JP6067296B2 - Denture cleaning agent - Google Patents
Denture cleaning agent Download PDFInfo
- Publication number
- JP6067296B2 JP6067296B2 JP2012210733A JP2012210733A JP6067296B2 JP 6067296 B2 JP6067296 B2 JP 6067296B2 JP 2012210733 A JP2012210733 A JP 2012210733A JP 2012210733 A JP2012210733 A JP 2012210733A JP 6067296 B2 JP6067296 B2 JP 6067296B2
- Authority
- JP
- Japan
- Prior art keywords
- denture
- denture cleaning
- cleaning agent
- weight
- component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Cosmetics (AREA)
Description
本発明は、義歯洗浄剤を投入した水の上面に、気泡が重なり合って集積された状態を形成させる作用が強く、且つその持続性が良好である義歯洗浄剤に関する。更に、本発明は、当該義歯洗浄剤を用いた義歯洗浄方法に関する。 The present invention relates to a denture cleaning agent that has a strong effect of forming a state in which air bubbles overlap and accumulate on the upper surface of water charged with a denture cleaning agent, and has good durability. Furthermore, this invention relates to the denture cleaning method using the said denture cleaning agent.
義歯は、総義歯、部分床義歯の別に関わらず、細菌、バイオフィルム、その他沈着物等が付着しやすく、洗浄せずに放置しておくと、口臭の原因になるだけでなく、歯周病等の口腔内疾患を誘発する一因になることがある。そのため、口腔ケアの一環として、義歯を洗浄し清潔に保つことが不可欠である。義歯に付着した細菌や汚れは、ブラシによる清掃では十分に除去できないため、義歯洗浄剤による洗浄が重要である。 Regardless of whether the denture is a complete denture or a partial denture, bacteria, biofilm, and other deposits are likely to adhere to it, and if left unwashed, it will not only cause bad breath, but also periodontal disease. It may contribute to induce oral diseases such as Therefore, it is indispensable to clean and keep the denture clean as part of oral care. Bacteria and dirt adhering to the denture cannot be sufficiently removed by cleaning with a brush, so cleaning with a denture cleaner is important.
義歯洗浄剤による義歯の洗浄は、一般に、義歯洗浄剤を水に投入して調製された義歯洗浄水に義歯を浸漬放置する方法で行われている。従来、義歯洗浄剤としては、界面活性剤及び発泡剤を含むことで、水に投入した際に水中で発泡し、水の上面に気泡が重なり合って集積される発泡錠剤タイプのものが広く利用されている。発泡錠剤タイプの義歯洗浄剤では、界面活性化作用による化学的洗浄力と発泡作用による物理的洗浄力を兼ね備えることにより、洗浄力が高まるように設計されている。当該義歯洗浄剤は、水に投入すると、水中にて発泡すると同時に界面活性剤が水中に溶け出すため、水の上面に、気泡が重なり合って集積され（以下、かかる状態を「泡積り」と表記することもある）、当該泡積りが最大量に到達すると、一定時間その状態を維持し、洗浄が終わるにつれて泡積りが消失していき、やがて水面上の泡は完全に消失する。 Generally, denture cleaning with a denture cleaning agent is performed by immersing the denture in a denture cleaning water prepared by adding the denture cleaning agent into water. Conventionally, as a denture cleaning agent, a foamed tablet type that contains a surfactant and a foaming agent and foams in water when it is put into water and bubbles accumulate on the upper surface of the water is widely used. ing. The effervescent tablet type denture cleaning agent is designed to increase the detergency by combining the chemical detergency due to the surface activation action and the physical detergency due to the foaming action. When the denture cleaning agent is poured into water, it foams in the water and at the same time the surfactant dissolves in the water, so that bubbles overlap and accumulate on the upper surface of the water (hereinafter, this state is referred to as “bubble accumulation”). When the foam accumulation reaches the maximum amount, the state is maintained for a certain period of time, and the foam accumulation disappears as the washing is completed, and eventually the foam on the water surface disappears completely.
従来、このような発泡錠剤タイプの義歯洗浄剤について、洗浄効果等を向上させるために種々の改良が行われている。例えば、発泡錠剤タイプの義歯洗浄剤に、ポリビニルピロリドンとポリエチレングリコールを３：７〜７：３の重量比で配合することにより、起泡力を増大させ得ることが報告されている（特許文献１参照）。 Conventionally, various improvements have been made on such effervescent tablet type denture cleaners in order to improve the cleaning effect and the like. For example, it has been reported that foaming power can be increased by blending polyvinylpyrrolidone and polyethylene glycol in a weight ratio of 3: 7 to 7: 3 in an effervescent tablet type denture cleaner (Patent Document 1). reference).
発泡錠剤タイプの義歯洗浄剤では、義歯洗浄剤を投入した水の上面に、気泡が重なり合って集積された状態を形成させる作用が強く、その持続性が良好であることが重要とされている。このように、泡積り作用が強く、その持続性が良好であることが、義歯洗浄剤の洗浄効果を高めることに繋がり、更には使用者が視覚的に感じる満足感を向上させる上で有効となる。しかしながら、従来の発泡錠剤タイプの義歯洗浄剤では、泡積りを形成させる作用が弱い、或いは泡積りの持続性が悪い等の欠点があり、これらを克服できる製剤処方について報告がなされていないのが現状である。 In the effervescent tablet type denture cleaning agent, it is important that the upper surface of the water charged with the denture cleaning agent has a strong effect of forming a state in which air bubbles are overlapped and accumulated, and its durability is good. Thus, the foaming action is strong and its sustainability is good for improving the cleaning effect of the denture cleaner, and further effective for improving the user's visual satisfaction. Become. However, the conventional foaming tablet type denture cleaner has drawbacks such as weak foaming action or poor foaming sustainability, and there is no report on a pharmaceutical formulation that can overcome these problems. Currently.
このような従来技術を背景として、泡積りを形成させる作用に優れ、且つその持続性も良好な発泡錠剤タイプの義歯洗浄剤の開発が望まれている。 Against the background of such conventional technology, there is a demand for the development of an effervescent tablet type denture cleaning agent that is excellent in the action of forming foam and has good durability.
本発明は、泡積りを形成させる作用に優れ、且つその持続性も良好な義歯洗浄剤を提供することを主な目的とする。 The main object of the present invention is to provide a denture cleaning agent that is excellent in the action of forming foam and has good durability.
