JP5888665B2 - Biocompatible polymer substrate - Google Patents

Biocompatible polymer substrate Download PDF

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JP5888665B2
JP5888665B2 JP2010293125A JP2010293125A JP5888665B2 JP 5888665 B2 JP5888665 B2 JP 5888665B2 JP 2010293125 A JP2010293125 A JP 2010293125A JP 2010293125 A JP2010293125 A JP 2010293125A JP 5888665 B2 JP5888665 B2 JP 5888665B2
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polymer substrate
biocompatible polymer
substrate
volume ratio
dsdt
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JP2012139306A (en
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浩幸 濱田
浩幸 濱田
行平 樋口
行平 樋口
前中　一介
一介 前中
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Japan Science and Technology Agency
University of Hyogo
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University of Hyogo
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本発明は、被貼付物に貼付することが可能な生体適合性ポリマー基板に関するものである。   The present invention relates to a biocompatible polymer substrate that can be attached to an object to be attached.

従来から、下記特許文献１に開示されているように、被接触物に接触することが意図されたポリマー組成物を含む製品が公知となっている。   Conventionally, as disclosed in the following Patent Document 1, products including a polymer composition intended to come into contact with an object to be contacted are known.

特開２０１０−４７７６４号公報JP 2010-47764 A

近年では、例えば、生体データを取得するために、皮膚などの被貼付物に貼付可能な生体適合性を有したポリマー基板が望まれる場合があるが、上記特許文献１のポリマー組成物は、生体適合性を有しているものの、被貼付物に貼付して使用することができるものではない（上記特許文献１の段落００４８、００４９参照）。   In recent years, for example, in order to obtain biometric data, there is a case where a polymer substrate having biocompatibility that can be applied to an object to be applied such as skin is desired. Although it has compatibility, it cannot be used by being attached to an object to be pasted (see paragraphs 0048 and 0049 of Patent Document 1).

そこで、本発明の目的は、生体適合性を有していながらも、皮膚など様々な被貼付物に貼付することが可能なポリマー基板を提供することである。   Accordingly, an object of the present invention is to provide a polymer substrate that can be applied to various objects to be applied such as skin while having biocompatibility.

（１） 本発明は、生体データの検出に用いる検出部を有した基体を備えている生体適合性ポリマー基板であって、前記基体の一方側の面が、ジメチルビニル末端ジメチルシロキサン（以下、ＤＳＤＴ（Dimethyl siloxane,Dimethylvinyl-terminated）と表現することがある。）とテトラメチルテトラビニルシクロテトラシロキサン（以下、ＴＴＣ（Tetrametyhyl tetravinyl cyclotetrasiloxane）と表現することがある。）とを、１００：２〜７３：１の体積比で重合させてなるものであり、前記基体の他方側の面が、ジメチルビニル末端ジメチルシロキサンとテトラメチルテトラビニルシクロテトラシロキサンとを、１０：１〜９：２の体積比で重合させてなるものであり、前記一方側の面から前記他方側の面方向に硬さが段階的に傾斜変化するように、前記一方側の面と前記他方側の面との間の層は、前記ジメチルビニル末端ジメチルシロキサンと前記テトラメチルテトラビニルシクロテトラシロキサンとを７３：１の値より小さく９：２の値より大きい範囲のいずれかの体積比で重合させてなるものである。なお、この傾斜変化には、前記一方側の面と前記他方側の面との間で、（i）一部だけ３層以上で段階的に傾斜変化している場合、（ii）数箇所において３層以上で段階的に傾斜変化している場合、が含まれる。
(1) The present invention is a biocompatible polymer substrate provided with a substrate having a detection unit used for detection of biological data, wherein one surface of the substrate has a dimethylvinyl-terminated dimethylsiloxane (hereinafter referred to as DSDT). (Sometimes expressed as dimethyl siloxane, dimethylvinyl-terminated) and tetramethyltetravinylcyclotetrasiloxane (hereinafter sometimes referred to as TTC) 100: 2-73: The volume on the other side of the substrate is polymerized with dimethylvinyl-terminated dimethylsiloxane and tetramethyltetravinylcyclotetrasiloxane at a volume ratio of 10: 1 to 9: 2. The surface on the one side so that the hardness changes in a stepwise manner from the surface on the one side to the surface direction on the other side. And the other side surface has a volume of any of the dimethylvinyl-terminated dimethylsiloxane and the tetramethyltetravinylcyclotetrasiloxane in a range less than 73: 1 and greater than 9: 2. also because by polymerizing a ratio. In addition, in this inclination change, in the case where (i) only a part of the slope changes gradually in three or more layers between the one side surface and the other side surface, (ii) in several places In the case where there are three or more layers and the slope changes stepwise, it is included.

