JP5945142B2 - しわ改善効果について化粧料を評価する方法 - Google Patents
しわ改善効果について化粧料を評価する方法 Download PDFInfo
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- JP5945142B2 JP5945142B2 JP2012071065A JP2012071065A JP5945142B2 JP 5945142 B2 JP5945142 B2 JP 5945142B2 JP 2012071065 A JP2012071065 A JP 2012071065A JP 2012071065 A JP2012071065 A JP 2012071065A JP 5945142 B2 JP5945142 B2 JP 5945142B2
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/8803—Visual inspection
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/88—Investigating the presence of flaws or contamination
- G01N21/8851—Scan or image signal processing specially adapted therefor, e.g. for scan signal adjustment, for detecting different kinds of defects, for compensating for structures, markings, edges
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
- G06K7/00—Methods or arrangements for sensing record carriers, e.g. for reading patterns
- G06K7/0004—Hybrid readers
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0004—Industrial image inspection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
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- General Health & Medical Sciences (AREA)
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- Immunology (AREA)
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- Artificial Intelligence (AREA)
- Cosmetics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
(1) 角層シートに折りじわを付ける工程;
候補化粧料に浸漬する工程;
乾燥する工程;及び
角層シートの折りじわの改善度を測定する工程;
を含む、候補化粧料のしわ改善効果についての評価方法。
(2) 折りじわの改善度の測定が目視により行われる項目1に記載の評価方法。
(3) 候補化粧料への浸漬工程前、及び乾燥工程の後に、角層シートを撮影する工程を含む、項目1に記載の評価方法。
(4) 折りじわの改善度の測定が、撮影された角層シートの画像処理により行われる、項目3に記載の評価方法。
(5) しわ改善効果がのこりじわの改善効果であることを特徴とする項目1〜4のいずれか一つに記載の評価方法。
角層シートに折りじわを付ける工程;
候補化粧料に浸漬する工程;
乾燥する工程;及び
角層シートの折りじわの改善度を測定する工程;
からなる群から選ばれる1以上の工程を含む。
1名の被験者において、石鹸にて洗顔後、人工気候室(温度22〜24℃、湿度10〜45%RH)中で10〜30分間馴化を行い、馴化後に、目尻のしわを撮影した(図1左)。続いて、強く目を閉じる、開けるの動作を5秒ごとに10回行い、これを表情運動とした。表情運動直後における目尻のしわを撮影した(図1右)。図1において矢印で示した通り、表情運動直後において、元々存在する大じわを延長するようにのこりじわが形成されることが示された。
株式会社ジャパン・ティッシュ・エンジニアリングよりヒト表皮再構成モデルを購入した。これをトリプシン処理して角層シートを32℃、湿度60%で乾燥させて透明な角層シートを得る。これを角度90度に折り曲げ、元に戻すことにより角層シートに折れじわを形成させた。折れじわ部分は、角層透明度が低下しており、ダメージ部位が可視化された(図2写真左)。折れじわ付き角層シートを、表情変化により皮膚が伸縮した際に皮膚表面で生じるのこりじわのモデルとして、美容法又は化粧料の評価に使用した。折れじわ付き角層シートを、室温(23℃)でモデル化粧水(10%グリセリン、3%エチルアルコール、0.3%HCO60(ポリエチレングリコール(60)水添硬化ひまし油エーテル(日光ケミカルズ株式会社))、0.09%クエン酸ナトリウム,0.01%クエン酸)、又はエタノールに30分間浸漬し、これを32℃、湿度60%で18時間乾燥させ、写真を撮影した(図2)。その結果、モデル化粧水の方が、角層折れじわの修復に対し有効であることが示された。
1名の被験者において、石鹸にて洗顔後、人工気候室(温度22〜24℃、湿度10〜45%RH)中で10〜30分間馴化を行い、馴化直後に記載の方法に従い皮膚レプリカを採取した。次にパネルに表情運動(強く目をつぶる動作を複数回)を行わせた後のレプリカを採取した。その後、モデル化粧水を塗布し、その10分後に先に行った方法によりレプリカを採取した。採取したレプリカに関しては、特許文献4に記載の方法に従い作成した画像解析ソフトを用いて3次元画像解析を行い、しわの面積率を算出した。結果を図3に示す。この実験により、表情運動により形成されたのこりじわは、モデル化粧水の塗布などによりしわを改善することができることがin vivoの実験においても示され、折れじわ付き角層シートが、適切にのこりじわをモデル化しており、本願発明の折れじわ付き角層シートによる化粧料又は美容法のスクリーニング方法により選別された化粧料が実際にin vivoの実験においてもしわを改善可能であることが示された。
Claims (5)
- 培養角層シートに折りじわを付ける工程;
当該培養角層シートを候補化粧料に浸漬する工程;
当該培養角層シートを乾燥する工程;及び
当該培養角層シートの折りじわの改善度を測定する工程;
を含む、候補化粧料のしわ改善効果についての評価方法。 - 折りじわの改善度の測定が目視により行われる、請求項1に記載の評価方法。
- 候補化粧料に浸漬工程前及び乾燥工程の後に、培養シートを撮影する工程を含む、請求項1に記載の評価方法。
- 折りじわの改善度の測定が、撮影された培養シートの画像処理により行われる、請求項3に記載の評価方法。
