JP6225114B2 - クラスタ検出に関する装置 - Google Patents
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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Description
少なくとも1つのサンプルチャンバ(反応チャンバ)を備える基本的に平面アーキテクチャを持つカートリッジと、
少なくとも1つのサンプルチャンバにおいて磁気粒子のクラスタの磁気作用に関する構成を備えるリーダー器具と、
少なくとも1つのサンプルチャンバにおいて磁気粒子を光学的に励起させる光学構成と、
少なくとも1つのサンプルチャンバにおいて磁気粒子から散乱された光を検出する光学検出構成であって、光学検出の軸が好ましくは、カートリッジ法線に実質的に平行である(即ちカートリッジ平面に垂直である)、光学検出構成とを有する。
により制限されるか、又は、サンプルチャンバ間隔が、
となるよう選択されるべきである。
透過的な底部基質113と、
透過的な上部基質111と、
複数のサンプルチャンバ114を含む中間的な層112とを有する。
Claims (22)
- サンプルにおいて磁気粒子を持つクラスタを検出するセンサ装置であって、
a)前記サンプルが提供されることができる少なくとも1つのサンプルチャンバを持つ外側表面がフラットな平面のカートリッジと、
b)前記サンプルチャンバに励起光を放出する光源と、
c)前記サンプルチャンバにおいて変調された磁場とパルス化された連鎖磁場を生成する磁場生成器と、
d)前記サンプルチャンバにおいて励起光により生成された出力光を検出する光検出器とを有する、センサ装置。 - サンプルにおいて磁気粒子を持つクラスタを検出する方法において、
a)外側表面がフラットな平面カートリッジの少なくとも1つのサンプルチャンバに前記サンプルを導入するステップと、
b)前記サンプルチャンバに励起光を放出するステップと、
c)前記サンプルチャンバにおいて変調された磁場とパルス化された連鎖磁場を生成するステップと、
d)前記サンプルチャンバにおいて励起光により生成された出力光を光検出器で検出するステップとを有する、方法。 - 前記光検出器が、前記カートリッジの外側表面に隣接して配置される、請求項1に記載のセンサ装置。
- 前記光検出器が、前記カートリッジの外側表面に隣接して配置される、請求項2に記載の方法。
- 前記変調された磁場が、前記励起光及び/又は前記出力光を有する平面において、回転する、請求項1に記載のセンサ装置。
- 前記変調された磁場が、前記励起光及び/又は前記出力光を有する平面において、回転する、請求項2に記載の方法。
- 時間的スペクトルに関して前記検出器信号を評価する評価ユニットが提供される、請求項1に記載のセンサ装置。
- 時間的スペクトルに関して前記検出器信号を評価する評価ユニットが提供される、請求項2に記載の方法。
- 非透過ブロッキングスポットが、前記サンプルチャンバと前記励起光が焦束される前記光検出器との間に提供される、請求項1に記載のセンサ装置。
- 非透過ブロッキングスポットが、前記サンプルチャンバと前記励起光が焦束される前記光検出器との間に提供される、請求項2に記載の方法。
- 前記光検出器上へ出力光を向けるため、光学要素が、前記サンプルチャンバ及び前記光検出器の間に提供される、請求項1に記載のセンサ装置。
- 前記光検出器上へ出力光を向けるため、光学要素が、前記サンプルチャンバ及び前記光検出器の間に提供される、請求項2に記載の方法。
- 分布要素が提供され、前記分布要素が、前記カートリッジの外側表面に対して平行な前記分布要素に到達する励起光を前記サンプルチャンバへと向ける、請求項1に記載のセンサ装置。
- 分布要素が提供され、前記分布要素が、前記カートリッジの外側表面に対して平行な前記分布要素に到達する励起光を前記サンプルチャンバへと向ける、請求項2に記載の方法。
- 前記分布要素が、少なくとも1つの部分的な鏡を有する、請求項13に記載のセンサ装置。
- 前記分布要素が、少なくとも1つの部分的な鏡を有する、請求項14に記載の方法。
- 前記出力光が、クラスタの蛍光により生成される光を有する、請求項1に記載のセンサ装置。
- 前記出力光が、クラスタの蛍光により生成される光を有する、請求項2に記載の方法。
- 出力光の通過を可能にしつつ、励起光をスペクトル的に除去するため、前記サンプルチャンバ及び前記光検出器の間に、フィルタ要素が提供される、請求項17に記載のセンサ装置。
- 出力光の通過を可能にしつつ、励起光をスペクトル的に除去するため、前記サンプルチャンバ及び前記光検出器の間に、フィルタ要素が提供される、請求項18に記載の方法。
- a)少なくとも1つのサンプルチャンバが形成される透過的な層であって、前記層を通り励起光が伝搬する、透過的な層と、
b)前記励起光が反射される前記透過的な層に隣接した追加的な層とを有する、請求項1に記載のセンサ装置に関するカートリッジ。 - 前記透過的な層が、前記透過的な層より低い屈折率を持つ2つの追加的な層の間に配置される、請求項21に記載のカートリッジ。
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US201161559307P | 2011-11-14 | 2011-11-14 | |
