JP6197234B2 - Soap with garlic extract containing vitamin B1 - Google Patents
Soap with garlic extract containing vitamin B1 Download PDFInfo
- Publication number
- JP6197234B2 JP6197234B2 JP2013219166A JP2013219166A JP6197234B2 JP 6197234 B2 JP6197234 B2 JP 6197234B2 JP 2013219166 A JP2013219166 A JP 2013219166A JP 2013219166 A JP2013219166 A JP 2013219166A JP 6197234 B2 JP6197234 B2 JP 6197234B2
- Authority
- JP
- Japan
- Prior art keywords
- soap
- garlic
- extract
- thiamine
- polyoxyethylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000344 soap Substances 0.000 title claims description 67
- 239000006000 Garlic extract Substances 0.000 title claims description 19
- 235000020706 garlic extract Nutrition 0.000 title claims description 19
- 229960003495 thiamine Drugs 0.000 title claims description 11
- 229930003451 Vitamin B1 Natural products 0.000 title 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 title 1
- 239000011691 vitamin B1 Substances 0.000 title 1
- 235000010374 vitamin B1 Nutrition 0.000 title 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 48
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 29
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 22
- 229940032094 squalane Drugs 0.000 claims description 22
- 239000007787 solid Substances 0.000 claims description 17
- 150000003544 thiamines Chemical class 0.000 claims description 12
- 235000019157 thiamine Nutrition 0.000 claims description 10
- 239000011721 thiamine Substances 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- JTLXCMOFVBXEKD-FOWTUZBSSA-N fursultiamine Chemical group C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N JTLXCMOFVBXEKD-FOWTUZBSSA-N 0.000 claims description 4
- 229950006836 fursultiamine Drugs 0.000 claims description 4
- UDCIYVVYDCXLSX-SDNWHVSQSA-N n-[(4-amino-2-methylpyrimidin-5-yl)methyl]-n-[(e)-5-hydroxy-3-(propyldisulfanyl)pent-2-en-2-yl]formamide Chemical group CCCSS\C(CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N UDCIYVVYDCXLSX-SDNWHVSQSA-N 0.000 claims description 4
- 240000002234 Allium sativum Species 0.000 description 42
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- 239000000284 extract Substances 0.000 description 30
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
- 150000004665 fatty acids Chemical class 0.000 description 10
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Landscapes
- Cosmetics (AREA)
Description
本発明は、ビタミンB1含有ニンニクエキス配合石けんに関する。 The present invention relates to a vitamin B 1 containing garlic extract combination soap.
従来、ニンニクB1エキスがアトピー性皮膚炎の改善に有効であることが知られており、その補助療法用にニンニクB1エキスを配合した入浴剤が上市されている。また、ニンニクB1エキス配合の入浴剤は保湿効果にすぐれ、健常人用の入浴剤としても用いられている。 Conventionally, it is known that garlic B 1 extract is effective in improving atopic dermatitis, and a bath preparation containing garlic B 1 extract is marketed for its adjuvant therapy. Moreover, the bath additive containing garlic B 1 extract has an excellent moisturizing effect and is also used as a bath additive for healthy people.
一方、ニンニクB1エキス配合の石けんも開発されている(特許文献1)。石けんは入浴剤と異なり、個人的利用が可能であり、洗面やシャワー時にも使用できるなど、湯舟に入らずとも簡単に使用できる利点がある。 On the other hand, soap garlic B 1 extract combination has been developed (Patent Document 1). Unlike bathing agents, soap has the advantage that it can be used easily without entering the bath, such as being able to be used personally and used in the bathroom or shower.
しかしながら、ニンニクB1エキスはニンニク特有の臭いを生じさせるため、ごくわずかしか石けん中に配合することができなかった。また、配合量を少量にしても、特に湿気の多い場所や高温での保存時にニンニク臭が経時的に強くなる問題があった。
一方、従来の石けんで使用するポリフェノール、フラボノイド等の消臭剤は、ニンニク臭に対する消臭効果が不充分であった。
したがって、ニンニクB1エキス配合石けんにおいて、ニンニク臭の発生を抑制することが望まれていた。
However, since garlic B 1 extract produces a garlic-specific odor, very little can be blended in soap. Moreover, even when the blending amount is small, there is a problem that the garlic odor becomes stronger with time especially when stored in a humid place or at a high temperature.
On the other hand, deodorizers such as polyphenols and flavonoids used in conventional soaps have insufficient deodorizing effects on garlic odor.
Therefore, in the soap containing garlic B 1 extract, it has been desired to suppress the generation of garlic odor.
