JP5917522B2 - 生物医学的用途のマイクロデバイス及びその使用 - Google Patents

生物医学的用途のマイクロデバイス及びその使用 Download PDF

Info

Publication number: JP5917522B2
Authority: JP; Japan
Prior art keywords: micro; microdevice; properties; mechanical; function
Prior art date: 2010-09-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP2013529116A

Other languages

English (en)

Japanese (ja)

Other versions

JP2013539669A (ja

JP2013539669A5 (pt

Inventor

ユ、クリス、チャン

ユ、ヘ

Original Assignee

チャングヘバイオ−メディカルサイエンス（ヤンジョウ）カンパニーリミテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-09-17

Filing date

2010-09-17

Publication date

2016-05-18

2010-09-17 Application filed by チャングヘバイオ−メディカルサイエンス（ヤンジョウ）カンパニーリミテッド, チャングヘバイオ−メディカルサイエンス（ヤンジョウ）カンパニーリミテッド filed Critical チャングヘバイオ−メディカルサイエンス（ヤンジョウ）カンパニーリミテッド

2013-10-28 Publication of JP2013539669A publication Critical patent/JP2013539669A/ja

2013-12-05 Publication of JP2013539669A5 publication Critical patent/JP2013539669A5/ja

2016-05-18 Application granted granted Critical

2016-05-18 Publication of JP5917522B2 publication Critical patent/JP5917522B2/ja

Status Expired - Fee Related legal-status Critical Current

2030-09-17 Anticipated expiration legal-status Critical

Links

230000006870 function Effects 0.000 claims description 84
239000000126 substance Substances 0.000 claims description 52
238000000034 method Methods 0.000 claims description 37
206010028980 Neoplasm Diseases 0.000 claims description 33
201000011510 cancer Diseases 0.000 claims description 33
238000001514 detection method Methods 0.000 claims description 30
239000012620 biological material Substances 0.000 claims description 25
210000000056 organ Anatomy 0.000 claims description 24
239000000463 material Substances 0.000 claims description 21
239000003814 drug Substances 0.000 claims description 20
239000012528 membrane Substances 0.000 claims description 19
238000004519 manufacturing process Methods 0.000 claims description 18
201000010099 disease Diseases 0.000 claims description 17
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
238000005259 measurement Methods 0.000 claims description 16
229940079593 drug Drugs 0.000 claims description 15
238000005498 polishing Methods 0.000 claims description 14
230000003287 optical effect Effects 0.000 claims description 13
238000012545 processing Methods 0.000 claims description 12
238000001179 sorption measurement Methods 0.000 claims description 10
238000010521 absorption reaction Methods 0.000 claims description 9
230000002265 prevention Effects 0.000 claims description 9
239000006096 absorbing agent Substances 0.000 claims description 8
230000002906 microbiologic effect Effects 0.000 claims description 8
238000003672 processing method Methods 0.000 claims description 8
239000000523 sample Substances 0.000 claims description 8
238000005406 washing Methods 0.000 claims description 8
230000009471 action Effects 0.000 claims description 6
238000004458 analytical method Methods 0.000 claims description 6
238000003745 diagnosis Methods 0.000 claims description 6
238000001727 in vivo Methods 0.000 claims description 6
238000002347 injection Methods 0.000 claims description 6
239000007924 injection Substances 0.000 claims description 6
238000004377 microelectronic Methods 0.000 claims description 6
239000000203 mixture Substances 0.000 claims description 6
230000000284 resting effect Effects 0.000 claims description 6
238000012360 testing method Methods 0.000 claims description 6
230000000977 initiatory effect Effects 0.000 claims description 5
239000004065 semiconductor Substances 0.000 claims description 5
238000004090 dissolution Methods 0.000 claims description 4
239000007788 liquid Substances 0.000 claims description 4
229920000642 polymer Polymers 0.000 claims description 4
230000000930 thermomechanical effect Effects 0.000 claims description 4
238000004891 communication Methods 0.000 claims description 3
238000007405 data analysis Methods 0.000 claims description 3
239000011368 organic material Substances 0.000 claims description 3
230000003068 static effect Effects 0.000 claims description 3
230000005540 biological transmission Effects 0.000 claims description 2
238000004364 calculation method Methods 0.000 claims description 2
239000000919 ceramic Substances 0.000 claims description 2
238000012993 chemical processing Methods 0.000 claims description 2
239000004020 conductor Substances 0.000 claims description 2
238000001816 cooling Methods 0.000 claims description 2
230000005684 electric field Effects 0.000 claims description 2
238000010438 heat treatment Methods 0.000 claims description 2
229910010272 inorganic material Inorganic materials 0.000 claims description 2
239000011147 inorganic material Substances 0.000 claims description 2
239000012212 insulator Substances 0.000 claims description 2
238000002493 microarray Methods 0.000 claims description 2
238000005070 sampling Methods 0.000 claims description 2
238000001308 synthesis method Methods 0.000 claims description 2
230000031018 biological processes and functions Effects 0.000 claims 3
238000011065 in-situ storage Methods 0.000 claims 2
210000004027 cell Anatomy 0.000 description 88
238000011282 treatment Methods 0.000 description 22
238000004140 cleaning Methods 0.000 description 18
238000012377 drug delivery Methods 0.000 description 8
238000002406 microsurgery Methods 0.000 description 8
210000003462 vein Anatomy 0.000 description 8
239000002245 particle Substances 0.000 description 7
230000008569 process Effects 0.000 description 7
210000004204 blood vessel Anatomy 0.000 description 6