上記（１）の構成によれば、前記一方側の面は、生体適合性を有したものであるとともに粘性を有しているので、皮膚などに長時間貼り付けたまま、生体データを検出することが可能である。また、前記一方側の面から厚さ方向に途中まで適度な柔軟性があるので、皮膚などに長時間貼り付けてもストレスを最小限に抑えることができる。逆に、他方側の面は一方側の面よりも硬いが可撓性を有しているので、生体適合性ポリマー基板自体の保護部材としてだけでなく、曲部への貼付にも対応できるようになっている。また、前記検出部に接続されている電極を前記一方側の面の内側に有している場合には、皮膚などを電極が圧迫するのを防止できるので、長時間貼り付けてもストレスを最小限に抑えることができる。また、ジメチルビニル末端ジメチルシロキサンと、テトラメチルテトラビニルシクロテトラシロキサンとを、１００：２の体積比で含むようにして一方側の面を形成した場合には、本発明のポリマー基板は、皮膚などへの貼付と剥離とを何回も繰り返すことができる。
According to the configuration of (1) above, the surface on the one side has biocompatibility and has viscosity, so that it detects biometric data while being stuck on the skin for a long time. It is possible. In addition, since there is a moderate flexibility from the one side surface in the thickness direction, stress can be minimized even if it is applied to the skin for a long time. On the other hand, the other side is harder than the one side but has flexibility, so that it can be used not only as a protective member for the biocompatible polymer substrate itself but also for sticking to a curved portion. It has become. In addition, when the electrode connected to the detection unit is provided on the inner side of the one side, the electrode can be prevented from being pressed against the skin or the like. To the limit. In addition, when one side surface is formed so as to contain dimethylvinyl-terminated dimethylsiloxane and tetramethyltetravinylcyclotetrasiloxane in a volume ratio of 100: 2, the polymer substrate of the present invention is applied to the skin or the like. Affixing and peeling can be repeated many times.

（２） 上記（１）のポリマー基板においては、前記電極に接続されている配線が、前記一方側の面の内側に埋設されていることが好ましい。 (2) In the polymer substrate of (1), it is preferable that the wiring connected to the electrode is embedded inside the one surface.

（３） 上記（１）のポリマー基板においては、前記電極に接続されている配線が、前記他方側の面の内側に埋設されていることが好ましい。 (3) In the polymer substrate of (1), it is preferable that the wiring connected to the electrode is embedded inside the surface on the other side.

上記（２）又は（３）の構成によれば、配線を保護することができるとともに、生体適合性ポリマー基板をより小型化することができる。   According to the configuration of (2) or (3), the wiring can be protected and the biocompatible polymer substrate can be further downsized.

本発明の第１実施形態に係る生体適合性ポリマー基板を示した概略図であって、（ａ）が側面図、（ｂ）が上視図である。It is the schematic which showed the biocompatible polymer board | substrate which concerns on 1st Embodiment of this invention, (a) is a side view, (b) is a top view. 本発明の第２実施形態に係る生体適合性ポリマー基板を示した側面概略図である。It is the side surface schematic which showed the biocompatible polymer substrate which concerns on 2nd Embodiment of this invention. 本発明の実施例１及び比較例９に係るポリマー組成物のスチロールへの貼り付き性の実験結果を示すグラフである。It is a graph which shows the experimental result of the sticking property to the styrene of the polymer composition which concerns on Example 1 and Comparative Example 9 of this invention. 本発明の実施例１及び比較例９に係るポリマー組成物の人の皮膚への貼り付き性の実験結果を示すグラフである。It is a graph which shows the experimental result of the sticking property to the human skin of the polymer composition which concerns on Example 1 and Comparative Example 9 of this invention.

＜第１実施形態＞
以下、図１を用いて、本発明の第１実施形態に係る生体適合性ポリマー基板について説明する。 <First Embodiment>
Hereinafter, the biocompatible polymer substrate according to the first embodiment of the present invention will be described with reference to FIG.

生体適合性ポリマー基板１００は、一方側の面１０と他方側の面１１とを有した基体１と、一方側の面１０表面に設けられている電極１２、１３、１４と、他方側の面１１の表面に設けられているデータ取得用モジュール（検出部）１５と、を備えているものである。   The biocompatible polymer substrate 100 includes a base 1 having a surface 10 on one side and a surface 11 on the other side, electrodes 12, 13, and 14 provided on the surface of the surface 10 on the one side, and a surface on the other side. 11, a data acquisition module (detection unit) 15 provided on the surface of 11.

基体１は、一方側の面１０から他方側の面１１方向に硬さが段階的に傾斜変化しているものである。   The base body 1 has a hardness that changes in a stepwise manner from the surface 10 on one side to the surface 11 on the other side.