本発明者は、上記課題を鑑み、鋭意検討した結果、ニンニクB1エキス配合石けんにスクワランを配合することで、ニンニク臭の発生を顕著に抑制することができることを見出し、本発明を完成させるに至った。
すなわち、本発明は、以下の態様を含む。
〔1〕(i)チアミン、ビタミンB1活性を有するチアミン誘導体またはその塩を含有するニンニクエキスと、
(ii)スクワラン
とを配合したことを特徴とする石けん。
〔2〕該チアミン誘導体がアリチアミンである上記〔1〕記載の石けん。
〔3〕該チアミン誘導体がチアミンプロピルジスルフィドである上記〔1〕記載の石けん。
〔4〕該チアミン誘導体がチアミンテトラヒドロフルフリルジスルフィドである上記〔1〕記載の石けん。
〔5〕該ニンニクエキスの固形分に対して、スクワランを0.5倍量(質量)〜20倍量(質量)配合したことを特徴とする上記〔1〕〜〔4〕のいずれかに記載の石けん。
〔6〕該ニンニクエキスの配合量が、石けん全体に対して、固形分として0.01〜5.0質量%であることを特徴とする上記〔1〕〜〔5〕のいずれかに記載の石けん。
As a result of intensive investigations in view of the above problems, the present inventors have found that the generation of garlic odor can be remarkably suppressed by adding squalane to garlic B 1 extract-containing soap, thereby completing the present invention. It came.
That is, the present invention includes the following aspects.
[1] (i) garlic extract containing thiamine, a thiamine derivative having vitamin B 1 activity or a salt thereof;
(ii) Soap characterized by blending with squalane.
[2] The soap according to the above [1], wherein the thiamine derivative is alithiamine.
[3] The soap according to [1], wherein the thiamine derivative is thiaminepropyl disulfide.
[4] The soap according to [1], wherein the thiamine derivative is thiamine tetrahydrofurfuryl disulfide.
[5] The composition according to any one of [1] to [4], wherein squalane is mixed in an amount of 0.5 times (mass) to 20 times (mass) with respect to the solid content of the garlic extract. Soap.
[6] The amount of the garlic extract is 0.01 to 5.0% by mass as a solid content with respect to the whole soap, according to any one of the above [1] to [5] Soap.
本発明は、ニンニク臭の発生を顕著に抑制したニンニクB1エキス配合石けんを提供するものである。これによりニンニクB1エキス配合石けんのニンニク臭に対する使用者の不快感を低減することが可能になる。
また、本発明の石けんは、ニンニクB1エキスによる効果(保湿効果、アトピー性皮膚炎の改善効果)に加えて、スクワランによる皮膚に対するエモリエント効果を有する。したがって、本発明の石けんは、皮膚に非常に優しい石けんであり、アトピー性皮膚炎患者の補助療法においても有用なものである。
The present invention is to provide a garlic B 1 extract combination soap significantly inhibited the generation of garlic odor. This makes it possible to reduce the user discomfort for garlic odor of garlic B 1 extract combination soap.
Also, soaps of the present invention, the effect of garlic B 1 extract in addition to the (moisturizing effect, improvement of atopic dermatitis), having a emollient effect on the skin due squalane. Therefore, the soap of the present invention is a soap that is very gentle to the skin, and is also useful in an adjuvant therapy for patients with atopic dermatitis.
本明細書における「ニンニクB1エキス」とは、チアミン、ビタミンB1活性を有するチアミン誘導体またはその塩(以下、単に「チアミン等」と称する場合もある)を含有するニンニクエキスを意味する。 The “garlic B 1 extract” in the present specification means a garlic extract containing thiamine, a thiamine derivative having vitamin B 1 activity or a salt thereof (hereinafter sometimes simply referred to as “thiamine etc.”).
上記ビタミンB1活性を有するチアミン誘導体とは、優れた腸管吸収および組織移行性を示し、体内持続性が良く、かつ生体内で容易にチアミンに戻る誘導体を指す。例えば、アリチアミン、チアミンプロピルジスルフィド、チアミンテトラヒドロフルフリルジスルフィド、オクトチアミン、チアミンジスルフィド、ビスベンチアミン、ビスブチチアミン、ビスイブチアミン、チアミンモノホスフェイトジスルフィド等のジスルフィド結合を有するチアミン誘導体のほか、チアミンピロリン酸、ベンフォチアミン、ジセチアミン、シコチアミン等が挙げられる。
また、チアミンおよびその誘導体の塩としては、それらの塩酸塩、硝酸塩等が挙げられる。
The thiamine derivative having vitamin B 1 activity refers to a derivative that exhibits excellent intestinal absorption and tissue transfer, has good body persistence, and easily returns to thiamine in vivo. For example, thiamine pyrroline in addition to thiamine derivatives having disulfide bonds such as alythiamine, thiamine propyl disulfide, thiamine tetrahydrofurfuryl disulfide, octothiamine, thiamine disulfide, bisbenchamine, bisbuthiamine, bisivethiamine, thiamine monophosphate disulfide, etc. Examples include acids, benfotiamine, dicetiamine, and chicotiamine.
In addition, examples of salts of thiamine and its derivatives include hydrochlorides and nitrates thereof.
