JP6051786B2 - 医療用三層チューブおよび三層チューブの押出成形方法 - Google Patents
医療用三層チューブおよび三層チューブの押出成形方法 Download PDFInfo
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- JP6051786B2 JP6051786B2 JP2012242659A JP2012242659A JP6051786B2 JP 6051786 B2 JP6051786 B2 JP 6051786B2 JP 2012242659 A JP2012242659 A JP 2012242659A JP 2012242659 A JP2012242659 A JP 2012242659A JP 6051786 B2 JP6051786 B2 JP 6051786B2
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- 239000000463 material Substances 0.000 claims description 85
- 229920002857 polybutadiene Polymers 0.000 claims description 69
- 239000005062 Polybutadiene Substances 0.000 claims description 68
- 229920002803 thermoplastic polyurethane Polymers 0.000 claims description 34
- 239000004433 Thermoplastic polyurethane Substances 0.000 claims description 33
- 239000011347 resin Substances 0.000 claims description 12
- 229920005989 resin Polymers 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 10
- 239000000853 adhesive Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 238000003892 spreading Methods 0.000 claims description 3
- 239000010410 layer Substances 0.000 description 202
- 239000004800 polyvinyl chloride Substances 0.000 description 22
- 229920000915 polyvinyl chloride Polymers 0.000 description 22
- 238000001802 infusion Methods 0.000 description 16
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- 239000004014 plasticizer Substances 0.000 description 10
- 239000003814 drug Substances 0.000 description 9
- 239000002356 single layer Substances 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000004698 Polyethylene Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 230000032798 delamination Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000000470 constituent Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000004808 2-ethylhexylester Substances 0.000 description 1
- 239000004803 Di-2ethylhexylphthalate Substances 0.000 description 1
- KRADHMIOFJQKEZ-UHFFFAOYSA-N Tri-2-ethylhexyl trimellitate Chemical compound CCCCC(CC)COC(=O)C1=CC=C(C(=O)OCC(CC)CCCC)C(C(=O)OCC(CC)CCCC)=C1 KRADHMIOFJQKEZ-UHFFFAOYSA-N 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
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- 238000010828 elution Methods 0.000 description 1
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- 238000013213 extrapolation Methods 0.000 description 1
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- 230000005484 gravity Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
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- 230000000704 physical effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920002743 polystyrene-poly(ethylene-ethylene/propylene) block-polystyrene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003763 resistance to breakage Effects 0.000 description 1
- 229920000468 styrene butadiene styrene block copolymer Polymers 0.000 description 1
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229920002725 thermoplastic elastomer Polymers 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Description
また、内外層それぞれに要求特性において好適な素材を用いつつ、耐破断性その他の要求特性を持たせる結果内層または外層の少なくとも一方とは相溶しない素材を中間層の構成素材として用いる場合であっても、医療用に好適なチューブを得ることができる。
101 輸液バッグ
102 チューブ
103 静脈針
104 点滴筒
105 クランプ
121 内層
122 中間層
123 外層
S スタンド
C 患者
Claims (4)
- 内層がポリブタジエン、外層がポリブタジエンであり、
内層と外層との間に、ポリブタジエンと相溶する素材およびポリブタジエンと相溶しない耐破断性素材の混合樹脂であり、内層および外層との局所的な溶着箇所が全域にわたったメカニカルロックが形成された中間層を設け、
内層および中間層ならびに外層および中間層が合着した耐破断性素材として成型したことを特徴とする医療用三層チューブ。 - 中間層は、ポリブタジエンと熱可塑性ポリウレタンの混合樹脂であり、ポリブタジエン:熱可塑性ポリウレタン=25wt%:75wt%〜60wt%:40wt%の配合比、肉厚を、全体の肉厚の15%〜50%としたことを特徴とする請求項1に記載の医療用三層チューブ。
- 医療用三層チューブを押出成形する方法であって、
内層が薬剤非吸着性と可塑剤非溶出性とを備える素材、外層がコネクタその他の医療用接続部品に対する易接着性素材ないし易接合性素材であり、
中間層に、内層素材と外層素材との何れにも相溶する素材、および、内層素材と外層素材との少なくとも一方には相溶しない素材であって耐破断性を発現する素材を用い、
当該二素材を加熱により混合して溶融し、
押出成形により、中間層領域で当該二素材同士によるメカニカルロックを形成させつつ、内層素材および外層素材との局所的な溶着箇所を全域にわたらせ、全体として内層および中間層ならびに外層および中間層が合着した三層チューブを得ることを特徴とする医療用三層チューブの押出成形方法。 - 内層素材および外層素材をポリブタジエン、中間層をポリブタジエンと熱可塑性ポリウレタンとの混合樹脂とし、中間層を、ポリブタジエン:熱可塑性ポリウレタン=25wt%:75wt%〜60wt%:40wt%の配合比、肉厚を、全体の肉厚の15%〜50%としたことを特徴とする請求項3に記載の医療用三層チューブの押出成形方法。
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JP2013116320A JP2013116320A (ja) | 2013-06-13 |
JP6051786B2 true JP6051786B2 (ja) | 2016-12-27 |
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Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101513531B1 (ko) * | 2014-02-04 | 2015-04-21 | 한국생산기술연구원 | 압출선재 및 그 제조방법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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NL126099C (ja) * | 1964-11-02 | 1900-01-01 | ||
US4707389A (en) * | 1983-09-30 | 1987-11-17 | Baxter Travenol Laboratories, Inc. | Multilayer tube, assembly and method |
JPH06171040A (ja) * | 1992-12-09 | 1994-06-21 | Terumo Corp | ポリオレフィン系医療容器用基材 |
JP2001269403A (ja) * | 2000-03-27 | 2001-10-02 | Kawasumi Lab Inc | 医療用チューブ |
JP4995471B2 (ja) * | 2006-03-10 | 2012-08-08 | テルモ株式会社 | 医療用チューブ |
JP4855145B2 (ja) * | 2006-05-24 | 2012-01-18 | テルモ株式会社 | 医療器の製造方法 |
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