US61/559,307 | 2011-11-14 | ||
PCT/IB2012/056186 WO2013072806A1 (en) | 2011-11-14 | 2012-11-06 | Apparatus for cluster detection |
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JP2014535060A JP2014535060A (ja) | 2014-12-25 |
JP2014535060A5 JP2014535060A5 (ja) | 2015-12-24 |
JP6225114B2 true JP6225114B2 (ja) | 2017-11-01 |
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US (1) | US9863863B2 (ja) |
EP (1) | EP2780692A1 (ja) |
JP (1) | JP6225114B2 (ja) |
CN (1) | CN103930765B (ja) |
BR (1) | BR112014011259A2 (ja) |
IN (1) | IN2014CN03614A (ja) |
WO (1) | WO2013072806A1 (ja) |
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TWI654419B (zh) | 2011-08-29 | 2019-03-21 | 美商安美基公司 | 用於非破壞性檢測-流體中未溶解粒子之方法及裝置 |
WO2014195917A2 (en) | 2013-06-07 | 2014-12-11 | Malvern Instruments Limited | Array based sample characterization |
JP7028454B2 (ja) | 2016-11-30 | 2022-03-02 | 国立研究開発法人産業技術総合研究所 | 標的物質検出装置及び標的物質検出方法 |
JP7028455B2 (ja) * | 2016-11-30 | 2022-03-02 | 国立研究開発法人産業技術総合研究所 | 標的物質検出装置及び標的物質検出方法 |
US10088660B2 (en) | 2017-02-10 | 2018-10-02 | Amgen Inc. | Imaging system for counting and sizing particles in fluid-filled vessels |
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CN107121649B (zh) * | 2017-03-29 | 2023-10-10 | 金华职业技术学院 | 一种使用磁强计测量磁性分子团簇磁矩的方法 |
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CN116121051B (zh) * | 2023-03-14 | 2023-09-01 | 鲲鹏(徐州)科学仪器有限公司 | 一种光学检测装置 |
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2012
- 2012-11-06 EP EP12798404.5A patent/EP2780692A1/en not_active Withdrawn
- 2012-11-06 CN CN201280055621.9A patent/CN103930765B/zh active Active
- 2012-11-06 BR BR112014011259A patent/BR112014011259A2/pt not_active Application Discontinuation
- 2012-11-06 WO PCT/IB2012/056186 patent/WO2013072806A1/en active Application Filing
- 2012-11-06 US US14/357,790 patent/US9863863B2/en active Active
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CN103930765A (zh) | 2014-07-16 |
JP2014535060A (ja) | 2014-12-25 |
US20140302619A1 (en) | 2014-10-09 |
US9863863B2 (en) | 2018-01-09 |
EP2780692A1 (en) | 2014-09-24 |
WO2013072806A1 (en) | 2013-05-23 |
IN2014CN03614A (ja) | 2015-10-09 |
BR112014011259A2 (pt) | 2017-04-25 |
CN103930765B (zh) | 2017-10-13 |
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