本発明におけるニンニクB1エキスとしては、好ましくはアリチアミン、チアミンプロピルジスルフィド、チアミンテトラヒドロフルフリルジスルフィド等のチアミン誘導体を含有するニンニクエキスが挙げられる。これらのニンニクB1エキスは、ニンニクエキス特有の臭気をほとんど無臭に近い程減臭化されている点で好ましい。 The garlic B 1 extract in the present invention is preferably a garlic extract containing a thiamine derivative such as alitiamine, thiamine propyl disulfide, thiamine tetrahydrofurfuryl disulfide. These garlic B 1 extracts are preferable in that the odor characteristic of garlic extract is almost reduced to odorless so that the odor is reduced.
本発明に用いるニンニクB1エキスにおけるチアミン等の含有量は、ニンニクB1エキス全体(固形分)に対して、通常0.5〜20.0質量%、好ましくは1.0〜10.0質量%である。チアミン等の含有量がこのような範囲内であれば、ほとんど無臭に近いニンニクB1エキスを得ることができる点で好ましい。 The content of thiamine and the like in the garlic B 1 extract used in the present invention is usually 0.5 to 20.0% by mass, preferably 1.0 to 10.0% by mass, based on the entire garlic B 1 extract (solid content). %. Within such a range content, such as thiamine, preferable in that it is possible to obtain a garlic B 1 extract an almost odorless.
本発明におけるニンニクB1エキスは、既知の方法(特開昭63−307812号公報、特開平05−117140号公報等)にしたがい、上記チアミン等とニンニクエキスを混合することによって調製することができる。 The garlic B 1 extract in the present invention can be prepared by mixing the thiamine and the like with a garlic extract according to a known method (JP 63-307812 A, JP 05-117140 A, etc.). .
例えば、アリチアミン含有ニンニクエキスは、特開昭63−307812号公報に記載されているように、ビタミンB1とニンニクエキスを適当な条件下で共存させることによってアリチアミンを生成することができるので、以下に例示する方法によれば、効率よくアリチアミン含有ニンニクエキスを得ることができる。まず、常法によりニンニクを磨砕、搾汁して得たニンニク搾汁液にビタミンB1塩(例えば、塩酸塩、硝酸塩等)を原料ニンニク当り0.05〜3.0%(質量%、以下同じ)、好ましくは0.5〜2.0%添加し、pH6.0〜9.0、好ましくはpH7.0〜8.5に調整する。次に、処理温度を50〜70℃、好ましくは55〜65℃とし、5分〜4時間、好ましくは、30分〜2時間保温する。この後、直ちに生じた沈殿物を濾過または遠心沈殿で除去することにより、ほとんど無臭に近いアリチアミン含有ニンニクエキスを得ることができる。 For example, as described in Japanese Patent Laid-Open No. 63-307812, an arithiamine-containing garlic extract can produce arithiamine by coexisting vitamin B 1 and garlic extract under appropriate conditions. According to the method exemplified in (1), it is possible to efficiently obtain an artiamine-containing garlic extract. First, vitamin B 1 salt (for example, hydrochloride, nitrate, etc.) is added to a garlic juice obtained by grinding and squeezing garlic according to a conventional method, and 0.05 to 3.0% (mass%, below) per raw garlic The same), preferably 0.5 to 2.0%, and adjusted to pH 6.0 to 9.0, preferably pH 7.0 to 8.5. Next, the treatment temperature is 50 to 70 ° C., preferably 55 to 65 ° C., and the temperature is kept for 5 minutes to 4 hours, preferably 30 minutes to 2 hours. Thereafter, the precipitate generated immediately is removed by filtration or centrifugal precipitation, whereby an aliquoted garlic extract that is almost odorless can be obtained.
上記ビタミンB1塩の添加量、pH、処理温度および処理時間が、それぞれ示した下限数値未満では、アリチアミンの生成が不充分であり、反対に上限数値を超えると、ニンニクエキスの成分が変質する可能性がある。なお、生じた沈殿物を濾過または遠心沈殿で除去するとき、必要に応じてセライト、パーライト等の濾過助剤や塩化カルシウム、塩化マグネシウム等の蛋白凝集剤を用いてもよい。また、pH3〜5として蛋白を沈殿させて行ってもよい。 When the addition amount, pH, treatment temperature, and treatment time of the vitamin B 1 salt are less than the lower limit values shown, the formation of alithiamine is insufficient, and conversely, when the upper limit value is exceeded, the components of garlic extract are altered. there is a possibility. When removing the generated precipitate by filtration or centrifugal precipitation, a filter aid such as celite or pearlite or a protein aggregating agent such as calcium chloride or magnesium chloride may be used as necessary. Alternatively, the protein may be precipitated at pH 3-5.
本発明の石けんにおけるニンニクB1エキスの配合量は、特に限定するものではないが、石けん全体に対して、固形分として、通常0.01〜5.0質量%、好ましくは0.05〜1.0質量%、より好ましくは0.1〜0.5質量%である。石けん中のニンニクB1エキスの配合量をこのような範囲内にすることで、ニンニクB1エキスの効果を充分に発揮させることができる。 The amount of garlic B 1 Extract the soap of the present invention is not particularly limited with respect to the total soap, as a solid content, usually 0.01 to 5.0 wt%, preferably from 0.05 to 1 It is 0.0 mass%, More preferably, it is 0.1-0.5 mass%. The amount of garlic B 1 extract in soap By within such a range, it is possible to sufficiently exhibit the effect of garlic B 1 extract.
