効率よくセンサ部７へ輸送される。   After the saliva collection, as shown in FIG. 2A, the movable tube 10 is slid to the front position so that the absorber 3 is wrapped by the movable tube 10, and the collector is placed at a predetermined position of the analyzer 30. While inserting, as shown in FIG. 3, the probe 32 is set on the electrode 7 e of the sensor unit 7. In the embodiment, if the roller 33 is rolled onto the movable tube 10 and a load is applied, the movable tube 10, the absorber 3, and the covering portion 4 are sequentially crushed, and as a result, the absorber 3. The collected saliva is collected in the covering part 4 and efficiently transported to the sensor part 7 through the reservoir part 1F and the capillary part 6.

このとき、上記吸収体３で不純物が濾過され、溜り部１Ｆでは唾液の押し出される圧力が逃がされ、毛細管部６に対して輸送圧力を与えることがないので、検出・分析に適した量がセンサ部７へ供給される。また、被覆部４に加わる荷重が減少した場合であっても、溜り部１Ｆが設けられているため、センサ部７へ輸送された唾液の量が変化することはない。なお、上記ローラー３３の代わりに、可動チューブ１０の側面を両側から挟むような部材等の他の押圧部材を用いてもよい。   At this time, impurities are filtered by the absorber 3, the pressure at which saliva is pushed out is released in the reservoir 1F, and no transport pressure is applied to the capillary 6, so that an amount suitable for detection and analysis is obtained. It is supplied to the sensor unit 7. Even if the load applied to the covering portion 4 decreases, the amount of saliva transported to the sensor portion 7 does not change because the reservoir portion 1F is provided. Instead of the roller 33, another pressing member such as a member that sandwiches the side surface of the movable tube 10 from both sides may be used.

図４には、第２実施例の唾液採取器の構成が示されており、この第２実施例は、可撓性の可動チューブ１５をホルダ１６に取り付け、このホルダ１６内にスティック１７をスライド可能にしたものである。上記ホルダ１６に、ロック部材２と開口１６ａが形成され、スティック１７には、第１実施例と同様に、吸収体３、被覆部４、毛細管部６及びセンサ部７が配置されると共に、開口１７ａが設けられる。なお、上記スティック１７の外側面、可動チューブ１５の内外側面には、それらの回転を防止して直線スライドさせるためのガイド部１５ｂ、１７ｂが形成され、ホルダ１６の内側面にもガイド部が設けられる。   FIG. 4 shows the configuration of the saliva collector of the second embodiment. In the second embodiment, a flexible movable tube 15 is attached to a holder 16 and a stick 17 is slid into the holder 16. It is possible. The holder 16 is formed with the lock member 2 and the opening 16a, and the stick 17 is provided with the absorber 3, the covering portion 4, the capillary portion 6 and the sensor portion 7 as in the first embodiment, and the opening. 17a is provided. Note that guide portions 15b and 17b are formed on the outer surface of the stick 17 and the inner and outer surfaces of the movable tube 15 so as to prevent them from rotating linearly, and guide portions are also provided on the inner surface of the holder 16. It is done.

このような第２実施例の場合は、図４（Ａ），（Ｂ）のように、可動チューブ１５及びホルダ１６内をスティック１７が移動することになり、図４（Ａ）において、可動チューブ１５を前側位置へセット（固定）し、吸収体３は露出するが開口１７ａを塞ぐ状態として唾液採取を行い、採取後は、図４（Ｂ）のように、可動チューブ１５が吸収体３を覆い、かつ開口１６ａ，１７ａを開ける状態に移動して、図５に示されるように、分析装置３０による分析が行われる。   In the case of the second embodiment as described above, the stick 17 moves in the movable tube 15 and the holder 16 as shown in FIGS. 4A and 4B. In FIG. 15 is set (fixed) to the front position, and the absorber 3 is exposed, but the opening 17a is blocked, and saliva is collected. After the collection, the movable tube 15 holds the absorber 3 as shown in FIG. It moves to the state which covers and opens the openings 16a and 17a, and the analysis by the analyzer 30 is performed as shown in FIG.

