JP6047207B2 - 生体分子の部位活性化複合体形成方法及び材料 - Google Patents
生体分子の部位活性化複合体形成方法及び材料 Download PDFInfo
- Publication number
- JP6047207B2 JP6047207B2 JP2015146637A JP2015146637A JP6047207B2 JP 6047207 B2 JP6047207 B2 JP 6047207B2 JP 2015146637 A JP2015146637 A JP 2015146637A JP 2015146637 A JP2015146637 A JP 2015146637A JP 6047207 B2 JP6047207 B2 JP 6047207B2
- Authority
- JP
- Japan
- Prior art keywords
- plant
- composition
- polyphenol
- hydrogen peroxide
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims description 78
- 239000000463 material Substances 0.000 title description 44
- 241000196324 Embryophyta Species 0.000 claims description 160
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 141
- 239000000203 mixture Substances 0.000 claims description 136
- 235000013824 polyphenols Nutrition 0.000 claims description 127
- 150000008442 polyphenolic compounds Chemical class 0.000 claims description 115
- 102000004190 Enzymes Human genes 0.000 claims description 72
- 108090000790 Enzymes Proteins 0.000 claims description 72
- 239000007800 oxidant agent Substances 0.000 claims description 53
- 239000003642 reactive oxygen metabolite Substances 0.000 claims description 49
- 239000003054 catalyst Substances 0.000 claims description 32
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 27
- 241000894006 Bacteria Species 0.000 claims description 21
- 238000004519 manufacturing process Methods 0.000 claims description 20
- 230000006378 damage Effects 0.000 claims description 18
- 206010012735 Diarrhoea Diseases 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
- 239000003638 chemical reducing agent Substances 0.000 claims description 14
- 239000000284 extract Substances 0.000 claims description 14
- 235000006468 Thea sinensis Nutrition 0.000 claims description 11
- MJKVTPMWOKAVMS-UHFFFAOYSA-N 3-hydroxy-1-benzopyran-2-one Chemical compound C1=CC=C2OC(=O)C(O)=CC2=C1 MJKVTPMWOKAVMS-UHFFFAOYSA-N 0.000 claims description 9
- 235000014360 Punica granatum Nutrition 0.000 claims description 9
- 229920001864 tannin Polymers 0.000 claims description 9
- 235000018553 tannin Nutrition 0.000 claims description 9
- 239000001648 tannin Substances 0.000 claims description 9
- 210000002249 digestive system Anatomy 0.000 claims description 8
- 229930003935 flavonoid Natural products 0.000 claims description 7
- 150000002215 flavonoids Chemical class 0.000 claims description 7
- 235000017173 flavonoids Nutrition 0.000 claims description 7
- 229920005610 lignin Polymers 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- 230000000415 inactivating effect Effects 0.000 claims description 6
- BHDAXLOEFWJKTL-UHFFFAOYSA-L dipotassium;carboxylatooxy carbonate Chemical compound [K+].[K+].[O-]C(=O)OOC([O-])=O BHDAXLOEFWJKTL-UHFFFAOYSA-L 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 5
- 239000004599 antimicrobial Substances 0.000 claims description 4
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 claims description 4
- 229940045872 sodium percarbonate Drugs 0.000 claims description 4
- 230000029663 wound healing Effects 0.000 claims description 4
- 229940078916 carbamide peroxide Drugs 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 2
- 241000219991 Lythraceae Species 0.000 claims 4
- 244000052707 Camellia sinensis Species 0.000 claims 3
- 239000012141 concentrate Substances 0.000 claims 1
- 208000019836 digestive system infectious disease Diseases 0.000 claims 1
- 230000002000 scavenging effect Effects 0.000 claims 1
- 244000052769 pathogen Species 0.000 description 72
- 229940088598 enzyme Drugs 0.000 description 70
- 229920001222 biopolymer Polymers 0.000 description 68
- 241001465754 Metazoa Species 0.000 description 66
- 210000001519 tissue Anatomy 0.000 description 58
- 230000001717 pathogenic effect Effects 0.000 description 52
- AZQWKYJCGOJGHM-UHFFFAOYSA-N para-benzoquinone Natural products O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 51
- 239000000243 solution Substances 0.000 description 50
- 238000006243 chemical reaction Methods 0.000 description 48
- 235000018102 proteins Nutrition 0.000 description 45
- 102000004169 proteins and genes Human genes 0.000 description 45
- 108090000623 proteins and genes Proteins 0.000 description 45
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 40
- 230000001590 oxidative effect Effects 0.000 description 33
- 150000001875 compounds Chemical class 0.000 description 30
- 230000000694 effects Effects 0.000 description 29
- 238000001994 activation Methods 0.000 description 28
- 230000004913 activation Effects 0.000 description 27
- 239000000126 substance Substances 0.000 description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 25
- 210000004027 cell Anatomy 0.000 description 23
- 208000027418 Wounds and injury Diseases 0.000 description 22
- 230000027455 binding Effects 0.000 description 22
- 230000000845 anti-microbial effect Effects 0.000 description 21
- 206010052428 Wound Diseases 0.000 description 20
- 230000000844 anti-bacterial effect Effects 0.000 description 20
- 238000007254 oxidation reaction Methods 0.000 description 19
- 239000000758 substrate Substances 0.000 description 19
- 102000004316 Oxidoreductases Human genes 0.000 description 18
- 108090000854 Oxidoreductases Proteins 0.000 description 18
- 238000002474 experimental method Methods 0.000 description 18
- 238000009472 formulation Methods 0.000 description 18
- 102000003992 Peroxidases Human genes 0.000 description 16
- 238000004132 cross linking Methods 0.000 description 15
- 239000012530 fluid Substances 0.000 description 15
- 229920002521 macromolecule Polymers 0.000 description 15
- 102000003425 Tyrosinase Human genes 0.000 description 14
- 108060008724 Tyrosinase Proteins 0.000 description 14
- 150000004676 glycans Chemical class 0.000 description 14
- 230000003647 oxidation Effects 0.000 description 14
- 229920001282 polysaccharide Polymers 0.000 description 14
- 239000005017 polysaccharide Substances 0.000 description 14
- 239000000843 powder Substances 0.000 description 14
- 241000700605 Viruses Species 0.000 description 13
- 230000001965 increasing effect Effects 0.000 description 13
- 230000008569 process Effects 0.000 description 13
- -1 quinone compound Chemical class 0.000 description 13
- 150000004053 quinones Chemical class 0.000 description 13
- 230000009471 action Effects 0.000 description 12
- 208000015181 infectious disease Diseases 0.000 description 12
- 230000007246 mechanism Effects 0.000 description 12
- 230000000813 microbial effect Effects 0.000 description 12
- 229940072417 peroxidase Drugs 0.000 description 12
- 108040007629 peroxidase activity proteins Proteins 0.000 description 12
- 150000003254 radicals Chemical class 0.000 description 12
- 230000004044 response Effects 0.000 description 12
- 230000015572 biosynthetic process Effects 0.000 description 11
- 238000010790 dilution Methods 0.000 description 11
- 239000012895 dilution Substances 0.000 description 11
- 244000005700 microbiome Species 0.000 description 11
- 102000030523 Catechol oxidase Human genes 0.000 description 10
- 108010031396 Catechol oxidase Proteins 0.000 description 10
- 244000269722 Thea sinensis Species 0.000 description 10
- 230000004888 barrier function Effects 0.000 description 9