238000005516 engineering process Methods 0.000 description 6
238000005520 cutting process Methods 0.000 description 5
238000000338 in vitro Methods 0.000 description 5
230000010354 integration Effects 0.000 description 5
210000001519 tissue Anatomy 0.000 description 5
239000002246 antineoplastic agent Substances 0.000 description 4
210000001367 artery Anatomy 0.000 description 4
210000003850 cellular structure Anatomy 0.000 description 4
230000006378 damage Effects 0.000 description 4
238000013461 design Methods 0.000 description 4
230000003449 preventive effect Effects 0.000 description 4
238000001356 surgical procedure Methods 0.000 description 4
238000013459 approach Methods 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000008280 blood Substances 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
238000011161 development Methods 0.000 description 3
238000002430 laser surgery Methods 0.000 description 3
241000894006 Bacteria Species 0.000 description 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
208000007536 Thrombosis Diseases 0.000 description 2
230000008859 change Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
238000012631 diagnostic technique Methods 0.000 description 2
230000035487 diastolic blood pressure Effects 0.000 description 2
230000006806 disease prevention Effects 0.000 description 2
230000000694 effects Effects 0.000 description 2
238000001914 filtration Methods 0.000 description 2
239000003517 fume Substances 0.000 description 2
238000002615 hemofiltration Methods 0.000 description 2
210000005260 human cell Anatomy 0.000 description 2
229910052588 hydroxylapatite Inorganic materials 0.000 description 2
238000013532 laser treatment Methods 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012544 monitoring process Methods 0.000 description 2
208000010125 myocardial infarction Diseases 0.000 description 2
238000001579 optical reflectometry Methods 0.000 description 2
230000007170 pathology Effects 0.000 description 2
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
238000012552 review Methods 0.000 description 2
229910052710 silicon Inorganic materials 0.000 description 2
239000010703 silicon Substances 0.000 description 2
239000012798 spherical particle Substances 0.000 description 2
238000003860 storage Methods 0.000 description 2
229920002994 synthetic fiber Polymers 0.000 description 2
238000002626 targeted therapy Methods 0.000 description 2
239000004254 Ammonium phosphate Substances 0.000 description 1
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
241001481166 Nautilus Species 0.000 description 1
229910052581 Si3N4 Inorganic materials 0.000 description 1
208000006011 Stroke Diseases 0.000 description 1
206010053648 Vascular occlusion Diseases 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
229910000148 ammonium phosphate Inorganic materials 0.000 description 1
235000019289 ammonium phosphates Nutrition 0.000 description 1
239000003124 biologic agent Substances 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
238000010170 biological method Methods 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000036772 blood pressure Effects 0.000 description 1
238000009530 blood pressure measurement Methods 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
201000006491 bone marrow cancer Diseases 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
235000010216 calcium carbonate Nutrition 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
239000012830 cancer therapeutic Substances 0.000 description 1
229910002090 carbon oxide Inorganic materials 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
238000006388 chemical passivation reaction Methods 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000002131 composite material Substances 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000012937 correction Methods 0.000 description 1
230000008021 deposition Effects 0.000 description 1
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 1
230000036541 health Effects 0.000 description 1
235000004280 healthy diet Nutrition 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
201000005787 hematologic cancer Diseases 0.000 description 1
208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
238000001990 intravenous administration Methods 0.000 description 1
238000009533 lab test Methods 0.000 description 1
238000003698 laser cutting Methods 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
230000002934 lysing effect Effects 0.000 description 1
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
239000004137 magnesium phosphate Substances 0.000 description 1
229910000157 magnesium phosphate Inorganic materials 0.000 description 1
229960002261 magnesium phosphate Drugs 0.000 description 1
235000010994 magnesium phosphates Nutrition 0.000 description 1
230000008816 organ damage Effects 0.000 description 1
229920000620 organic polymer Polymers 0.000 description 1
JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
238000007517 polishing process Methods 0.000 description 1
229910021420 polycrystalline silicon Inorganic materials 0.000 description 1
239000002861 polymer material Substances 0.000 description 1
229920005591 polysilicon Polymers 0.000 description 1
230000002980 postoperative effect Effects 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000011272 standard treatment Methods 0.000 description 1
238000011477 surgical intervention Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
208000021331 vascular occlusion disease Diseases 0.000 description 1
238000010626 work up procedure Methods 0.000 description 1

