JP6259660B2 - 流圧を管理するためのデバイス - Google Patents
流圧を管理するためのデバイス Download PDFInfo
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- JP6259660B2 JP6259660B2 JP2013538863A JP2013538863A JP6259660B2 JP 6259660 B2 JP6259660 B2 JP 6259660B2 JP 2013538863 A JP2013538863 A JP 2013538863A JP 2013538863 A JP2013538863 A JP 2013538863A JP 6259660 B2 JP6259660 B2 JP 6259660B2
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- fluid
- container
- pressure
- control device
- outlet port
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/481—Diagnostic techniques involving the use of contrast agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Description
本発明は、2010年11月9日付けの米国仮特許出願第61/411,856号の優先権を主張し、その全体を本明細書に組み入れる。
Claims (17)
- 既定の圧力以下の圧力で流体を身体構造へ提供するための流圧制御デバイスであって、少なくとも、
流体のための第1の容器と、
出口ポートと、
流圧を利用して前記既定の圧力で開く圧力安全弁であって、前記出口ポートと前記流体のための第1の容器との間で流体接続状態にある圧力安全弁と、
流体が前記流体のための第1の容器から前記出口ポートへ向かって移動するように、前記流体のための第1の容器内の流体へ力を提供するための要素と、
前記圧力安全弁と流体接続状態にある第2の容器であって、前記既定の圧力を超えると前記圧力安全弁が開いて前記第2の容器内へ流体が流入する第2の容器と
を含む、流圧制御デバイス。 - 既定の圧力以下の圧力で流体を身体構造へ提供するための流圧制御デバイスであって、少なくとも、
液体のための第1の容器、及び空気のための第2の容器と、
出口ポートと、
流圧を利用して前記既定の圧力で開く圧力安全弁であって、前記出口ポートと前記第1の容器との間で及び前記出口ポートと第2の容器との間で流体接続状態にある圧力安全弁と、
液体が前記第1の容器から前記出口ポートへ向かって移動するとともに空気が前記第2の容器から前記出口ポートへ向かって移動するように、前記流体のための第1の容器内の液体へ力を提供するための要素、及び前記空気のための第2の容器内の空気へ力を提供するための要素と、
前記圧力安全弁と流体接続状態にある第3の容器であって、前記既定の圧力を超えると前記圧力安全弁が開いて前記第3の容器内へ流体が流入する第3の容器と
を含む、流圧制御デバイス。 - 前記身体構造は、哺乳動物の少なくとも1つの卵管である、請求項1又は2に記載の流圧制御デバイス。
- 前記身体構造は、哺乳動物の子宮である、請求項1又は2に記載の流圧制御デバイス。
- 前記流体は、超音波検査によって可視化可能である、請求項1又は2に記載の流圧制御デバイス。
- 前記流体は、蛍光光度分析によって可視化可能である、請求項1又は2に記載の流圧制御デバイス。
- 前記圧力安全弁は、200mbar(150mmHg)〜267mbar(200mmHg)で開く、請求項1又は2に記載の流圧制御デバイス。
- 前記流体は、治療流体である、請求項1又は2に記載の流圧制御デバイス。
- 前記身体構造は、変容した身体構造である、請求項1又は2に記載の流圧制御デバイス。
- 前記変容した身体構造は、少なくとも1つの閉塞、遮断、または切断された卵管である、請求項9に記載の流圧制御デバイス。
- 前記変容した身体構造は、子宮である、請求項9に記載の流圧制御デバイス。
- 前記既定の圧力は、33mbar(25mmHg)〜1330mbar(1000mmHg)で開く、請求項1に記載の流圧制御デバイス。
- 身体構造への流体の制御された流圧の流動のためのデバイスであって、少なくとも、
出口ポートと流体接続状態にある、流体のための第1の容器と、
出口ポートと、
流圧を利用して既定の圧力で開く圧力安全弁であって、前記出口ポートと前記流体のための第1の容器との間で流体接続状態にある圧力安全弁と、
前記流体のための第1の容器から前記出口ポートへ向かって前記流体を移動させるための要素と、
前記圧力安全弁と流体接続状態にある第2の容器であって、前記既定の圧力を超えると前記圧力安全弁が開いて前記第2の容器内へ流体が流入する第2の容器と
を含む、デバイス。 - 身体構造への流体の制御された流圧の流動のためのデバイスであって、少なくとも、
出口ポートと、
それぞれが前記出口ポートと流体接続状態にある、液体のための第1の容器、及び空気のための第2の容器と、
流圧を利用して既定の圧力で開く圧力安全弁であって、前記出口ポートと前記液体のための第1の容器及び前記空気のための第2の容器との間で流体接続状態にある圧力安全弁と、
前記第1の容器から前記出口ポートへ向かって前記液体を移動させるための要素と、
前記第2の容器から前記出口ポートへ向かって前記空気を移動させるための要素と、
前記圧力安全弁と流体接続状態にある第3の容器であって、前記既定の圧力を超えると前記圧力安全弁が開いて前記第3の容器内へ流体が流入する第3の容器と
を含む、デバイス。 - 造影剤生成デバイスをさらに含む、請求項13又は14に記載のデバイス。
- カテーテル送達デバイスをさらに含む、請求項13又は14に記載のデバイス。
- 造影パターン生成室をさらに含む、請求項15又は16に記載のデバイス。
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11583625B2 (en) | 2010-11-09 | 2023-02-21 | Femasys Inc. | Methods and devices for managing fluid pressure |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2576127T3 (es) * | 2010-04-12 | 2016-07-05 | Hoffmann Neopac Ag | Tubo con válvula unidireccional para la regulación de la descarga en tubos y procedimiento para fabricar dicha válvula unidireccional |