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 9
- 239000001301 oxygen Substances 0.000 description 9
- 229910052760 oxygen Inorganic materials 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 102000016938 Catalase Human genes 0.000 description 8
- 108010053835 Catalase Proteins 0.000 description 8
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 8
- 230000007613 environmental effect Effects 0.000 description 8
- 230000002255 enzymatic effect Effects 0.000 description 8
- 238000000605 extraction Methods 0.000 description 8
- 235000013305 food Nutrition 0.000 description 8
- 150000002989 phenols Chemical class 0.000 description 8
- 230000009919 sequestration Effects 0.000 description 8
- 230000001954 sterilising effect Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241000233866 Fungi Species 0.000 description 7
- 150000001413 amino acids Chemical class 0.000 description 7
- 230000003115 biocidal effect Effects 0.000 description 7
- 230000003197 catalytic effect Effects 0.000 description 7
- 230000001413 cellular effect Effects 0.000 description 7
- 230000012010 growth Effects 0.000 description 7
- 239000001257 hydrogen Substances 0.000 description 7
- 230000002779 inactivation Effects 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 239000002243 precursor Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 241000282887 Suidae Species 0.000 description 6
- 230000002776 aggregation Effects 0.000 description 6
- 238000004220 aggregation Methods 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 230000028993 immune response Effects 0.000 description 6
- 238000001556 precipitation Methods 0.000 description 6
- 125000004151 quinonyl group Chemical group 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 238000004659 sterilization and disinfection Methods 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 230000009885 systemic effect Effects 0.000 description 6
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 5
- 244000294611 Punica granatum Species 0.000 description 5
- 230000003213 activating effect Effects 0.000 description 5
- 235000021120 animal protein Nutrition 0.000 description 5
- 229940088710 antibiotic agent Drugs 0.000 description 5
- 230000000975 bioactive effect Effects 0.000 description 5
- 229940098773 bovine serum albumin Drugs 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 239000000417 fungicide Substances 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 230000009545 invasion Effects 0.000 description 5
- 230000037353 metabolic pathway Effects 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000003755 preservative agent Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- 238000006722 reduction reaction Methods 0.000 description 5
- 241000894007 species Species 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- 238000012384 transportation and delivery Methods 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 4
- 108700020962 Peroxidase Proteins 0.000 description 4
- 210000004102 animal cell Anatomy 0.000 description 4
- 244000052616 bacterial pathogen Species 0.000 description 4
- 239000012620 biological material Substances 0.000 description 4
- 230000005540 biological transmission Effects 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 230000007123 defense Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 230000036571 hydration Effects 0.000 description 4
- 238000006703 hydration reaction Methods 0.000 description 4
- 210000000987 immune system Anatomy 0.000 description 4
- 230000000977 initiatory effect Effects 0.000 description 4
- 210000005007 innate immune system Anatomy 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 102000005962 receptors Human genes 0.000 description 4
- 108020003175 receptors Proteins 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 150000003384 small molecules Chemical class 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 102000018697 Membrane Proteins Human genes 0.000 description 3
- 108010052285 Membrane Proteins Proteins 0.000 description 3
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000008272 agar Substances 0.000 description 3
- 229930013930 alkaloid Natural products 0.000 description 3
- 235000011399 aloe vera Nutrition 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 235000019606 astringent taste Nutrition 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000000645 desinfectant Substances 0.000 description 3
- 239000003599 detergent Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 210000001035 gastrointestinal tract Anatomy 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229940094952 green tea extract Drugs 0.000 description 3
- 235000020688 green tea extract Nutrition 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000003100 immobilizing effect Effects 0.000 description 3
- 230000001976 improved effect Effects 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000009149 molecular binding Effects 0.000 description 3
- 239000000178 monomer Substances 0.000 description 3
- 230000004899 motility Effects 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 239000000419 plant extract Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 2
- 244000144927 Aloe barbadensis Species 0.000 description 2
- 235000002961 Aloe barbadensis Nutrition 0.000 description 2
- 108010017384 Blood Proteins Proteins 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 2
- 206010006326 Breath odour Diseases 0.000 description 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- 239000004971 Cross linker Substances 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 241000206602 Eukaryota Species 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 101000609762 Gallus gallus Ovalbumin Proteins 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 108010015776 Glucose oxidase Proteins 0.000 description 2
- 239000004366 Glucose oxidase Substances 0.000 description 2
- 208000032139 Halitosis Diseases 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 108010029541 Laccase Proteins 0.000 description 2
- 206010024769 Local reaction Diseases 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 244000061176 Nicotiana tabacum Species 0.000 description 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
- 108010058846 Ovalbumin Proteins 0.000 description 2
- 102000029797 Prion Human genes 0.000 description 2
- 108091000054 Prion Proteins 0.000 description 2
- 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 description 2
- 102100026858 Protein-lysine 6-oxidase Human genes 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 208000002847 Surgical Wound Diseases 0.000 description 2
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 230000037037 animal physiology Effects 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 230000002924 anti-infective effect Effects 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000003793 antidiarrheal agent Substances 0.000 description 2
- 229940125714 antidiarrheal agent Drugs 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 238000005842 biochemical reaction Methods 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
- 235000005487 catechin Nutrition 0.000 description 2
- 210000003850 cellular structure Anatomy 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 208000019902 chronic diarrheal disease Diseases 0.000 description 2