Images

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0089—Particulate, powder, adsorbate, bead, sphere
- A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
- A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B7/00—Microstructural systems; Auxiliary parts of microstructural devices or systems
- B81B7/02—Microstructural systems; Auxiliary parts of microstructural devices or systems containing distinct electrical or optical devices of particular relevance for their function, e.g. microelectro-mechanical systems [MEMS]
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B17/320758—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with a rotating cutting instrument, e.g. motor driven
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00084—Temperature
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00345—Micromachines, nanomachines, microsystems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/06—Measuring instruments not otherwise provided for
- A61B2090/064—Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Medical Informatics (AREA)
Nanotechnology (AREA)
Veterinary Medicine (AREA)
Surgery (AREA)
Animal Behavior & Ethology (AREA)
Immunology (AREA)
Public Health (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Pathology (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
General Physics & Mathematics (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Pharmacology & Pharmacy (AREA)
Crystallography & Structural Chemistry (AREA)
General Engineering & Computer Science (AREA)
Vascular Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Food Science & Technology (AREA)
Microelectronics & Electronic Packaging (AREA)
Dermatology (AREA)
Computer Hardware Design (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Oncology (AREA)
Cell Biology (AREA)
Microbiology (AREA)

JP2013529116A 2010-09-17 2010-09-17 生物医学的用途のマイクロデバイス及びその使用 Expired - Fee Related JP5917522B2 (ja)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2010/049298 WO2012036697A1 (en)	2010-09-17	2010-09-17	Micro devices biomedical applications and uses of the same

Publications (3)

Publication Number	Publication Date
JP2013539669A JP2013539669A (ja)	2013-10-28
JP2013539669A5 JP2013539669A5 (pt)	2013-12-05
JP5917522B2 true JP5917522B2 (ja)	2016-05-18

Family

ID=45831887

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2013529116A Expired - Fee Related JP5917522B2 (ja)	2010-09-17	2010-09-17	生物医学的用途のマイクロデバイス及びその使用

Country Status (10)

