JP6345714B2 - 貫通要素を有するエアロゾル発生システム - Google Patents
貫通要素を有するエアロゾル発生システム Download PDFInfo
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- JP6345714B2 JP6345714B2 JP2015562118A JP2015562118A JP6345714B2 JP 6345714 B2 JP6345714 B2 JP 6345714B2 JP 2015562118 A JP2015562118 A JP 2015562118A JP 2015562118 A JP2015562118 A JP 2015562118A JP 6345714 B2 JP6345714 B2 JP 6345714B2
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- 239000000443 aerosol Substances 0.000 title claims description 227
- 230000000149 penetrating effect Effects 0.000 title claims description 99
- 150000001875 compounds Chemical class 0.000 claims description 85
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 66
- 230000002708 enhancing effect Effects 0.000 claims description 64
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 58
- 229960002715 nicotine Drugs 0.000 claims description 57
- 230000000903 blocking effect Effects 0.000 claims description 46
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- 239000007788 liquid Substances 0.000 claims description 34
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- 238000011144 upstream manufacturing Methods 0.000 claims description 18
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- 229910052751 metal Inorganic materials 0.000 claims description 5
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- 230000001419 dependent effect Effects 0.000 claims 1
- 239000003570 air Substances 0.000 description 72
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 32
- 239000000463 material Substances 0.000 description 19
- 235000019270 ammonium chloride Nutrition 0.000 description 16
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical class CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 description 15
- 238000007373 indentation Methods 0.000 description 10
- -1 polypropylene Polymers 0.000 description 10
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 8
- 239000007789 gas Substances 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 235000019504 cigarettes Nutrition 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 238000001179 sorption measurement Methods 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 4
- 229910052782 aluminium Inorganic materials 0.000 description 4
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 4
- 235000019506 cigar Nutrition 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 229940107700 pyruvic acid Drugs 0.000 description 4
- 230000000391 smoking effect Effects 0.000 description 4
- RFEJUZJILGIRHQ-OMDKHLBYSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-OMDKHLBYSA-N 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- GPPUPQFYDYLTIY-UHFFFAOYSA-N 2-oxooctanoic acid Chemical compound CCCCCCC(=O)C(O)=O GPPUPQFYDYLTIY-UHFFFAOYSA-N 0.000 description 2
- HDJBTCAJIMNXEW-PPHPATTJSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;hydrochloride Chemical compound Cl.CN1CCC[C@H]1C1=CC=CN=C1 HDJBTCAJIMNXEW-PPHPATTJSA-N 0.000 description 2
- QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000004696 Poly ether ether ketone Substances 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000004716 alpha keto acids Chemical class 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 229920000295 expanded polytetrafluoroethylene Polymers 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920001707 polybutylene terephthalate Polymers 0.000 description 2
- 229920002530 polyetherether ketone Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229940076788 pyruvate Drugs 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000009834 vaporization Methods 0.000 description 2
- 230000008016 vaporization Effects 0.000 description 2
- MVJLYXCJBPXRCY-UHFFFAOYSA-N 2-methylbutyl propanoate Chemical compound CCC(C)COC(=O)CC MVJLYXCJBPXRCY-UHFFFAOYSA-N 0.000 description 1
- KDVFRMMRZOCFLS-UHFFFAOYSA-N 2-oxopentanoic acid Chemical compound CCCC(=O)C(O)=O KDVFRMMRZOCFLS-UHFFFAOYSA-N 0.000 description 1
- 239000001388 3-methyl-2-oxobutanoic acid Substances 0.000 description 1
- BKAJNAXTPSGJCU-UHFFFAOYSA-N 4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O BKAJNAXTPSGJCU-UHFFFAOYSA-N 0.000 description 1
- 239000001142 4-methyl-2-oxopentanoic acid Substances 0.000 description 1
- 229920001824 Barex® Polymers 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 229910000272 alkali metal oxide Inorganic materials 0.000 description 1
- 229910000287 alkaline earth metal oxide Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 229940061720 alpha hydroxy acid Drugs 0.000 description 1
- 150000001280 alpha hydroxy acids Chemical class 0.000 description 1
- 239000012080 ambient air Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 239000007961 artificial flavoring substance Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 229940069688 nicotine bitartrate Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229920005594 polymer fiber Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 229920005992 thermoplastic resin Polymers 0.000 description 1
- 239000006200 vaporizer Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/20—Devices without heating means
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/60—Constructional details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/06—Inhaling appliances shaped like cigars, cigarettes or pipes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
- B05B7/2402—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/004—Details of the piercing or cutting means with fixed piercing or cutting means
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Catching Or Destruction (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Nozzles (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Claims (16)
- エアロゾル発生システムであって、
エアロゾル発生物品と連携するエアロゾル発生装置と、
前記エアロゾル発生物品が、
管状の多孔性要素および前記管状の多孔性要素上に収着された送達促進化合物を含む、第一のシールされた区画と、
揮発性液体を含む第二の区画とを備え、
前記エアロゾル発生装置が、
前記エアロゾル発生物品を受けるように適応された外側ハウジングと、
前記エアロゾル発生物品の前記第一の区画と前記第二の区画を貫通するための細長い貫通部材とを備え、
ここで、前記細長い貫通部材が、
前記細長い貫通部材の遠位端に隣接した貫通部分と、
軸部分と、