- 229950001002 cianidanol Drugs 0.000 description 2
- 239000012459 cleaning agent Substances 0.000 description 2
- 239000000701 coagulant Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 239000000356 contaminant Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 231100000517 death Toxicity 0.000 description 2
- 230000008260 defense mechanism Effects 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 238000002716 delivery method Methods 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 230000000741 diarrhetic effect Effects 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 235000014103 egg white Nutrition 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 230000029142 excretion Effects 0.000 description 2
- 210000000416 exudates and transudate Anatomy 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 235000021472 generally recognized as safe Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 229940116332 glucose oxidase Drugs 0.000 description 2
- 235000019420 glucose oxidase Nutrition 0.000 description 2
- 238000011194 good manufacturing practice Methods 0.000 description 2
- 238000003306 harvesting Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- DLINORNFHVEIFE-UHFFFAOYSA-N hydrogen peroxide;zinc Chemical compound [Zn].OO DLINORNFHVEIFE-UHFFFAOYSA-N 0.000 description 2
- 230000002458 infectious effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000003999 initiator Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 239000006193 liquid solution Substances 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 210000004779 membrane envelope Anatomy 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 230000003278 mimic effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 210000003097 mucus Anatomy 0.000 description 2
- 230000000269 nucleophilic effect Effects 0.000 description 2
- 235000015816 nutrient absorption Nutrition 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 230000006461 physiological response Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 210000005000 reproductive tract Anatomy 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- 230000000087 stabilizing effect Effects 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 239000003106 tissue adhesive Substances 0.000 description 2
- 229940075469 tissue adhesives Drugs 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 210000001635 urinary tract Anatomy 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 229940105296 zinc peroxide Drugs 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- WOAHJDHKFWSLKE-UHFFFAOYSA-N 1,2-benzoquinone Chemical compound O=C1C=CC=CC1=O WOAHJDHKFWSLKE-UHFFFAOYSA-N 0.000 description 1
- UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 1
- XSVSPKKXQGNHMD-UHFFFAOYSA-N 5-bromo-3-methyl-1,2-thiazole Chemical compound CC=1C=C(Br)SN=1 XSVSPKKXQGNHMD-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 235000012871 Arctostaphylos uva ursi Nutrition 0.000 description 1
- 208000035404 Autolysis Diseases 0.000 description 1
- 108010077805 Bacterial Proteins Proteins 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102100037084 C4b-binding protein alpha chain Human genes 0.000 description 1
- 239000004343 Calcium peroxide Substances 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- 241000206575 Chondrus crispus Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 244000018436 Coriandrum sativum Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 108700033069 EC 1.97.-.- Proteins 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000237858 Gastropoda Species 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061217 Infestation Diseases 0.000 description 1
- 208000032984 Intraoperative Complications Diseases 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- 102100038609 Lactoperoxidase Human genes 0.000 description 1
- 108010023244 Lactoperoxidase Proteins 0.000 description 1
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 description 1
- 102000003896 Myeloperoxidases Human genes 0.000 description 1
- 108090000235 Myeloperoxidases Proteins 0.000 description 1
- 241000237536 Mytilus edulis Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000237502 Ostreidae Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 101710136733 Proline-rich protein Proteins 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 244000088415 Raphanus sativus Species 0.000 description 1
- 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 108091007187 Reductases Proteins 0.000 description 1
- 241000533293 Sesbania emerus Species 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000694058 Stenocereus thurberi Species 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 244000003892 Vaccinium erythrocarpum Species 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 210000005006 adaptive immune system Anatomy 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000004931 aggregating effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000013566 allergen Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000000507 anthelmentic effect Effects 0.000 description 1
- 239000000921 anthelmintic agent Substances 0.000 description 1
- 229940124339 anthelmintic agent Drugs 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000002519 antifouling agent Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000011641 antimicrobial peptide production Effects 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 235000021053 average weight gain Nutrition 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 239000000227 bioadhesive Substances 0.000 description 1
- 230000032770 biofilm formation Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- 235000020279 black tea Nutrition 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 1
- 235000019402 calcium peroxide Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 230000002925 chemical effect Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 210000000991 chicken egg Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 229920002770 condensed tannin Polymers 0.000 description 1
- 230000001268 conjugating effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 238000009109 curative therapy Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000004040 defense response to microbe Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical group [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 description 1
- 235000019621 digestibility Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 229910001882 dioxygen Inorganic materials 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009510 drug design Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000018927 edible plant Nutrition 0.000 description 1
- 230000002828 effect on organs or tissue Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 210000003278 egg shell Anatomy 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 244000000015 environmental pathogen Species 0.000 description 1
