JP6104513B2 - 人工呼吸器 - Google Patents
人工呼吸器 Download PDFInfo
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- JP6104513B2 JP6104513B2 JP2012053018A JP2012053018A JP6104513B2 JP 6104513 B2 JP6104513 B2 JP 6104513B2 JP 2012053018 A JP2012053018 A JP 2012053018A JP 2012053018 A JP2012053018 A JP 2012053018A JP 6104513 B2 JP6104513 B2 JP 6104513B2
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- oxygen
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- 239000007789 gas Substances 0.000 claims description 231
- 239000001301 oxygen Substances 0.000 claims description 224
- 229910052760 oxygen Inorganic materials 0.000 claims description 224
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 223
- 229910052734 helium Inorganic materials 0.000 claims description 69
- 239000001307 helium Substances 0.000 claims description 68
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 68
- 238000009423 ventilation Methods 0.000 claims description 29
- 210000003437 trachea Anatomy 0.000 claims description 11
- 230000003434 inspiratory effect Effects 0.000 claims description 7
- 230000000241 respiratory effect Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 description 154
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 84
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- 241000283973 Oryctolagus cuniculus Species 0.000 description 54
- 229910002092 carbon dioxide Inorganic materials 0.000 description 42
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- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
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- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 4
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- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 2
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 2
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- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- 241000283977 Oryctolagus Species 0.000 description 1
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- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
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- DPYMFVXJLLWWEU-UHFFFAOYSA-N desflurane Chemical compound FC(F)OC(F)C(F)(F)F DPYMFVXJLLWWEU-UHFFFAOYSA-N 0.000 description 1
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- BCQZXOMGPXTTIC-UHFFFAOYSA-N halothane Chemical compound FC(F)(F)C(Cl)Br BCQZXOMGPXTTIC-UHFFFAOYSA-N 0.000 description 1
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- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
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- Health & Medical Sciences (AREA)
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- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
本発明の人工呼吸器において、第1のガス供給装置は高頻度振動換気法により酸素を含むガスを供給することが好ましい。
まず、非特許文献2で開示されている方法(以下、「方法A」とする)(比較例1)によるヘリウム・酸素吸入療法が、従来からの一般的な人工換気法、すなわちヘリウムおよび酸素混合ガスを用いないHFO人工呼吸(以下、「方法B」とする)(比較例2)より優れているか否かについて、事前に検証を行なった。
(1)方法Bで換気した後、動脈血酸素分圧および動脈血二酸化炭素分圧を測定した。
図1に示した例の本発明の人工呼吸器1を用いて、ヘリウムと酸素との混合ガスを気管外管路8の中途の分岐から供給したHFO人工呼吸(以下、「方法C」とする)(実施例1)と、上述した方法A(比較例1)とを交互に行ない、ウサギの動脈血酸素分圧および動脈血二酸化炭素分圧の変動を調べ、方法Cが方法Aと同等以上の効果があるかを検証した。
(1)方法Aで換気した後、動脈血酸素分圧および動脈血二酸化炭素分圧を測定した。
(5)方法Aで換気した後、動脈血酸素分圧および動脈血二酸化炭素分圧を測定した。
図2に示した例の本発明の人工呼吸器31を用いて、ヘリウムと酸素との混合ガスを気管内管路7の先端から供給したHFO人工呼吸(以下、「方法D」とする)(実施例2)と、上述した方法A(比較例1)とを交互に行ない、ウサギの動脈血酸素分圧および動脈血二酸化炭素分圧の変動を調べ、方法Dが方法Aと同等以上の効果があるかを検証した。
(1)方法Aで換気した後、動脈血酸素分圧および動脈血二酸化炭素分圧を測定した。
(5)方法Aで換気した後、動脈血酸素分圧および動脈血二酸化炭素分圧を測定した。
Claims (7)
- 酸素とヘリウムとを混合したガスを吸気ガスとして患者に供与する人工呼吸器であって、
高頻度振動換気法により酸素を含むガスを供給する第1のガス供給装置と、
患者の気管に挿入され、留置される気管内管路と、
第1のガス供給装置と気管内管路とを接続し、患者に第1のガス供給装置からの酸素を含むガスを導くための気管外管路であって、中途に分岐を有する気管外管路と、
気管外管路のうち一端が気管内管路に接続され、他端が前記分岐に接続された管路、または、気管内管路に接続され、酸素とヘリウムとの混合ガスを気管外管路の前記管路または気管内管路に供給する第2のガス供給装置とを備える、人工呼吸器。 - 第2のガス供給装置と、気管外管路のうち一端が気管内管路に接続され、他端が前記分岐に接続された管路、または、気管内管路との間に、酸素とヘリウムとの混合ガスの流量を測定するための流量計が接続されている、請求項1に記載の人工呼吸器。
- 第2のガス供給装置と気管外管路のうち一端が気管内管路に接続され、他端が前記分岐に接続された管路、または、気管内管路との間に、酸素とヘリウムとの混合ガス中の酸素濃度を測定するための酸素濃度計が接続されている、請求項1または2に記載の人工呼吸器。
- 気管外管路と第1のガス供給装置との間に、第2のガス供給装置が接続された箇所より呼吸器側の酸素を含むガス中の酸素濃度を測定するための酸素濃度計が接続されている、請求項1〜3のいずれかに記載の人工呼吸器。
- 気管内管路が、独立した2つの流路を有し、一方の流路を第1のガス供給装置からの酸素を含むガスが流れ、他方の流路を第2のガス供給装置からの酸素とヘリウムとの混合ガスが流れるように構成されている、請求項1〜4のいずれかに記載の人工呼吸器。
- 第1のガス供給装置からの酸素を含むガスが圧縮空気を含む、請求項1〜5のいずれかに記載の人工呼吸器。
- 第1のガス供給装置は、気管内管路、気管外管路を経た患者からの呼気ガスを排気するように構成されている、請求項1〜6のいずれかに記載の人工呼吸器。
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JP2012053018A JP6104513B2 (ja) | 2012-03-09 | 2012-03-09 | 人工呼吸器 |
EP13757687.2A EP2823844B1 (en) | 2012-03-09 | 2013-02-28 | Artificial respirator |
PCT/JP2013/055360 WO2013133117A1 (ja) | 2012-03-09 | 2013-02-28 | 人工呼吸器 |
US14/383,498 US20150059743A1 (en) | 2012-03-09 | 2013-02-28 | Ventilator |
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US11167146B2 (en) | 2020-04-10 | 2021-11-09 | Jerome Canady Research Institute for Advanced Biological and Technological Sciences | System for treatment of respiratory infections and cancers of the respiratory system using cold atmospheric plasma |
LU101785B1 (en) | 2020-05-08 | 2021-11-08 | Jerome Canady Research Institute For Advanced Biological And Tech Sciences | System for treatment of respiratory infections and lung cancer with cold atmospheric plasma |
WO2021206771A1 (en) | 2020-04-10 | 2021-10-14 | Jerome Canady Research Institute for Advanced Biological and Technological Sciences | System and method for treatment of respiratory infections and lung cancer with cold atmospheric plasma |
US11793968B2 (en) | 2020-04-10 | 2023-10-24 | Jerome Canady Research Institute for Advanced Biological and Technological Sciences | Method for treatment of respiratory infections and cancers of the respiratory system using cold atmospheric plasma |
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