本発明者は、前記課題を解決すべく鋭意検討を行ったところ、驚くべきことに、（Ａ）発泡剤、（Ｂ）アルキルスルホ酢酸塩、及び（Ｃ）アルキル硫酸塩を含有する義歯洗浄剤は、泡積りを形成させる作用に優れ、しかも泡積りの持続性が良好であることを見出した。また、更に（Ｄ）シリカを含有させることで、泡積りの持続性を維持しながらも、泡積りの最大量を増加させ、義歯洗浄剤を水に投入した後に泡積りが最高量に到達するまでの時間を短縮できることも見出した。本発明は、かかる知見に基づいて、更に検討を重ねることにより完成したものである。 The present inventor has conducted extensive studies to solve the above problems, and surprisingly, a denture cleaning agent containing (A) a foaming agent, (B) an alkyl sulfoacetate salt, and (C) an alkyl sulfate salt. Has been found to be excellent in the action of forming foam and has good persistence of foam. Further, by further containing (D) silica, while maintaining the sustainability of foaming, the maximum amount of foaming is increased, and the foaming reaches the maximum amount after the denture cleaning agent is added to water. It has also been found that the time until the time can be shortened. The present invention has been completed by further studies based on this finding.
即ち、本発明は、下記に掲げる義歯洗浄剤及び義歯洗浄方法を提供する。
項１．（Ａ）発泡剤、（Ｂ）アルキルスルホ酢酸塩、及び（Ｃ）アルキル硫酸塩を含有することを特徴とする、義歯洗浄剤。
項２．更に（Ｄ）シリカを含む、項１に記載の義歯洗浄剤。
項３．（Ｂ）アルキルスルホ酢酸塩１００重量部当たり、（Ｃ）アルキル硫酸塩を２０〜５００重量部の比率で含有する、項１又は２に記載の義歯洗浄剤。
項４．更に（Ｅ）油性成分を含む、項１〜３のいずれかに記載の義歯洗浄剤。
項５．項１〜４のいずれかに記載の義歯洗浄剤を入れた水に、義歯を浸積することを特徴とする、義歯の洗浄方法。
That is, this invention provides the denture cleaning agent and denture cleaning method which are hung up below.
Item 1. A denture cleaning agent comprising (A) a foaming agent, (B) an alkyl sulfoacetate salt, and (C) an alkyl sulfate salt.
Item 2. Furthermore, (D) Denture cleaning agent of claim | item 1 containing a silica.
Item 3. (B) The denture cleaning agent of claim | item 1 or 2 which contains (C) alkyl sulfate in the ratio of 20-500 weight part per 100 weight part of alkyl sulfoacetates.
Item 4. Item 4. The denture cleaner according to any one of Items 1 to 3, further comprising (E) an oil component.
Item 5. Item 5. A denture cleaning method, wherein the denture is immersed in water containing the denture cleaning agent according to any one of Items 1 to 4.
本発明の義歯洗浄剤は、義歯洗浄時に泡積りを形成させる作用に優れ、しかも泡積りの持続性も格段に向上しており、優れた洗浄効果を奏すると共に、使用者が視覚的に感じる満足感を向上させることができる。 The denture cleaning agent of the present invention is excellent in the action of forming foam during denture cleaning, and also has a drastic improvement in the sustainability of foaming, providing an excellent cleaning effect and satisfying the user visually. A feeling can be improved.
更に、従来の義歯洗浄剤において、義歯からの汚れを含んだ泡が容器の壁面に付着した状態で乾燥すると、汚れが壁面上に斑状に残る（輪染みになる）ため、使用者に不快感を与えていたが、本発明の義歯洗浄剤は油性成分及び／又はテルペノイドを含む場合には、泡積りは義歯洗浄後には速やかに消失するので、汚れを含んだ泡が容器壁面に残り難いため、汚れが斑状に残る（輪染みになる）ことがないだけでなく、洗浄後の義歯及び容器の濯ぎが容易になり、使用者の利便性を高めることもできる。 Furthermore, in conventional denture cleaning agents, if the foam containing dirt from the dentures is dried while adhering to the wall surface of the container, the dirt remains mottled on the wall surface (ring stains), which makes the user uncomfortable. However, when the denture cleaning agent of the present invention contains an oily component and / or a terpenoid, the foam buildup disappears quickly after the denture cleaning, so that the foam containing dirt hardly remains on the wall surface of the container. In addition to the fact that the stain does not remain in the form of spots (ring stains), the denture and the container after washing can be easily rinsed, and the convenience of the user can be enhanced.
１．義歯洗浄剤
本発明の義歯洗浄剤は、（Ａ）発泡剤、（Ｂ）アルキルスルホ酢酸塩、及び（Ｃ）アルキル硫酸塩を含有することを特徴とする。以下、本発明の義歯洗浄剤について詳述する。
1. Denture cleaning agent The denture cleaning agent of this invention is characterized by containing (A) foaming agent, (B) alkyl sulfoacetate, and (C) alkyl sulfate. Hereinafter, the denture cleaning agent of this invention is explained in full detail.
本発明の義歯洗浄剤に使用される発泡剤（以下、「（Ａ）成分」と表記することもある）としては、特に制限されず、義歯洗浄剤で通常使用されるもの（即ち、水中で二酸化炭素を発生できるもの）を広く用いることができる。 The foaming agent used in the denture cleaning agent of the present invention (hereinafter also referred to as “component (A)”) is not particularly limited, and is usually used in denture cleaning agents (that is, in water). Those capable of generating carbon dioxide) can be widely used.