- しわ改善効果がのこりじわの改善効果であることを特徴とする請求項1〜4のいずれか一項に記載の評価方法。
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012071065A JP5945142B2 (ja) | 2012-03-27 | 2012-03-27 | しわ改善効果について化粧料を評価する方法 |
EP13767680.5A EP2833124B1 (en) | 2012-03-27 | 2013-03-06 | Method for evaluating cosmetic for effectiveness in improving wrinkles |
KR1020147026135A KR102107865B1 (ko) | 2012-03-27 | 2013-03-06 | 주름 개선 효과에 관해 화장료를 평가하는 방법 |
RU2014143023A RU2610215C2 (ru) | 2012-03-27 | 2013-03-06 | Способ оценки эффективности косметических средств против морщин |
IN1833MUN2014 IN2014MN01833A (ja) | 2012-03-27 | 2013-03-06 | |
PCT/JP2013/056174 WO2013146151A1 (ja) | 2012-03-27 | 2013-03-06 | しわ改善効果について化粧料を評価する方法 |
ES13767680.5T ES2581292T3 (es) | 2012-03-27 | 2013-03-06 | Método para evaluación de la eficacia de un cosmético en la mejora de las arrugas |
CN201380015586.2A CN104185785B (zh) | 2012-03-27 | 2013-03-06 | 用于评价化妆品的皱纹改善效果的方法 |
US14/388,542 US9488590B2 (en) | 2012-03-27 | 2013-03-06 | Method for evaluating cosmetic for effectiveness in improving wrinkles |
TW102108893A TWI558867B (zh) | 2012-03-27 | 2013-03-13 | Evaluation method of cosmetic effect on wrinkle improvement effect |
HK15104692.6A HK1204064A1 (en) | 2012-03-27 | 2015-05-18 | Method for evaluating cosmetic for effectiveness in improving wrinkles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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JP2012071065A JP5945142B2 (ja) | 2012-03-27 | 2012-03-27 | しわ改善効果について化粧料を評価する方法 |
Publications (2)
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JP2013205053A JP2013205053A (ja) | 2013-10-07 |
JP5945142B2 true JP5945142B2 (ja) | 2016-07-05 |
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Application Number | Title | Priority Date | Filing Date |
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JP2012071065A Active JP5945142B2 (ja) | 2012-03-27 | 2012-03-27 | しわ改善効果について化粧料を評価する方法 |
Country Status (11)
Country | Link |
---|---|
US (1) | US9488590B2 (ja) |
EP (1) | EP2833124B1 (ja) |
JP (1) | JP5945142B2 (ja) |
KR (1) | KR102107865B1 (ja) |
CN (1) | CN104185785B (ja) |
ES (1) | ES2581292T3 (ja) |
HK (1) | HK1204064A1 (ja) |
IN (1) | IN2014MN01833A (ja) |
RU (1) | RU2610215C2 (ja) |
TW (1) | TWI558867B (ja) |
WO (1) | WO2013146151A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11142739B2 (en) | 2016-03-04 | 2021-10-12 | The University Of Toledo | Loading platform for three-dimensional tissue engineered scaffolds |
KR102429838B1 (ko) * | 2016-03-11 | 2022-08-05 | (주)아모레퍼시픽 | 피부결 블랍을 기초로한 피부결 평가 장치 및 그 방법 |
RU2690908C2 (ru) * | 2017-11-22 | 2019-06-06 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ижевская государственная медицинская академия" Министерства здравоохранения Российской Федерации | Способ оценки косметологических процедур на коже лица |
CN109271963A (zh) * | 2018-10-10 | 2019-01-25 | 杭州德肤修生物科技有限公司 | 基于时间序列图像比对的化妆品功效量化评价方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20000076136A (ko) * | 1997-03-11 | 2000-12-26 | 스즈키 츠네시 | 피부 상태 개선제의 평가 방법 및 피부 외용제의 제조 방법 |
JP3589558B2 (ja) * | 1997-12-15 | 2004-11-17 | 株式会社資生堂 | 人工角層 |
US6495126B1 (en) * | 1999-07-20 | 2002-12-17 | Mary Kay Inc. | Treatment and composition for achieving skin anti-aging benefits by corneum protease activation |
JP2003201229A (ja) | 2001-10-23 | 2003-07-18 | Shiseido Co Ltd | マトリックスメタロプロテアーゼ活性阻害剤および抗老化用化粧料 |
FR2840686B1 (fr) * | 2002-06-10 | 2008-11-14 | Oreal | Procede pour determiner l'aptitude a diffuser et/ou a absorber la lumiere d'un produit cosmetique |
EP1428523A1 (en) * | 2002-11-29 | 2004-06-16 | Takasago International Corporation | Skin cosmetics |
TWI256893B (en) * | 2003-03-25 | 2006-06-21 | Fancl Corp | Composition for promoting production of type I collagen and/or elastin |
US8088570B2 (en) * | 2006-04-18 | 2012-01-03 | Kao Corporation | Method for screening an agent for preventing or ameliorating wrinkles |
JP2009139335A (ja) * | 2007-12-10 | 2009-06-25 | Shiseido Co Ltd | 培養皮膚シワモデル、その製造方法及び抗シワ薬剤評価方法 |
JP2010119428A (ja) | 2008-11-17 | 2010-06-03 | Shiseido Co Ltd | 肌状態解析方法、肌状態解析装置、肌状態解析プログラム、及び該プログラムが記録された記録媒体 |
FR2940977B1 (fr) * | 2009-01-13 | 2016-11-18 | Oreal | Utilisation de formes complexes de la proteine de type calmodulin-like skin protein clsp |
JP2010172200A (ja) | 2009-01-27 | 2010-08-12 | Shiseido Co Ltd | 乾燥させた表皮を用いた肌荒れモデル、及びこれを用いた角層透明度を高める薬剤の評価方法 |
JP5399726B2 (ja) | 2009-01-27 | 2014-01-29 | 株式会社 資生堂 | 生体組織の脂質構造の計測方法及び表皮の脂質構造の評価装置 |
JP2011232290A (ja) * | 2010-04-30 | 2011-11-17 | Pola Chem Ind Inc | テラヘルツ波を用いた皮膚角層成分の計測方法 |
JP5595164B2 (ja) * | 2010-07-30 | 2014-09-24 | 株式会社 資生堂 | 真皮黄色化の評価モデル |
WO2012116081A2 (en) * | 2011-02-22 | 2012-08-30 | The Procter & Gamble Company | Methods for identifying cosmetic agents for skin care compositions |
JP2014163405A (ja) * | 2013-02-21 | 2014-09-08 | Osaka Gas Co Ltd | 手動操作式バルブ用の開閉操作治具とその治具を使用して手動操作式バルブを閉じるバルブ閉止方法 |
-
2012
- 2012-03-27 JP JP2012071065A patent/JP5945142B2/ja active Active
-
2013
- 2013-03-06 EP EP13767680.5A patent/EP2833124B1/en active Active
- 2013-03-06 CN CN201380015586.2A patent/CN104185785B/zh active Active
- 2013-03-06 US US14/388,542 patent/US9488590B2/en active Active
- 2013-03-06 ES ES13767680.5T patent/ES2581292T3/es active Active
- 2013-03-06 WO PCT/JP2013/056174 patent/WO2013146151A1/ja active Application Filing
- 2013-03-06 RU RU2014143023A patent/RU2610215C2/ru not_active IP Right Cessation
- 2013-03-06 IN IN1833MUN2014 patent/IN2014MN01833A/en unknown
- 2013-03-06 KR KR1020147026135A patent/KR102107865B1/ko active IP Right Grant
- 2013-03-13 TW TW102108893A patent/TWI558867B/zh not_active IP Right Cessation
-
2015
- 2015-05-18 HK HK15104692.6A patent/HK1204064A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1204064A1 (en) | 2015-11-06 |
JP2013205053A (ja) | 2013-10-07 |
KR102107865B1 (ko) | 2020-05-07 |
EP2833124B1 (en) | 2016-06-29 |
US9488590B2 (en) | 2016-11-08 |
CN104185785B (zh) | 2016-08-24 |
US20150168308A1 (en) | 2015-06-18 |
ES2581292T3 (es) | 2016-09-05 |
EP2833124A1 (en) | 2015-02-04 |
IN2014MN01833A (ja) | 2015-07-03 |
CN104185785A (zh) | 2014-12-03 |
TWI558867B (zh) | 2016-11-21 |
EP2833124A4 (en) | 2015-11-11 |
RU2014143023A (ru) | 2016-05-20 |
TW201339382A (zh) | 2013-10-01 |
KR20140138746A (ko) | 2014-12-04 |
WO2013146151A1 (ja) | 2013-10-03 |
RU2610215C2 (ru) | 2017-02-08 |
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