JP6442496B2 - 再石灰化口腔ケア製品 - Google Patents
再石灰化口腔ケア製品 Download PDFInfo
- Publication number
- JP6442496B2 JP6442496B2 JP2016526495A JP2016526495A JP6442496B2 JP 6442496 B2 JP6442496 B2 JP 6442496B2 JP 2016526495 A JP2016526495 A JP 2016526495A JP 2016526495 A JP2016526495 A JP 2016526495A JP 6442496 B2 JP6442496 B2 JP 6442496B2
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tooth
- oral care
- care product
- phosphate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/882—Mixing prior to application
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cosmetics (AREA)
- Dental Preparations (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Description
(i)増粘剤、湿潤剤及び歯の再石灰化剤を含む非水性液体連続相を有する第1の組成物であって;歯の再石灰化剤が、歯への送達時に歯においてその場でヒドロキシアパタイトを生成する、カルシウム源及びリン酸塩源の混合物である、第1の組成物;
(ii)増粘剤及び湿潤剤を含む水性液体連続相を有する第2の組成物であって、(第2の組成物の総重量に基づく重量で)少なくとも30重量%の水及び(第2の組成物の総重量に基づく重量で)2.5重量%未満のリン酸塩源を含む第2の組成物;
を含み、
製品使用前に第2の組成物中の水と第1の組成物中の歯の再石灰化剤との接触を避けるような方法で、第2の組成物が第1の組成物とは別に保管され;
また、第1の組成物及び第2の組成物が混合されて、持続的に接触させるために歯の表面へ適用されることに適している、口腔ケア製品を提供する。
本発明の製品の第1の組成物は、歯への送達時に歯においてその場でヒドロキシアパタイトを生成する、とりわけ、ケイ酸カルシウム及びリン酸塩源の混合物である歯の再石灰化剤を含む、非水性液体連続相を有する。
(i)湿潤剤(例えばグリセロール)及び液体ポリエチレングリコール(例えばPEG400)の混合物を形成する工程;
(ii)固体ポリエチレングリコール(例えばPEG3000)の融点を超える温度まで混合物を加熱して、固体ポリエチレングリコールを混合物中に分散させる工程;
(iii)粉末化成分(例えば研磨性洗浄剤及び/又は界面活性剤)をこのように得た混合物に添加する工程;
(iv)増粘剤をこのように得た混合物に添加する工程並びに
(v)混合物を冷却して(1又は複数の)固体ポリエチレングリコールの結晶を形成する工程;
を含む。
本発明の製品の第2の組成物は、特に増粘剤及び湿潤剤を含む水性液体連続相を有する。
本発明の口腔ケア製品において、製品使用前に、第2の組成物中の水と第1の組成物中の歯の再石灰化剤との接触を避けるような方法で、第2の組成物は、第1の組成物とは別に保管される。
本発明の口腔ケア製品において、第1及び第2の組成物は、混合されて、持続的に接触させるために歯の表面へ適用されることに適している。
製品を熱可塑性材料から形成したガムシールド成形アプリケータを介して歯に適用する。
Claims (6)
- 口腔ケア製品であって、
(i)増粘剤、湿潤剤及び歯の再石灰化剤を含む第1の組成物であって;前記歯の再石灰化剤が、歯への送達時に歯においてその場でヒドロキシアパタイトを生成する、ケイ酸カルシウム及びリン酸塩源の混合物である、組成物、及び
(ii)増粘剤及び湿潤剤を含む水性液体連続相を有する第2の組成物であって、(前記第2の組成物の総重量に基づく重量で)少なくとも30重量%の水及び(前記第2の組成物の総重量に基づく重量で)2.5重量%未満のリン酸塩源を含む第2の組成物
を含み、
第2の組成物が第1の組成物とは別に収納されている、口腔ケア製品。 - 前記リン酸塩源がリン酸三ナトリウム及びリン酸二水素ナトリウムの混合物である、請求項1に記載の口腔ケア製品。
- 前記第1の組成物中の前記増粘剤がカルボキシルビニルポリマーである、請求項1又は請求項2に記載の口腔ケア製品。
- 前記第2の組成物中の前記増粘剤がセルロースエーテルである、請求項1から3のいずれかに記載の口腔ケア製品。
- 歯を再石灰化する方法のための、請求項1から4のいずれか一項に記載の口腔ケア製品であって、前記方法において、該口腔ケア製品が口内への配置に適したアプリケータ器具によって歯の表面に適用され、第1の組成物及び第2の組成物が混合されて、歯の表面へ適用される、前記口腔ケア製品。
- 前記アプリケータ器具が、内面が歯の前面に接触させて使用するのに適した前壁と、歯の咬合縁に接触させて使用するのに適したブリッジ部と、内面が歯の後面に接触させて使用するのに適した後壁とを備える、請求項5に記載の口腔ケア製品。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13177296 | 2013-07-19 | ||
EP13177296.4 | 2013-07-19 | ||
PCT/EP2014/063706 WO2015007503A1 (en) | 2013-07-19 | 2014-06-27 | Remineralising oral care products |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016531101A JP2016531101A (ja) | 2016-10-06 |
JP6442496B2 true JP6442496B2 (ja) | 2018-12-19 |
Family
ID=48794015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016526495A Expired - Fee Related JP6442496B2 (ja) | 2013-07-19 | 2014-06-27 | 再石灰化口腔ケア製品 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20160136065A1 (ja) |
EP (1) | EP3021817B1 (ja) |
JP (1) | JP6442496B2 (ja) |
CN (1) | CN105377218B (ja) |
BR (1) | BR112015032853B1 (ja) |
CL (1) | CL2015003717A1 (ja) |
PH (1) | PH12016500058A1 (ja) |
WO (1) | WO2015007503A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3302349B1 (en) | 2015-06-05 | 2019-11-20 | Unilever PLC | Oral care device |
CN114209604B (zh) * | 2022-01-12 | 2024-01-12 | 北京幸福益生高新技术有限公司 | 一种口腔护理无水组合物及其制备方法和应用 |
WO2023180107A1 (en) | 2022-03-24 | 2023-09-28 | Unilever Ip Holdings B.V. | Method for demonstrating efficacy of oral care product |