発泡剤として、具体的には、炭酸塩、炭酸水素塩、及びこれらの複塩の少なくとも１種（以下、炭酸化合物と表記することもある）と、酸との組み合わせが例示される。炭酸塩としては、特に制限されないが、例えば、炭酸ナトリウム、炭酸カリウム等の炭酸のアルカリ金属塩が挙げられる。炭酸水素塩としては、特に制限されないが、例えば、炭酸水素ナトリウム、炭酸水素カリウム等の炭酸水素のアルカリ金属塩が挙げられる。炭酸塩と炭酸水素塩の複塩としては、特に制限されないが、例えば、セスキ炭酸ナトリウム等が挙げられる。これらの炭酸化合物は、１種単独で使用してもよく、また２種以上を組み合わせて使用してもよい。また、酸としては、特に制限されないが、例えば、クエン酸、酒石酸、フマル酸、リンゴ酸、マレイン酸、グルコン酸、コハク酸、サリチル酸、シュウ酸等の有機酸；リン酸、スルファミン酸等の無機酸等が挙げられる。これらの酸は、１種単独で使用してもよく、また２種以上を組み合わせて使用してもよい。 Specific examples of the blowing agent include a combination of carbonate, hydrogen carbonate, at least one of these double salts (hereinafter sometimes referred to as a carbonate compound) and an acid. Although it does not restrict | limit especially as carbonate, For example, the alkali metal salt of carbonates, such as sodium carbonate and potassium carbonate, is mentioned. Although it does not restrict | limit especially as hydrogencarbonate, For example, alkali metal salts of hydrogencarbonate, such as sodium hydrogencarbonate and potassium hydrogencarbonate, are mentioned. The double salt of carbonate and bicarbonate is not particularly limited, and examples thereof include sodium sesquicarbonate. These carbonic acid compounds may be used alone or in combination of two or more. In addition, the acid is not particularly limited, but for example, citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, gluconic acid, succinic acid, salicylic acid, oxalic acid and other organic acids; phosphoric acid, sulfamic acid and other inorganic acids An acid etc. are mentioned. These acids may be used individually by 1 type, and may be used in combination of 2 or more type.
発泡剤を構成する炭酸化合物として、好ましくは炭酸水素のアルカリ金属塩、更に好ましくは炭酸水素ナトリウムが挙げられる。また、発泡剤を構成する酸として、好ましくは有機酸、更に好ましくはクエン酸が挙げられる。 The carbonate compound constituting the foaming agent is preferably an alkali metal salt of hydrogen carbonate, more preferably sodium hydrogen carbonate. The acid constituting the foaming agent is preferably an organic acid, more preferably citric acid.
発泡剤において、炭酸化合物と酸の比率については、水中で両者が反応して二酸化炭素を発生できることを限度として特に制限されないが、例えば、炭酸化合物１００重量部当たり、酸が通常５０〜１２０重量部、好ましくは６０〜９０重量部、更に好ましくは７０〜８５重量部が挙げられる。 In the foaming agent, the ratio of the carbonic acid compound and the acid is not particularly limited as long as both can react to generate carbon dioxide in water. For example, the acid is usually 50 to 120 parts by weight per 100 parts by weight of the carbonic acid compound. , Preferably 60-90 weight part, More preferably, 70-85 weight part is mentioned.
本発明の義歯洗浄剤における（Ａ）成分の含有量（炭酸化合物と酸の合計量）については、義歯の洗浄時に発泡作用を発揮させ得る限り、特に制限されないが、例えば１０〜７０重量％、好ましくは２０〜６０重量％、更に好ましくは２０〜５０重量％、特に好ましくは３０〜６０重量％が挙げられる。 The content of the component (A) in the denture cleaning agent of the present invention (total amount of carbonic acid compound and acid) is not particularly limited as long as the foaming action can be exerted during cleaning of the denture, but it is, for example, 10 to 70% by weight, Preferably 20 to 60% by weight, more preferably 20 to 50% by weight, and particularly preferably 30 to 60% by weight.
また、本発明の義歯洗浄剤に使用されるアルキルスルホ酢酸塩（以下、「（Ｂ）成分」と表記することもある）としては、特に制限されず、陰イオン性界面活性剤として一般に使用されているものを広く用いることができる。 The alkylsulfoacetate used in the denture cleaning agent of the present invention (hereinafter sometimes referred to as “component (B)”) is not particularly limited and is generally used as an anionic surfactant. Can be widely used.
アルキルスルホ酢酸塩を構成するアルキル基の炭素数については、特に制限されないが、例えば８〜２０、好ましくは１０〜１８、更に好ましくは１２〜１８が挙げられる。また、アルキルスルホ酢酸塩を構成するアルキル基は、直鎖状、分岐状のいずれであってもよいが、好ましくは直鎖状が挙げられる。 Although it does not restrict | limit especially about carbon number of the alkyl group which comprises alkyl sulfoacetate salt, For example, 8-20, Preferably it is 10-18, More preferably, 12-18 is mentioned. In addition, the alkyl group constituting the alkylsulfoacetate may be either linear or branched, preferably linear.
また、アルキルスルホ酢酸塩を構成する塩としては、ナトリウム、カリウム等のアルカリ金属塩が挙げられる。 Examples of the salt constituting the alkyl sulfoacetate include alkali metal salts such as sodium and potassium.
本発明の義歯洗浄剤において、アルキルスルホ酢酸塩の中でも、泡積りを形成させる作用及びその持続性をより一層向上させるという観点から、ラウリルスルホ酢酸塩及びミリスチル酢酸塩が挙げられ、好ましくはラウリルスルホ酢酸塩、より好ましくはラウリルスルホ酢酸アルカリ金属塩、更に好ましくはラウリルスルホ酢酸ナトリウムが挙げられる。ラウリルスルホ酢酸ナトリウムについては、例えば、日光ケミカルズ株式会社等から商業的に入手可能である。 In the denture cleaning agent of the present invention, among alkylsulfoacetates, laurylsulfoacetate and myristylacetate can be mentioned from the viewpoint of further improving the action of forming foam and its sustainability, preferably laurylsulfosulfate. An acetate, More preferably, a lauryl sulfoacetate alkali metal salt, More preferably, a sodium lauryl sulfoacetate is mentioned. Sodium lauryl sulfoacetate is commercially available from, for example, Nikko Chemicals Corporation.
本発明の義歯洗浄剤において、アルキルスルホ酢酸塩は、１種単独で使用してもよく、また２種以上を組み合わせて使用してもよい。 In the denture cleaning agent of the present invention, alkyl sulfoacetates may be used singly or in combination of two or more.
本発明の義歯洗浄剤における（Ｂ）成分の含有量については、特に制限されないが、例えば０．１〜５．０重量％、好ましくは０．２〜２重量％、更に好ましくは０．２５〜１．２５重量％、特に好ましくは０．２５〜１．０重量％が挙げられる。 Although it does not restrict | limit especially about content of (B) component in the denture cleaning agent of this invention, For example, 0.1-5.0 weight%, Preferably it is 0.2-2 weight%, More preferably, it is 0.25-0.25. Examples include 1.25% by weight, particularly preferably 0.25 to 1.0% by weight.
