JP6426344B2 - 織られたプロテーゼ及びその製造方法 - Google Patents
織られたプロテーゼ及びその製造方法 Download PDFInfo
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Description
適用せず。
適用せず。
本発明の幾つかの実施形態の製造方法と一致する及びそれらから結果的に得られるプロテーゼは、種々の特定の方法で構築されてもよい。或る実施形態では、本発明の例は、(i)平織ステップ、(ii)切断ステップ、(iii)ヒートセットステップ、及び(iv)滅菌ステップを含む4つのステップで製造される場合がある。ヒートセットステップは、2段階の様態、すなわち、プロテーゼの幾つかの部分の表面の或る部分を捲縮させ及び波形にするために捲縮マンドレルを通じて熱を適用することを含む第1のステップ、並びに、プロテーゼに熱が適用され、プロテーゼの所望の最終形状と一致する形状を提供するように構成される伸張可能なブラダーの使用を通じてプロテーゼが伸張された状態で「セット」又は「形状記憶」されるシェイピングステップで達成される場合がある。さらに、直径遷移領域で1つ又は複数の基準線を挿入する随意的なステップ(v)を採用することができる可能性がある。こうしたステップは、こうした遷移の視覚的識別を強化するための直径遷移領域でのよこ糸通過の色の変化を通じて区別されてもよい。こうしたステップは、第1のよこ糸に関して選ばれた糸とは異なる色の第2のよこ糸が視覚的に異なり(別の色、好ましくはより暗い色にされる)、且つ第1のよこ糸と併せて又はこの代わりに用いられる、多色よこ糸挿入機構の使用を通じて行われてもよい。
本発明の第1の実施例では、大動脈プロテーゼは、およそ32ミリメートルの小直径及びおよそ40ミリメートルの最大直径を有するように構築される。プロテーゼは、例えば図1及び図8で表される要素に準じて構築される。
本発明の第2の実施例では、大動脈プロテーゼは、およそ24ミリメートルの小直径及びおよそ32ミリメートルの最大直径を有するように構築される。プロテーゼは、例えば図1及び図8で表される要素に準じて構築される。
本発明の第3の実施例では、大動脈プロテーゼは、およそ12ミリメートルの小直径及びおよそ36ミリメートルの最大直径を有するように構築される。プロテーゼは、例えば図24A及び図24Bで表される幾つかの実施形態に準じて構築される。
本発明の第4の実施例では、大動脈プロテーゼは、およそ12ミリメートルの小直径及びおよそ36ミリメートルの最大直径を有するように構築される。プロテーゼは、例えば図25A及び図25Bで表される幾つかの実施形態に従って構築される。
Claims (9)
- 概して管状のグラフトとして構成される埋入可能な医療プロテーゼであって、
よこ糸通過と織り合わされるベースたて糸を備える織られたベースを含む側壁であり、前記ベースたて糸の少なくとも一部は、第1の交絡の頻度を有するようにたて糸方向に織られており、プロテーゼのより小直径の部分及びより大直径の部分を少なくとも部分的に形成する、織られたベースを含む側壁と、
前記より小直径の部分と前記より大直径の部分との両方の一部を形成し、前記第1の交絡の頻度よりも小さい第2の交絡の頻度をたて糸方向に有するように、前記よこ糸通過と織り合わされた1つ又は複数のベロア糸と、
前記より大直径の部分の少なくとも一部において、前記第2の交絡の頻度で前記よこ糸通過と織り合わされた1つ又は複数の前記ベロア糸のうちの少なくとも1つが、前記織られたベースの中に組み込まれ、前記第2の交絡の頻度より大きい交絡の頻度をたて糸方向に有するように前記よこ糸通過と織り合わされ、
ここで前記より大直径の部分における前記織られたベースの前記ベースたて糸と前記1つ又は複数のベロア糸との間隔が、前記より小直径の部分における前記ベースたて糸間の間隔とほぼ同じに維持され、これにより前記側壁の多孔度が全体を通して一様であり、