一方側の面１０は、ＤＳＤＴとＴＴＣとを６０℃程度〜８０℃程度の範囲の温度環境下において、１００：２〜７３：１の範囲のうちいずれかの値の体積比で重合させてなるＰＤＭＳによって形成されている。このＰＤＭＳは、生体適合性を有しているものでもある。また、他方側の面１１は、ＤＳＤＴとＴＴＣとを６０℃程度〜８０℃程度の範囲の温度環境下において、１０：１〜９：２の範囲のうちいずれかの値の体積比で重合させてなるＰＤＭＳからなるものである。なお、他方側の面１１は一方側の面１０よりも硬いものである。
The surface 10 on one side is obtained by polymerizing DSDT and TTC at a volume ratio of any value in the range of 100: 2 to 73: 1 in a temperature environment of about 60 ° C to 80 ° C. It is formed by PDMS. This PDMS is also biocompatible. Further, the other surface 11 is made to polymerize DSDT and TTC at a volume ratio of any value in the range of 10: 1 to 9: 2 in a temperature environment of about 60 ° C. to about 80 ° C. It consists of PDMS. The other surface 11 is harder than the one surface 10.

電極１２、１３、１４は、被対象物からデータを取得するための部位であり、順に、配線１６、１７、１８を介して、データ取得用モジュール１５に接続されている。なお、配線１６、１８の一部及び配線１７は、基体１に埋設されており、保護されている。   The electrodes 12, 13, and 14 are parts for acquiring data from the object, and are sequentially connected to the data acquisition module 15 via the wirings 16, 17, and 18. A part of the wirings 16 and 18 and the wiring 17 are embedded in the base 1 and are protected.

データ取得用モジュール１５は、電極１２、１３、１４及び配線１６、１７、１８を介して得た生体データなどを記憶する記憶部と、外部と前記記憶部における生体データなどを送受信可能に接続することができる送受信部（図示せず）とを有した基板である。   The data acquisition module 15 is connected to a storage unit for storing biometric data obtained through the electrodes 12, 13, 14 and the wirings 16, 17, 18 so that the biometric data in the storage unit can be transmitted and received externally. And a transmission / reception unit (not shown).

次に、生体適合性ポリマー基板１００の製造方法の一例について説明する。まず、生体適合性ポリマー基板１００の底部及び側部の形状を内部に有した鋳型（図示せず）の底部の所定箇所に、配線１６、１７、１８のそれぞれを介してデータ取得用モジュール１５に接続されている電極１２、１３、１４を載置する。次に、一方側の面１０を形成するために、ＤＳＤＴとＴＴＣとを１００：２の体積比で混合した第１の液体（重合前のもの）を、鋳型の途中の高さまで流し込み、６０℃程度〜８０℃程度の範囲の温度環境下におく。続いて、第１の液体の重合が終了してＰＤＭＳが形成されてしまう前に、ＤＳＤＴとＴＴＣとを１００：５の体積比で混合した第２の液体（重合前のもの）を、鋳型の途中の高さまで流し込み、６０℃程度〜８０℃程度の範囲の温度環境下におく。続いて、第２の液体の重合が終了してＰＤＭＳが形成されてしまう前に、ＤＳＤＴとＴＴＣとを１００：８の体積比で混合した第３の液体（重合前のもの）を、鋳型の途中の高さまで流し込み、６０℃程度〜８０℃程度の範囲の温度環境下におく。続いて、他方側の面１１を形成するために、第３の液体の重合が終了してＰＤＭＳが形成されてしまう前に、ＤＳＤＴとＴＴＣとを１００：１０の体積比で混合した第４の液体（重合前のもの）を、データ取得用モジュール１５の下方面の高さまで流し込むとともに、配線１７が完全に埋没するように、且つ、配線１６、１８が図１に示した状態となるように位置を調整し、６０℃程度〜８０℃程度の範囲の温度環境下において、第４の液体を重合させ、ＰＤＭＳを形成する。これらの一連の工程により、生体適合性ポリマー基板１００が完成する。
Next, an example of a method for manufacturing the biocompatible polymer substrate 100 will be described. First, the data acquisition module 15 is connected to predetermined locations on the bottom of a mold (not shown) having the shape of the bottom and sides of the biocompatible polymer substrate 100 through the wirings 16, 17, and 18, respectively. The connected electrodes 12, 13, and 14 are placed. Next, in order to form the surface 10 on one side, a first liquid (before polymerization) in which DSDT and TTC are mixed at a volume ratio of 100: 2 is poured to a height in the middle of the mold, and 60 ° C. It is placed in a temperature environment in the range of about ~ 80 ° C. Subsequently, before the polymerization of the first liquid is completed and PDMS is formed, a second liquid (before polymerization) in which DSDT and TTC are mixed at a volume ratio of 100: 5 is used as a template. Pour to halfway height and place in a temperature environment in the range of about 60 ° C to about 80 ° C. Subsequently, before the polymerization of the second liquid is completed and PDMS is formed, a third liquid (before polymerization) in which DSDT and TTC are mixed at a volume ratio of 100: 8 is used as a template. Pour to halfway height and place in a temperature environment in the range of about 60 ° C to about 80 ° C. Subsequently, in order to form the surface 11 on the other side, the fourth liquid in which DSDT and TTC were mixed at a volume ratio of 100: 10 before the polymerization of the third liquid was completed and PDMS was formed. Liquid (before polymerization) is poured into the lower surface of the data acquisition module 15 so that the wiring 17 is completely buried and the wirings 16 and 18 are in the state shown in FIG. The position is adjusted, and the fourth liquid is polymerized in a temperature environment in the range of about 60 ° C. to about 80 ° C. to form PDMS. The biocompatible polymer substrate 100 is completed through a series of these steps.