また、本発明の義歯洗浄剤に使用されるアルキル硫酸塩（アルキル硫酸エステル塩）（以下、「（Ｃ）成分」と表記することもある）としては、特に制限されず、陰イオン性界面活性剤として一般に使用されているものを広く用いることができる。 Further, the alkyl sulfate (alkyl sulfate ester salt) (hereinafter sometimes referred to as “component (C)”) used in the denture cleaning agent of the present invention is not particularly limited, and has an anionic surface activity. What is generally used as an agent can be widely used.
アルキル硫酸塩を構成するアルキル基の炭素数については、特に制限されないが、例えば８〜２０、好ましくは１０〜１８、更に好ましくは１２〜１８が挙げられる。また、アルキル硫酸塩を構成するアルキル基は、直鎖状、分岐状のいずれであってもよいが、好ましくは直鎖状が挙げられる。 Although it does not restrict | limit especially about carbon number of the alkyl group which comprises an alkyl sulfate, For example, 8-20, Preferably it is 10-18, More preferably, 12-18 is mentioned. Moreover, the alkyl group constituting the alkyl sulfate may be either linear or branched, and preferably is linear.
また、アルキル硫酸塩を構成する塩としては、ナトリウム、カリウム等のアルカリ金属塩が挙げられる。 Moreover, as a salt which comprises an alkyl sulfate, alkali metal salts, such as sodium and potassium, are mentioned.
アルキル硫酸塩の中でも、泡積りを形成させる作用及びその持続性をより一層向上させるという観点から、ラウリル硫酸塩及びミリスチル硫酸塩が挙げられ、好ましくはラウリル硫酸塩、より好ましくはラウリル硫酸アルカリ金属塩、更に好ましくはラウリル硫酸ナトリウムが挙げられる。ラウリル硫酸ナトリウムについては、例えば、東邦化学工業株式会社、花王株式会社等から商業的に入手可能である。 Among alkyl sulfates, lauryl sulfate and myristyl sulfate can be mentioned from the viewpoint of further improving the action of forming foam and its sustainability, preferably lauryl sulfate, more preferably alkali metal lauryl sulfate. More preferably, sodium lauryl sulfate is used. Sodium lauryl sulfate is commercially available from, for example, Toho Chemical Industry Co., Ltd. and Kao Corporation.
本発明の義歯洗浄剤において、アルキル硫酸塩は、１種単独で使用してもよく、また２種以上を組み合わせて使用してもよい。 In the denture cleaning agent of the present invention, the alkyl sulfate may be used alone or in combination of two or more.
本発明の義歯洗浄剤において、（Ｂ）成分と（Ｃ）成分の比率については、特に制限されないが、泡積りの持続性をより一層向上させるという観点から、（Ｂ）成分１００重量部に対して、（Ｃ）成分が通常１０〜１０００重量部、好ましくは２０〜５００重量部、更に好ましくは５０〜５００重量部、特に好ましくは５０〜２００重量部が挙げられる。 In the denture cleaning agent of the present invention, the ratio of the component (B) and the component (C) is not particularly limited, but from the viewpoint of further improving the sustainability of foaming, it is based on 100 parts by weight of the component (B). The component (C) is usually 10 to 1000 parts by weight, preferably 20 to 500 parts by weight, more preferably 50 to 500 parts by weight, and particularly preferably 50 to 200 parts by weight.
本発明の義歯洗浄剤における（Ｃ）成分の含有量については、特に制限されないが、例えば０．１〜５．０重量％、好ましくは０．２〜２重量％、更に好ましくは０．２５〜１．２５重量％、特に好ましくは０．５〜１．２５重量％が挙げられる。 Although it does not restrict | limit especially about content of (C) component in the denture cleaning agent of this invention, For example, 0.1-5.0 weight%, Preferably it is 0.2-2 weight%, More preferably, it is 0.25- Examples include 1.25% by weight, particularly preferably 0.5 to 1.25% by weight.
本発明の義歯洗浄剤には、更にシリカ（以下、「（Ｄ）成分」と表記することもある）が含まれていてもよい。シリカとは、二酸化ケイ素、又は二酸化ケイ素によって構成される物質の総称である。シリカを含有することにより、泡積りの持続性を維持しながらも、泡積り量を増大させ、且つ義歯洗浄剤を水に投入した後に泡積りが最高量に到達するまでの時間を短縮させることが可能になるため、更に洗浄効果感及び視覚的に得られる満足感を高めることができる。 The denture cleaning agent of the present invention may further contain silica (hereinafter also referred to as “component (D)”). Silica is a general term for silicon dioxide or a substance composed of silicon dioxide. By containing silica, while maintaining the sustainability of foaming, increase the amount of foaming and shorten the time until foaming reaches the maximum amount after the denture cleaning agent is added to water. Therefore, it is possible to further enhance the feeling of cleaning effect and the satisfaction obtained visually.
本発明の義歯洗浄剤に（Ｄ）成分を含有させる場合、（Ｂ）成分と（Ｃ）成分の総量に対する（Ｄ）成分の比率については、特に制限されないが、泡積り量の増大効果、及び泡積りが最高量に到達するまでの時間の短縮効果をより一層顕著に奏させるという観点から、（Ｂ）成分と（Ｃ）成分の総量１００重量部に対して、（Ｄ）成分が通常１０〜４００重量部、好ましくは４０〜２５０重量部、更に好ましくは６０〜２５０重量部が挙げられる。 When the component (D) is contained in the denture cleaning agent of the present invention, the ratio of the component (D) to the total amount of the components (B) and (C) is not particularly limited, but the effect of increasing the amount of foam accumulation, and From the viewpoint of making the effect of shortening the time until foaming reaches the maximum amount more remarkably, the component (D) is usually 10 parts per 100 parts by weight of the total amount of the component (B) and the component (C). -400 weight part, Preferably it is 40-250 weight part, More preferably, 60-250 weight part is mentioned.