Country	Link
EP (1)	EP2615968A4 (pt)
JP (1)	JP5917522B2 (pt)
KR (1)	KR101761259B1 (pt)
CN (2)	CN105403690A (pt)
AU (2)	AU2010360764A1 (pt)
BR (1)	BR112013006299B8 (pt)
CA (1)	CA2812189C (pt)
IL (1)	IL225284B (pt)
WO (1)	WO2012036697A1 (pt)
ZA (1)	ZA201302375B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW202109037A (zh)	2012-07-16	2021-03-01	大陸商昌和生物醫學科技（揚州）有限公司	增強疾病檢測與鑒定的器件與方法
EP2967429B1 (en)	2013-03-15	2019-01-02	ANPAC Bio-Medical Science Co., Ltd.	Methods and apparatus for enhanced detection of diseases
CN106255881A (zh) *	2014-05-02	2016-12-21	公立大学法人大阪府立大学	癌细胞检测用高分子膜及其制造方法、以及使用该高分子膜的癌细胞检测装置
CN104965002B (zh) *	2014-12-16	2018-04-17	湖南省茶叶研究所（湖南省茶叶检测中心）	降低触角电位仪背景噪音的装置及使用该装置检测触角的方法
FR3032106B1 (fr) *	2015-02-02	2020-07-31	Centre Nat Rech Scient	Microdispositif pour la capture in vivo de biomarqueurs cellulaires circulants.
WO2018056584A1 (ko)	2016-09-21	2018-03-29	삼성전자 주식회사	피부 상태 측정 방법 및 이를 위한 전자 장치
TWI636775B (zh) *	2017-10-27	2018-10-01	研能科技股份有限公司	微型泵浦
CN112023271B (zh) *	2020-09-22	2023-11-28	天津工业大学	亚毫米尺寸活体植入式多通道微磁刺激器
WO2022169773A1 (en) *	2021-02-02	2022-08-11	Sheehan Daniel P	Thermal diffusion membrane, devices, systems and methods