次に、電極１２、１３、１４側を人の皮膚に貼り付けた際の生体適合性ポリマー基板１００の動作について説明する。まず、電極１２、１３、１４において、人の皮膚から心筋由来電圧信号を検出し、順に、配線１６、１７、１８を介して、データ取得用モジュール１５に送信する。心筋由来電圧信号を受信したデータ取得用モジュール１５は、記憶部において、心筋由来電圧信号を記憶する。記憶された生体データは、前記送受信部から外部のデータ蓄積部（図示せず）に送信され、該生体データが蓄積される。   Next, the operation of the biocompatible polymer substrate 100 when the electrodes 12, 13, and 14 are attached to human skin will be described. First, in the electrodes 12, 13, and 14, a myocardium-derived voltage signal is detected from human skin, and sequentially transmitted to the data acquisition module 15 via the wirings 16, 17, and 18. The data acquisition module 15 that has received the myocardial voltage signal stores the myocardial voltage signal in the storage unit. The stored biometric data is transmitted from the transmission / reception unit to an external data storage unit (not shown), and the biometric data is stored.

本実施形態によれば、一方側の面１０は生体適合性を有したものであるとともに粘性を有しているので、皮膚などに長時間貼り付けたまま、生体データを検出することが可能である。また、一方側の面１０は柔軟性があるので、皮膚などに長時間貼り付けてもストレスを最小限に抑えることができる。また、ＤＳＤＴとＴＴＣとを１００：２の体積比で混合して一方側の面１０を形成した場合には、生体適合性ポリマー基板１００は、皮膚などへの貼付と剥離とを何回も繰り返すことができる。
According to the present embodiment, the surface 10 on one side is biocompatible and has viscosity, so that it is possible to detect biometric data while being attached to the skin for a long time. is there. Moreover, since the surface 10 on one side is flexible, stress can be minimized even if it is applied to the skin for a long time. In addition, when one surface 10 is formed by mixing DSDT and TTC at a volume ratio of 100: 2, the biocompatible polymer substrate 100 repeats sticking to and peeling from the skin and the like many times. be able to.

また、一方側の面１０よりも硬い他方側の面１１により、データ取得用モジュール１５を生体適合性ポリマー基板１００に固定しやすくなっている。また、他方側の面１１は一方側の面１０よりも硬いが可撓性を有しているので、生体適合性ポリマー基板１００自体の保護部材としてだけでなく、曲部への貼付にも対応できるようになっている。このように、生体適合性ポリマー基板１００は、柔軟な面から比較的硬いが可撓性を有した面までを厚さ方向に傾斜的に併せ持つものである。   Further, the data acquisition module 15 is easily fixed to the biocompatible polymer substrate 100 by the other surface 11 that is harder than the one surface 10. In addition, since the other surface 11 is harder than the one surface 10 and has flexibility, it can be used not only as a protective member for the biocompatible polymer substrate 100 itself but also for application to a curved portion. It can be done. As described above, the biocompatible polymer substrate 100 has both a soft surface and a relatively hard but flexible surface in an inclined manner in the thickness direction.

＜第２実施形態＞
次に、図２を用いて、本発明の第２実施形態に係る生体適合性ポリマー基板について説明する。なお、本実施形態における符号２２〜２８の部位は、順に、第１実施形態における符号１２〜１８の部位と同様のものであるので、説明を省略することがある。 Second Embodiment
Next, a biocompatible polymer substrate according to a second embodiment of the present invention will be described with reference to FIG. In addition, since the site | part of the codes | symbols 22-28 in this embodiment is the same as the site | parts of the codes | symbols 12-18 in 1st Embodiment in order, description may be abbreviate | omitted.

生体適合性ポリマー基板２００は、一方側の面２０と他方側の面２１とを有した基体２を備えており、一方側の面２０の内側に電極２２、２３、２４及び配線２６、２８が埋設されている点、他方側の面２１の内側にデータ取得用モジュール２５が埋設されている点で、第１実施形態における生体適合性ポリマー基板１００と異なっている。   The biocompatible polymer substrate 200 includes a base body 2 having a surface 20 on one side and a surface 21 on the other side, and electrodes 22, 23, 24 and wirings 26, 28 are provided inside the surface 20 on the one side. It differs from the biocompatible polymer substrate 100 in the first embodiment in that it is embedded and the data acquisition module 25 is embedded inside the surface 21 on the other side.