本発明の義歯洗浄剤に（Ｄ）成分を含有させる場合、その含有量としては、特に制限されないが、例えば０．１〜１０．０重量％、好ましくは０．１〜６．０重量％、更に好ましくは０．６〜３．７５重量％、特に好ましくは０．９〜３．７５重量％が挙げられる。 When the component (D) is contained in the denture cleaning agent of the present invention, the content is not particularly limited, but is, for example, 0.1 to 10.0% by weight, preferably 0.1 to 6.0% by weight, More preferred is 0.6 to 3.75% by weight, and particularly preferred is 0.9 to 3.75% by weight.
また、本発明の義歯洗浄剤には、油性成分（以下、「（Ｅ）成分」と表記することもある）が含まれていてもよい。油性成分を含有することにより、義歯洗浄後に泡積りを速やかに消失させることが可能になるので、義歯の洗浄後に汚れを含んだ泡が原因で生じる、容器壁面上の輪染みができ難く、且つ洗浄後の義歯及び容器の濯ぎが容易になり、使用者の利便性を高めることができる。 In addition, the denture cleaning agent of the present invention may contain an oily component (hereinafter also referred to as “(E) component”). By containing an oily component, it becomes possible to quickly eliminate foam buildup after denture cleaning, and it is difficult to cause ring stains on the container wall caused by bubbles containing dirt after cleaning of the denture, and The denture after washing and the container can be easily rinsed, and the convenience for the user can be improved.
油性成分としては、特に制限されないが、具体的には、流動パラフィン、スクワラン、マイクロクリスタリンワックス、セレシンワックス、パラフィンワックス、ワセリン等の炭化水素；ヒマシ油、オリーブ油、カカオ油、パーム油、椿油、ヤシ油、木ロウ、ホホバ油、グレープシード油、アボカド油、ダイズ油等の植物油；ミンク油、卵黄油等の動物油脂；ミツロウ、鯨ロウ、ラノリン、カルナウバロウ、キャンデリラロウ等のロウ；ラウリン酸、ミリスチン酸、ステアリン酸、オレイン酸、イソステアリン酸、ベヘニン酸等の脂肪酸；セタノール、ステアリルアルコール、ヘキシルデカノール、オクチルドデカノール、ラウリルアルコール等の高級アルコール；ミリスチン酸イソプロピル、パルミチン酸イソプロピル、ミリスチン酸オクチルドデシル、オレイン酸オクチルドデシル、コレステロールオレート等の脂肪酸エステル等が挙げられる。 Although it does not restrict | limit especially as an oil component, Specifically, hydrocarbons, such as a liquid paraffin, squalane, microcrystalline wax, ceresin wax, paraffin wax, petroleum jelly; castor oil, olive oil, cacao oil, palm oil, coconut oil, palm Vegetable oils such as oil, tree wax, jojoba oil, grape seed oil, avocado oil, soybean oil; animal oils such as mink oil, egg yolk oil; waxes such as beeswax, whale wax, lanolin, carnauba wax, candelilla wax; lauric acid, Fatty acids such as myristic acid, stearic acid, oleic acid, isostearic acid, behenic acid; higher alcohols such as cetanol, stearyl alcohol, hexyl decanol, octyldodecanol, lauryl alcohol; isopropyl myristate, isopropyl palmitate, octyl myristate Rudodeshiru include octyldodecyl oleate, such as a fatty acid ester of cholesterol oleate or the like.
本発明の義歯洗浄剤に（Ｅ）成分を含有させる場合、上記油性成分の中から１種を選択して使用してもよく、また２種以上を組み合わせて使用してもよい。 When the component (E) is contained in the denture cleaning agent of the present invention, one type may be selected from the above oily components, or two or more types may be used in combination.
本発明の義歯洗浄剤に（Ｅ）成分を含有させる場合、（Ｂ）成分と（Ｃ）成分の総量に対する（Ｅ）成分の比率については、特に制限されないが、義歯洗浄後の泡積りの消失効果をより一層顕著に奏させるという観点から、（Ｂ）成分と（Ｃ）成分の総量１００重量部に対して、（Ｅ）成分が通常１０〜２００重量部、好ましくは２０〜１５０重量部、更に好ましくは５０〜１００重量部が挙げられる。 When the denture cleaning agent of the present invention contains the (E) component, the ratio of the (E) component to the total amount of the (B) component and the (C) component is not particularly limited, but the disappearance of foam build-up after the denture cleaning From the viewpoint of producing the effect more remarkably, the component (E) is usually 10 to 200 parts by weight, preferably 20 to 150 parts by weight with respect to 100 parts by weight of the total amount of the components (B) and (C). More preferably, 50-100 weight part is mentioned.
本発明の義歯洗浄剤に（Ｅ）成分を含有させる場合、その含有量としては、特に制限されないが、例えば０．１〜５．０重量％、好ましくは０．５〜１．５重量％が挙げられる。 When (E) component is contained in the denture cleaning agent of the present invention, the content is not particularly limited, but is, for example, 0.1 to 5.0% by weight, preferably 0.5 to 1.5% by weight. Can be mentioned.
また、本発明の義歯洗浄剤には、テルペノイド（以下、「（Ｆ）成分」と表記することもある）が含まれていてもよい。テルペノイドは、上記油性成分と同様に、義歯洗浄後に泡積りを速やかに消失させる作用を示し、使用者の利便性を高めることができる。 Further, the denture cleaning agent of the present invention may contain a terpenoid (hereinafter also referred to as “(F) component”). A terpenoid shows the effect | action which eliminates foaming rapidly after denture washing | cleaning similarly to the said oil-based component, and can improve a user's convenience.
テルペノイドとしては、特に制限されないが、具体的には、メントール、カンフル、シネオール、オイゲノール、シトラール、シトロネラール、ボルネオール、リナロール、ゲラーオール、チモール、スピラントール、ピネン、リモネン等が挙げられる。これらのテルペノイドの中から、１種を選択してもよく、また２種以上を組み合わせて使用してもよい。また、これらのテルペノイドは、精油の形態で使用してもよい。前記テルペノイドを含有する精油としては、例えば、スペアミント油、ペパーミント油、ハッカ油、ベルガモット油、ラベンダー油、ユーカリ油、ローズマリー油、タイム油、ジャスミン油、スペアミント油、ローズ油、ライム油、シダーウッド油、シソ油、マジョラム油、メリッサ油、ゼラニウム油、アニス油、ウイキョウ油、オレンジ油等が挙げられる。 The terpenoid is not particularly limited, and specific examples include menthol, camphor, cineole, eugenol, citral, citronellal, borneol, linalool, gellarol, thymol, spiranthol, pinene, limonene and the like. One of these terpenoids may be selected, or two or more may be used in combination. These terpenoids may be used in the form of essential oils. Examples of the essential oil containing the terpenoid include spearmint oil, peppermint oil, mint oil, bergamot oil, lavender oil, eucalyptus oil, rosemary oil, thyme oil, jasmine oil, spearmint oil, rose oil, lime oil, cedarwood oil. , Perilla oil, marjoram oil, melissa oil, geranium oil, anise oil, fennel oil, orange oil and the like.