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US663615A (en) *	1900-08-10	1900-12-11	Eugene J Gregory	Pyrographical tool.
US6240312B1 (en) *	1997-10-23	2001-05-29	Robert R. Alfano	Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment
US6092530A (en)	1999-03-24	2000-07-25	The B.F. Goodrich Company	Remotely interrogated implant device with sensor for detecting accretion of biological matter
US20020094515A1 (en) *	2000-11-30	2002-07-18	Erlach Julian Van	Method and apparatus for attaching a microdevice or a nanodevice to a biological member
US6663615B1 (en) *	2001-09-04	2003-12-16	The Ohio State University	Dual stage microvalve and method of use
KR100417163B1 (ko) *	2001-11-12	2004-02-05	한국과학기술연구원	마이크로 캡슐형 로봇
US6682490B2 (en) *	2001-12-03	2004-01-27	The Cleveland Clinic Foundation	Apparatus and method for monitoring a condition inside a body cavity
US20030216622A1 (en) *	2002-04-25	2003-11-20	Gavriel Meron	Device and method for orienting a device in vivo
AU2003298538A1 (en) *	2002-08-01	2004-05-04	The Johns Hopkins University	Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence
JP3883001B2 (ja)	2002-10-07	2007-02-21	国立循環器病センター総長	子宮内埋め込み型胎児モニタリング装置
US6936003B2 (en) *	2002-10-29	2005-08-30	Given Imaging Ltd	In-vivo extendable element device and system, and method of use
US6922118B2 (en)	2002-11-01	2005-07-26	Hrl Laboratories, Llc	Micro electrical mechanical system (MEMS) tuning using focused ion beams
CN1218756C (zh) *	2003-05-14	2005-09-14	厦门大学	无痛给药装置
US20050228313A1 (en) *	2003-12-04	2005-10-13	University Technologies International Inc.	Fluid sampling, analysis and delivery system
JP4436707B2 (ja)	2004-03-25	2010-03-24	オリンパス株式会社	カプセル型医療装置及びカプセル型医療装置システム
US7857767B2 (en) *	2004-04-19	2010-12-28	Invention Science Fund I, Llc	Lumen-traveling device
PL1737899T3 (pl) *	2004-04-20	2016-01-29	Dendritic Nanotechnologies Inc	Polimery dendrytyczne o ulepszonej amplifikacji i wewnętrznych grupach funkcyjnych
JP4746308B2 (ja) *	2004-11-29	2011-08-10	オリンパス株式会社	体内医療装置および体内医療システム
JP2007000177A (ja)	2005-06-21	2007-01-11	Konica Minolta Medical & Graphic Inc	医療用カプセル内視鏡
US8547248B2 (en) *	2005-09-01	2013-10-01	Proteus Digital Health, Inc.	Implantable zero-wire communications system
JP2008012094A (ja) *	2006-07-06	2008-01-24	Kenichi Katsu	カプセル内視鏡
KR101611240B1 (ko) *	2006-10-25	2016-04-11	프로테우스 디지털 헬스, 인코포레이티드	복용 가능한 제어된 활성화 식별자
US20080269948A1 (en) *	2006-11-13	2008-10-30	Solomon Research Llc	Hybrid control system for collectives of evolvable nanorobots and microrobots
CN100493451C (zh) *	2007-08-16	2009-06-03	上海交通大学	电磁式胃肠动力功能无创诊查***
CN100534381C (zh) *	2007-09-06	2009-09-02	上海交通大学	胃肠道出血无创监测***
FR2934949B1 (fr) *	2008-08-14	2010-09-10	Quidd	Capsule autonome de detection destinee a etre introduite dans un conduit d'un corps humain ou animal
US20110282144A1 (en) *	2008-11-17	2011-11-17	Mayo Foundation For Medical Education And Research	Diagnostic capsules, delivery/retrieval systems, kits and methods
BRPI1005285A2 (pt) *	2009-01-29	2020-09-01	Given Imaging Ltda	dispositivo, sistema e método de detecção de sangramento
CN101828907B (zh) *	2010-02-11	2012-06-20	上海交通大学	植入式微型生理参数检测***

2010
- 2010-09-17 KR KR1020137008453A patent/KR101761259B1/ko active IP Right Grant
- 2010-09-17 EP EP10857394.0A patent/EP2615968A4/en not_active Ceased
- 2010-09-17 JP JP2013529116A patent/JP5917522B2/ja not_active Expired - Fee Related
- 2010-09-17 CA CA2812189A patent/CA2812189C/en active Active
- 2010-09-17 CN CN201510770386.9A patent/CN105403690A/zh active Pending
- 2010-09-17 CN CN201080070042.2A patent/CN103237492B/zh active Active
- 2010-09-17 AU AU2010360764A patent/AU2010360764A1/en not_active Abandoned
- 2010-09-17 BR BR112013006299A patent/BR112013006299B8/pt active IP Right Grant
- 2010-09-17 WO PCT/US2010/049298 patent/WO2012036697A1/en active Application Filing
2013
- 2013-03-17 IL IL225284A patent/IL225284B/en active IP Right Grant
- 2013-04-02 ZA ZA2013/02375A patent/ZA201302375B/en unknown
2017
- 2017-01-19 AU AU2017200356A patent/AU2017200356A1/en not_active Abandoned

Also Published As

Publication number	Publication date
AU2010360764A1 (en)	2013-04-11
CN103237492A (zh)	2013-08-07
JP2013539669A (ja)	2013-10-28
BR112013006299A2 (pt)	2016-06-07
CN103237492B (zh)	2016-02-17
AU2017200356A1 (en)	2017-02-02
EP2615968A1 (en)	2013-07-24
CA2812189A1 (en)	2012-03-22
IL225284A0 (en)	2013-06-27
BR112013006299B1 (pt)	2020-12-22
BR112013006299B8 (pt)	2021-07-27
CA2812189C (en)	2021-09-21
EP2615968A4 (en)	2014-03-12
WO2012036697A1 (en)	2012-03-22
IL225284B (en)	2018-11-29
CN105403690A (zh)	2016-03-16
KR101761259B1 (ko)	2017-07-25
AU2010360764A8 (en)	2013-04-18
KR20130124484A (ko)	2013-11-14
ZA201302375B (en)	2014-02-26