次に、生体適合性ポリマー基板２００の製造方法の一例について説明する。まず、一方側の面１０を形成するために、生体適合性ポリマー基板２００の底部及び側部の形状を内部に有した鋳型（図示せず）の底部に、ＤＳＤＴとＴＴＣとを１００：２の体積比で混合した第１の液体（重合前のもの）を、鋳型の途中の高さまで流し込み、６０℃程度〜８０℃程度の範囲の温度環境下におく。次に、第１の液体の重合が終了してＰＤＭＳが形成されてしまう前に、配線１６、１７、１８のそれぞれを介してデータ取得用モジュール１５に接続されている電極１２、１３、１４を載置し、ＤＳＤＴとＴＴＣとを１００：５の体積比で混合した第２の液体（重合前のもの）を、鋳型の途中の高さまで流し込み、６０℃程度〜８０℃程度の範囲の温度環境下におく。続いて、第２の液体の重合が終了してＰＤＭＳが形成されてしまう前に、ＤＳＤＴとＴＴＣとを１００：６の体積比で混合した第３の液体（重合前のもの）を、鋳型の途中の高さまで流し込み、６０℃程度〜８０℃程度の範囲の温度環境下におく。続いて、第３の液体の重合が終了してＰＤＭＳが形成されてしまう前に、ＤＳＤＴとＴＴＣとを１００：８の体積比で混合した第４の液体（重合前のもの）を、配線２６、２７、２８が完全に埋没するように、データ取得用モジュール２５の上方面の高さまで流し込み、６０℃程度〜８０℃程度の範囲の温度環境下におく。続いて、第４の液体の重合が終了してＰＤＭＳが形成されてしまう前に、ＤＳＤＴとＴＴＣとを１００：１０の体積比で混合した第５の液体（重合前のもの）を鋳型に流し込み、６０℃程度〜８０℃程度の範囲の温度環境下におき、ＰＤＭＳからなる他方側の面２１を形成する。これらの一連の工程により、生体適合性ポリマー基板２００が完成する。
Next, an example of a method for manufacturing the biocompatible polymer substrate 200 will be described. First, in order to form the surface 10 on one side, DSDT and TTC are 100: 2 on the bottom of a mold (not shown) having the shape of the bottom and sides of the biocompatible polymer substrate 200 inside. The first liquid mixed at a volume ratio (before polymerization) is poured to a height in the middle of the mold and placed in a temperature environment in the range of about 60 ° C to about 80 ° C. Next, before the polymerization of the first liquid is completed and the PDMS is formed, the electrodes 12, 13, and 14 connected to the data acquisition module 15 through the wirings 16, 17, and 18 are connected. A second liquid (before polymerization) in which DSDT and TTC are mixed at a volume ratio of 100: 5 is poured to a height in the middle of the mold, and the temperature environment is in the range of about 60 ° C to about 80 ° C. Put it down. Subsequently, before the polymerization of the second liquid is completed and PDMS is formed, a third liquid (before polymerization) in which DSDT and TTC are mixed at a volume ratio of 100: 6 is used as a template. Pour to halfway height and place in a temperature environment in the range of about 60 ° C to about 80 ° C. Subsequently, before the polymerization of the third liquid is completed and PDMS is formed, a fourth liquid (before polymerization) in which DSDT and TTC are mixed at a volume ratio of 100: 8 is connected to the wiring 26. , 27 and 28 are poured to the height of the upper surface of the data acquisition module 25 so as to be completely buried and placed in a temperature environment in the range of about 60 ° C. to about 80 ° C. Subsequently, before the polymerization of the fourth liquid is completed and PDMS is formed, the fifth liquid (before polymerization) in which DSDT and TTC are mixed at a volume ratio of 100: 10 is poured into the mold. The other surface 21 made of PDMS is formed under a temperature environment in the range of about 60 ° C. to about 80 ° C. The biocompatible polymer substrate 200 is completed by these series of steps.

本実施形態によれば、第１実施形態と同様の作用効果を奏することができる。また、基体２内にデータ取得用モジュール２５及び配線２６、２８を埋設することで、データ取得用モジュール２５及び配線２６、２８を保護することができる。また、基体２内に配線２６、２８を埋設しない場合（例えば、幅方向に配線が飛び出ているような場合）に比べて、生体適合性ポリマー基板２００を小型化することができる。   According to this embodiment, the same operational effects as those of the first embodiment can be achieved. Further, the data acquisition module 25 and the wirings 26 and 28 can be protected by embedding the data acquisition module 25 and the wirings 26 and 28 in the base 2. In addition, the biocompatible polymer substrate 200 can be reduced in size compared to the case where the wirings 26 and 28 are not embedded in the base 2 (for example, when the wiring protrudes in the width direction).