図５において、第２実施例では、プローブ３２は開口１６ａ，１７ａを介して基板８のセンサ部（７）へ挿入され、第１実施例と同様に、唾液は、ローラー３３を用いた絞り出し、被覆部４、毛細管部（６）による輸送がなされた後、センサ部による分析が行われる。   In FIG. 5, in the second embodiment, the probe 32 is inserted into the sensor part (7) of the substrate 8 through the openings 16a and 17a, and the saliva is squeezed out using the roller 33, as in the first embodiment. After the transport by the covering part 4 and the capillary part (6), the analysis by the sensor part is performed.

図６には、第３実施例の唾液採取器の構成が示されており、この第３実施例は、スティック（本体）１８、可動チューブ１９の径方向の外形を角形とし、ホルダ１９の内形を角形としたものである。これによれば、円形とした場合よりも全体を薄く作製でき、側面に設けたガイド部１８ｂ，１９ｂがなくても、ホルダ１９内でスティック１８が回転しないという利点がある。   FIG. 6 shows the configuration of the saliva collector of the third embodiment. In the third embodiment, the stick (main body) 18 and the movable tube 19 have a rectangular outer shape in the radial direction. The shape is a square. According to this, the whole can be made thinner than in the case of a circular shape, and there is an advantage that the stick 18 does not rotate in the holder 19 without the guide portions 18b and 19b provided on the side surfaces.

図７には、第４実施例の唾液採取器の構成が示されており、この第４実施例は、基板８に毛細管部を設けない場合の例である。図７（Ａ），（Ｂ）に示されるように、被覆部４の後方に基板８上のセンサ部３５を配置し、被覆部４から送られる試料（唾液）を受ける位置に、試薬３７等を載せたワーク電極３５ｗ、カウンタ電極３５ｃ、リファレンス電極３５ｒを設け、センサ部内の後方に上記電極３５ｗ，３５ｃ，３５ｒの端子３５ｅを配置する。
この第４実施例によれば、上記毛細管部６を介さずに、試料が被覆部４からセンサ部３５へ直接供給され、端子３５ｅにプローブ３２がセットされることにより、分析装置３０による分析が行われる。 FIG. 7 shows the configuration of the saliva collector of the fourth embodiment. This fourth embodiment is an example in which the capillary portion is not provided on the substrate 8. As shown in FIGS. 7A and 7B, a sensor unit 35 on the substrate 8 is arranged behind the covering unit 4 and a reagent 37 or the like is placed at a position for receiving a sample (saliva) sent from the covering unit 4. Is provided with a work electrode 35w, a counter electrode 35c, and a reference electrode 35r, and terminals 35e of the electrodes 35w, 35c, and 35r are arranged behind the sensor section.
According to the fourth embodiment, the sample is directly supplied from the covering unit 4 to the sensor unit 35 without passing through the capillary unit 6, and the probe 32 is set on the terminal 35e, so that the analysis by the analyzer 30 can be performed. Done.

なお、上記各実施例では、唾液を採取する唾液採取器の例を説明したが、本発明は、唾液だけでなく、血液等の生体試料を採取する採取器及び分析器に適用することができる。   In each of the above embodiments, an example of a saliva collector that collects saliva has been described. However, the present invention can be applied not only to saliva but also to a collector and an analyzer that collect biological samples such as blood. .

１…採取器本体、 １Ｆ…溜り部、
１ａ，１６ａ，１７ａ，１８ａ，２０ａ…開口、
３…吸収体、 ４…被覆部、
６…毛細管部、 ７…センサ部、
７ｅ，３５ｃ，３５ｒ，３５ｗ，３５ｅ…電極、
８…基板、 １０，１５，１９…可動チューブ、
１６…ホルダ、 １７…スティック（採取器本体）、
３０…分析装置、 ３１…分析部、
３２…プローブ、 ３３…ローラー。 1 ... collector body, 1F ... reservoir,
1a, 16a, 17a, 18a, 20a ... opening,
3 ... Absorber, 4 ... Covering part,
6 ... capillary part, 7 ... sensor part,
7e, 35c, 35r, 35w, 35e ... electrodes,
8 ... substrate, 10, 15, 19 ... movable tube,
16 ... Holder, 17 ... Stick (collector body),
30 ... Analyzer, 31 ... Analyzer,
32 ... probe, 33 ... roller.