- 230000006353 environmental stress Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000003979 eosinophil Anatomy 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Chemical group O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 239000008394 flocculating agent Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000021022 fresh fruits Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 239000003673 groundwater Substances 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 230000010243 gut motility Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000002874 hemostatic agent Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 244000038280 herbivores Species 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 229920000140 heteropolymer Polymers 0.000 description 1
- 238000010562 histological examination Methods 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 230000005745 host immune response Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 229920001461 hydrolysable tannin Polymers 0.000 description 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000012642 immune effector Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000008235 industrial water Substances 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000009878 intermolecular interaction Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000008863 intramolecular interaction Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000003410 keratolytic agent Substances 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 229940057428 lactoperoxidase Drugs 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 239000001366 lippia graveolens leaf Substances 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 229960004995 magnesium peroxide Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013384 milk substitute Nutrition 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 230000004677 mucosal permeability Effects 0.000 description 1
- 235000020638 mussel Nutrition 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 239000002773 nucleotide Chemical group 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000006916 nutrient agar Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000019645 odor Nutrition 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000000082 organ preservation Substances 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 150000001451 organic peroxides Chemical class 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 229940092253 ovalbumin Drugs 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 125000004430 oxygen atom Chemical group O* 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 235000020636 oyster Nutrition 0.000 description 1
- WURFKUQACINBSI-UHFFFAOYSA-M ozonide Chemical compound [O]O[O-] WURFKUQACINBSI-UHFFFAOYSA-M 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 231100000255 pathogenic effect Toxicity 0.000 description 1
- 230000007918 pathogenicity Effects 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 125000001474 phenylpropanoid group Chemical group 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 230000008654 plant damage Effects 0.000 description 1
- 230000037039 plant physiology Effects 0.000 description 1
- 125000003367 polycyclic group Chemical group 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 239000005297 pyrex Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000007348 radical reaction Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000012048 reactive intermediate Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000003938 response to stress Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 239000003229 sclerosing agent Substances 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000028043 self proteolysis Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 229940001593 sodium carbonate Drugs 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 235000021012 strawberries Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 229920005613 synthetic organic polymer Polymers 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 235000013616 tea Nutrition 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 108010057919 tobacco anionic peroxidase Proteins 0.000 description 1
- 230000008791 toxic response Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/22—Anacardiaceae (Sumac family), e.g. smoketree, sumac or poison oak
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
- C07G1/00—Lignin; Lignin derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Inorganic Chemistry (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Animal Husbandry (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
Description
本特許出願は、2009年3月4日に出願された、「反応性植物性収斂剤(REACTIVE PLANT BASED ASTRINGENT)」というタイトルの特許文献1の優先権を主張するものであり、これは、あらゆる目的のためにその全体が参照により本明細書に組み込まれる。
精製した粉末ウシ血清アルブミン(BSA)の3つの試料を、水溶液中に調製した。試料#1はBSAのみを含んでいた。試料#2は、BSAとポリフェノールオキシダーゼを含んでいた。試料#3は、BSAとポリフェノールオキシダーゼと過酸化水素とを含んでいた。30分後、分光光度計で測定したときに、各試料は、同様の定常状態の濁りを示した。五倍子由来のポリフェノール(タンニン)の水溶液をこれらの試料の各々に添加した。1時間後、試料#1は、目に見える変化をほとんど示さなかった。試料#2は、粒径の増加による濁りの増加を示し、わずかなタンパク質凝固を示唆した。試料#3は、試験チューブの底に大量の沈殿があることと、濁りがないこととを示し、ポリフェノールと活性酸素種源との酵素的反応によって、タンパク質凝固の大幅な増加を達成することができることを示した。
五倍子と過酸化水素の溶液を(1)水で再構成した粉末ニワトリ卵白(粉末卵白の製造において用いられる乾燥プロセスは酵素を変性させる)を含むチューブ及び(2)水に新鮮ニワトリ卵アルブミンを含むチューブに添加した。はるかに大量の沈殿が新鮮ニワトリ卵アルブミン試料で観察され、植物ポリフェノールを動物起源の酵素で触媒して、植物創傷で示されるキノン形成と一致するタンパク質結合を増大させることができることが示された。
製剤Aを下記の方法を用いて調製した。1グラムの市販の緑茶粉末を、1リットルの脱イオン水を含む1リットルのPyrexビーカー中に調製し、室温で6時間抽出した。この溶液に35%食品等級過酸化水素を添加し、4時間静置した後、2ミクロンのメッシュ媒体またはフィルターに通して濾過した。得られた原液を18Mohm水で1000:1、200:1、及び100:1に希釈した。15mlの希釈溶液を、107個の野生株大腸菌(E.coli)培養物を含む等量の培養溶液(水対照)に添加し、37℃でインキュベートした。2時間、4時間、6時間、及び8時間で、各試験シリーズからの試料を寒天プレート上に満たしてインキュベートし、手作業でコロニーカウントを行なった。100:1の試料は4時間で100%の殺菌を達成し、200:1の試料は6時間で100%の殺菌を達成し、1000:1の試料は静菌的でしかなかった。これにより、原材料とエネルギー入力を非常に少なくして殺菌能力の高い植物性組成物を製造する可能性が示されている。
野生株大腸菌培養物を3つの試料に添加した。試料Aは、水に25ppmの過酸化水素を含んでいた。試料Bは、同じ25ppmの過酸化水素の割合になるまで希釈した製剤Aの溶液を含んでいた。試料Cは、製剤Aと同じ濃度の緑茶抽出物を含むが、過酸化水素を含まない溶液を含んでいた。過酸化水素(試料A)中の細菌個体群は、初めは減少したが、16時間後には目に見える濁りの増加を示し始め、抗微生物能の枯渇を示唆した。緑茶抽出物のみ(試料C)では、目に見える抗微生物活性がほとんど示されなかった。製剤A(試料B)は、殺菌し続けて、3日後に逆戻りを示さず、100%の殺菌及び/または抗微生物効果の増大を示した。これにより、緑茶抽出物と過酸化水素の組合せがもたらした殺菌性能の顕著な増加が示されている。
試料#2は、上記の製剤Aを用いて事前調製した溶液であり、事前調製した試料#1と同じポリフェノール濃度を再現するように希釈した溶液であった。試料#3では、ポリフェノールと希釈過酸化水素を組み合わせて、試料#2と同じポリフェノール対過酸化水素比を達成した。各試料の連続希釈を調製し、24時間放置した。105個/mlの野生株大腸菌を含む溶液を各試料に添加し、その後、これらをインキュベートし、目視によるコロニーカウントのために寒天上にすべてプレーティングした。事前調製した試料#2のポリフェノール−酸化性物質溶液は、試料#3希釈液中よりもかなり低い濃度で効果的に殺菌し続けた。これにより、ポリフェノール基質−酸化性物質組成物が、希釈前に(活性のあるオキシドレダクターゼまたは他の還元作用物質の非存在下で)高濃度で産生された場合、低い濃度での性能が高まることが示され、安定性を改善するための分子間力による隔離という概念が裏付けられた。
以下は、製剤Bの調製方法であり、ポリフェノール基質抽出プロセスを説明したものである。30グラムの乾燥したザクロの皮を用いる。ザクロの皮は、150℃で1時間乾燥させ、すりつぶして細かい粉末状にし、80℃で20分間加熱した10リットルの脱イオン水と合わせた後、室温まで2時間冷却したものであった。35%食品等級過酸化水素を添加し、6時間静置した後、5ミクロンの媒体に通して濾過した。ポリフェノールとの過剰反応を防ぐために、添加された過酸化水素溶液は、溶液への添加後、溶液中10%未満とした。得られた溶液を水で連続希釈したものを107〜108個の細菌の培養液に添加した。得られた溶液を24時間インキュベートし、濁りを目視観察した。表1に示すように、濁り(+濁りあり、−濁りなし)は生菌を示す。
実験用マウス表面のメスによる左右対称の創傷に製剤Aの200:1希釈物を適用すると、生理食塩水対照または抗生物質軟膏で処置した創傷の約3分の1において創傷閉鎖が示された。
製剤Aの200:1希釈物に浸漬した綿パッドを、炎症を起こした口腔粘膜に10分間当てた。3人のボランティアのうち、全員が1時間以内に疼痛や腫脹の顕著な軽減を経験した。感染は2人において完全に消失しており、粘膜組織に対する抗炎症能と抗感染能が示された。
現在頻回下痢または慢性下痢の症状を有する及び過去に頻回下痢または慢性下痢の症状の既往歴がある10人のヒトボランティアに対して、製剤Bを水250mlに40:1希釈したものを5ml、5日間投与した。9人が、1週間以上の間、不快感や症状の顕著な軽減を示した。
製剤A及び製剤Bの100:1希釈物0.5mlを、表面に大腸菌が植菌されたヒツジ血液注入寒天プレート上の穴の開いたウェルに導入した。ウェルの周囲には、PP−O複合体を透過させない不透明な架橋された血液タンパク質の領域が素早く形成され、ウェルの周辺に細菌抑制帯は示されなかった。それに比べて、血液タンパク質を含まない最小栄養寒天では、培地中へのPP−Oの拡散を示す顕著な抑制帯が示された。これにより、毒性ポテンシャルの低下を裏付ける、組成物の組織透過の低さが示された。