これらのテルペノイドの中でも、義歯洗浄後の泡積りの消失効果を一層顕著に奏させるという観点から、好ましくはメントール及びメントールを含む精油が挙げられる。 Among these terpenoids, menthol and essential oil containing menthol are preferably used from the viewpoint of more remarkably exhibiting the effect of eliminating foaming after denture washing.
本発明の義歯洗浄剤に（Ｆ）成分を含有させる場合、（Ｂ）成分と（Ｃ）成分の総量に対する（Ｆ）成分の比率については、特に制限されないが、義歯洗浄後の泡積りの消失効果をより一層顕著に奏させるという観点から、（Ｂ）成分と（Ｃ）成分の総量１００重量部に対して、（Ｆ）成分が通常１０〜２００重量部、好ましくは２０〜１５０重量部、更に好ましくは５０〜１００重量部が挙げられる。 When the component (F) is contained in the denture cleaning agent of the present invention, the ratio of the component (F) to the total amount of the component (B) and the component (C) is not particularly limited, but the disappearance of foam accumulation after the denture cleaning From the viewpoint of producing the effect more remarkably, the component (F) is usually 10 to 200 parts by weight, preferably 20 to 150 parts by weight, with respect to 100 parts by weight of the total amount of the components (B) and (C). More preferably, 50-100 weight part is mentioned.
本発明の義歯洗浄剤に（Ｆ）成分を含有させる場合、その含有量としては、特に制限されないが、例えば０．１〜５．０重量％、好ましくは０．５〜１．５重量％が挙げられる。 When the component (F) is contained in the denture cleaning agent of the present invention, the content is not particularly limited, but is, for example, 0.1 to 5.0% by weight, preferably 0.5 to 1.5% by weight. Can be mentioned.
本発明の義歯洗浄剤には、前記成分の他に、本発明の効果を妨げないことを限度として、必要に応じて、キレート剤、酵素、着色料、甘味料、消臭剤、発泡安定化剤、保存剤、漂白剤、抗菌・殺菌剤、防腐剤、前記（Ｂ）及び（Ｃ）成分以外の界面活性剤、結合剤、滑沢剤、賦形剤、崩壊剤、ｐＨ調整剤、流動化剤等の添加剤を含んでいてもよい。 In the denture cleaning agent of the present invention, in addition to the above components, chelating agents, enzymes, coloring agents, sweeteners, deodorants, foam stabilization, as long as they do not interfere with the effects of the present invention Agent, preservative, bleaching agent, antibacterial / bactericidal agent, antiseptic agent, surfactant other than the components (B) and (C), binder, lubricant, excipient, disintegrant, pH adjuster, fluid An additive such as an agent may be included.
本発明の義歯洗浄剤は、錠剤、粒剤、顆粒剤等の固形状であればよいが、水に投入した際に沈降するタイプの義歯洗浄剤は、水中で生じた二酸化炭素の気泡を義歯に物理的に接触させ、洗浄効果を高めることができるので、前記剤形の中でも最も沈降しやすい錠剤状であることが望ましい。また、錠剤状にする場合には、錠剤１個当たりの重量は、１回の義歯洗浄に必要な量に設定しておくことが望ましい。 The denture cleaning agent of the present invention may be in the form of a solid such as a tablet, granule, granule, etc., but the denture cleaning agent of the type that settles when poured into water dentures carbon dioxide bubbles generated in water. In order to improve the cleaning effect, it is desirable that the tablet form is most easily settled among the dosage forms. Moreover, when making into tablet form, it is desirable to set the weight per tablet to an amount necessary for one denture cleaning.
本発明の義歯洗浄剤を水に加えた状態で洗浄対象となる義歯を共存させると、含有成分の溶解と共に発泡剤による発泡が生じ、前記（Ａ）成分が反応することで生じる二酸化炭素の気泡が義歯に接触することによる物理的な刺激と前記（Ｂ）及び（Ｃ）成分による界面活性作用によって義歯が洗浄される。 When the denture to be cleaned coexists with the denture cleaning agent of the present invention added to water, foaming by the foaming agent occurs along with dissolution of the components, and carbon dioxide bubbles generated by reaction of the component (A) The denture is cleaned by the physical stimulation caused by the contact with the denture and the surface active action by the components (B) and (C).
本発明の義歯洗浄剤を用いて義歯を洗浄する際に使用される水としては、特に制限されないが、水道水、精製水、生理食塩水等が挙げられる。 Although it does not restrict | limit especially as water used when wash | cleaning dentures using the denture cleaning agent of this invention, Tap water, purified water, physiological saline, etc. are mentioned.
本発明の義歯洗浄剤を用いて義歯を洗浄する際には、水に義歯を浸漬した後に本発明の義歯洗浄剤を加えてもよく、また水に本発明の義歯洗浄剤を加えた後に義歯を浸漬させてもよい。 When washing dentures using the denture cleaning agent of the present invention, the denture cleaning agent of the present invention may be added after immersing the denture in water, or after adding the denture cleaning agent of the present invention to water. May be immersed.