前記ベースたて糸及び前記1つ又は複数のベロア糸の量が、前記より大直径の部分において前記より小直径の部分と同じであり、
前記医療プロテーゼが滅菌手順に供されたものである、
埋入可能な医療プロテーゼ。 - 前記より小直径の部分内で、1つ又は複数の前記ベロア糸のうちの少なくとも1つが、前記織られたベースの中に組み込まれず、前記織られたベースと一致する織パターンを呈さない、請求項1に記載の概して管状のグラフトとして構成される埋入可能な医療プロテーゼ。
- 前記より大直径の部分が、前記グラフトの長手方向の軸線に沿って直径が変化する前記グラフトの部分内にあり、前記より小直径の部分が、概して一様な直径を有する前記グラフトの部分内にある、請求項1に記載の概して管状のグラフトとして構成される埋入可能な医療プロテーゼ。
- 前記プロテーゼが、概して管状のグラフトであり、前記より大直径の部分及び前記より小直径の部分が、前記グラフトの長手方向の軸線に沿った直径に関して前記プロテーゼの部分内にある、請求項1に記載の概して管状のグラフトとして構成される埋入可能な医療プロテーゼ。
- 前記より小直径の部分の少なくとも一部において、1つ又は複数の前記ベロア糸が、前記より大直径の部分には全く存在しない又はより小さく存在する浮きを呈する、請求項1に記載の概して管状のグラフトとして構成される埋入可能な医療プロテーゼ。
- 前記ベースたて糸及び前記1つ又は複数のベロア糸が、前記より小直径の部分と前記より大直径の部分との間で連続して織られる、請求項1に記載の概して管状のグラフトとして構成される埋入可能な医療プロテーゼ。
- 前記プロテーゼが、前記より小直径の部分及び前記より大直径の部分のうちの少なくとも1つの上に配置される第2の織られた層を備え、前記第2の層を形成する糸の一部が、前記より大直径の部分の前記ベース層の中に組み込まれる、請求項1に記載の概して管状のグラフトとして構成される埋入可能な医療プロテーゼ。
- 概して管状のグラフトとして構成される埋入可能な医療プロテーゼであって、
第1の開口端と、第2の開口端と、その間に配置された側壁とを有する管状の構造であって、ここで前記管状の構造が(i)前記管状の構造の長手方向に沿って位置するが、前記第1の開口端において位置しておらず、(ii)第1の開口端にテーパする、大直径部分を備える、管状の構造と、
前記大直径部分の直径より小さい直径を有する、前記第1の開口端と、前記大直径部分との間に位置する前記管状の構造の部分と
を備え、
前記管状の構造の側壁は、前記第1の開口端と、前記第2の開口端との間で、複数のよこ糸通過と連続的に織り合わされる、複数のたて糸を備え、
前記第1の開口端に向かう方向において、前記大直径部分と前記第1の開口端との間をテーパする前記管状の構造の一部は、ベース層としてより、ベロア層として織られるたて糸の増加した割合を有し、
前記たて糸の量が、前記第1の開口端と、前記第2の開口端との間で同じであり、
ここで前記大直径部分の前記ベース層として織られた前記たて糸間の間隔が、前記管状の構造の残りの部分の間隔とほぼ同じサイズであり、これにより前記側壁の多孔度が全体を通して一様であり、
前記医療プロテーゼが滅菌手順に供されたものであり、
前記側壁がコラーゲン又はゲルでコーティングされ、これによりコーティングを含む前記側壁の多孔度は、組織の内部成長を提供するのに十分であり、かつ120mmHgで毎分5mL/cm 2 未満である。
埋入可能な医療プロテーゼ。 - 前記ベース層が1/1平織パターンを持ち、前記ベロア層が5/1平織パターンを持つ、請求項8に記載の埋入可能な医療プロテーゼ。
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