商品生産農場の5日齢のアジア産ランドレース雑種ブタを試験被験体13頭と対照被験体3頭に分けて、全頭に生まれてから3カ月まで同じ量及び同じ種類の餌を与えた。試験被験体には、給水中の5マイクログラム(乾燥植物重量当量)の製剤Aを3日ごとに投与し、下痢が観察された場合には、同じ用量を毎日投与した。対照には、下痢を治療するための抗生物質注射を施した。21日の時点で、試験群は対照よりも下痢になる頻度が低く、平均して1.0kg重かった。3カ月の時点で、試験被験体の平均体重は、胴回りの測定に基づくと、対照群の体重よりも25〜30%大きく、製剤Aが予防・成長促進物としての抗生物質代替品として実現可能であることが示された。
純血種のランドレース子ブタ99頭の成長を追跡し、評価した。子ブタには、製剤Bの酸化性物質−ポリフェノール組成物を含むブタ代用乳を与えた。21日齢のスターターは、環境移行によるストレスを受ける傾向があり、約1週間、下痢の発生率が上昇した。実験群は、この期間中に対照群よりも18%高い平均体重増加を示し、成長の最適化や代用乳との適合性の点で商業的価値を示した。
特定病原体が感染していない純血種ランドレースブタ10頭(各々23日齢)を用いて、毒物学的安全性を試験した。これらのブタに、250μgまたは2500μg用量を毎日1回、45日間投与した。血液化学と成長をモニタリングし、組織検査を行なったところ、組織または器官への悪影響は全く示されなかった。
離乳したスターター子ブタ50頭を5つの群に分け、3日ごとに1回12μg用量を5週間投与した。統計解析からは、実験群におけるより大きい体重増加が示されている。上記の実験は、病原体の制御におけるポリフェノール−酸化性物質組成物の効果的利用の証拠となるものであり、多くの商業上及び医療上有用な用途における相当に重要な価値を示している。これらの実験は、農業用動物生産における直接的な成長促進利益を示しているが、ブタは、ヒトと生理学的及び免疫学的にかなり類似していることが知られており、ヒトにおける性能や安全性の予測判断材料として一般に用いられている。したがって、潜在的な効果をヒトについて推定し、主張することができる。これは、原因が不特定のたまの消化障害や下痢がすぐに治まるという直接体験によって裏付けられる。20〜250μg(乾燥重量当量)の単回用量は、ヒトの下痢を消失させるのに有効であることが観察されており、症状の緩和は、通常1時間以内に認められる。
本発明の好ましい態様は、下記の通りである。
〔1〕a.ヒドロキシル基を有する分子を含む処理された流体と、
b.そのヒドロキシル基を酸化作用物質や触媒で酸化することにより分子を活性化する活性化機構であって、分子の活性化が分子の結合親和性を増大させる機構と、
を含むことを特徴とする組成物。
〔2〕前記分子が、高分子または高分子化合物を含む、前記〔1〕に記載の組成物。
〔3〕前記分子が、ポリフェノールを含む、前記〔1〕に記載の組成物。
〔4〕前記ポリフェノールが、植物に由来する、前記〔3〕に記載の組成物。
〔5〕前記植物が、カメリア・シネンシスの葉、ザクロの皮、またはそれらの組合せを含む、前記〔4〕に記載の組成物。
〔6〕前記分子が、タンニン、リグニン、フラボノイド、ヒドロキシクマリン、アルカロイド類、またはそれらの組合せを含む、前記〔3〕に記載の組成物。
〔7〕前記分子が、少なくとも1つの人工合成部分を含む、前記〔1〕に記載の組成物。
〔8〕前記触媒が、オキシドレダクターゼを含む、前記〔1〕に記載の組成物。
〔9〕前記触媒が、カタラーゼ、ペルオキシダーゼ、フェノールオキシダーゼ、チロシナーゼ、金属触媒、またはそれらの組合せを含む、前記〔1〕に記載の組成物。
〔10〕前記触媒が、動物細胞にある、前記〔1〕に記載の組成物。
〔11〕前記触媒が、病原体によって生成される、前記〔1〕に記載の組成物。
〔12〕前記病原体が、ウイルス、細菌、真菌、真核生物、プリオン、またはそれらの組合せを含む、前記〔11〕に記載の組成物。
〔13〕前記酸化作用物質が、活性酸素種(ROS)を含む、前記〔1〕に記載の組成物。
〔14〕前記活性酸素種が、過酸化水素を含む、前記〔13〕に記載の組成物。
〔15〕前記活性酸素種が、オゾン還元産物を含む、前記〔13〕に記載の組成物。
〔16〕前記流体が、ポリフェノール、多糖、またはそれらの組合せを含む乾燥混合物から調製される、前記〔1〕に記載の組成物。
〔17〕前記ポリフェノール、前記多糖、または前記それらの組合せが、溶液中の前記触媒や前記酸化作用物質と接触したときに、前記活性化機構が開始される、前記〔16〕に記載の組成物。
〔18〕前記ヒドロキシル基の活性化の後、ヒドロキシル基がカルボニル基になる、前記〔1〕に記載の組成物。
〔19〕前記ヒドロキシル基の活性化の後、前記分子がキノン基を含む、前記〔1〕に記載の組成物。
〔20〕前記ヒドロキシル基の活性化の後、前記分子が病原体の不活化において効果を有する、前記〔1〕に記載の組成物。
〔21〕前記酸化作用物質が、フリーラジカルを提供する、前記〔1〕に記載の組成物。
〔22〕前記活性化分子が、フリーラジカルを提供する、前記〔1〕に記載の組成物。
〔23〕a.植物から1以上の生体高分子を得ることと、
b.その1以上の生体高分子の分子結合親和性を増大させるために、その1以上の生体高分子上のヒドロキシル基を活性化することと、
を含むことを特徴とする組成物の調製方法。
〔24〕前記1以上の生体高分子が、ポリフェノール、多糖、またはそれらの組合せを含む、前記〔23〕に記載の方法。
〔25〕前記1以上の生体高分子を実質的に乾燥した形態で動物に与えることを含む、前記〔23〕に記載の方法。
〔26〕前記活性化が、前記1以上の生体高分子を酵素、酸化作用物質、またはそれらの組合せと接触させることを含む、前記〔23〕に記載の方法。
〔27〕前記酸化作用物質を実質的に乾燥した形態で動物に与えることを含む、前記〔26〕に記載の方法。
〔28〕前記活性化された1以上の生体高分子を動物のタンパク質と架橋することを含む、前記〔23〕に記載の方法。
〔29〕前記1以上の生体高分子が、それら同士で架橋構造を形成する、前記〔23〕に記載の方法。
〔30〕前記1以上の生体高分子を1以上の病原体と結合させることを含む、前記〔23〕に記載の方法。
〔31〕前記1以上の生体高分子を前記1以上の病原体と結合させることによって凝集の沈殿が生じ、その結果、前記沈殿を濾過し、除去することができる、前記〔30〕に記載の方法。
〔32〕前記結合が、前記病原体の繁殖を停止させる、前記〔30〕に記載の方法。
〔33〕前記1以上の活性化された生体高分子が、病原体またはウイルスの代謝経路または機能を阻止することができる、前記〔23〕に記載の方法。
〔34〕前記1以上の活性化された生体高分子を用いて、動物の下痢症状を治療することを含む、前記〔23〕に記載の方法。
〔35〕前記ヒドロキシル基の活性化が、動物の部位表面の酵素によって誘発される、前記〔23〕に記載の方法。
〔36〕前記ヒドロキシル基の活性化が、酵素を外から添加することによって達成される、前記〔23〕に記載の方法。
〔37〕酸化性物質と反応するオキシドレダクターゼまたは還元化合物の除去、不活化、またはそれらの組合せを含む、前記〔23〕に記載の方法。
〔38〕病原体の侵入を防ぐように、前記1以上の生体高分子を動物のタンパク質と架橋してバリアを形成させることを含む、前記〔23〕に記載の方法。
〔39〕a.添加された活性酸素種を生体高分子上のヒドロキシル基の反応近傍に局在化させることと、
b.その生体高分子のヒドロキシル基を活性化することと、
c.その生体高分子を標的部位に適用することと、
を含むことを特徴とする局所反応を容易にする方法。
〔40〕前記生体高分子が、ポリフェノール、多糖、またはそれらの組合せを含む、前記〔39〕に記載の方法。
〔41〕前記活性化が、酵素に接触させることを含む、前記〔39〕に記載の方法。
〔42〕前記活性酸素種が、過酸化水素を含む、前記〔39〕に記載の方法。
〔43〕前記過酸化水素を前記生体高分子を含む溶液に添加して、前記ヒドロキシル基の反応近傍における前記過酸化水素の密度を増加させることを含む、前記〔42〕に記載の方法。
〔44〕前記生体高分子が、多数のヒドロキシル基を含む、前記〔39〕に記載の方法。
〔45〕a.予め選択された化学物質を含む1以上の生体分子を調製することと、
b.その1以上の生体分子が動物組織を透過する速度を制御するために、サイズ、重量、またはそれらの組合せを選択することと、
を含むことを特徴とする制御された化学物質送達方法。
〔46〕前記化学物質が、フェノール化合物を含む、前記〔45〕に記載の方法。
〔47〕前記化学物質が、キノン化合物を含む、前記〔45〕に記載の方法。
〔48〕前記生体分子が、植物由来の抽出物を含む、前記〔45〕に記載の方法。
〔49〕前記調製することが前記生体分子を単離することを含む、前記〔45〕に記載の方法。
〔50〕前記選択することが、前記生体分子を抽出することを含む、前記〔45〕に記載の方法。
〔51〕前記生体分子を前記動物組織に適用しても前記動物組織からの毒性反応が生じないように、前記透過速度を適度に調整する、前記〔45〕に記載の方法。
Claims (18)
- 抗微生物薬としての使用のためのポリフェノール−酸化性物質組成物であって、
(i)タンニンを含むポリフェノールを含む植物組織の水溶性抽出物、および
(ii)外因性過酸化水素
の組合せを含み、活性還元作用物質及び酵素を実質的に含まないことを特徴とする組成物。 - 消化器系の感染または消化器系への損傷の処置における使用のための、請求項1に記載の組成物。
- 前記抽出物が、前記組合せ中の前記過酸化水素に対する捕捉効果を有し、前記組成物が、細菌と接触したときに細菌を死滅させるものであり、かつ、前記植物組織が、五倍子、カメリア・シネンシスの葉およびザクロの皮からなる群から選択される成分を含む、請求項1に記載の組成物。
- 前記ポリフェノール及び前記過酸化水素が組み合わされ、前記組成物においてフェノール単位の近接において前記過酸化水素を安定化および濃縮させる、請求項1に記載の組成物。
- 前記植物組織が、カメリア・シネンシスの葉およびザクロの皮の組合せを含む、請求項1に記載の組成物。
- 前記抽出物が、リグニン、フラボノイド、ヒドロキシクマリンおよびアルカロイドからなる群から選択される成分を含む、請求項1に記載の組成物。
- 前記組成物が、3.9〜500μg/mlの範囲の濃度で前記抽出物を有する水性製剤である、請求項1ないし5のいずれかに記載の組成物。
- 下痢を治療するのに使用するための、請求項1ないし6のいずれかに記載の組成物。
- 感染組織を治療するのに使用するための、請求項1ないし6のいずれかに記載の組成物。
- 標的組織の創傷治癒に使用するための、請求項1ないし6のいずれかに記載の組成物。
- 損傷組織を保護するのに使用するための、請求項1ないし6のいずれかに記載の組成物。
- 20〜250μgの範囲の用量で対象に投与するための薬物を産生するのに使用するための、請求項1ないし6のいずれかに記載の組成物。
- 乾燥した安定な形態の請求項1ないし6のいずれかに記載の組成物を含むキット。
- 前記外因性過酸化水素が、過炭酸ナトリウム、過炭酸カリウム、過酸化カルバミドおよび過酸化尿素からなる群から選択される活性酸素種源の形態である、請求項13に記載のキット。
- 前記活性酸素種が、乾燥した過炭酸カリウムまたは過炭酸ナトリウムを含む、請求項14に記載のキット。
- 請求項1ないし6のいずれかに記載のポリフェノール−酸化性物質組成物を産生する方法であって、
前記植物組織をカメリア・シネンシスの葉およびザクロの皮から選択するステップ、
前記植物組織から活性のある還元作用物質または触媒を不活性化または除去することを含む内因性酵素を変性させるステップ、
前記植物組織を粉砕するステップ、
溶媒を用いて前記植物組織から前記ポリフェノールを抽出して、抽出物を生成させるステップ、および
活性酸素種源の形態の外因性過酸化水素を有効量で前記抽出物に添加するステップ
を含む、前記方法。 - 前記植物組織が、カメリア・シネンシスの葉およびザクロの皮の組合せを含む、請求項16に記載の方法。
- 前記抽出物が、タンニン、リグニン、フラボノイド、ヒドロキシクマリンおよびアルカロイドからなる群から選択される成分を含む、請求項16に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20926009P | 2009-03-04 | 2009-03-04 | |
US61/209,260 | 2009-03-04 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011553012A Division JP2012519690A (ja) | 2009-03-04 | 2010-03-01 | 生体分子の部位活性化複合体形成方法及び材料 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016225240A Division JP2017061529A (ja) | 2009-03-04 | 2016-11-18 | 生体分子の部位活性化複合体形成方法及び材料 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2016000743A JP2016000743A (ja) | 2016-01-07 |
JP6047207B2 true JP6047207B2 (ja) | 2016-12-21 |
Family
ID=42709967
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011553012A Pending JP2012519690A (ja) | 2009-03-04 | 2010-03-01 | 生体分子の部位活性化複合体形成方法及び材料 |
JP2015146637A Active JP6047207B2 (ja) | 2009-03-04 | 2015-07-24 | 生体分子の部位活性化複合体形成方法及び材料 |
JP2016225240A Pending JP2017061529A (ja) | 2009-03-04 | 2016-11-18 | 生体分子の部位活性化複合体形成方法及び材料 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011553012A Pending JP2012519690A (ja) | 2009-03-04 | 2010-03-01 | 生体分子の部位活性化複合体形成方法及び材料 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2016225240A Pending JP2017061529A (ja) | 2009-03-04 | 2016-11-18 | 生体分子の部位活性化複合体形成方法及び材料 |
Country Status (23)
Country | Link |
---|---|
US (7) | US8343552B2 (ja) |
EP (1) | EP2403938B1 (ja) |
JP (3) | JP2012519690A (ja) |
KR (1) | KR101790352B1 (ja) |
CN (1) | CN102421891B (ja) |
AU (1) | AU2010221579B2 (ja) |
BR (1) | BRPI1006287A2 (ja) |
CA (1) | CA2754226C (ja) |
DK (1) | DK2403938T3 (ja) |
ES (1) | ES2791485T3 (ja) |
HK (1) | HK1164916A1 (ja) |
HR (1) | HRP20200392T1 (ja) |
HU (1) | HUE049150T2 (ja) |
IL (2) | IL214951A (ja) |
MX (1) | MX344857B (ja) |
MY (1) | MY172676A (ja) |
PH (2) | PH12015502712A1 (ja) |
PL (1) | PL2403938T3 (ja) |
RU (1) | RU2571924C2 (ja) |
SG (3) | SG10201503255SA (ja) |
TW (2) | TWI632856B (ja) |
WO (1) | WO2010101844A1 (ja) |