本発明に用いられるスクワランとしては、特に限定されず、医薬部外品用原料の他、化粧品原料として市販されているものでよい。例えば、サメ肝油等から分離抽出されたスクワレンに水素添加して生成したスクワラン等の動物由来のスクワラン(動物性スクワラン)、米ぬか油、オリーブ油等から分離抽出されたスクワレンに水素添加して生成したスクワラン等の植物由来のスクワラン(植物性スクワラン)等が挙げられる。
本発明の石けんにおいては、近年、消費者は動物由来の原料を回避し、植物由来の原料から得られる材料を好む傾向があることから、植物性スクワランが好ましい。
植物性スクワランとしては、例えば、フランス・ソフィム社製の商品名「フィトスクワラン」が挙げられる。当該スクワランは、オリーブ油から分離抽出したスクワレンに水素添加生成して得られた精製植物性スクワランである。
The squalane used in the present invention is not particularly limited, and may be a commercially available raw material for cosmetics in addition to a raw material for quasi drugs. For example, squalene produced by hydrogenation of squalene derived from animals such as squalane (animal squalene), rice bran oil, olive oil, etc. Plant-derived squalane (plant-based squalane) and the like.
In the soaps of the present invention, vegetable squalane is preferred since in recent years consumers tend to avoid animal-derived ingredients and prefer materials derived from plant-derived ingredients.
An example of a plant-based squalane is a trade name “Phyto squalane” manufactured by Sophim, France. The squalane is a purified vegetable squalane obtained by hydrogenating and producing squalene separated and extracted from olive oil.
本発明の石けんにおけるスクワランの配合量は、特に限定されないが、配合されるニンニクB1エキスの固形分に対して、通常0.5倍量(質量)〜20倍量(質量)、好ましくは等量(質量)〜10倍量(質量)である。スクワランの配合量をこのような範囲内にすることで、ニンニクB1エキスから生じるニンニク臭の発生を充分に抑制することができる。
また、石けん全体に対するスクワランの配合量は、特に限定するものではないが、通常0.1〜10.0質量%、好ましくは0.2〜5.0質量%である。石けん中のスクワランの配合量をこのような範囲内にすることで、スクワランの効果を充分に発揮させることができる。
The amount of squalane in the soap of the present invention is not particularly limited, but is usually 0.5 times (mass) to 20 times (mass), preferably equal to the solid content of the garlic B 1 extract to be blended. Amount (mass) to 10 times (mass). By making the compounding amount of squalane within such a range, generation of garlic odor generated from the garlic B 1 extract can be sufficiently suppressed.
Moreover, the compounding quantity of squalane with respect to the whole soap is although it does not specifically limit, Usually, 0.1-10.0 mass%, Preferably it is 0.2-5.0 mass%. By making the amount of squalane in the soap within such a range, the effect of squalane can be sufficiently exhibited.
本発明の石けんは、固形石けん、液体石けん、クリーム石けん(ムース型石けん)等、通常の形態の石けんとすることができる。なかでも、固形石けんが好ましい。 The soap of the present invention can be a soap of a normal form such as solid soap, liquid soap, cream soap (mousse soap). Of these, solid soap is preferable.
本発明の石けんは、油脂のけん化、塩析法、脂肪酸中和法、脂肪酸エステルけん化法等の常法によってニートソープを製造し、従来の石けんに配合される既知の任意成分を配合して均一に混合し、これにスクワランに分散させたニンニクB1エキスを添加し、枠練り、もしくは機械練りにより製造することができる。ニートソープの製造方法としては、特に、脂肪酸中和法が好ましい。
例えば、本発明の石けんが固形石けんである場合、石けん素地に、従来の石けんに配合される既知の任意成分を配合して均一に混合し、これにスクワランに分散させたニンニクB1エキスを添加して均一に混合した後、任意の質量になるよう型打ちして製造される。
The soap of the present invention is a neat soap produced by conventional methods such as fat saponification, salting-out method, fatty acid neutralization method, fatty acid ester saponification method, etc., and blended with known optional ingredients blended in conventional soap. The garlic B 1 extract mixed with and dispersed in squalane can be added thereto, and the mixture can be produced by frame kneading or mechanical kneading. As a method for producing neat soap, a fatty acid neutralization method is particularly preferable.
For example, when the soap of the present invention is a solid soap, the soap base is blended with known optional ingredients blended in a conventional soap and mixed uniformly, and then garlic B 1 extract dispersed in squalane is added thereto And after mixing uniformly, it stamps and manufactures so that it may become arbitrary mass.