US10085879B2 (en) | 2012-04-17 | 2018-10-02 | Empire Technology Development, Llc | Heat treatment device |
US11219719B2 (en) | 2012-08-28 | 2022-01-11 | Osprey Medical, Inc. | Volume monitoring systems |
US11116892B2 (en) | 2012-08-28 | 2021-09-14 | Osprey Medical, Inc. | Medium injection diversion and measurement |
US9999718B2 (en) | 2012-08-28 | 2018-06-19 | Osprey Medical, Inc. | Volume monitoring device utilizing light-based systems |
US10022497B2 (en) | 2012-08-28 | 2018-07-17 | Osprey Medical, Inc. | Reservoir for collection and reuse of diverted medium |
US9320846B2 (en) | 2012-08-28 | 2016-04-26 | Osprey Medical, Inc. | Devices and methods for modulating medium delivery |
US10413677B2 (en) | 2012-08-28 | 2019-09-17 | Osprey Medical, Inc. | Volume monitoring device |
US10010673B2 (en) | 2012-08-28 | 2018-07-03 | Osprey Medical, Inc. | Adjustable medium diverter |
WO2015034467A1 (en) * | 2013-09-03 | 2015-03-12 | Empire Technologies Development Llc | Thermal bacterial decolonization |
CN113908373B (zh) * | 2015-08-13 | 2023-05-09 | 拜耳医药保健有限公司 | 指示可替换部件的有效寿命的装置 |
KR102011503B1 (ko) * | 2018-03-30 | 2019-08-16 | (주)휴러스트 | 냉각 효율 및 작동성이 향상된 블레이드를 구비하는 외과 수술용 초음파 절삭기 |
EP4385529A2 (en) | 2018-05-02 | 2024-06-19 | Femasys, Inc. | Devices for controlled delivery |
CN109350114B (zh) * | 2018-11-28 | 2023-07-04 | 广东省人民医院(广东省医学科学院) | 一种多功能心脏彩超声学造影检查装置 |
US20200305742A1 (en) * | 2019-03-27 | 2020-10-01 | Kamran Ghodsian | System and method for child-birth monitoring and assistance |
WO2020210623A1 (en) | 2019-04-12 | 2020-10-15 | Osprey Medical Inc. | Energy-efficient position determining with multiple sensors |
CN110279432B (zh) * | 2019-07-26 | 2021-09-07 | 河南科技大学第一附属医院 | 一种tcd检查用微气泡造影剂制备及注射装置 |
USD982741S1 (en) * | 2020-05-06 | 2023-04-04 | Femasys Inc. | Delivery device with controls and cassette assembly |
US20230016549A1 (en) * | 2021-07-19 | 2023-01-19 | Otsuka Medical Devices Co., Ltd. | Treatment system having generator and fluid transfer cartridge |
CN115750260B (zh) * | 2022-11-24 | 2024-07-05 | 新疆敦华绿碳技术股份有限公司 | 一种co2注采用柱塞泵*** |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55118830A (en) | 1979-03-06 | 1980-09-12 | Hitachi Ltd | Reinforcing method for plastic molded product |
CH668017A5 (fr) | 1986-10-03 | 1988-11-30 | Kulbus S A | Pince pour pieces a usiner. |
JP2563061B2 (ja) * | 1993-04-05 | 1996-12-11 | アトムメディカル株式会社 | 婦人用診療装置 |
US5439022A (en) * | 1994-02-14 | 1995-08-08 | Summers; Daniel A. | Lavage valve |
DE69638173D1 (de) * | 1995-06-07 | 2010-06-10 | Robert S Neuwirth | Verfahren und mittel zur intrauterinen nekrosierung |
US6059747A (en) * | 1997-07-16 | 2000-05-09 | Medex, Inc. | Syringe pump infusion control set |
US6290672B1 (en) * | 1997-07-30 | 2001-09-18 | Mick Abae | Exploratory tubular sonogenic catheter |