ZA (1) | ZA201106974B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017061529A (ja) * | 2009-03-04 | 2017-03-30 | ライブリーフ,インコーポレーテッド | 生体分子の部位活性化複合体形成方法及び材料 |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8734867B2 (en) * | 2007-12-28 | 2014-05-27 | Liveleaf, Inc. | Antibacterial having an extract of pomegranate combined with hydrogen peroxide |
US8722040B2 (en) * | 2011-06-24 | 2014-05-13 | Liveleaf, Inc. | Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites |
US9192635B2 (en) | 2011-06-24 | 2015-11-24 | Liveleaf, Inc. | Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide |
CN103155953A (zh) * | 2011-12-19 | 2013-06-19 | 陕西恒田化工有限公司 | 一种石榴皮多酚植物杀菌剂、用途以及制备方法 |
US20150328258A1 (en) * | 2012-05-30 | 2015-11-19 | Ibh Ventures, Llc | Polyphenol-reactive oxygen species compositions and methods |
US9526754B1 (en) * | 2012-11-26 | 2016-12-27 | Manuel Serrano | Plant polyphenols extraction and activation thereof |
US8716351B1 (en) | 2012-12-23 | 2014-05-06 | Liveleaf, Inc. | Methods of treating gastrointestinal spasms |
AU2013367193A1 (en) * | 2012-12-26 | 2015-07-16 | A-Z Ltd. | Wound healing accelerator |
EP3245871A1 (en) * | 2014-04-30 | 2017-11-22 | Matoke Holdings Limited | Antimicrobial compositions |
WO2015192136A1 (en) * | 2014-06-13 | 2015-12-17 | Liveleaf, Inc. | Non-toxic agent for a broad-spectrum, bactericidal or bacteriostatic treatment of antibiotic-resistant bacteria in animals |
CN107921073B (zh) | 2015-06-01 | 2022-10-18 | 塞诺生物科学股份有限公司 | 用于调节肠道微生物群及管理体重的方法和组合物 |
CN110520111B (zh) * | 2016-11-30 | 2023-12-19 | 塞诺生物科学股份有限公司 | 用以管理体重和调节肠道微生物群的药物制剂和方法 |
CN107094996B (zh) * | 2017-04-24 | 2020-07-24 | 浙江省农业科学院 | 一种含石榴皮复合植物提取物及其制备方法和应用 |
CN107114562B (zh) * | 2017-04-24 | 2020-08-14 | 浙江省农业科学院 | 一种抗炎兼具抑菌和抗氧化功能的复合型植物水提物及其制备方法和应用 |
WO2019036686A1 (en) * | 2017-08-17 | 2019-02-21 | Apeel Technology, Inc. | PREVENTING PHYSIOLOGICAL DETERIORATION AFTER HARVEST USING SULFUR DONOR COMPOUNDS |
GB201716986D0 (en) | 2017-10-16 | 2017-11-29 | Matoke Holdings Ltd | Antimicrobial compositions |
IT201800004842A1 (it) * | 2018-04-24 | 2019-10-24 | Sistema di cottura | |
CN108822184A (zh) * | 2018-04-25 | 2018-11-16 | 浙江工业大学 | 一种蛋白功能改性的方法 |
CN109251865B (zh) * | 2018-09-30 | 2021-06-15 | 哈尔滨工业大学 | 一种小球藻细胞表面耗氧保护层的制备方法 |
CN109297916B (zh) * | 2018-11-20 | 2021-03-30 | 中国农业科学院农产品加工研究所 | 分析多酚化合物氧化产物的人工神经网络及预测方法 |
CN109699954A (zh) * | 2019-03-08 | 2019-05-03 | 合浦果香园食品有限公司 | 一种制备海参水果馅料的方法 |
JP7381251B2 (ja) * | 2019-08-23 | 2023-11-15 | セッツ株式会社 | 抗ノロウイルス剤、消毒剤及び洗浄剤 |
CN111713510B (zh) * | 2020-06-08 | 2021-11-23 | 西北农林科技大学 | 五倍子提取物用于制备植物源诱抗剂的应用及诱抗剂 |
CN111777979A (zh) * | 2020-07-16 | 2020-10-16 | 江苏明天胶业有限公司 | 一种高强度耐候型改性硅烷密封胶及其制备工艺 |
WO2022016131A1 (en) * | 2020-07-17 | 2022-01-20 | Scientlce, Llc | Anti-fouling and foul-releasing compositions and methods of making and using same |
WO2022223736A1 (en) | 2021-04-23 | 2022-10-27 | Aurena Laboratories Holding Ab | Transition metal oxide adducts for regulated generation of reactive oxygen species |
NL2029251B1 (nl) | 2021-09-24 | 2023-03-31 | Cindro Holding B V | Gestabiliseerd waterstofperoxide |
Family Cites Families (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB191400001A (en) * | 1913-01-10 | 1915-05-20 | Loche & Cie Soc | Improvements in or relating to Brooms or the like. |
US1844018A (en) * | 1929-04-18 | 1932-02-09 | Mead Res Engineering Company | Method of preparing tanning substances |
DE530650C (de) * | 1930-12-09 | 1931-07-31 | Hoffmann La Roche & Co Akt Ges | Verfahren zur Herstellung von Protocatechualdehyd und seinen Substitutionsprodukten |
US1965458A (en) * | 1932-05-18 | 1934-07-03 | Hoffmann La Roche | Process for the manufacture of aromatic hydroxy aldehydes |
US3484248A (en) * | 1967-07-03 | 1969-12-16 | Lipton Inc Thomas J | Alkaline conversion of green tea using hydrogen peroxide |
GB1204585A (en) * | 1968-01-23 | 1970-09-09 | Tenco Brooke Bond Ltd | Improvements in or relating to the fermentation of tea |
US3817835A (en) * | 1969-03-26 | 1974-06-18 | Squibb & Sons Inc | Process for the production of antimicrobial agents |
US3692904A (en) * | 1970-05-25 | 1972-09-19 | Daiichi Seiyaku Co | Method for treating scours in domestic livestock |
US3824184A (en) * | 1970-09-04 | 1974-07-16 | Economics Lab | Slime control in industrial waters |
GB1377396A (en) * | 1971-04-26 | 1974-12-18 | Unilever Ltd | Instant tea powder |
IT986371B (it) * | 1972-06-02 | 1975-01-30 | Degussa | Procedimento per la produzione di percarbonato alcalino |
US3860694A (en) * | 1972-08-31 | 1975-01-14 | Du Pont | Process for the preparation of perhydrates |
JPS5429599B2 (ja) * | 1974-12-28 | 1979-09-25 | ||
SE7601543L (sv) * | 1975-02-21 | 1976-08-23 | Snam Progetti | Forfarande for extrahering av fenoler och oligosackarider ur vegetabiliskt material |
US4171280A (en) | 1977-11-03 | 1979-10-16 | The Clorox Company | Powder percarbonate bleach and formation thereof |
US4171281A (en) * | 1978-02-03 | 1979-10-16 | Bystrenin Mikhail N | Graphitization and reducing charge |
US4514334A (en) * | 1979-05-31 | 1985-04-30 | General Electric Company | Polyphenolic compounds |
FR2486523A1 (fr) * | 1980-07-11 | 1982-01-15 | Rhone Poulenc Ind | Procede de preparation de polyphenols comportant eventuellement un groupement aldehyde |
US4623465A (en) * | 1981-04-20 | 1986-11-18 | Massachusetts Institute Of Technology | Removal of combined organic substances from aqueous solutions |
US4472302A (en) * | 1983-03-09 | 1984-09-18 | Merck & Co., Inc. | Heat shock process for the isolation of bacterial protein |
US4472602A (en) * | 1983-08-11 | 1984-09-18 | At&T Technologies, Inc. | Telephone set with transducer/ringer |
US5141611A (en) * | 1985-05-16 | 1992-08-25 | Memtec Limited | Removing and recovering plant polyphenols |
US4829001A (en) * | 1985-11-08 | 1989-05-09 | Minnesota Mining And Manufacturing Company | Enzymatic neutralization of hydrogen peroxide |
US4647952A (en) * | 1985-11-13 | 1987-03-03 | The Mead Corporation | Phenolic developer resins |
GB8528307D0 (en) * | 1985-11-18 | 1985-12-24 | Beecham Group Plc | Veterinary compositions |
US4696757A (en) | 1986-06-16 | 1987-09-29 | American Home Products Corporation | Stable hydrogen peroxide gels |
US5296376A (en) * | 1986-11-04 | 1994-03-22 | Imperial Chemical Industries Plc | DNA, constructs, cells and plants derived therefrom |
US4966762A (en) * | 1988-10-06 | 1990-10-30 | Fmc Corporation | Process for manufacturing a soda ash peroxygen carrier |
US5231193A (en) * | 1989-03-29 | 1993-07-27 | Kikkoman Corporation | Process for producing ellagic acid |
JPH0791302B2 (ja) | 1989-03-29 | 1995-10-04 | キッコーマン株式会社 | エラグ酸の製造法 |
US5389369A (en) * | 1991-02-21 | 1995-02-14 | Exoxemis, Inc. | Halo peroxidase containing compositions for killing yeast and sporular microorganisms |
US5756090A (en) * | 1991-02-21 | 1998-05-26 | Eoe, Inc. | Oxygen activatable formulations for disinfection or sterilization |
US5208010A (en) * | 1991-06-17 | 1993-05-04 | Dental Concepts Inc. | Tooth whitening dentifrice |
CN1079393A (zh) * | 1992-06-05 | 1993-12-15 | 郭干举 | 治疗慢性胃炎复方五倍子成药方法 |
US5260021A (en) * | 1992-06-29 | 1993-11-09 | Allergan, Inc. | Hydrogen peroxide-containing gels and contact lens disinfecting using same |
JPH07503376A (ja) | 1992-07-30 | 1995-04-13 | ケイヘーネ・エヌ・ベー | Dna構築物並びにそれから誘導される細胞及び植物 |
DK144392D0 (da) * | 1992-12-01 | 1992-12-01 | Novo Nordisk As | Aktivering af enzymer |
