JP5937321B2 - 皮膚外用剤 - Google Patents
皮膚外用剤 Download PDFInfo
- Publication number
- JP5937321B2 JP5937321B2 JP2011210419A JP2011210419A JP5937321B2 JP 5937321 B2 JP5937321 B2 JP 5937321B2 JP 2011210419 A JP2011210419 A JP 2011210419A JP 2011210419 A JP2011210419 A JP 2011210419A JP 5937321 B2 JP5937321 B2 JP 5937321B2
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- Prior art keywords
- skin
- component
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- ether
- glycol
- Prior art date
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- 239000012459 cleaning agent Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- JUWXVJKQNKKRLD-UHFFFAOYSA-N dec-3-yne Chemical compound CCCCCCC#CCC JUWXVJKQNKKRLD-UHFFFAOYSA-N 0.000 description 1
- ACUZDYFTRHEKOS-UHFFFAOYSA-N decan-2-ol Chemical compound CCCCCCCCC(C)O ACUZDYFTRHEKOS-UHFFFAOYSA-N 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000002332 glycine derivatives Chemical class 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 239000003676 hair preparation Substances 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 229940031957 lauric acid diethanolamide Drugs 0.000 description 1
- VMPHSYLJUKZBJJ-UHFFFAOYSA-N lauric acid triglyceride Natural products CCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCC)COC(=O)CCCCCCCCCCC VMPHSYLJUKZBJJ-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- ONHFWHCMZAJCFB-UHFFFAOYSA-N myristamine oxide Chemical compound CCCCCCCCCCCCCC[N+](C)(C)[O-] ONHFWHCMZAJCFB-UHFFFAOYSA-N 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 229940056211 paraffin Drugs 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- GGOZGYRTNQBSSA-UHFFFAOYSA-N pyridine-2,3-diol Chemical class OC1=CC=CN=C1O GGOZGYRTNQBSSA-UHFFFAOYSA-N 0.000 description 1
- 229960001141 pyrithione zinc Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 244000005714 skin microbiome Species 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- BRGJIIMZXMWMCC-UHFFFAOYSA-N tetradecan-2-ol Chemical compound CCCCCCCCCCCCC(C)O BRGJIIMZXMWMCC-UHFFFAOYSA-N 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002569 water oil cream Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
R1−OH (a1)
(式中、R1は炭素数9〜18の炭化水素基を示す。)
R2−O−(EO)n−H (a2)
(式中、R2は炭素数8〜18の炭化水素基を示し、EOはエチレンオキシ基を示し、nは1〜15の整数を示す。)
本発明の方法に皮膚外用剤は、成分(A)として、下記一般式(a1)で表される化合物及び一般式(a2)で表される化合物から選ばれる1種以上の化合物を含有する。
R1−OH (a1)
(式中、R1は炭素数9〜18の炭化水素基、好ましくは炭素数9〜18の直鎖又は分岐鎖のアルキル基又はアルケニル基を示す。)
R2−O−(EO)n−H (a2)