また、人の皮膚などに貼り付けた場合の電極２２、２３、２４による接触的なストレスをなくすことができる。すなわち、皮膚などを電極２２、２３、２４が圧迫するのを防止できるので、長時間貼り付けてもストレスを最小限に抑えることができる。また、電極２２、２３、２４分の貼り付け面積を減少させることも可能であるため、電極２２、２３、２４を基体２に埋設しない場合に比べて、生体適合性ポリマー基板２００をより小型化することが可能である。   Further, contact stress due to the electrodes 22, 23, 24 when pasted on human skin or the like can be eliminated. That is, since the electrodes 22, 23, 24 can be prevented from being pressed against the skin or the like, the stress can be minimized even if it is applied for a long time. In addition, since it is possible to reduce the bonding area of the electrodes 22, 23, and 24, the biocompatible polymer substrate 200 can be made smaller than when the electrodes 22, 23, and 24 are not embedded in the base 2. Is possible.

次に、実施例を用いて、上記第１実施形態に係る一方側の面１０を構成するポリマー組成物について説明する。   Next, the polymer composition constituting the one-side surface 10 according to the first embodiment will be described using examples.

下記表１の実施例１〜４及び比較例１〜８に示した体積比で、ＤＳＤＴとＴＴＣとを混合した後、８０℃の環境下で放置し、ポリマー組成物を生成することを試みた。その結果、比較例６〜８についてはポリマー組成物を生成することができなかったが、実施例１〜４及び比較例１〜４については、ポリマー組成物を生成することができた。なお、実施例１〜４及び比較例１〜４の条件で生成されたポリマー組成物を、各条件につき数個ずつ作成し、該ポリマー組成物それぞれについて人の皮膚への貼り付き耐久性を調査した。該調査の結果を表１に示す。   After mixing DSDT and TTC in the volume ratios shown in Examples 1 to 4 and Comparative Examples 1 to 8 in Table 1 below, the mixture was allowed to stand in an environment at 80 ° C. to try to produce a polymer composition. . As a result, a polymer composition could not be produced for Comparative Examples 6 to 8, but a polymer composition could be produced for Examples 1 to 4 and Comparative Examples 1 to 4. In addition, several polymer compositions produced under the conditions of Examples 1 to 4 and Comparative Examples 1 to 4 were prepared for each condition, and the durability of sticking to human skin was investigated for each of the polymer compositions. did. The results of the investigation are shown in Table 1.

Figure 0005888665
Figure 0005888665

表１から、生体適合性を有した実施例１〜４に係るポリマー組成物は、直接、人の皮膚などに長期間貼り付けることが可能であることがわかった。実施例２〜４に係るポリマー組成物に関しては、実施例１に係るポリマー組成物よりも粘着性は強いが、柔らかいために貼り付けた場所から移動してしまうことがあった。   From Table 1, it was found that the polymer compositions according to Examples 1 to 4 having biocompatibility can be directly applied to human skin or the like for a long period of time. About the polymer composition which concerns on Examples 2-4, although the adhesiveness is stronger than the polymer composition which concerns on Example 1, since it was soft, it might move from the sticking place.

また、実施例１に係るポリマー組成物と比較例９に係る市販商品（ジョンソン・エンド・ジョンソン（株）製のＢＡＮＤ−ＡＩＤ（登録商標））とについて、スチロールの表面と人の皮膚とに貼ったり剥がしたりすることを繰り返して、貼り付き性の変化を調査した。スチロールの表面について行った調査の結果を図３のグラフに示し、人の皮膚について行った調査の結果を図４のグラフに示す。なお、実施例１に係るポリマー組成物又は比較例９に係る市販商品を被対象物に貼って剥がしてという２つの作業を１サイクルと定義し、図３及び図４のｘ軸にサイクル数を示す。また、図３及び図４のｙ軸は、実施例１に係るポリマー組成物と比較例９に係る市販商品を剥がす際に必要な張力の値を示すものである。   In addition, the polymer composition according to Example 1 and the commercial product according to Comparative Example 9 (BAND-AID (registered trademark) manufactured by Johnson & Johnson Co., Ltd.) were applied to the surface of styrene and human skin. The change of sticking property was investigated by repeating the peeling and peeling. The result of the investigation conducted on the surface of styrene is shown in the graph of FIG. 3, and the result of the investigation conducted on the human skin is shown in the graph of FIG. In addition, the two operations of attaching the polymer composition according to Example 1 or the commercial product according to Comparative Example 9 to the object and peeling off are defined as one cycle, and the number of cycles is defined on the x-axis in FIGS. 3 and 4. Show. Moreover, the y-axis of FIG.3 and FIG.4 shows the value of tension | tensile_strength required when peeling the polymer composition which concerns on Example 1, and the commercial item which concerns on the comparative example 9. FIG.