US5328706A (en) * | 1993-04-29 | 1994-07-12 | Endico Felix W | Food manufacturing process utilizing hydrogen peroxide for microbial control |
US6068862A (en) * | 1993-06-30 | 2000-05-30 | Taiyo Kagaku Co., Ltd. | Tea-derived feed additive and animal feed containing the same |
US5653746A (en) * | 1994-03-08 | 1997-08-05 | Meadox Medicals, Inc. | Radially expandable tubular prosthesis |
US5661170A (en) * | 1994-03-21 | 1997-08-26 | Woodward Laboratories, Inc. | Antimicrobial compositions and methods for using the same |
US5614501A (en) * | 1994-07-21 | 1997-03-25 | The University Of Montana | Compositions and methods for animal husbandry and for treating gastrointestinal disorders |
TW449485B (en) | 1995-03-31 | 2001-08-11 | Colgate Palmolive Co | Skin care products containing anti itching/anti irritant agents |
US5824414A (en) * | 1995-04-28 | 1998-10-20 | Mitsui Chemicals, Inc. | Preparation of spherical polyphenol particles |
US7048906B2 (en) * | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
US5839369A (en) * | 1995-10-20 | 1998-11-24 | Eastman Kodak Company | Method of controlled laser imaging of zirconia alloy ceramic lithographic member to provide localized melting in exposed areas |
US6063428A (en) * | 1996-02-26 | 2000-05-16 | The Procter & Gamble Company | Green tea extract subjected to cation exchange treatment and nanofiltration to improve clarity and color |
JP3320307B2 (ja) * | 1996-06-06 | 2002-09-03 | 株式会社エス・ディー・エス バイオテック | フェノール性化合物等の高分子化方法及びその利用 |
US6642277B1 (en) * | 1996-09-20 | 2003-11-04 | The Howard Foundation | Food supplements containing polyphenols |
CA2269078C (en) * | 1996-10-16 | 2012-01-24 | Shaman Pharmaceuticals, Inc. | Enteric formulations of proanthocyanidin polymer antidiarrheal compositions |
US6436342B1 (en) * | 1996-11-13 | 2002-08-20 | The Procter & Gamble Company | Sprayable disinfecting compositions and processes for disinfecting surfaces therewith |
TR199901146T2 (xx) * | 1996-11-25 | 1999-08-23 | Unilever N.V. | Enzimatik oksidasyon yöntemi. |
US5891440A (en) | 1996-12-31 | 1999-04-06 | Lansky; Ephraim Philip | Phytoestrogen supplement prepared from pomegranate seeds and a herbal mixture or coconut milk |
JPH1143696A (ja) * | 1997-07-29 | 1999-02-16 | Saito Shigeru | 緑茶入り洗浄料 |
GB9721139D0 (en) | 1997-10-07 | 1997-12-03 | Glaxo Group Ltd | Medicaments |
JP4137224B2 (ja) * | 1998-03-31 | 2008-08-20 | 天野エンザイム株式会社 | 酵素による蛋白質の架橋法 |
JP4357624B2 (ja) * | 1998-04-01 | 2009-11-04 | 大正製薬株式会社 | 殺菌剤および消化酵素を配合した組成物 |
US6071541A (en) * | 1998-07-31 | 2000-06-06 | Murad; Howard | Pharmaceutical compositions and methods for managing skin conditions |
WO2000020406A1 (en) * | 1998-10-06 | 2000-04-13 | Research Development Foundation | ANTIBACTERIAL AND ANTIFUNGAL FLAVANONES FROM $i(EYSENHARDTIA TEXANA) |
US20030078212A1 (en) | 1998-10-30 | 2003-04-24 | Jia-He Li | Pharmaceutical compositions containing poly(adp-ribose) glycohydrolase inhibitors and methods of using the same |
US6630163B1 (en) * | 1999-04-22 | 2003-10-07 | Howard Murad | Method of treating dermatological disorders with fruit extracts |
US7297344B1 (en) | 1999-05-27 | 2007-11-20 | Euro-Celtique, S.A. | Preparations for the promotion of wound healing in the upper respiratory tract and/or ear |
US7504251B2 (en) * | 1999-06-03 | 2009-03-17 | Biobalance Llc | Bacterial strain, processed plant extracts, compositions containing same, processes for their preparation and their therapeutic and industrial applications |
GB9918028D0 (en) * | 1999-07-30 | 1999-09-29 | Unilever Plc | Skin care composition |
US6716805B1 (en) * | 1999-09-27 | 2004-04-06 | The Procter & Gamble Company | Hard surface cleaning compositions, premoistened wipes, methods of use, and articles comprising said compositions or wipes and instructions for use resulting in easier cleaning and maintenance, improved surface appearance and/or hygiene under stress conditions such as no-rinse |
KR100366608B1 (ko) * | 2000-02-15 | 2003-01-09 | 마스터진(주) | 형질전환 식물체로부터 생산된 재조합 인간 파필로마바이러스 백신 |
US20020034553A1 (en) * | 2000-09-19 | 2002-03-21 | Janice Zayas | Skin healing, conditioning and enhancing lotion |
EP1322167B1 (en) * | 2000-09-29 | 2006-11-02 | The Procter & Gamble Company | Allergen neutralization compositions |
HUP0401100A2 (hu) * | 2001-01-16 | 2004-11-29 | Unilever N.V. | Fogápoló készítmény |
US7381427B2 (en) * | 2001-02-09 | 2008-06-03 | Mickey Miller | Seborrheic keratosis treatment |
JP4382295B2 (ja) * | 2001-02-15 | 2009-12-09 | 森永乳業株式会社 | ウレアーゼ不活性化組成物及び飲食品 |
US20030044474A1 (en) | 2001-08-03 | 2003-03-06 | Shaklee Corporation | High molecular weight, lipophilic, orally ingestible bioactive agents in formulations having improved bioavailability |
EP1312412B1 (en) * | 2001-11-20 | 2013-03-13 | Mitsubishi Gas Chemical Company, Inc. | Process for producing hydrogen-containing gas |
ES2261952T3 (es) * | 2002-02-28 | 2006-11-16 | Unilever N.V. | Composiciones de limpieza liquidas. |
US20030228379A1 (en) * | 2002-05-28 | 2003-12-11 | Wenyuan Shi | Herbs and herbal combinations useful for the treatment of microbial infections |
US20040001665A1 (en) | 2002-07-01 | 2004-01-01 | Majd Zoorob | Optical device |
US6911196B2 (en) * | 2002-07-31 | 2005-06-28 | Samir I. Hamtini | Topical medicament for treating nappy rash |
AU2003293082A1 (en) * | 2002-11-27 | 2004-06-23 | Tufts University | Antioxidant-functionalized polymers |
KR100505819B1 (ko) * | 2002-12-23 | 2005-08-03 | (주)오비티 | 식물의 흰가루병 방제제 |
US20040228831A1 (en) * | 2003-05-15 | 2004-11-18 | Belinka Benjamin A. | Polymeric conjugates for tissue activated drug delivery |
KR20050028755A (ko) * | 2003-09-19 | 2005-03-23 | 한국염색기술연구소 | 오배자로부터 천연항균제를 추출하는 방법 |
CN1905804A (zh) * | 2004-01-16 | 2007-01-31 | 荷兰联合利华有限公司 | 生产茶产品的方法和所得产品 |
PL1703800T3 (pl) * | 2004-01-16 | 2008-07-31 | Unilever Nv | Sposób wytwarzania herbacianego produktu i produkty otrzymane tym sposobem |
WO2007053182A2 (en) * | 2005-05-27 | 2007-05-10 | University Of Central Florida Research Foundation, Inc. | Plant produced vaccine for amebiasis |
US7744555B2 (en) * | 2004-02-06 | 2010-06-29 | Depuy Spine, Inc. | Implant having a photocatalytic unit |
CA2559813A1 (en) | 2004-03-16 | 2005-09-22 | Combi Co. | Antidiarrheal agent for livestock and poultry |
CA2560826C (en) * | 2004-03-23 | 2014-05-13 | Lifeline Nutraceuticals Corporation | Antioxidant-promoting herbal extract compositions for alleviating oxidative stress in a mammal |
WO2005097053A1 (en) * | 2004-04-01 | 2005-10-20 | Smithkline Beecham Corporation | Dissolvable tooth whitening strip |
US20060024385A1 (en) | 2004-07-27 | 2006-02-02 | Pedersen Mark A | Metabolic capacity enhancing compositions and methods for use in a mammal |
US20060024339A1 (en) * | 2004-07-29 | 2006-02-02 | Howard Murad | Methods of managing the redness associated with a dermatological condition |
JP4798973B2 (ja) * | 2004-08-04 | 2011-10-19 | 丸善製薬株式会社 | 抗菌用組成物 |
WO2006038893A1 (en) | 2004-10-06 | 2006-04-13 | Agency For Science, Technology And Research | Oxidation of phenolic compound with hydrogen peroxide generated in the presence of the phenolic compound |
JP2006182727A (ja) * | 2004-12-28 | 2006-07-13 | Kao Corp | 酸化染毛剤 |
US20060165812A1 (en) * | 2005-01-21 | 2006-07-27 | Amershire Investment Corporation | Method and topical formulation for treating headaches |
AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
WO2007003068A1 (fr) | 2005-06-30 | 2007-01-11 | Hangzhou Lixin Biotechnology Co. Ltd. | Additif pour nourriture, procédé de préparation de celui-ci et application de celui-ci |
RU2319494C2 (ru) * | 2005-11-11 | 2008-03-20 | РАНХЕЛЬ Хосе Анхель ОЛАЛДЕ | Синергетическая композиция растительного происхождения (варианты), способ лечения заболеваний с ее использованием |
US20070110812A1 (en) | 2005-11-14 | 2007-05-17 | Bausch & Lomb Incorporated | Ophthalmic composition for dry eye therapy |
WO2007079331A2 (en) * | 2005-12-13 | 2007-07-12 | Richard Paul Bonfiglio | Antibacterial oral rinse formulation for preventing coronary artery disease |
WO2007092085A2 (en) * | 2005-12-20 | 2007-08-16 | Howard Murad | Fragranced therapeutic delivery system |
WO2007090096A2 (en) * | 2006-01-27 | 2007-08-09 | Rdx Technologies, Inc. | Electrochemical methods for redox control to preserve, stabilize and activate compounds |
US20100278759A1 (en) * | 2006-02-08 | 2010-11-04 | Howard Murad | Topical Therapeutic Delivery System |
RS52678B (en) | 2006-05-01 | 2013-06-28 | Napo Pharmaceuticals Inc. | PROCEDURE FOR TREATMENT OF IRITABLE TEST SYNDROME WITH PREDOMINANT CONSTIPATION |
JP4892727B2 (ja) * | 2006-09-21 | 2012-03-07 | 国立大学法人 鹿児島大学 | 高分子タンニンの酵素的架橋反応 |
CN1939468B (zh) * | 2006-09-27 | 2010-04-14 | 西南大学 | 复方五倍子渔用抗菌剂配方 |
JP2008143808A (ja) * | 2006-12-07 | 2008-06-26 | Airomin Seiyaku Kk | 高濃度のコロイド状の有機ヨウ素を含有する液体製剤及びその製造方法 |
WO2008079898A1 (en) * | 2006-12-20 | 2008-07-03 | Pharmwest, Inc. | Methods and topical formulations comprising colloidal metal for treating or preventing skin conditions |
KR100870138B1 (ko) * | 2007-05-15 | 2008-11-24 | 한국식품연구원 | 삶은 나물의 신선도 유지를 위한 천연항균제 및 동천연항균제를 포함하는 삶은 나물 용기 |
CA2696438C (en) * | 2007-08-16 | 2015-12-08 | The University Of Chicago | The use of azelaic acid for priming a plant to induce a resistance response against a pathogen |
US8343552B2 (en) * | 2007-12-28 | 2013-01-01 | Liveleaf, Inc. | Therapeutic composition produced using punica granatum and hydrogen peroxide |
CN101260129A (zh) * | 2008-04-12 | 2008-09-10 | 竹山县天新医药化工有限责任公司 | 一种单宁酸的提纯方法 |
WO2010018418A1 (en) | 2008-08-12 | 2010-02-18 | Novatech D.O.O. | Formulation based on micronized clinoptilolite as therapeutic agent providing highly bioavailable silicon |
US8722040B2 (en) * | 2011-06-24 | 2014-05-13 | Liveleaf, Inc. | Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites |
US8716351B1 (en) * | 2012-12-23 | 2014-05-06 | Liveleaf, Inc. | Methods of treating gastrointestinal spasms |
-
2010
- 2010-03-01 US US12/715,270 patent/US8343552B2/en active Active
- 2010-03-01 AU AU2010221579A patent/AU2010221579B2/en active Active
- 2010-03-01 RU RU2011138328/10A patent/RU2571924C2/ru active
- 2010-03-01 BR BRPI1006287-4A patent/BRPI1006287A2/pt not_active Application Discontinuation
- 2010-03-01 MY MYPI2011004116A patent/MY172676A/en unknown
- 2010-03-01 CN CN201080019845.5A patent/CN102421891B/zh active Active
- 2010-03-01 PL PL10749160T patent/PL2403938T3/pl unknown
- 2010-03-01 CA CA2754226A patent/CA2754226C/en active Active
- 2010-03-01 JP JP2011553012A patent/JP2012519690A/ja active Pending
- 2010-03-01 WO PCT/US2010/025805 patent/WO2010101844A1/en active Application Filing
- 2010-03-01 KR KR1020117023149A patent/KR101790352B1/ko active IP Right Grant
- 2010-03-01 EP EP10749160.7A patent/EP2403938B1/en active Active
- 2010-03-01 SG SG10201503255SA patent/SG10201503255SA/en unknown
- 2010-03-01 DK DK10749160.7T patent/DK2403938T3/da active
- 2010-03-01 SG SG10201502453SA patent/SG10201502453SA/en unknown
- 2010-03-01 MX MX2011009242A patent/MX344857B/es active IP Right Grant
- 2010-03-01 HU HUE10749160A patent/HUE049150T2/hu unknown
- 2010-03-01 ES ES10749160T patent/ES2791485T3/es active Active
- 2010-03-01 SG SG2011062767A patent/SG173905A1/en unknown
- 2010-03-03 TW TW099106177A patent/TWI632856B/zh active
- 2010-03-03 TW TW105118724A patent/TW201634053A/zh unknown
-
2011
- 2011-09-04 IL IL214951A patent/IL214951A/en active IP Right Grant
- 2011-09-23 ZA ZA2011/06974A patent/ZA201106974B/en unknown
-
2012
- 2012-05-03 HK HK12104309.4A patent/HK1164916A1/xx unknown
- 2012-11-16 US US13/680,007 patent/US8586110B2/en active Active
-
2013
- 2013-09-15 US US14/027,235 patent/US20140072655A1/en not_active Abandoned
- 2013-09-15 US US14/027,228 patent/US20140072660A1/en not_active Abandoned
-
2014
- 2014-02-12 US US14/178,459 patent/US20140161902A1/en not_active Abandoned
-
2015
- 2015-07-24 JP JP2015146637A patent/JP6047207B2/ja active Active
- 2015-12-04 PH PH12015502712A patent/PH12015502712A1/en unknown
-
2016
- 2016-05-22 IL IL245765A patent/IL245765A0/en unknown
- 2016-11-18 JP JP2016225240A patent/JP2017061529A/ja active Pending
-
2017
- 2017-10-27 PH PH12017501978A patent/PH12017501978A1/en unknown
-
2018
- 2018-01-23 US US15/878,239 patent/US20190000909A1/en not_active Abandoned
-
2020
- 2020-03-04 US US16/809,076 patent/US20210038674A1/en not_active Abandoned
- 2020-03-10 HR HRP20200392TT patent/HRP20200392T1/hr unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017061529A (ja) * | 2009-03-04 | 2017-03-30 | ライブリーフ,インコーポレーテッド | 生体分子の部位活性化複合体形成方法及び材料 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6047207B2 (ja) | 生体分子の部位活性化複合体形成方法及び材料 | |
CN107708752A (zh) | 抗微生物纤维和组合物 | |
JP7462868B2 (ja) | 乳酸菌生産物質含有組成物、エクオール生成方法および乳酸菌生産物質含有組成物の製造方法 | |
EP2934511A2 (en) | Methods of treating gastrointestinal spasms | |
WO2014041440A1 (en) | Honey-based dressing for the treatment of wounds and burns | |
Alfei et al. | Reactive Oxygen Species (ROS)-Mediated Antibacterial Oxidative Therapies: Available Methods to Generate ROS and a Novel Option Proposal | |
US20230149496A1 (en) | Blocking a pathogen from expressing a virulence factor | |
CN113015432B (zh) | 包含硫酸化半乳糖的组合物及其实施方式 | |
KR20190045887A (ko) | 만성 비염 개선 식품조성물 | |
Burger | Evidence of the Existence of a Large Amount of Cationic Antimicrobial Peptides in Propolis, with a Strong Physical/Electrostatic Mechanism of Action (Detergent-like), and their Possible Promising Effects in the Treatment of COVID-19 by means of Propolis Extract Inhalation | |
RU2285434C2 (ru) | Способ получения биологически активного препарата для животных на основе каллизии душистой | |
Budi et al. | Tekelan Leaves (Chromolaena odorata) Infusion and 10% Povidone-Iodine on Incision Wound Healing Process of Mice (Mus musculus) Infected with Staphylococcus aureus | |
KR20190045027A (ko) | 만성 방광염 개선 식품조성물 | |
CN111296759A (zh) | 一种具有保护胃黏膜功能的组合物、应用及其制备方法 | |
KR20190046438A (ko) | 만성 치주질환 개선 식품조성물 | |
Gonta | cement of A al Bacteric | |
MXPA98000539A (en) | Acid and alcal microwave |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151001 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20160512 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20160518 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20160512 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160620 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160916 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20161031 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20161118 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6047207 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |