JP6067590B2 - 非合焦超音波による超音波振動法 - Google Patents
非合焦超音波による超音波振動法 Download PDFInfo
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Description
Claims (22)
- 対象物の機械的特性を測定する装置であって、
前記対象物に少なくとも1つの非合焦超音波ビームを印加して前記対象物の中に伝搬可能なせん断波を生成するように構成された伝送機と、
前記伝送機で生成された前記せん断波が存在している前記対象物の中の少なくとも1箇所で測定する測定情報を取得するように構成された検出器と、
前記検出器で取得した前記測定情報を用いて前記対象物の機械的特性を算出するように構成されたコントローラと、
を備えたことを特徴とする装置。 - 前記検出器が超音波装置とされ、
前記対象物の中の少なくとも1箇所に超音波エネルギが印加されることによって、前記測定情報が取得されることを特徴とする請求項1に記載の装置。 - 前記印加される超音波エネルギが、合焦超音波エネルギおよび非合焦超音波エネルギの少なくとも1つであることを特徴とする請求項2に記載の装置。
- 前記検出器が、光学検出器、磁気共鳴画像装置、および電磁波検出器の少なくとも1つとされ、電磁エネルギが前記対象物の少なくとも1箇所に印加されることによって、前記測定情報が取得されることを特徴とする請求項1に記載の装置。
- 前記伝送機が、超音波トランスデューサを備え、かつ該超音波トランスデューサからくし型状に外側へ延びる複数の非合焦超音波ビームを生成して前記対象物に少なくとも1つの非合焦超音波ビームを印加するように構成されたことを特徴とする請求項1に記載の装置。
- 前記伝送機が、前記超音波トランスデューサの表面に亘って均等に離れる前記複数の非合焦超音波ビームを生成するように構成されたことを特徴とする請求項5に記載の装置。
- 異なる方向に伝搬するせん断波間の干渉が軽減するように、前記コントローラが、前記取得した測定情報に配向フィルタを適用するように構成されたことを特徴とする請求項5に記載の装置。
- 請求項5に記載の装置であって、
前記コントローラが、
前記測定情報から、第1の方向に伝搬するせん断波の測定に対応した第1測定情報サブセットを形成し、
前記測定情報から、第2の方向に伝搬するせん断波の測定に対応した第2測定情報サブセットを形成し、
前記第1測定情報サブセットおよび前記第2測定情報サブセットを選択的に結合するように構成されたことを特徴とする装置。 - 前記第1の方向と、前記第2の方向が反対方向であることを特徴とする請求項8に記載の装置。
- 複数の超音波トランスデューサ構成要素を超音波トランスデューサの第1の方向に活性化させることによって、非合焦超音波エネルギを前記対象物の平坦領域に印加し、前記せん断波が前記平坦領域から外側に延びる方向に沿って伝搬するように、前記伝送機が構成されたことを特徴とする請求項1に記載の装置。
- 前記検出器が、超音波装置とされ、かつ、複数の超音波トランスデューサ構成要素を超音波トランスデューサの前記第1の方向に直交する第2の方向に沿って活性させることによって、前記対象物の少なくとも1箇所に超音波エネルギを印加し前記測定情報を取得するように構成されたことを特徴とする請求項10に記載の装置。
- 前記検出器には、前記伝送機の前記超音波トランスデューサと異なる超音波トランスデューサが設けられていることを特徴とする請求項11に記載の装置。
- 前記伝送機が、少なくとも2つの非合焦超音波ビームを前記対象物に印加するように構成されていることを特徴とする請求項1に記載の装置。
- 前記検出器が、超音波装置とされ、かつ超音波エネルギを前記対象物に印加することで前記測定情報を取得するように構成され、
前記伝送機が、複数の非合焦超音波トーンバーストを前記対象物に印加するように構成され、
前記検出器が、前記伝送機によって印加される前記複数の非合焦超音波トーンバーストと時間的にインタレースされた複数の超音波トーンバーストを印加するように構成されている
ことを特徴とする請求項1に記載の装置。 - 前記伝送機が、超音波トランスデューサによって生成された少なくとも1つの非合焦超音波ビームを前記トランスデューサの表面に対する所定の角度で印加するように構成されていることを特徴とする請求項1に記載の装置。
- 対象物の機械的特性を超音波で測定する方法であって、
イ)軸方向の複数の深度において複数の細胞変形を生成するために、少なくとも1つの非合焦超音波ビームを対象物に印加する工程と、
ロ)前記対象物の中の、前記複数の細胞変形のうちの少なくとも1つが配置されている少なくとも1箇所に、超音波エネルギを印加することによって、前記対象物から測定情報を取得する工程と、
ハ)前記ロ)の工程で取得した測定情報を用いて前記対象物の機械的特性を算出する工程と、
を含むことを特徴とする方法。 - 前記ロ)の工程で印加する超音波エネルギが、合焦超音波エネルギおよび非合焦超音波エネルギの少なくとも1つとされることを特徴とする請求項16に記載の方法。
- 前記複数の細胞変形に、複数のせん断波が含まれていることを特徴とする請求項16に記載の方法。
- 超音波トランスデューサを有する超音波装置で対象物の機械的特性を測定する方法であって、
イ)前記超音波エネルギが前記超音波トランスデューサの表面に直交する方向に力を発生するように、前記対象物に超音波エネルギを印加することによって、前記超音波トランスデューサから外側に延びる少なくとも1つの方向に前記対象物に伝搬するせん断波であって、前記対象物に少なくとも1つの非合焦超音波ビームを印加することで生成されるせん断波を前記超音波トランスデューサで生成する工程と、
ロ)前記イ)の工程で生成されたせん断波の存在する対象物の少なくとも1箇所に超音波エネルギを印加することによって測定情報を取得する工程と、
ハ)前記ロ)の工程で取得した測定情報を用いて前記対象物の機械的特性を算出する工程と、
を含むことを特徴とする方法。 - 前記イ)の工程で印加する前記超音波エネルギが、合焦超音波エネルギおよび非合焦超音波エネルギのうちの少なくとも1つであることを特徴とする請求項19に記載の方法。
- 前記イ)の工程で生成される前記せん断波が前記超音波トランスデューサの表面に直交する方向に伝搬することを特徴とする請求項19に記載の方法。
- 前記イ)の工程で生成される前記せん断波の少なくとも1つが前記超音波トランスデューサの表面の1箇所から放射方向に伝搬するせん断波とされることを特徴とする請求項19に記載の方法。
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US201161446839P | 2011-02-25 | 2011-02-25 | |
US61/446,839 | 2011-02-25 | ||
PCT/US2012/026769 WO2012116364A1 (en) | 2011-02-25 | 2012-02-27 | Ultrasound vibrometry with unfocused ultrasound |
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US11179581B2 (en) | 2015-03-09 | 2021-11-23 | The Research Foundation For The State University Of New York | Systems and methods for promoting cellular activities for tissue maintenance, repair, and regeneration |
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WO2012116364A1 (en) | 2012-08-30 |
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