上記任意成分としては、限定するものではないが、石けん素地、キレート剤、界面活性剤、アルコール類、高級アルコール類、酸化防止剤、金属封鎖剤、抗炎症剤、無機塩類、無機顔料、保湿剤、防腐剤、香料、油性成分、滑沢剤、水溶性高分子、着色剤、可溶化剤、ニンニクエキス以外の植物抽出エキス等が例示される。これらの任意成分は、石けんの用途または剤形に応じて、1種又は2種以上を混合して配合することができる。 Examples of the optional components include, but are not limited to, soap bases, chelating agents, surfactants, alcohols, higher alcohols, antioxidants, metal sequestering agents, anti-inflammatory agents, inorganic salts, inorganic pigments, and humectants. Examples include preservatives, fragrances, oily ingredients, lubricants, water-soluble polymers, colorants, solubilizers, plant extract extracts other than garlic extract, and the like. These optional components can be blended in one or more kinds depending on the use or dosage form of the soap.
石けん素地は、例えば、牛脂、羊脂等の動物油脂、ヤシ油、パーム油、パーム核油、大豆油、オリーブ油、綿実油等の植物油脂、の各単独もしくは混合物を苛性ソーダでけん化するか、あるいはこれらの油脂を分解して得られる脂肪酸の各単独もしくは混合物を苛性ソーダ、苛性カリ、アルカノールアミン等で中和することによって得ることができる。 For example, the soap base may be saponified with caustic soda, for example, animal oils such as beef tallow and sheep fat, vegetable oils such as coconut oil, palm oil, palm kernel oil, soybean oil, olive oil, and cottonseed oil. It can be obtained by neutralizing each or a mixture of fatty acids obtained by decomposing oil and fat with caustic soda, caustic potash, alkanolamine and the like.
石けん素地は、通常知られている固形石けんであれば、特段の限定無く適用でき、脂肪酸のナトリウム石けんやトリエタノールアミン石けんを主成分とする固形石けんはもとより、アシル化グルタミン酸ナトリウムを主成分とする石けんなどにも適用できる。又、通常の不透明な固形石けんにも、透明な固形石けんにも適用できる。 Soap base can be applied without particular limitation as long as it is a generally known solid soap, and it is mainly composed of acylated sodium glutamate as well as solid soaps mainly composed of fatty acid sodium soap and triethanolamine soap. It can also be applied to soap. Also, it can be applied to ordinary opaque solid soap and transparent solid soap.
キレート剤としては、EDTA、DTPA(ジエチレントリアミンテトラ酢酸)、ヒドロキシエタンジホスホン酸等が挙げられる。 Examples of the chelating agent include EDTA, DTPA (diethylenetriaminetetraacetic acid), hydroxyethanediphosphonic acid, and the like.
界面活性剤としては、ラウリル硫酸ナトリウム、アルキルスルホコハク酸エステル等のアニオン界面活性剤、4級アルキルアミン塩等のカチオン界面活性剤、ポリオキシエチレンセチルエーテル、モノステアリン酸ポリエチレングリコール、モノステアリン酸グリセリン、ポリオキシエチレンソルビタンモノラウリン酸エステル、ポリオキシエチレンラウリルエーテル、ポリオキシエチレンポリオキシプロピレングリコール、脂肪酸モノグリセライド、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビンタン脂肪酸エステル、ポリオキシエチレンステアリルエーテル、ポリオキシエチレンオレイルエーテル、ポリオキシエチレン高級アルコールエーテル、ポリオキシアルキルアリルエーテル、ポリオキシエチレンジスチレン化フェニルエーテル、ポリオキシエチレン誘導体、ソルビタンモノラウレート、ソルビタンモノオレート、ソルビンタンセスキオレエート、ソルビンタンモノライレート、ポリオキシエチレンモノラウレート、ポリオキシエチレンソルビタンラウレート、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレンソルビタンモノオレエート、1−ポリオキシエチレンソルビタンモノラウレート、ポリオキシエチレンソルビタンモノオレエート、テトラオレイン酸ポリオキシエチレンソルビタン、ポリエチレングリコールモノラウレート、ポリエチレングリコールモノオレート、ポリオキシチエレンヒマシ油、ポリオキシエチレンラノリン等のノニオン界面活性剤、アルキルベタイン、グリシン型、アルキルアミノベタイン、イミダゾリン型、L−アルギニン型、L−リジン型等の両性界面活性剤、モノステアリン酸ポリオキシエチレンソルビタン、ポリオキシエチレンステアリン酸アミド等の非イオン性界面活性剤が挙げられる。 Surfactants include anionic surfactants such as sodium lauryl sulfate and alkylsulfosuccinates, cationic surfactants such as quaternary alkylamine salts, polyoxyethylene cetyl ether, polyethylene glycol monostearate, glyceryl monostearate, Polyoxyethylene sorbitan monolaurate, polyoxyethylene lauryl ether, polyoxyethylene polyoxypropylene glycol, fatty acid monoglyceride, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene stearyl ether, polyoxyethylene oleyl Ether, polyoxyethylene higher alcohol ether, polyoxyalkyl allyl ether, polyoxyethylene distyrenated Nyl ether, polyoxyethylene derivative, sorbitan monolaurate, sorbitan monooleate, sorbitan sesquioleate, sorbitan monolaurate, polyoxyethylene monolaurate, polyoxyethylene sorbitan laurate, polyoxyethylene sorbitan monostearate, Polyoxyethylene sorbitan monooleate, 1-polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate, polyethylene glycol monolaurate, polyethylene glycol monooleate, polyoxythielen castor Nonionic surfactant such as oil, polyoxyethylene lanolin, alkylbetaine, glycine type, alkylaminobetaine, imidazo Emission type, L- arginine and amphoteric surfactants such as L- lysine-type, monostearate polyoxyethylene sorbitan, nonionic surfactants such as polyoxyethylene stearic acid amide.