Claims (6)

吸収体により生体試料を採取する試料採取部と、
この試料採取部で得られた生体試料中の成分に応じた電気信号を出力するセンサ部と、
上記試料採取部の吸収体の後方部分を被覆し、荷重が掛けられたときの変形により生体試料を上記センサ部へ供給する可撓性被覆部と、
上記試料採取部の吸収体を試料採取時に露出し、採取後に覆う状態に移動する可撓性の可動チューブと、を設け、
上記吸収体を覆った上記可動チューブを押し潰すことによりこの吸収体の生体試料を上記被覆部側へ送るようにした生体試料採取器。 A sample collection unit for collecting a biological sample with an absorber;
A sensor unit that outputs an electrical signal corresponding to a component in the biological sample obtained by the sample collection unit;
A flexible covering portion that covers a rear portion of the absorber of the sample collection portion and supplies a biological sample to the sensor portion by deformation when a load is applied;
A flexible movable tube that exposes the absorber of the sample collection section during sample collection and moves to a state of covering after collection; and
A biological sample collector for sending a biological sample of the absorbent to the covering portion side by crushing the movable tube covering the absorbent. 上記試料採取部で得られた生体試料を毛細管現象により上記センサ部へ輸送する毛細管部を設け、この毛細管部は、内部に界面活性剤を塗布し乾燥させたことを特徴とする請求項１記載の生体試料採取器。   The capillary part which conveys the biological sample obtained by the said sample collection part to the said sensor part by capillary phenomenon is provided, and this capillary part apply | coated the surfactant inside and dried it. Biological sampler. 上記被覆部と毛細管部を分離して生体試料の溜り部を設け、上記毛細管部に輸送圧力が掛からないようにしたことを特徴とする請求項１又は２記載の生体試料採取器。   The biological sample collector according to claim 1 or 2, wherein the covering portion and the capillary portion are separated to provide a biological sample reservoir so that transport pressure is not applied to the capillary portion. 採取器本体の上記センサ部の外装に、分析装置のプローブを挿入するための開口が配設される構成とし、このセンサ部開口を試料採取時に塞ぎ、採取後に開くように移動する可動部材を設けたことを特徴とする請求項１乃至３のいずれかに記載の生体試料採取器。 Adopted to the exterior of the sensor unit of Toki body, a structure in which an opening for inserting the probe of the analyzer is arranged, closing the sensor opening during sampling, a movable member which moves to open after collection The biological sample collector according to any one of claims 1 to 3, wherein the biological sample collector is provided. 上記センサ部は、試薬を配置したワーク電極、カウンタ電極及びリファレンス電極を有することを特徴とする請求項１乃至４のいずれかに記載の生体試料採取器。   The biological sample collector according to any one of claims 1 to 4, wherein the sensor unit includes a work electrode, a counter electrode, and a reference electrode on which a reagent is arranged. 吸収体を有する試料採取部と、
この試料採取部の吸収体の後方部分を被覆する可撓性の被覆部と、
上記試料採取部で得られた生体試料中の成分に応じた電気信号を出力するセンサ部と、
上記試料採取部の吸収体及び被覆部を覆うための可撓性の可動チューブと、を設けた生体試料採取器を用い、
上記試料採取部の吸収体に生体試料を吸収させた後、
上記試料採取部の吸収体及び被覆部を上記可動チューブで覆う状態とし、この可動チューブに外部から荷重を掛け、この可動チューブを変形させることにより生体試料を上記センサ部側へ送るようにした生体試料の採取方法。 A sampling part having an absorber;
A flexible covering portion covering the rear portion of the absorber of the sampling portion;
A sensor unit that outputs an electrical signal corresponding to a component in the biological sample obtained by the sample collection unit;
Using a biological sample collector provided with a flexible movable tube for covering the absorber of the sample collection unit and the covering unit,
After absorbing the biological sample in the absorber of the sample collection unit,
A living body in which the absorber and the covering part of the sample collection unit are covered with the movable tube, a load is applied to the movable tube from the outside, and the movable sample is deformed to send the biological sample to the sensor unit side. Sample collection method.
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