また、義歯の洗浄において、本発明の義歯洗浄剤と水との比率は、本発明の義歯洗浄剤の組成、洗浄対象となる義歯の汚れの程度等に応じて適宜設定されるが、例えば、水１００重量部に対して、義歯洗浄剤を通常１〜１０重量部程度、好ましくは１〜５重量部程度とすればよい。より具体的には、１回の義歯の洗浄において、水１００〜２００ｍＬを準備し、これに本発明の義歯洗浄剤１〜２０ｇ、好ましくは１〜１０ｇを加えればよい。 In denture cleaning, the ratio of the denture cleaning agent and water of the present invention is appropriately set according to the composition of the denture cleaning agent of the present invention, the degree of dirt on the denture to be cleaned, etc. The denture cleaning agent is usually about 1 to 10 parts by weight, preferably about 1 to 5 parts by weight with respect to 100 parts by weight of water. More specifically, in one denture cleaning, 100 to 200 mL of water is prepared, and 1 to 20 g, preferably 1 to 10 g of the denture cleaning agent of the present invention may be added thereto.
義歯洗浄時の水温は５〜３０℃程度とすればよい。また、本発明の義歯洗浄剤を加えた水に義歯を浸積する時間は、通常５分〜１２時間程度、好ましくは通常３０分〜８時間程度が挙げられる。 What is necessary is just to make the water temperature at the time of denture washing | cleaning into about 5-30 degreeC. Moreover, the time which a denture is immersed in the water which added the denture cleaning agent of this invention is about 5 minutes-about 12 hours normally, Preferably about 30 minutes-about 8 hours are mentioned.
２．義歯洗浄方法
本発明の義歯洗浄方法は、前記義歯洗浄剤を用いて義歯を洗浄する方法である。即ち、本発明の義歯洗浄方法は、前記義歯洗浄剤を入れた水に、義歯を浸積して義歯を洗浄する方法である。本発明の義歯洗浄方法の具体的実施態様については、前記「１．義歯洗浄剤」の欄に記載の通りである。
2. Denture Cleaning Method The denture cleaning method of the present invention is a method for cleaning a denture using the denture cleaning agent. That is, the denture cleaning method of the present invention is a method for cleaning a denture by immersing the denture in water containing the denture cleaning agent. The specific embodiment of the denture cleaning method of the present invention is as described in the column of “1. Denture cleaning agent”.
以下に実施例を示し、本発明を具体的に説明する。但し、本発明はこれらに限定されない。 Hereinafter, the present invention will be specifically described with reference to examples. However, the present invention is not limited to these.
試験例１
表１に示す組成の錠剤状の義歯洗浄剤を調製した。具体的には、表１に示す成分を混合した組成物を、径２５φの金型を用いて７Ｍｐａで打錠成型することにより、１個当たり２．６５ｇの錠剤状の義歯洗浄剤を調製した。
Test example 1
Tablet-like denture cleaning agents having the compositions shown in Table 1 were prepared. Specifically, 2.65 g of tablet-like denture cleaning agent was prepared by tableting the composition in which the components shown in Table 1 were mixed at 7 Mpa using a mold having a diameter of 25φ. .
得られた各義歯洗浄剤１個を３００ｍＬ容のメスシリンダーに入れた２５℃の水１８０ｍＬに投入し、水の上面に気泡が重なり合って集積することにより形成された気泡層の量（泡積り量）を経時的に計測した。泡積り量の最大値（最大泡積り量）と、泡積り量の最大値に達した時点から１２０秒後の泡積り量を測定し、下記の式に従って、１２０秒後の泡積りの持続性の相対値（％）を算出した。 Each of the obtained denture cleaning agents was put into 180 mL of water at 25 ° C. placed in a 300 mL measuring cylinder, and the amount of bubble layer formed by the accumulation and accumulation of bubbles on the upper surface of water (the amount of foam accumulation) ) Was measured over time. The maximum value of the foam volume (maximum foam volume) and the foam volume after 120 seconds from the time when the maximum value of the foam volume is reached are measured. The relative value (%) of was calculated.
得られた結果を表１に示す。この結果から、ラウリルスルホ酢酸ナトリウム及びラウリル硫酸ナトリウムの何れか一方を欠く義歯洗浄剤（比較例１〜２）では、１２０秒後の泡積りの持続性の相対値が９０％未満となり、泡積りの持続性が悪いが、これらの双方を含む義歯洗浄剤（実施例１〜５）では、泡積りの持続性が大幅に向上することが明らかとなった。とりわけ、ラウリルスルホ酢酸ナトリウム１００重量部当たりラウリル硫酸ナトリウムを２０〜５００重量部の割合で使用した場合には、泡積りの持続性が顕著に向上し、特に、５０〜５００重量部の割合で使用した場合には、１２０秒後の泡積りの持続性の相対値が９５％以上となり、泡積りの持続性が顕著に向上することも確認された。なお、実施例１〜５の義歯洗浄剤の最大泡積り量は、いずれも、高い値を示していた。 The obtained results are shown in Table 1. From this result, in the denture cleaning agent (Comparative Examples 1-2) lacking either one of sodium lauryl sulfoacetate and sodium lauryl sulfate, the relative value of the persistence of foaming after 120 seconds was less than 90%, and the foaming However, in the denture cleaning agents (Examples 1 to 5) containing both of these, it was revealed that the persistence of foaming was greatly improved. In particular, when sodium lauryl sulfate is used at a rate of 20 to 500 parts by weight per 100 parts by weight of sodium lauryl sulfoacetate, the persistence of foaming is remarkably improved, especially at a rate of 50 to 500 parts by weight. In this case, the relative value of the persistence of foaming after 120 seconds was 95% or more, and it was confirmed that the sustainability of foaming was significantly improved. In addition, all the maximum foam amount of the denture cleaning agent of Examples 1-5 showed the high value.
試験例２
試験例１と同様の方法で、表２に示す組成の錠剤状の義歯洗浄剤（１個当たり２．６５ｇ）を調製した。得られた各義歯洗浄剤１個を３００ｍＬ容のメスシリンダーに入れた２５℃の水１８０ｍＬに投入し、泡積り量を経時的に計測し、最大泡積り量及び最大泡積り量に到達するまでの時間を測定した。また、試験例１と同様の方法で、１２０秒後の泡積りの持続性の相対値についても算出した。
Test example 2
In the same manner as in Test Example 1, tablet-like denture cleaning agents (2.65 g per tablet) having the composition shown in Table 2 were prepared. Each obtained denture cleaning agent is put into 180 mL of water at 25 ° C. placed in a 300 mL measuring cylinder, and the amount of foam accumulation is measured over time until the maximum amount of foam accumulation and the maximum amount of foam accumulation are reached. Was measured. Further, the relative value of the persistence of foam accumulation after 120 seconds was also calculated in the same manner as in Test Example 1.