アルコール類としては、エタノール、プロパノール、グリセリン、プロピレングリコール、1,3−ブチレングリコールが挙げられる。 Examples of alcohols include ethanol, propanol, glycerin, propylene glycol, and 1,3-butylene glycol.
高級アルコール類としては、セタノール、ステアリルアルコール、カプリルアルコール、ラウリルアルコール、ミリスチルアルコール、セチルアルコール、コレステロール、フィトステロール、ヘキシルデカノール、オクチルドデカノールおよびベヘニルアルコールが挙げられる。 Examples of higher alcohols include cetanol, stearyl alcohol, capryl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, cholesterol, phytosterol, hexyl decanol, octyldodecanol and behenyl alcohol.
酸化防止剤としては、ビタミンEおよびブチルヒドロキシトルエン(BHT)が挙げられる。 Antioxidants include vitamin E and butylhydroxytoluene (BHT).
金属封鎖剤としては、エデト酸二ナトリウム、エデト酸三ナトリウム、エデト酸四ナトリウム、クエン酸ナトリウム、ポリリン酸ナトリウム、メタリン酸ナトリウムおよびグルコン酸が挙げられる。 Examples of metal sequestering agents include disodium edetate, trisodium edetate, tetrasodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate and gluconic acid.
抗炎症剤としては、β−グリチルレチン酸、およびトラネキサム酸が挙げられる。 Anti-inflammatory agents include β-glycyrrhetinic acid and tranexamic acid.
無機塩類としては、硫酸ナトリウム、硫酸マグネシウム、塩化ナトリウム、塩化カリウム、チオ硫酸ナトリウム、酸化マグネシウム、硫酸アルミニウム、ミョウバン、メタケイ酸塩が挙げられる。 Examples of inorganic salts include sodium sulfate, magnesium sulfate, sodium chloride, potassium chloride, sodium thiosulfate, magnesium oxide, aluminum sulfate, alum, and metasilicate.
無機顔料としては、酸化チタン、炭酸カルシウム、炭酸マグネシウム、酸化亜鉛、タルク、ケイ酸カルシウム、無水ケイ酸、カオリン、ベントナイト、雲母チタンが挙げられる。 Examples of the inorganic pigment include titanium oxide, calcium carbonate, magnesium carbonate, zinc oxide, talc, calcium silicate, anhydrous silicic acid, kaolin, bentonite, and mica titanium.
保湿剤としては、ソルビトール、キシリトール、マルチトール、デキストリン、グルコース、マルトース、ラクトース、サッカロース、キシロース、フルクトース、マンニトール、ラクチトール等の糖類;エチレングリコール、プロピレングリコール、3−メチル−1,3−ブタンジオール、グリセリン、1,3−ブチレングリコール(BG)等の多価アルコール類;ピロリドンカルボン酸ナトリウム、グルタミン酸ナトリウム等のアミノ酸類;尿素が挙げられる。 As the humectant, saccharides such as sorbitol, xylitol, maltitol, dextrin, glucose, maltose, lactose, saccharose, xylose, fructose, mannitol, lactitol; ethylene glycol, propylene glycol, 3-methyl-1,3-butanediol, Examples include polyhydric alcohols such as glycerin and 1,3-butylene glycol (BG); amino acids such as sodium pyrrolidonecarboxylate and sodium glutamate; and urea.
防腐剤としては、パラオキシ安息香酸エステル(例えば、メチルパラベン)、安息香酸、安息香酸塩、フェノキシエタノールが挙げられる。 Examples of the preservative include paraoxybenzoic acid ester (for example, methylparaben), benzoic acid, benzoate, and phenoxyethanol.
香料としては、ラベンダー油、ジャスミン油、レモン油等の天然香料、またはゲラニオール、シトロネロール、フェネチルアルコール等の合成香料が挙げられる。 Examples of the fragrances include natural fragrances such as lavender oil, jasmine oil, and lemon oil, and synthetic fragrances such as geraniol, citronellol, and phenethyl alcohol.