(式中、R2は炭素数8〜18の炭化水素基、好ましくは炭素数8〜18の直鎖又は分岐鎖のアルキル基又はアルケニル基を示し、EOはエチレンオキシ基を示し、nは1〜15の整数を示す。)
本発明の皮膚外用剤は、成分(B)として、本発明の成分(A)を対象物に均等に適用する観点から、炭素数2〜3の1価アルコールを含有する。成分(B)としては、エタノール、プロパノール、イソプロパノールが挙げられる。皮膚刺激性の観点から、エタノールおよびイソプロパノールが好ましく、特に、エタノールが好ましい。
本発明の皮膚外用剤は、成分(A)を分散、可溶化又は乳化するために、(A)以外の界面活性剤、(A)以外の溶剤、及び、(B)以外の溶剤から選ばれる成分(C)を配合してもよい。
(A−1) 1−ノナノール
(A−2) 1−デカノール
(A−3) 1−ウンデカノール
(A−4) トランス−2−ドデセン−1−オール
(A−5) 1−ドデカノール
(A−6) 1−トリデカノール
(A−7) 1−テトラデカノール
(A−8) 1−ペンタデカノール
(A−9) 1−ヘキサデカノール
(A−10) 2−ヘキサデカノール
(A−11) 1−ヘプタデカノール
(A−12) 1−オクタデカノール
(A−13) ジエチレングリコールモノデシルエーテル
(A−14) トリエチレングリコールモノデシルエーテル
(A−15) テトラエチレングリコールモノデシルエーテル
(A−16) ペンタエチレングリコールモノデシルエーテル
(A−17) オクタエチレングリコールモノデシルエーテル
(A−18) ジエチレングリコールモノドデシルエーテル
(A−19) トリエチレングリコールモノドデシルエーテル
(A−20) テトラエチレングリコールモノドデシルエーテル
(A−21) ペンタエチレングリコールモノドデシルエーテル
(A−22) ヘキサエチレングリコールモノドデシルエーテル
(A−23) ヘプタエチレングリコールモノドデシルエーテル
(A−24) オクタエチレングリコールモノドデシルエーテル
(A−25) ドデカエチレングリコールモノドデシルエーテル
(A−26) トリエチレングリコールモノテトラデシルエーテル
(A−27) テトラエチレングリコールモノテトラデシルエーテル
(A−28) ペンタエチレングリコールモノテトラデシルエーテル
(A−29) ヘキサエチレングリコールモノテトラデシルエーテル
(A’−1) 1−ペンタノール
(A’−2) 1−オクタノール
(B−1) エタノール
(B−2) 1−プロパノール
(B−3) 2−プロパノール(イソプロパノール)
(C−1) ポリオキシエチレン(エチレンオキシド平均付加モル数4.5)ドデシルエーテル酢酸ナトリウム
(C−2) モノドデカン酸ポリエチレングリコール(エチレンオキシド平均付加モル数12)
(C−3) ドデシルグルコシド
(C−4) プロピレングリコール
成分(A)又は成分(A’)、成分(B)、成分(C)及びイオン交換水を表1〜3に示す含有量で配合し、本発明品、比較品の皮膚外用剤を調製した。皮膚外用剤のpH(20℃)は、6.5〜7.0の範囲とした。
常法により表4の化粧料を製造した。試験は本発明品、比較品各群について頭皮のかゆみの自覚症状を持つ各10名に対して行った。試験品使用直前に頭皮のかゆみの状態を下記の基準で自己申告させた。洗髪後に試験品を1日に1回3mLを頭皮全体に均一に塗布し、7日間使用させた後、試験開始日から8日後に再度、頭皮のかゆみの状態を下記の基準で自己申告させた。尚、試験品使用開始1週間前より試験終了までの間、かゆみ抑制剤、殺菌剤含有シャンプー及びリンス、コンディショナー、整髪料等の使用は禁止し、全員が殺菌剤未配合の同じシャンプーのみを使用した。10名の評点の平均で評価した。結果を表4に示す。
1, かゆみを全く感じない
2, かゆみを少し感じる
3, かゆみを感じる
4, かゆみを強く感じる
成分(A)としてトリエチレングリコールモノドデシルエーテルを0.01質量%、成分(B)として95度エタノールを80質量%、成分(C)としてグリセリンを0.1質量%、精製水を19.89質量%含有する手指用アルコール製剤。
成分(A)としてトリエチレングリコールモノドデシルエーテルを0.01質量%、成分(B)として95度エタノールを25質量%、成分(C)としてポリオキシエチレン硬化ヒマシ油(EO60モル)を0.1質量%、成分(C)としてグリセリンを0.1質量%、パラオキシ安息香酸メチルを0.1質量%、香料を0.05%、精製水を74.64質量%含有する頭皮ケア剤。
Claims (6)
- 下記一般式(a1)で表される化合物及び一般式(a2)で表される化合物から選ばれる1種以上の化合物(A)を0.001〜5重量%、並びに、炭素数2〜3の1価アルコール(B)を25〜85重量%含有する、黄色ブドウ球菌のδ−トキシン産生抑制に用いる皮膚外用剤。
R1−OH (a1)
(式中、R1は炭素数9〜18の炭化水素基を示す。)
R2−O−(EO)n−H (a2)
(式中、R2は炭素数8〜18の炭化水素基を示し、EOはエチレンオキシ基を示し、nは1〜15の整数を示す。) - 更に、(A)以外の界面活性剤、(A)以外の溶剤、及び、(B)以外の溶剤から選ばれる成分(C)を含有する、請求項1記載の皮膚外用剤。
- 成分(C)として、(A)以外の界面活性剤を0.0005〜50重量%含有する、請求項2記載の皮膚外用剤。
- 成分(C)として、(A)以外の溶剤、及び、(B)以外の溶剤から選ばれる溶剤を0.05〜50重量%含有する、請求項2又は3記載の皮膚外用剤。
- 手指に用いる請求項1〜4の何れか1項記載の皮膚外用剤。
- 頭皮に用いる請求項1〜4の何れか1項記載の皮膚外用剤。
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