WO2023180108A1 (en) | 2022-03-24 | 2023-09-28 | Unilever Ip Holdings B.V. | Method for demonstrating efficacy of oral care product |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1408922A (en) | 1972-02-02 | 1975-10-08 | Blendax Werke Schneider Co | Process and composition for the remineralisation and prevention of demineralisation of human teeth |
IE42129B1 (en) * | 1974-10-10 | 1980-06-04 | Procter & Gamble | Compositions for remineralizing tooth enamel |
US4083955A (en) | 1975-04-02 | 1978-04-11 | The Procter & Gamble Company | Processes and compositions for remineralization of dental enamel |
US4453979A (en) * | 1983-03-23 | 1984-06-12 | Lever Brothers Company | Dispersion of hydrophilic gums to form non-swelling aqueous alcoholic mixtures |
GB8528117D0 (en) * | 1985-11-14 | 1985-12-18 | Unilever Plc | Toothpastes |
JPH06122616A (ja) * | 1992-10-12 | 1994-05-06 | Sangi Co Ltd | 白色の練歯磨き組成物 |
JPH07223930A (ja) * | 1994-02-10 | 1995-08-22 | Sumitomo Osaka Cement Co Ltd | 歯磨組成物 |
US5605675A (en) | 1995-06-06 | 1997-02-25 | Enamelon Inc. | Processes and compositions for remineralization and prevention of demineralization of dental enamel |
US5833954A (en) | 1996-08-20 | 1998-11-10 | American Dental Association Health Foundation | Anti-carious chewing gums, candies, gels, toothpastes and dentifrices |
US5853704A (en) * | 1997-09-22 | 1998-12-29 | Colgate-Palmolive Company | Fluoride dentifrices of enhanced efficacy |
US6521215B2 (en) * | 1999-05-28 | 2003-02-18 | Devin Okay | Compositions and methods for tooth treatment |
JP2002053417A (ja) * | 2000-08-08 | 2002-02-19 | Gc Corp | 再石灰化促進材 |
JP3905836B2 (ja) * | 2000-10-13 | 2007-04-18 | ブロック ドラッグ カンパニー インコーポレイテッド | 不適合成分をデリバリーするための無水歯磨き処方 |
US6869595B2 (en) * | 2001-12-21 | 2005-03-22 | J.M. Huber Corporation | Abrasive compositions for clear toothpaste |
GB0130907D0 (en) * | 2001-12-22 | 2002-02-13 | Ineos Silicas Ltd | Amorphous silica |
US20060002865A1 (en) * | 2004-06-30 | 2006-01-05 | Adonis Buelo | Stable baking soda/peroxide with calcium and phosphate whitening product |
WO2008068149A1 (en) * | 2006-12-05 | 2008-06-12 | Unilever Plc | Oral care product |
WO2009134783A1 (en) * | 2008-05-02 | 2009-11-05 | The Procter & Gamble Company | Products and methods for disclosing conditions in the oral cavity |
CN102946847B (zh) | 2010-06-23 | 2016-08-24 | 荷兰联合利华有限公司 | 非水性口腔护理组合物 |
JP5838524B2 (ja) * | 2010-10-06 | 2016-01-06 | クラレノリタケデンタル株式会社 | 象牙質知覚過敏抑制材及びその製造方法 |
WO2013034421A2 (en) * | 2011-09-08 | 2013-03-14 | Unilever N.V. | Tooth remineralizing dentifrice |
-
2014
- 2014-06-27 CN CN201480040731.7A patent/CN105377218B/zh active Active
- 2014-06-27 WO PCT/EP2014/063706 patent/WO2015007503A1/en active Application Filing
- 2014-06-27 BR BR112015032853-9A patent/BR112015032853B1/pt active IP Right Grant
- 2014-06-27 EP EP14733204.3A patent/EP3021817B1/en active Active
- 2014-06-27 US US14/904,789 patent/US20160136065A1/en not_active Abandoned
- 2014-06-27 JP JP2016526495A patent/JP6442496B2/ja not_active Expired - Fee Related
-
2015
- 2015-12-23 CL CL2015003717A patent/CL2015003717A1/es unknown
-
2016
- 2016-01-08 PH PH12016500058A patent/PH12016500058A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
PH12016500058B1 (en) | 2016-03-28 |
CN105377218A (zh) | 2016-03-02 |
BR112015032853A2 (pt) | 2017-07-25 |
US20160136065A1 (en) | 2016-05-19 |
CN105377218B (zh) | 2019-06-11 |
JP2016531101A (ja) | 2016-10-06 |
BR112015032853B1 (pt) | 2020-12-01 |
CL2015003717A1 (es) | 2016-10-28 |
PH12016500058A1 (en) | 2016-03-28 |
EP3021817A1 (en) | 2016-05-25 |
EP3021817B1 (en) | 2016-12-28 |
WO2015007503A1 (en) | 2015-01-22 |
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