油性成分としては、大豆油、ヌカ油、ホホバ油、アボガド油、アーモンド油、オリーブ油、カカオ脂、ゴマ油、パーシック油、ヒマシ油、ヤシ油、ミンク油、牛脂、豚脂等の天然油脂、これらの天然油脂を水素添加して得られる硬化油およびミリスチン酸グリセリド、2−エチルヘキサン酸グリセリド等の合成グリセリド、ジグリセリド等の油脂類;カルナウバロウ、鯨ロウ、ミツロウ、ラノリン等のロウ類;流動パラフィン、ワセリン、パラフィン、マイクロクリスタリンワックス、セレシン、プリスタン等の炭化水素類;ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、ベヘニン酸、オレイン酸、リノール酸、リノレン酸、ラノリン酸、イソステアリン酸等の高級脂肪酸類;ラウリルアルコール、セチルアルコール、ステアリルアルコール、オレイルアルコール、コレステロール、2−ヘキシルデカノール等の高級アルコール類;オクタン酸セチル、乳酸ミリスチル、乳酸セチル、ミリスチン酸イソプロピル、パルミチン酸イソプロピル、アジピン酸イソプロピル、ステアリン酸ブチル、オレイン酸デシル、イソステアリン酸コレステロール等のエステル類;精油類;シリコーン油類が挙げられる。 Oil components include soybean oil, nutka oil, jojoba oil, avocado oil, almond oil, olive oil, cacao butter, sesame oil, persic oil, castor oil, coconut oil, mink oil, beef tallow, pork fat, etc. Hardened oil obtained by hydrogenation of natural fats and oils, synthetic glycerides such as myristic acid glyceride and 2-ethylhexanoic acid glyceride, fats such as diglyceride; waxes such as carnauba wax, whale wax, beeswax, lanolin; liquid paraffin, petrolatum , Hydrocarbons such as paraffin, microcrystalline wax, ceresin and pristane; higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid and isostearic acid Lauryl alcohol, cetyl alcohol, steari Higher alcohols such as alcohol, oleyl alcohol, cholesterol, 2-hexyldecanol; cetyl octoate, myristyl lactate, cetyl lactate, isopropyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, decyl oleate, cholesterol isostearate, etc. Esters; essential oils; silicone oils.
滑沢剤としては、カオリン、ポリエチレングリコール、タルク、ステアリン酸マグネシウム、ステアリン酸カルシウム、シリコーン油、油性成分、澱粉が挙げられる。 Examples of the lubricant include kaolin, polyethylene glycol, talc, magnesium stearate, calcium stearate, silicone oil, oily component, and starch.
水溶性高分子としては、ニカワ、ゼラチン、コラーゲン蛋白、カゼイン、アルギン酸ナトリウム、カラギーナン、ファーセレラン、タマリンドガム、ペクチン、アラビアガム、グアーガム、キサンタンガム、トラガントガム、ローカストビーンガム、デキストラン、寒天、澱粉等の天然水溶性高分子;カルボキシメチルセルロース、メチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、酢酸フタル酸セルロース、アルギン酸プロピレングリコールエステル、酸化澱粉、エステル化澱粉、エーテル化澱粉、カチオン澱粉等の半合成水溶性高分子;ポリアクリル酸ナトリウム、ポリエチレンイミン、ポリビニルアルコール、ポリエチレングリコール、ポリビニルピロリドン等の合成水溶性高分子が挙げられる。 Examples of water-soluble polymers include natural water such as glue, gelatin, collagen protein, casein, sodium alginate, carrageenan, fur celerin, tamarind gum, pectin, gum arabic, guar gum, xanthan gum, tragacanth gum, locust bean gum, dextran, agar, starch, etc. Polymers: Semi-synthetic water-soluble polymers such as carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, cellulose acetate phthalate, propylene glycol alginate, oxidized starch, esterified starch, etherified starch, and cationic starch; polyacrylic Examples thereof include synthetic water-soluble polymers such as sodium acid, polyethyleneimine, polyvinyl alcohol, polyethylene glycol, and polyvinylpyrrolidone.
着色剤としては、リボフラビン(ビタミンB2)、カロチン、クロロフィルが挙げられる。 Examples of the colorant include riboflavin (vitamin B 2 ), carotene, and chlorophyll.