Legal Events

Date	Code	Title	Description
2013-07-25	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130723
2013-09-13	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130912
2013-09-13	A621	Written request for application examination	Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130912
2014-08-15	A977	Report on retrieval	Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20140814
2014-08-20	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140819
2014-11-20	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20141119
2015-05-08	A131	Notification of reasons for refusal	Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150507
2015-08-04	A601	Written request for extension of time	Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150804
2015-09-03	A521	Request for written amendment filed	Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150903
2016-03-22	TRDD	Decision of grant or rejection written
2016-03-30	A01	Written decision to grant a patent or to grant a registration (utility model)	Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160330
2016-04-14	A61	First payment of annual fees (during grant procedure)	Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160406
2016-04-15	R150	Certificate of patent or registration of utility model	Ref document number: 5917522 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150
2019-04-09	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2020-03-24	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2021-03-05	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2022-03-07	R250	Receipt of annual fees	Free format text: JAPANESE INTERMEDIATE CODE: R250
2022-11-29	S111	Request for change of ownership or part of ownership	Free format text: JAPANESE INTERMEDIATE CODE: R313113
2022-12-21	R350	Written notification of registration of transfer	Free format text: JAPANESE INTERMEDIATE CODE: R350
2023-04-15	LAPS	Cancellation because of no payment of annual fees
2023-11-14	S111	Request for change of ownership or part of ownership	Free format text: JAPANESE INTERMEDIATE CODE: R313113
2023-12-06	R371	Transfer withdrawn	Free format text: JAPANESE INTERMEDIATE CODE: R371

Publication	Publication Date	Title
JP5917522B2 (ja)	2016-05-18	生物医学的用途のマイクロデバイス及びその使用
US20130006103A1 (en)	2013-01-03	Micro-Devices for Biomedical Applications and Method of Use of Same
US20140187870A1 (en)	2014-07-03	Systems, apparatus and methods for tissue dissection
US8328720B2 (en)	2012-12-11	MEMS interstitial prothrombin time test
JP2001511041A (ja)	2001-08-07	生物体液を獲得するための装置
JP5995954B2 (ja)	2016-09-28	医療器具及びその製造方法
WO2005124336A1 (en)	2005-12-29	Combined ultrasonic imaging and spectroscopic molecular analysis
JP2013539669A5 (pt)	2013-12-05
US20200330016A1 (en)	2020-10-22	Wearable or insertable devices with microneedles that include mechanically-responsive material
EP2451443B1 (en)	2017-05-03	Method of drug delivery
JP2020504749A (ja)	2020-02-13	アプタマーでコーティングされたマイクロニードルベースの診断用皮膚パッチの製造方法及びそのパッチ
JP2014160072A (ja)	2014-09-04	アナライトを検出する方法および装置
US20160183800A1 (en)	2016-06-30	Device and method for measuring the elasticity of a macroscopic sample
CN100570351C (zh)	2009-12-16	区分敏感与耐药不同癌细胞的纳米生物传感器的制备方法
Huang et al.	2005	Detecting the process of blood coagulation and clot formation with high frequency ultrasound
Strohm et al.	2009	Quantifying the ultrasonic properties of cells during apoptosis using time resolved acoustic microscopy
Chaiken et al.	2007	Toward an improved assignment of spectral features in tissue modulated non-invasive Raman spectroscopy of human fingertips
WO2007034164A2 (en)	2007-03-29	Diagnostic device
Chen	2016	Micro-fabricated silicon based probes for biomedical applications: Reliable neural interface, electro-mechano tissue assay surgical tweezer, and fluid viscosity sensing
Ong et al.	2005	Surgical application of MEMS devices