JP6282013B2 - 個人化された閾値を用いる腫瘍組織の分類システム - Google Patents
個人化された閾値を用いる腫瘍組織の分類システム Download PDFInfo
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
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- A—HUMAN NECESSITIES
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- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
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- A—HUMAN NECESSITIES
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- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
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- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
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- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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Description
Claims (10)
- 異なる組織タイプの区別に対する少なくとも1つの閾値を得るシステムにおいて、前記システムが、
個別の患者の第1のタイプの組織内の1つ又は複数の位置において光測定結果を得る光学的プローブと、
前記光測定結果をスペクトル分析し、前記光測定結果における適合から得られる所定のスペクトル特性に基づいて第1の組織タイプクラスを形成するように多変数統計分析のスコアプロットにおいてデータ点を規定し、基準組織のスペクトル特性を使用することによりこの第1の組織タイプクラスに属するデータ点のクラウドに対する第1の閾値を規定するコンソールと、
を有し、
前記光学的プローブが、前記個別の患者の前記組織内の他の位置において他の光測定結果を取得し、
前記コンソールは、前記他の光測定結果に基づいて、前記他の光測定結果の所定のスペクトル特性が前記スコアプロットにおいて第1の閾値から外れるかどうか及びこれが第2の組織タイプクラスを規定する場合であるかどうかを試験する、
システム。 - 前記所定のスペクトル特性が、吸収及び散乱特性を有する、請求項1に記載のシステム。
- 前記所定のスペクトル特性が、蛍光特性を有する、請求項1に記載のシステム。
- 前記異なる組織タイプが、異なる正常タイプの組織、又は正常及び病変組織、又は正常及び腫瘍組織、又は正常組織、良性及び悪性組織を有する、請求項1に記載のシステム。
- 前記光学的プローブが、針、カテーテル又は内視鏡を有する、請求項1に記載のシステム。
- 前記コンソールが、前記スコアプロットにおけるデータ点のプロット形状から前記第2の組織タイプのデータ点を認識する、請求項1に記載のシステム。
- 前記第1の組織タイプクラスが、脂肪又は腺組織に関し、前記第2の組織タイプクラスが、腺がん又は非浸潤性乳管がんに関する、請求項1に記載のシステム。
- 前記コンソールが、第3の組織タイプクラスを規定し、組織タイプを前記第2及び第3の組織タイプクラスに割り当てるのに前記スコアプロットにおける3つの組織タイプクラスのデータ点により規定される三角形の幾何学的配置を使用する、請求項1に記載のシステム。
- 前記コンソールが、前記異なる組織タイプを区別するのに個別の患者スペクトルのデータベースとの測定されたスペクトルの相関を使用する、請求項1に記載のシステム。
- 前記コンソールが、抽出された水、脂質及びコラーゲン部分の少なくとも2つにより規定される空間における基準マップを生成し、前記組織タイプに基づいて前記空間を分類し、前記基準マップに対して前記光測定結果をタグ付けする、請求項1に記載のシステム。
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EP11162815.2 | 2011-04-18 | ||
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US201161557017P | 2011-11-08 | 2011-11-08 | |
US61/557,017 | 2011-11-08 | ||
PCT/IB2012/051742 WO2012143816A1 (en) | 2011-04-18 | 2012-04-10 | Classification of tumor tissue with a personalized threshold |
Publications (3)
Publication Number | Publication Date |
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JP2014511746A JP2014511746A (ja) | 2014-05-19 |
JP2014511746A5 JP2014511746A5 (ja) | 2015-05-28 |
JP6282013B2 true JP6282013B2 (ja) | 2018-02-21 |
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JP2014505748A Active JP6282013B2 (ja) | 2011-04-18 | 2012-04-10 | 個人化された閾値を用いる腫瘍組織の分類システム |
Country Status (6)
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US (1) | US9498136B2 (ja) |
EP (1) | EP2699142A1 (ja) |
JP (1) | JP6282013B2 (ja) |
CN (1) | CN103476321B (ja) |
RU (1) | RU2013151050A (ja) |
WO (1) | WO2012143816A1 (ja) |
Families Citing this family (5)
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US8912512B1 (en) | 2013-06-26 | 2014-12-16 | General Electric Company | System and method for optical biopsy tissue characterization |