図３及び図４のグラフから、実施例１に係るポリマー組成物の貼り付き性は、スチロールの表面について行った調査では、８０回未満では異なるものの８０回以上で比較例９に係る市販商品と同様のものとなった。また、実施例１に係るポリマー組成物の貼り付き性は、人の皮膚について行った調査では、４０回未満では異なるものの４０回以上で比較例９に係る市販商品と同様のものとなった。なお、実施例１に係るポリマー組成物の貼り付き性は、最初から２００回まで上記サイクルを繰り返しても変化せず、安定したものであることがわかった。したがって、実施例１のポリマー組成物は、被貼付物への貼付と剥離とを何回も繰り返すことができることがわかった。すなわち、実施例１のポリマー組成物を何回も使用することができることから、実施例１のポリマー組成物は、被貼付物への貼付と剥離とが１回でできなくなってしまうものに比べて経済的である。   From the graphs of FIG. 3 and FIG. 4, the sticking property of the polymer composition according to Example 1 is different from that of less than 80 times in the investigation conducted on the surface of styrene, but it is 80 times or more and the commercial product according to Comparative Example 9 It became the same thing. Moreover, the sticking property of the polymer composition which concerns on Example 1 became the same thing as the commercial item which concerns on the comparative example 9 in 40 times or more although it differed in less than 40 times in the investigation conducted about human skin. In addition, it turned out that the sticking property of the polymer composition which concerns on Example 1 does not change even if the said cycle is repeated 200 times from the beginning, and is stable. Therefore, it turned out that the polymer composition of Example 1 can repeat the sticking and peeling to a to-be-bonded object many times. That is, since the polymer composition of Example 1 can be used many times, the polymer composition of Example 1 is less than the one that cannot be applied to the object to be applied and peeled off once. Economical.

なお、実施例２〜４に係るポリマー組成物については、スチロールの表面又は人の皮膚に貼り付くものの、剥がすと、該ポリマー組成物がスチロールの表面又は人の皮膚にいくらか残留するという状況になった。   In addition, about the polymer composition which concerns on Examples 2-4, although it sticks on the surface of styrene or human skin, when it peels off, it will be in the situation where this polymer composition remains on the surface of styrene or human skin. It was.

＜変形例＞
なお、本発明は上記実施形態及び実施例に限定されるものではなく、本発明の趣旨に基づいて種々の変形が可能であり、これらを本発明の範囲から排除するものではない。例えば、上記第１実施形態においては、ＤＳＤＴとＴＴＣとを１００：２〜７３：１のいずれかの体積比で混合した４種類の重合前の液体を用いて作成した、硬さが傾斜的に変化しているＰＤＭＳからなる基体を有した生体適合性ポリマー基板を一例として示したが、これに限られない。例えば、ＤＳＤＴとＴＴＣとを１００：２〜７３：１のいずれかの体積比で混合した２種類、３種類、又は、５種類以上の重合前の液体を用いて作成した、硬さが一部だけ又は段階的に傾斜変化しているＰＤＭＳからなる基体を有した生体適合性ポリマー基板としてもよい。若しくは、ＤＳＤＴとＴＴＣとの混合体積比を経時的に徐々に変化させながら、連続的に積層形成したＰＤＭＳからなる基体を有している生体適合性ポリマー基板としてもよい。
<Modification>
In addition, this invention is not limited to the said embodiment and Example, A various deformation | transformation is possible based on the meaning of this invention, and these are not excluded from the scope of the present invention. For example, in the first embodiment, the hardness is gradiently prepared using four types of pre-polymerization liquid in which DSDT and TTC are mixed at a volume ratio of 100: 2 to 73: 1. Although a biocompatible polymer substrate having a substrate composed of changing PDMS is shown as an example, it is not limited thereto. For example, some hardness is created using two, three, or five or more pre-polymerization liquids in which DSDT and TTC are mixed at a volume ratio of 100: 2-73: 1. Alternatively, it may be a biocompatible polymer substrate having a substrate made of PDMS which is inclined or changed stepwise. Or it is good also as a biocompatible polymer substrate which has the base | substrate which consists of PDMS continuously laminated | stacked, changing the mixing volume ratio of DSDT and TTC gradually with time.

