JP6316011B2 - 抗癌剤が担持されたナノ粒子 - Google Patents
抗癌剤が担持されたナノ粒子 Download PDFInfo
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Description
(I-1) ポリグリセリンによって表面修飾されたナノ粒子であって、
該ポリグリセリンには抗癌作用を有する化合物が結合しており、
該ナノ粒子が、ナノダイヤモンド、カーボンナノチューブ、グラフェン、カーボンドット、酸化鉄ナノ粒子、酸化亜鉛ナノ粒子、アルミナナノ粒子、金ナノ粒子及びシリカナノ粒子からなる群から選択される少なくとも1種を含む、表面修飾ナノ粒子。
(I-2) 前記ポリグリセリンには、更に標的化ペプチドが結合している、(I-1)に記載の表面修飾ナノ粒子。
(I-3) 前記ナノ粒子が、ナノダイヤモンドである、(I-1)又は(I-2)に記載の表面修飾ナノ粒子。
(I-4) 前記抗癌作用を有する化合物が、Ptを含有するものである、(I-1)〜(I-3)のいずれか一項に記載の表面修飾ナノ粒子。
(I-5) 前記標的化ペプチドが、RGD、TAT及びLFPLHからなる群から選択される少なくとも1種である、(I-1)〜(I-4)のいずれか一項に記載の表面修飾ナノ粒子。
(II-1) (I-1)〜(I-5)のいずれか一項に記載の表面修飾ナノ粒子を含む癌治療用の医薬組成物。
シリカナノ粒子等が挙げられるが、好ましくは、ナノダイヤモンドである。ナノ粒子は、これらを単独で又は2種以上含んでいてもよい。
試験例で使用する化合物を図1に記載のスキームに従い合成した。以下に合成方法の詳細を記載する。
ヌードマウスの背部右側に癌細胞U87MGを移植し、10匹の担癌マウスを作成した。それらを2匹ずつランダムに5群に群分けし、各群に表1に示した溶液を1匹あたり0.20 mL ずつ尾静脈に投与した。
結果を以下の表2、表3及び図2に示す。
Claims (4)
- ポリグリセリンによって表面修飾されたナノ粒子であって、
該ポリグリセリンには抗癌作用を有する化合物及び標的化ペプチドが結合しており、
該ナノ粒子が、ナノダイヤモンドである、表面修飾ナノ粒子。 - 前記抗癌作用を有する化合物が、Ptを含有するものである、請求項1に記載の表面修飾ナノ粒子。
- 前記標的化ペプチドが、RGD、TAT及びLFPLHからなる群から選択される少なくとも1種である、請求項1又は2に記載の表面修飾ナノ粒子。
- 請求項1〜3のいずれか一項に記載の表面修飾ナノ粒子を含む癌治療用の医薬組成物。
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CN109071227B (zh) * | 2016-02-05 | 2022-12-02 | 迈阿密大学 | 用于诊断分析和药物递送的碳量子点 |
US10398732B2 (en) | 2016-10-13 | 2019-09-03 | Marshall University Research Corporation | Compositions and methods for treating striated muscle injury, treating striated muscle atrophy and/or for promoting striated muscle growth |
CN108743962B (zh) * | 2018-06-19 | 2021-07-02 | 东华大学 | 一种基于荧光碳点修饰的树状大分子的双载药靶向纳米平台的制备方法 |
EP3981740A4 (en) * | 2019-06-05 | 2023-10-18 | Daicel Corporation | SURFACE-MODIFIED NANODIAMOND AND METHOD FOR PRODUCING SURFACE-MODIFIED NANODIAMOND |
CN112353783A (zh) * | 2020-11-18 | 2021-02-12 | 湖北医药学院 | 一种利用血小板高效装载化疗药物阿霉素的方法 |
CN113181906A (zh) * | 2021-04-23 | 2021-07-30 | 西安交通大学 | 一种Pt@CDs复合纳米材料及其制备方法 |
WO2023223962A1 (ja) * | 2022-05-20 | 2023-11-23 | 国立大学法人京都大学 | 表面修飾ナノダイヤモンド |
CN115364215B (zh) * | 2022-08-25 | 2024-01-19 | 澳门大学 | 铂药碳纳米点及其制备方法、碳纳米点蛋白复合物及应用 |
CN116216712B (zh) * | 2023-02-09 | 2024-05-17 | 中国科学技术大学 | 表面修饰三苯基膦基团的纳米金刚石及其制备方法和应用 |
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