US6450963B1 (en) * | 2000-06-30 | 2002-09-17 | Ackrad Laboratories, Inc. | Apparatus and method for ultrasonic imaging of the uterus and fallopian tubes using air and saline |
US8540698B2 (en) * | 2004-04-16 | 2013-09-24 | Medrad, Inc. | Fluid delivery system including a fluid path set and a check valve connector |
US20080154214A1 (en) * | 2006-12-22 | 2008-06-26 | Medrad, Inc. | Flow Based Pressure Isolation and Fluid Delivery System Including Flow Based Pressure Isolation |
US7611503B2 (en) * | 2004-04-16 | 2009-11-03 | Medrad, Inc. | Fluid delivery system, fluid path set, sterile connector and improved drip chamber and pressure isolation mechanism |
EP1506022A2 (en) * | 2002-05-09 | 2005-02-16 | Ultrast LLC | Medium for contrast enhancement use for ultrasonic, endoscopic, and other medical examinations |
US20040116955A1 (en) * | 2002-12-12 | 2004-06-17 | Jonathan Foltz | Cervical canal dilator |
US8052669B2 (en) | 2004-02-25 | 2011-11-08 | Femasys Inc. | Methods and devices for delivery of compositions to conduits |
US8048101B2 (en) | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
US8048086B2 (en) * | 2004-02-25 | 2011-11-01 | Femasys Inc. | Methods and devices for conduit occlusion |
US20050240211A1 (en) * | 2004-04-21 | 2005-10-27 | Stefan Sporri | Apparatus and method for selectably treating a fallopian tube |
US7470253B2 (en) * | 2004-05-26 | 2008-12-30 | Bioquiddity, Inc. | Fluid delivery apparatus with adjustable flow rate control |
US7682336B2 (en) * | 2005-05-13 | 2010-03-23 | Micromedics, Inc. | Gas assisted endoscopic applicator system |
US8123693B2 (en) * | 2005-06-20 | 2012-02-28 | Conceptus, Inc. | Methods and devices for determining lumen occlusion |
CN101277733B (zh) * | 2005-06-21 | 2012-07-11 | 梅德拉股份有限公司 | 医用流体注射和充胀*** |
EP1896192A1 (en) * | 2005-06-29 | 2008-03-12 | Medmix Systems AG | Method and device for venting and eliminating unwanted material of a dispensing appliance |
EP2167000A1 (en) * | 2007-07-09 | 2010-03-31 | Velomedix, Inc | Hypothermia devices and methods |
US20100087798A1 (en) * | 2008-09-24 | 2010-04-08 | Interlace Medical, Inc. | Systems, methods and devices for using a flowable medium for distending a hollow organ |
US10070888B2 (en) * | 2008-10-03 | 2018-09-11 | Femasys, Inc. | Methods and devices for sonographic imaging |
US9554826B2 (en) * | 2008-10-03 | 2017-01-31 | Femasys, Inc. | Contrast agent injection system for sonographic imaging |
AU2010328203B2 (en) * | 2009-12-08 | 2014-05-15 | The United States Government As Represented By The Department Of Veterans Affairs | Improved methods and compositions for vein harvest and autografting |
WO2012064884A1 (en) | 2010-11-09 | 2012-05-18 | Femasys Inc. | Methods and devices for managing fluid pressure |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11583625B2 (en) | 2010-11-09 | 2023-02-21 | Femasys Inc. | Methods and devices for managing fluid pressure |
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