また、上記第２実施形態においては、ＤＳＤＴとＴＴＣとを１００：２〜７３：１のいずれかの体積比で混合した５種類の重合前の液体を用いて作成した、硬さが傾斜的に変化しているＰＤＭＳからなる基体を有した生体適合性ポリマー基板を一例として示したが、これに限られない。例えば、ＤＳＤＴとＴＴＣとを１００：２〜７３：１のいずれかの体積比で混合した２種類、３種類、４種類、又は、６種類以上の重合前の液体を用いて作成した、硬さが一部だけ又は段階的に傾斜変化しているＰＤＭＳからなる基体を有した生体適合性ポリマー基板としてもよい。若しくは、ＤＳＤＴとＴＴＣとの混合体積比を経時的に徐々に変化させながら、連続的に積層形成したＰＤＭＳからなる基体を有している生体適合性ポリマー基板としてもよい。

Moreover, in the said 2nd Embodiment, it created using the 5 types of liquids before superposition | polymerization which mixed DSDT and TTC with the volume ratio in any one of 100: 2-73: 1, and hardness is gradient. Although a biocompatible polymer substrate having a substrate composed of changing PDMS is shown as an example, it is not limited thereto. For example, hardness prepared using two, three, four, or six or more pre-polymerization liquids in which DSDT and TTC are mixed at a volume ratio of 100: 2-73: 1. May be a biocompatible polymer substrate having a substrate made of PDMS with a partial or stepwise change in slope. Or it is good also as a biocompatible polymer substrate which has the base | substrate which consists of PDMS continuously laminated | stacked, changing the mixing volume ratio of DSDT and TTC gradually with time.

また、上記第２実施形態においては、データ取得用モジュール２５及び配線２６、２８を基体２内に埋設したが、データ取得用モジュール２５及び配線２６、２８のうちいずれか１つ以上を埋設するだけでもよい。   Further, in the second embodiment, the data acquisition module 25 and the wirings 26 and 28 are embedded in the base body 2, but only one or more of the data acquisition module 25 and the wirings 26 and 28 are embedded. But you can.

また、上記第２実施形態においては、電極２２、２３、２４を基体２内に埋設したが、第１実施形態における電極と同様に、埋設していないものであってもよい。   Moreover, in the said 2nd Embodiment, although the electrodes 22, 23, and 24 were embedded in the base | substrate 2, like the electrode in 1st Embodiment, you may not embed.

１、２ 基体
１０、２０ 一方側の面
１１、２１ 他方側の面
１２、１３、１４、２２、２３、２４ 電極
１５、２５ データ取得用モジュール
１６、１７、１８、２６、２７、２８ 配線
１００、２００ 生体適合性ポリマー基板
1, 2, 10, 20 One side 11, 21 The other side 12, 13, 14, 22, 23, 24 Electrode 15, 25 Data acquisition module 16, 17, 18, 26, 27, 28 Wiring 100 200 Biocompatible polymer substrate

Claims (3)

生体データの検出に用いる検出部を有した基体を備えている生体適合性ポリマー基板であって、
前記基体の一方側の面が、ジメチルビニル末端ジメチルシロキサンとテトラメチルテトラビニルシクロテトラシロキサンとを、１００：２〜７３：１の体積比で重合させてなるものであり、
前記基体の他方側の面が、ジメチルビニル末端ジメチルシロキサンとテトラメチルテトラビニルシクロテトラシロキサンとを、１０：１〜９：２の体積比で重合させてなるものであり、
前記検出部に接続されている電極を前記一方側の面又は前記一方側の面の内側に有しており、
前記一方側の面から前記他方側の面方向に硬さが３層以上で段階的に傾斜変化するように、前記一方側の面と前記他方側の面との間の層は、前記ジメチルビニル末端ジメチルシロキサンと前記テトラメチルテトラビニルシクロテトラシロキサンとを７３：１の値より小さく９：２の値より大きい範囲のいずれかの体積比で重合させてなるものであることを特徴とする生体適合性ポリマー基板。 A biocompatible polymer substrate including a substrate having a detection unit used for detection of biological data,
One surface of the substrate is obtained by polymerizing dimethylvinyl-terminated dimethylsiloxane and tetramethyltetravinylcyclotetrasiloxane in a volume ratio of 100: 2 to 73: 1,
The other surface of the substrate is obtained by polymerizing dimethylvinyl-terminated dimethylsiloxane and tetramethyltetravinylcyclotetrasiloxane in a volume ratio of 10: 1 to 9: 2.
It has an electrode connected to the detection part on the inside of the one side surface or the one side surface,
The layer between the one side surface and the other side surface is the dimethylvinyl so that the hardness changes in a stepwise manner in three or more layers from the one side surface to the other side surface direction. the terminated dimethylsiloxane tetramethyltetravinylcyclotetrasiloxane and 73: 1 for less than the value 9: biocompatibility, wherein the polymerized is made by either of the volume ratio in a range of greater than 2 values Polymer substrate. 前記電極に接続されている配線が、前記一方側の面の内側に埋設されていることを特徴とする請求項１に記載の生体適合性ポリマー基板。   The biocompatible polymer substrate according to claim 1, wherein a wiring connected to the electrode is embedded inside the surface on the one side. 前記電極に接続されている配線が、前記他方側の面の内側に埋設されていることを特徴とする請求項１に記載の生体適合性ポリマー基板。
The biocompatible polymer substrate according to claim 1, wherein the wiring connected to the electrode is embedded inside the surface on the other side.
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