前記細長い貫通部材の近位端に隣接した遮断部分とを備え、
前記貫通部分の最大直径は前記軸部分の直径よりも大きく、前記遮断部分がエアロゾル発生物品がエアロゾル発生装置内に受けられたときに、前記物品の前記管状の多孔性要素内に適合するような外径を持つ、エアロゾル発生システム。 - 前記第一の区画の上流の少なくとも一つの空気吸込み口と、前記第二の区画の下流の少なくとも一つの空気出口とをさらに備え、前記少なくとも一つの空気吸込み口および前記少なくとも一つの空気出口が、少なくとも一つの空気吸込み口から少なくとも一つの空気出口へと延び、前記遮断部分を避けて前記第一の区画の前記管状の多孔性要素を経由して、また前記軸部分を避けて前記第二の区画を経由する空気の流れ経路を画定するように配列されている、請求項1に記載のエアロゾル発生システム。
- 前記第二の区画が管状の多孔性要素を含み、前記システムが前記第二の区画の上流の少なくとも一つの空気吸込み口と、前記第一の区画の下流の少なくとも一つの空気出口とをさらに備え、前記少なくとも一つの空気吸込み口および前記少なくとも一つの空気出口が少なくとも一つの空気吸込み口から少なくとも一つの空気出口へと延び、前記遮断部分を避けて前記第二の区画の前記管状の多孔性要素を経由し、前記軸部分を避けて前記第一の区画を経由する空気の流れ経路を画定するように配列されている、請求項1に記載のエアロゾル発生システム。
- 前記遮断部分が前記管状の多孔性要素内で締りばめを形成するような直径を持つ、請求項1、2または3に記載のエアロゾル発生システム。
- 前記遮断部分の長軸方向の長さが、前記管状の多孔性要素の前記長軸方向の長さの25%〜75%である、請求項1〜4のいずれか1項に記載のエアロゾル発生システム。
- 前記管状の多孔性要素が中空円筒である、請求項1〜5のいずれか1項に記載のエアロゾル発生システム。
- 前記貫通部分の最大直径が、前記中空円筒の内径の75%〜100%の最大直径を持つ、請求項6に記載のエアロゾル発生システム。
- 請求項1または2に依存するとき、前記第二の区画が中空円筒であり、かつ前記貫通部分の最大直径が、前記第二の区画の内径の50%〜75%である、請求項1〜7のいずれか1項に記載のエアロゾル発生システム。
- 前記細長い貫通部材の長軸方向の長さが前記第一の区画と前記第二の区画の合計長軸方向の長さよりも大きい、請求項1〜8のいずれか1項に記載のエアロゾル発生システム。
- 前記貫通部分が円錐体である、請求項1〜9のいずれか1項に記載のエアロゾル発生システム。
- 前記物品が少なくとも一つのさらなる要素をさらに含む、請求項1〜10のいずれか1項に記載のエアロゾル発生システム。
- 前記少なくとも一つのさらなる要素がマウスピースを含む、請求項11に記載のエアロゾル発生システム。
- 前記第一の区画の第一の端が壊れやすいバリアによってシールされ、前記第一の区画の第二の端と前記第二の区画の第一の端との間の界面が少なくとも一つの壊れやすいバリアによりシールされ、前記第二の区画の第二の端が壊れやすいバリアによってシールされる、請求項1〜12のいずれか1項に記載のエアロゾル発生システム。
- それぞれの壊れやすいバリアが金属膜で製造される、請求項12に記載のエアロゾル発生システム。
- エアロゾル発生システムで使用するためのエアロゾル発生装置であって、
エアロゾル発生物品を受けるように適応された外側ハウジングであって、前記物品が管状の多孔性要素を持つ第一のシールされた区画と、第二の区画とを持つものと、
物品が前記外側ハウジング内に受けられたときに、前記物品の前記第一の区画と前記第二の区画を貫通するように構成された細長い貫通部材とを備え、
ここで、前記細長い貫通部材が、
前記細長い貫通部材の遠位端に隣接した貫通部分と、
軸部分と、
前記細長い貫通部材の近位端に隣接した遮断部分とを備え、
前記貫通部分の最大直径は前記軸部分の直径よりも大きく、前記遮断部分が、物品が前記装置内に受けられたときに、前記物品の前記管状の多孔性要素内に適合するような外径を持つ、エアロゾル発生装置。 - エアロゾル発生システムのためのエアロゾル発生物品であって、
第一の端および第二の端を持つ第一のシールされた区画であって、管状の多孔性要素に収着された酸を含む前記管状の多孔性要素および送達促進化合物を含む区画と、
前記第一の区画の前記第二の端と隣接する第一の端とニコチン剤を含む揮発性液体を含む第二の端とを持つ、第二のシールされた区画とを備え、
第一の区画の前記第一の端が壊れやすいバリアによってシールされ、前記第一の区画の前記第二の端と前記第二の区画の前記第一の端との間の界面が少なくとも一つの壊れやすいバリアによりシールされ、前記第二の区画の前記第二の端が壊れやすいバリアによってシールされる、エアロゾル発生物品。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13159562.1 | 2013-03-15 | ||
EP13159562 | 2013-03-15 | ||
PCT/EP2014/054821 WO2014140087A1 (en) | 2013-03-15 | 2014-03-12 | Aerosol-generating system having a piercing element |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016516401A JP2016516401A (ja) | 2016-06-09 |
JP6345714B2 true JP6345714B2 (ja) | 2018-06-20 |
Family
ID=47900876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015562118A Active JP6345714B2 (ja) | 2013-03-15 | 2014-03-12 | 貫通要素を有するエアロゾル発生システム |
Country Status (25)
Country | Link |
---|---|
US (1) | US10028531B2 (ja) |
EP (1) | EP2967139B1 (ja) |
JP (1) | JP6345714B2 (ja) |
KR (1) | KR102231858B1 (ja) |
CN (1) | CN105072936B (ja) |
AR (1) | AR095507A1 (ja) |
AU (1) | AU2014230826B2 (ja) |
BR (1) | BR112015020436B1 (ja) |
CA (1) | CA2904769A1 (ja) |
ES (1) | ES2734024T3 (ja) |
HK (1) | HK1215846A1 (ja) |
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