WO2016015052A1 (en) * | 2014-07-25 | 2016-01-28 | The General Hospital Corporation | Apparatus, devices and methods for in vivo imaging and diagnosis |
US11406255B2 (en) | 2018-01-03 | 2022-08-09 | Koninklijke Philips N.V. | System and method for detecting abnormal tissue using vascular features |
EP3560415A1 (en) * | 2018-04-24 | 2019-10-30 | Koninklijke Philips N.V. | Tumor margin assessment |
DE102021134276A1 (de) * | 2021-12-22 | 2023-06-22 | Karl Storz Se & Co. Kg | Medizinische Vorrichtung und Verfahren zur Untersuchung eines organischen Gewebes |
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US7755757B2 (en) * | 2007-02-14 | 2010-07-13 | Chemimage Corporation | Distinguishing between renal oncocytoma and chromophobe renal cell carcinoma using raman molecular imaging |
WO2003043492A1 (en) | 2001-11-20 | 2003-05-30 | University Health Network | Optical transillumination and reflectance spectroscopy to quantify disease risk |
US7647092B2 (en) * | 2002-04-05 | 2010-01-12 | Massachusetts Institute Of Technology | Systems and methods for spectroscopy of biological tissue |
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JP4602765B2 (ja) * | 2002-08-05 | 2010-12-22 | インフラレドックス インコーポレーティッド | 血管壁の近赤外分光分析 |
US7689268B2 (en) * | 2002-08-05 | 2010-03-30 | Infraredx, Inc. | Spectroscopic unwanted signal filters for discrimination of vulnerable plaque and method therefor |
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US20050196023A1 (en) * | 2004-03-01 | 2005-09-08 | Eastman Kodak Company | Method for real-time remote diagnosis of in vivo images |
JP4545557B2 (ja) | 2004-11-10 | 2010-09-15 | 宇都宮機器株式会社 | ころ軸受用保持器 |
JPWO2006051847A1 (ja) * | 2004-11-12 | 2008-05-29 | 財団法人新産業創造研究機構 | Hiv等のウイルス感染の有無、又はプリオン感染の有無を近赤外線分光法により検査・判定する方法、及び同方法に使用する装置 |
US20060167350A1 (en) * | 2005-01-27 | 2006-07-27 | Monfre Stephen L | Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction |
KR100970295B1 (ko) * | 2005-04-13 | 2010-07-15 | 올림푸스 메디칼 시스템즈 가부시키가이샤 | 화상 처리 장치 및 화상 처리 방법 |
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US20080009748A1 (en) * | 2006-05-16 | 2008-01-10 | The Regents Of The University Of California | method and apparatus for the determination of intrinsic spectroscopic tumor markers by broadband-frequency domain technology |
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US20100169024A1 (en) | 2007-10-29 | 2010-07-01 | The Trustees Of The University Of Pennsylvania | Defining quantitative signatures for different gleason grades of prostate cancer using magnetic resonance spectroscopy |
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JP2010080950A (ja) | 2008-08-29 | 2010-04-08 | Semiconductor Energy Lab Co Ltd | 固体色素レーザ |
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2012
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Publication number | Publication date |
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RU2013151050A (ru) | 2015-05-27 |
JP2014511746A (ja) | 2014-05-19 |
US9498136B2 (en) | 2016-11-22 |
WO2012143816A1 (en) | 2012-10-26 |
EP2699142A1 (en) | 2014-02-26 |
CN103476321B (zh) | 2017-02-08 |
CN103476321A (zh) | 2013-12-25 |
US20140046197A1 (en) | 2014-02-13 |
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