得られた結果を表２に示す。この結果から、シリカ（二酸化ケイ素）を含む実施例６〜１０の義歯洗浄剤では、シリカを含まない実施例３の義歯洗浄剤に比して、泡積りの持続性を維持（１２０秒後の泡積りの持続性の相対値が９５％以上）しながら、最大泡積り量への到達時間が短縮されると共に、最大泡積り量が向上することが明らかとなった。とりわけ、（Ｂ）及び（Ｃ）成分の総量１００重量部当たり（Ｄ）成分を６０〜２５０重量部の割合で使用した場合には、顕著に最大泡積り量への到達時間が短縮されると共に、最大泡積り量が向上した。 The obtained results are shown in Table 2. From this result, in the denture cleaning agents of Examples 6 to 10 containing silica (silicon dioxide), the persistence of foaming was maintained as compared with the denture cleaning agent of Example 3 not containing silica (after 120 seconds). It was clarified that the time to reach the maximum foam accumulation amount was shortened and the maximum foam accumulation amount was improved while the relative value of the persistence of foam accumulation was 95% or more. In particular, when the component (D) is used at a ratio of 60 to 250 parts by weight per 100 parts by weight of the total amount of the components (B) and (C), the time to reach the maximum foam accumulation amount is remarkably shortened. The maximum amount of foam was improved.
試験例３
試験例１と同様の方法で、表３に示す組成の錠剤状の義歯洗浄剤（１個当たり２．６５ｇ）を調製した。得られた各義歯洗浄剤１個を３００ｍＬ容のメスシリンダーに入れた２５℃の水１８０ｍＬに投入し、義歯洗浄剤の投入から４時間後の泡積り量を計測した。
Test example 3
In the same manner as in Test Example 1, tablet-like denture cleaning agents (2.65 g per tablet) having the composition shown in Table 3 were prepared. Each obtained denture cleaning agent was put into 180 mL of water at 25 ° C. placed in a 300 mL measuring cylinder, and the amount of foam accumulated 4 hours after the insertion of the denture cleaning agent was measured.
得られた結果を表３に示す。この結果から、油性成分又はテルペノイドを含む実施例１１〜１４の義歯洗浄剤では、義歯洗浄剤投入４時間後の泡積りを低減できており、汚れを含んだ泡が容器壁面に残り難く、汚れが容器壁面に斑状に残る（輪染みになる）ことを防ぐことができることが明らかとなった。特に、メントールを含む実施例１１及び１２においてはその効果が顕著であった。 The obtained results are shown in Table 3. From this result, in the denture cleaners of Examples 11 to 14 containing the oil component or the terpenoid, the foam accumulation after 4 hours from the insertion of the denture cleaner can be reduced, and it is difficult for bubbles containing dirt to remain on the wall surface of the container. It has become clear that it is possible to prevent the surface of the container from remaining in the form of spots on the container wall surface (becoming a ring stain). In particular, the effects were remarkable in Examples 11 and 12 containing menthol.
処方例１〜６８
表４〜１１に示す処方例に従い、試験例１と同様の方法で錠剤状の義歯洗浄剤（１個当たり２．６５ｇ）を調製した。特に処方例１〜１６において、実施例と同様に「泡積りの持続性」の試験を行なったところ、いずれにおいても上記実施例と同様に優れた効果が認められた。なかでも、アルキルスルホ酢酸塩についてはラウリルスルホ酢酸ナトリウム、またアルキル硫酸塩についてはラウリル硫酸ナトリウムを使用した場合に、特に良好な結果が得られた。また、処方例１７〜２８についても泡積りの持続性に優れていた。
Formulation Examples 1 to 68
According to the prescription example shown to Tables 4-11, the tablet-like denture cleaning agent (2.65g per one) was prepared by the method similar to Test Example 1. In particular, in the prescription examples 1 to 16, when the test of “sustainability of foaming” was performed in the same manner as in the examples, the same excellent effects as those in the above examples were recognized. Particularly good results were obtained when sodium lauryl sulfoacetate was used for the alkylsulfoacetate and sodium laurylsulfate was used for the alkylsulfate. Moreover, the prescription examples 17-28 were excellent in the persistence of foam accumulation.
また、処方例２９〜６８について、実施例と同様に「義歯洗浄剤の投入から４時間後の泡積り量」の計測を行なったところ、いずれにおいても実施例と同様に優れた効果が認められた。特に処方例４１〜６４について、（Ｂ）成分と（Ｃ）成分の総量１００重量部に対して、テルペノイドを１０〜２００重量部（好ましくは２０〜１５０重量部）含有させた場合（二酸化ケイ素を含有しなくても）、義歯洗浄後の泡積りの消失効果を高めることができ、なかでも、テルペノイドとしてメントールを含む処方例４１〜４８についての効果が高かった。 Moreover, about the prescription examples 29-68, when the measurement of "the amount of foam accumulation after 4 hours after injection | throwing-in of a denture cleaning agent" was performed similarly to an Example, the effect excellent in all was recognized similarly to an Example. It was. In particular, with regard to Formulation Examples 41 to 64, when 10 to 200 parts by weight (preferably 20 to 150 parts by weight) of terpenoid is contained with respect to 100 parts by weight of the total amount of component (B) and component (C) (silicon dioxide is added). Even if it does not contain), the effect of disappearance of foaming after denture cleaning can be enhanced, and among them, the effects of Formulation Examples 41 to 48 containing menthol as a terpenoid were high.
Claims (4)
In water containing the denture cleansing composition according to any one of claims 1 to 3, characterized in that immersing the denture, denture cleaning method.
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| US3962107A (en) * | 1974-06-24 | 1976-06-08 | Johnson & Johnson | Enzyme-containing denture cleanser tablet |
| AU510235B2 (en) * | 1975-12-22 | 1980-06-19 | Johnson & Johnson | Denture cleanser tablet |
| JPS52151111A (en) * | 1976-06-08 | 1977-12-15 | Nippon Oil & Fats Co Ltd | Pentaerythritol derivatives, their preparation and cosmetics and ant-foaming agents containing same |
| DE3812693A1 (en) * | 1988-03-19 | 1989-09-28 | Reckitt Gmbh | CLEANING TABLET FOR DENTAL PROSTHESIS |
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