可溶化剤としては、例えば、ポリオキシエチレン脂肪酸エーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンアルキルエーテル、ポリオキシエチレンポリオキシプロピレンアルキルエーテル、ポリオキシエチレンアルキルフェニルエーテル、ポリオキシエチレンコレステリルエーテル、ポリオキシエチレンフィトステロールエーテル、ポリオキシエチレンポリオキシプロピレンフィトステロールエーテル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリオキシエチレン脂肪酸グリセリン、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、脂肪酸石けん、N−アシルグルタミン酸塩、アシルタウリン塩、アシルアルキルタウリン塩、高級アルキル硫酸エステル塩、アルキルエーテル硫酸エステル塩、N−アシルサルコシン酸塩、高級脂肪酸アミドスルホン酸塩、リン酸エステル塩、スルホコハク酸塩、アルキルベンゼンスルホン酸塩、ポリオキシエチレンメチルエーテルジメチコンおよびポリオキシエチレン・メチルポリシロキサンが挙げられる。 Examples of the solubilizer include polyoxyethylene fatty acid ether, polyoxyethylene fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene cholesteryl ether, polyoxyethylene Ethylene phytosterol ether, polyoxyethylene polyoxypropylene phytosterol ether, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyoxyethylene fatty acid glycerin, polyglycerin fatty acid ester, sucrose fatty acid ester, Fatty acid soap, N-acyl glutamate, acyl taurine salt, acyl alkyl taurine , Higher alkyl sulfates, alkyl ether sulfates, N-acyl sarcosinates, higher fatty acid amide sulfonates, phosphate esters, sulfosuccinates, alkylbenzene sulfonates, polyoxyethylene methyl ether dimethicone and polyoxy Ethylene methylpolysiloxane is mentioned.
ニンニクエキス以外の植物抽出エキスとしては、例えば、柑橘類果皮エキス、タイムエキス、ルイボスティーエキス、およびカミツレエキスが挙げられる。 Examples of plant extract other than garlic extract include citrus peel extract, thyme extract, rooibos tea extract, and chamomile extract.
本発明の石けんが固形石けんである場合、その水分量は、固形石けん全体に対して、好ましくは20.0質量%未満、より好ましくは16.0質量%未満である。固形石けん中の水分量がこのような範囲内であれば、ニンニクB1エキスから生じるニンニク臭の発生をより抑制することができる。 When the soap of the present invention is solid soap, the amount of water is preferably less than 20.0% by mass, more preferably less than 16.0% by mass, based on the entire solid soap. If the amount of water in the solid soap is within such a range, generation of garlic odor generated from the garlic B 1 extract can be further suppressed.
本発明の石けんは、通常の洗顔、手洗、全身用等の石けんと同じ用途に、また同じ方法により使用することができる。 The soap of the present invention can be used in the same application and in the same manner as normal soaps for face washing, hand washing, whole body and the like.
次に、実施例および試験例を挙げて本発明をさらに詳細に説明する。
実施例1〜3および比較例1
下記表1に記載の成分分量を量り、各成分を攪拌混合して、任意の質量になるよう型打ちして製造した。
2):ニンニク搾汁液に、ビタミンB1塩を原料ニンニク当り1.4%添加し、pH8.3に調整した。次に、処理温度を60℃とし、1時間保温後、直ちに生じた沈殿物を濾過した。その濾液を減圧下にて濃縮し、乾燥してニンニクB1エキス末を得た。
3):フランス・ソフィム社製、商品名:フィトスクワラン
4):P.T.Musim Mas社製、商品名:S2500
Next, the present invention will be described in more detail with reference to examples and test examples.
Examples 1 to 3 and Comparative Example 1
Ingredient amounts shown in Table 1 below were weighed, each component was stirred and mixed, and stamped to produce an arbitrary mass.
2) : Vitamin B 1 salt was added to the garlic juice, 1.4% per raw garlic, and adjusted to pH 8.3. Next, the treatment temperature was set to 60 ° C., and the precipitate formed immediately after filtration was filtered for 1 hour. The filtrate was concentrated under reduced pressure and dried to obtain garlic B 1 extract powder.
3) Product name: Phytosqualane, manufactured by Sophim, France
4) : P.I. T.A. Product name: S2500, manufactured by Musim Mas
試験例1 臭いの改善
表1に示す4組成物について同一質量の成型物を作製し試験品とした。各試験品を室温にて一ヶ月間したもの、40℃で一ヶ月間保管したものを用いて、 比較例1を基準として臭いの状態を臭気モニター5名にて評価を行った。
結果1 室温にて保管した組成物のニンニク臭について
実施例1〜3の組成物は、比較例1の組成物を使用した時の臭いと比較して、5名全員が臭いが改善されたと評価した。
結果2 40℃にて保管した組成物のニンニク臭について
実施例1〜3の組成物は、比較例1の組成物を使用した時の臭いと比較して、5名全員が臭いが改善されたと評価した。
Test Example 1 Improvement of odor A molded product having the same mass was prepared for the four compositions shown in Table 1 and used as test products. Each test article was evaluated for the odor state with five odor monitors using Comparative Example 1 as a reference, using a test article that was stored at room temperature for one month and stored at 40 ° C. for one month.
Result 1 About the garlic odor of the composition stored at room temperature The compositions of Examples 1 to 3 were all evaluated as having improved odor compared to the odor when using the composition of Comparative Example 1. did.
Result 2 About the garlic odor of the composition stored at 40 ° C. The compositions of Examples 1 to 3 were all improved in odor compared to the odor when the composition of Comparative Example 1 was used. evaluated.
Claims (6)
(ii)スクワラン
とを配合したことを特徴とする石けん。 (i) garlic extract containing thiamine, a thiamine derivative having vitamin B 1 activity or a salt thereof,
(ii) Soap characterized by blending with squalane.
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