JP5814242B2 - 新規なヘパリン体とその利用法 - Google Patents
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Description
この実施例では、ヘパリンと、コアとしての硫酸コリスチンとを含むヘパリン体の構成を説明する。このヘパリン体は、基板の表面に付着させるのに使用できる自由端アルデヒドを含んでいる。
この実施例では、ヘパリンと、コアとしての硫酸ネオマイシンとを含むヘパリン体の構成を説明する。このヘパリン体は、基板の表面に付着させるのに使用できる自由端アルデヒドを含んでいる。
この実施例では、ヘパリンと、コアとしての硫酸カプレオマイシンとを含むヘパリン体の構成を説明する。このヘパリン体は、基板の表面に付着させるのに使用できる自由端アルデヒドを含んでいる。
この実施例では、ヘパリンと、コアとしてのポリ-L-リシンとを含むヘパリン体の構成を説明する。このヘパリン体は、基板の表面に付着させるのに使用できる自由端アルデヒドを含んでいる。
この実施例では、ヘパリンと、コアとしてのポリエチレンイミン(PEI)とを含むヘパリン体の構成を説明する。このヘパリン体は、基板の表面に付着させるのに使用できる自由端アルデヒドを含んでいる。
この実施例では、ヘパリンと、コアとしてのエチレンジアミン(EDA)とを含むヘパリン体の構成を説明する。このヘパリン体は、基板の表面に付着させるのに使用できる自由端アルデヒドを含んでいる。
実施例1〜6の自由端アルデヒドを含むヘパリン体をePTFE基板の表面に固定化し、ATIII活性を試験した。
実施例2、3、4、6で製造した自由端アルデヒド含有ヘパリン体を分析して絶対分子量を調べた。
この実施例では、基板表面へのヘパリンまたはヘパリン体の付着法を識別する検出法を示す。この実施例では特に、自由端アルデヒドを含む単点付着とカルボジイミド共役を含む多点付着を利用したePTFE基板の表面への固定化を通じたヘパリンとヘパリン体の付着を見る。
この実施例では、殺菌後の基板表面へのヘパリン体の付着法を識別する検出法示す。この実施例では特に、自由端アルデヒドを含む単点付着を利用してePTFE基板の表面に固定化させることを通じてヘパリン体を付着させた後に殺菌してホウ酸で洗浄する場合を見る。
この実施例では、ヘパリナーゼ-1で解重合したヘパリン体を強陰イオン交換高性能液体クロマトグラフィ(SAX-HPLC)でオリゴ糖マッピングすることを利用してヘパリン体の組成を明らかにする検出法を示す。
この実施例では、ヘパリナーゼ-1で解重合したヘパリン体を強陰イオン交換高性能液体クロマトグラフィ(SAX-HPLC)でオリゴ糖マッピングすることを利用して、表面に固定化されたヘパリン体の組成を明らかにする検出法を示す。
この実施例では、ヘパリンと、ポリ-L-リシンを含むコアとを含むヘパリン体の構造を記載する。このヘパリン体は、基板の表面に付着させるのに使用できる自由端アルデヒドを含んでいない。このヘパリン体は、イオン結合を通じて基板の表面に付着させるのに使用できる。
実施例13のヘパリン体をイオン結合を通じてePTFE基板の表面に固定化した。
この実施例では、ヘパリンとヘパリン体を表面に固定化するための共役法をあきらかにするための検出法を示す。この実施例では特に、ヘパリナーゼ-1で解重合した後に、固定化されたヘパリンまたはヘパリン体の表面にある表面結合不飽和ヘパリン断片または“節”の検出を見る。ヘパリナーゼ-1によるヘパリンの解重合には、ヘパリンの非還元性末端ウロン酸が酵素によって開裂し、さまざまな検出分子(例えばチオール-テルビウム蛍光分子)と反応させることができる4,5-不飽和誘導体になることが含まれる。イオン結合したヘパリンの負の対照(実施例14)が含まれる。
この実施例では、ヘパリンとアンチトロンビンIII(ATIII)の結合が多い、ヘパリンと、アミン含有フルオロポリマーを含むコアとを含むヘパリン体に関する本発明の一実施態様の構成と利用法を説明する。このヘパリン体は、基板の表面に付着させるのに使用できる自由端アルデヒドを含んでいる。
この実施例では、ヘパリンとアンチトロンビンIIIの結合が多い、ヘパリンと、アミン含有フルオロポリマーを含むコアとを含むヘパリン体に関する本発明の一実施態様の構成と利用法を説明する。このヘパリン体は、基板の表面に付着させるのに使用できる、ヘパリン成分の長さに沿ったアルデヒドを含んでいる。
実施例7に記載した方法に従い、ヘパリンと、アミン含有フルオロポリマーを含むコアとを含む実施例16と17のヘパリン体をePTFE/PEI基板の表面に固定化したが、サンプルをEtOに曝露しなかった点が異なっている。実施例7に記載した方法に従ってATIII結合活性を測定した。
この実施例では、ヘパリンとアンチトロンビンIIIの結合が多い、ヘパリンと、アミン含有フルオロポリマーを含むコアとを含むヘパリン体に関する本発明の一実施態様の構成と利用法を説明する。このヘパリン体は、基板の表面に付着させるのに使用できる自由端アルデヒドを含んでいる。
Claims (21)
- 少なくとも1個のヘパリン分子を通じて基板の表面に結合したヘパリン体を含む医療用基板であって、該ヘパリン体が少なくとも1個のヘパリン分子と少なくとも1個のコア分子とを含み、該結合したヘパリン体がヘパリナーゼ感受性であり、かつ、該ヘパリン分子が該基板に対し、端点付着、ループ付着、端点アルデヒド付着またはアルデヒド付着により、該ヘパリンの長さに沿って付着している、医療用基板。
- 前記基板が、ポリエチレン、ポリウレタン、シリコーン、ポリアミド含有ポリマー、ポリプロピレン、ポリテトラフルオロエチレン、延伸ポリテトラフルオロエチレンおよび生体適合性金属からなる群から選ばれる、請求項1に記載の医療用基板。
- 前記基板が延伸ポリテトラフルオロエチレンである、請求項2に記載の医療用基板。
- 前記生体適合性金属がニチノールである、請求項2に記載の医療用基板。
- 前記基板が医療装置の一部品である、請求項1に記載の医療用基板。
- 前記医療装置が、グラフト、血管グラフト、ステント、ステント-グラフト、分岐グラフト、分岐ステント、分岐ステント-グラフト、パッチ、栓子、薬剤送達装置、カテーテル、心臓用リード線、バルーンおよび留置フィルタからなる群から選ばれる、請求項5に記載の医療用基板。
- 前記ステントを心臓、末梢、神経の用途に使用できる、請求項6に記載の医療用基板。
- 前記ステント-グラフトを心臓、末梢、神経の用途に使用できる、請求項6に記載の医療用基板。
- 前記コア分子が、環形、直線形、分岐形、樹枝形、Y字形、T字形または星形のいずれかである、請求項1に記載の医療用基板。
- 前記コア分子が、タンパク質、炭化水素、アミノグリコシド、多糖およびポリマーからなる群から選択される、請求項1に記載の医療用基板。
- 前記タンパク質が、アルブミン、コリスチンおよびポリリシンからなる群から選択される、請求項10に記載の医療用基板。
- 前記多糖が、シクロデキストリン、セルロースおよびキトサンからなる群から選択される、請求項10に記載の医療用基板。
- 前記ポリマーが、ポリエチレングリコール(PEG)およびテトラフルオロエチレンのコポリマーからなる群から選択される、請求項10に記載の医療用基板。
- 前記ヘパリンがウシ又はブタに由来する、請求項1に記載の医療用基板。
- ヘパリナーゼ処理の後、ヘパリンまたはその断片が前記基板上で検出されない、請求項1に記載の医療用基板。
- ヘパリナーゼ処理の後、ヘパリンまたはその断片が前記基板上で、ヘパリナーゼ処理の前よりも有意に低いレベルで検出される、請求項1に記載の医療用基板。
- 前記ヘパリンまたはその断片が、ヘパリンまたはその断片に結合する標識によって検出される、請求項15に記載の医療用基板。
- 前記ヘパリンまたはその断片に結合する前記標識が、染料、ポリクローナル抗体およびタンパク質からなる群から選ばれる、請求項17に記載の医療用基板。
- 前記染料がトルイジンブルーである、請求項18に記載の医療用基板。
- ヘパリナーゼ処理の後、わずかな量のトルイジンブルーが残留ヘパリンまたはその断片に結合するが、前記基板上では目視によって検出されない、請求項1に記載の医療用基板。
- ヘパリナーゼ処理の後、わずかな量のトルイジンブルーが残留ヘパリンまたはその断片に結合し、検出器の読みが、バックグラウンドのレベルであるか、またはヘパリン体なしの基板と比較してバックグラウンドと有意差がない、請求項1に記載の医療用基板。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US12/561,927 US8591932B2 (en) | 2009-09-17 | 2009-09-17 | Heparin entities and methods of use |
US12/561,927 | 2009-09-17 | ||
US12/579,308 | 2009-10-14 | ||
US12/579,308 US20110065085A1 (en) | 2009-09-17 | 2009-10-14 | Novel heparin entities and methods of use |
PCT/US2010/049078 WO2011035001A2 (en) | 2009-09-17 | 2010-09-16 | Novel heparin entities and methods of use |
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JP2015183860A Division JP6290840B2 (ja) | 2009-09-17 | 2015-09-17 | 新規なヘパリン体とその利用法 |
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JP2013505070A JP2013505070A (ja) | 2013-02-14 |
JP2013505070A5 JP2013505070A5 (ja) | 2013-11-07 |
JP5814242B2 true JP5814242B2 (ja) | 2015-11-17 |
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JP2015183860A Active JP6290840B2 (ja) | 2009-09-17 | 2015-09-17 | 新規なヘパリン体とその利用法 |
JP2017141575A Active JP6538767B2 (ja) | 2009-09-17 | 2017-07-21 | 新規なヘパリン体とその利用法 |
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EP (1) | EP2477668B1 (ja) |
JP (3) | JP5814242B2 (ja) |
CN (1) | CN102695530B (ja) |
AU (1) | AU2010295601B2 (ja) |
BR (1) | BR112012006144A2 (ja) |
CA (2) | CA2774494A1 (ja) |
ES (1) | ES2668220T3 (ja) |
RU (1) | RU2576803C2 (ja) |
WO (1) | WO2011035001A2 (ja) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8157951B2 (en) * | 2005-10-11 | 2012-04-17 | Applied Materials, Inc. | Capacitively coupled plasma reactor having very agile wafer temperature control |
US20130110137A1 (en) * | 2007-04-02 | 2013-05-02 | Ension, Inc. | Surface Treated Polymeric Synthetic Hernia Mesh Prosthesis, Surface Treated Sutures and Staples and Methods of Manufacturing the Same |
US9744033B2 (en) | 2011-04-01 | 2017-08-29 | W.L. Gore & Associates, Inc. | Elastomeric leaflet for prosthetic heart valves |
US9554806B2 (en) | 2011-09-16 | 2017-01-31 | W. L. Gore & Associates, Inc. | Occlusive devices |
AR087037A1 (es) * | 2012-07-02 | 2014-02-12 | Consejo Nac Invest Cient Tec | Fibras amiloides de lisozima, soporte solido, biocatalizador y procedimientos |
US9283072B2 (en) | 2012-07-25 | 2016-03-15 | W. L. Gore & Associates, Inc. | Everting transcatheter valve and methods |
CN102796723A (zh) * | 2012-09-11 | 2012-11-28 | 深圳市海普瑞药业股份有限公司 | 肝素酶i的固定化方法 |
US10092653B2 (en) * | 2012-09-13 | 2018-10-09 | W. L. Gore & Associates, Inc. | Polytetrafluoroethylene co-polymer emulsions |
CN102888390B (zh) * | 2012-10-30 | 2014-09-03 | 深圳市海普瑞药业股份有限公司 | 肝素酶ⅲ的固定化方法 |
US9737398B2 (en) | 2012-12-19 | 2017-08-22 | W. L. Gore & Associates, Inc. | Prosthetic valves, frames and leaflets and methods thereof |
US9968443B2 (en) | 2012-12-19 | 2018-05-15 | W. L. Gore & Associates, Inc. | Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet |
US9101469B2 (en) | 2012-12-19 | 2015-08-11 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with leaflet shelving |
US9144492B2 (en) | 2012-12-19 | 2015-09-29 | W. L. Gore & Associates, Inc. | Truncated leaflet for prosthetic heart valves, preformed valve |
US10966820B2 (en) | 2012-12-19 | 2021-04-06 | W. L. Gore & Associates, Inc. | Geometric control of bending character in prosthetic heart valve leaflets |
US10039638B2 (en) | 2012-12-19 | 2018-08-07 | W. L. Gore & Associates, Inc. | Geometric prosthetic heart valves |
US9447304B2 (en) | 2013-03-14 | 2016-09-20 | W. L. Gore & Associates, Inc. | Coating for a surface |
MX363474B (es) * | 2013-03-15 | 2019-03-25 | Baxter Int | Inmovilizacion de un agente activo en un sustrato. |
EP3003413B1 (en) * | 2013-06-07 | 2017-12-13 | Baxter International Inc. | Immobilization of an active agent on a substrate using compounds including trihydroxyphenyl groups |
US11911258B2 (en) | 2013-06-26 | 2024-02-27 | W. L. Gore & Associates, Inc. | Space filling devices |
WO2015048566A1 (en) * | 2013-09-26 | 2015-04-02 | The General Hospital Corporation | Methods of isolating extracellular vesicles |
US9504565B2 (en) | 2013-12-06 | 2016-11-29 | W. L. Gore & Associates, Inc. | Asymmetric opening and closing prosthetic valve leaflet |
WO2015122429A1 (ja) * | 2014-02-12 | 2015-08-20 | 東レ株式会社 | 人工血管 |
US11839698B2 (en) | 2014-03-13 | 2023-12-12 | W. L. Gore & Associates, Inc. | Drug composition and coating |
EP3182929B1 (en) | 2014-08-18 | 2023-08-09 | Edwards Lifesciences Corporation | Frame with integral sewing cuff for prosthetic valves |
US9827094B2 (en) | 2014-09-15 | 2017-11-28 | W. L. Gore & Associates, Inc. | Prosthetic heart valve with retention elements |
KR102140862B1 (ko) | 2015-05-14 | 2020-08-03 | 더블유.엘. 고어 앤드 어소시에이트스, 인코포레이티드 | 심방이의 폐색을 위한 디바이스 및 방법 |
EP3095509A1 (en) | 2015-05-18 | 2016-11-23 | Defymed | Membranes functionalized with heparin for bioartificial organs |
US10525376B2 (en) | 2015-07-20 | 2020-01-07 | W. L. Gore & Associates, Inc. | Affinity chromatography devices |
US10526367B2 (en) | 2015-07-20 | 2020-01-07 | W. L. Gore & Associates, Inc. | Affinity chromatography devices |
WO2017132642A1 (en) * | 2016-01-29 | 2017-08-03 | The Regents Of The University Of California | A wearable sensor, and method, to monitor anti-coagulation therapy |
AU2017246152B2 (en) | 2016-04-08 | 2020-06-11 | W.L. Gore & Associates, Inc. | Affinity chromatography devices |
US11173235B2 (en) | 2016-07-15 | 2021-11-16 | Cook Regentec Llc | Nitrite eluting devices and methods of use thereof |
RU2650667C1 (ru) * | 2016-12-02 | 2018-04-16 | Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт" - ГосНИИгенетика) | Мутантная рекомбинантная гепариназа I с повышенной удельной активностью из Pedobacter heparinus, фрагмент ДНК, кодирующий указанную гепариназу |
CN115568980A (zh) | 2017-09-12 | 2023-01-06 | W.L.戈尔及同仁股份有限公司 | 用于假体瓣膜的瓣叶框架附连件 |
WO2019067220A1 (en) | 2017-09-27 | 2019-04-04 | W. L. Gore & Associates, Inc. | PROSTHETIC VALVES WITH MECHANICALLY COUPLED VALVULAR BLADES |
AU2018342222B2 (en) | 2017-09-27 | 2021-05-20 | Edwards Lifesciences Corporation | Prosthetic valve with expandable frame and associated systems and methods |
JP7036912B2 (ja) | 2017-10-13 | 2022-03-15 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 嵌込式人工弁および送達システム |
US11173023B2 (en) | 2017-10-16 | 2021-11-16 | W. L. Gore & Associates, Inc. | Medical devices and anchors therefor |
WO2019089138A1 (en) | 2017-10-31 | 2019-05-09 | W. L. Gore & Associates, Inc. | Prosthetic heart valve |
WO2019089136A1 (en) | 2017-10-31 | 2019-05-09 | W. L. Gore & Associates, Inc. | Medical valve and leaflet promoting tissue ingrowth |
JP7072062B2 (ja) | 2017-10-31 | 2022-05-19 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 経カテーテル留置システム及び関連する方法 |
US11154397B2 (en) | 2017-10-31 | 2021-10-26 | W. L. Gore & Associates, Inc. | Jacket for surgical heart valve |
WO2019203898A1 (en) * | 2018-04-20 | 2019-10-24 | Ension, Inc. | Engineered heparin bioactive matrix for clinical application of blood contacting surface and method of manufacturing the same |
US20210338905A1 (en) | 2018-09-06 | 2021-11-04 | Biomodics Aps | A medical tubular device |
CA3118664C (en) | 2018-11-05 | 2023-02-14 | Matthew A. Johnson | Spiral wound protein separation device |
USD926322S1 (en) | 2018-11-07 | 2021-07-27 | W. L. Gore & Associates, Inc. | Heart valve cover |
CN109709292A (zh) * | 2018-12-29 | 2019-05-03 | 贵州金玖生物技术有限公司 | 一种肝素检测试剂盒及其应用 |
US11497601B2 (en) | 2019-03-01 | 2022-11-15 | W. L. Gore & Associates, Inc. | Telescoping prosthetic valve with retention element |
CN110917410B (zh) * | 2019-11-14 | 2020-11-24 | 浙江大学 | 一种基于双层异相结构的心血管支架涂层及其制备方法 |
CN111826418A (zh) * | 2020-08-28 | 2020-10-27 | 保定天岳生物工程有限公司 | 一种抗凝血酶iii测定试剂盒 |
KR20230066600A (ko) | 2020-09-11 | 2023-05-16 | 더블유.엘. 고어 앤드 어소시에이트스, 인코포레이티드 | 열처리된 피브릴화 폴리머 막을 포함하는 친화성 크로마토그래피 장치 및 이를 포함하는 매니폴드 |
IL307856A (en) | 2021-04-19 | 2023-12-01 | Gore & Ass | Electrochemical biosensors of test substance, related compositions of matter and methods of their manufacture and use |
CN113786518A (zh) * | 2021-09-15 | 2021-12-14 | 海思盖德(苏州)生物医学科技有限公司 | 用于医用材料表面修饰的复合涂层的制备方法 |
EP4218981A1 (en) | 2022-02-01 | 2023-08-02 | W. L. Gore & Associates, Inc. | Affinity chromatography devices containing a fibrillated polymer membrane for the separation of mrna and viral vectors from an aqueous mixture |
EP4218980A1 (en) | 2022-02-01 | 2023-08-02 | W.L. Gore & Associates Inc. | Affinity chromatography devices containing a heat treated fibrillated polymer membrane for the separation of mrna and viral vectors from an aqueous mixture |
CN115998963B (zh) * | 2023-03-22 | 2023-07-21 | 上海发微医用材料有限公司 | 抗凝涂层及其制备方法、应用 |
Family Cites Families (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA962021A (en) | 1970-05-21 | 1975-02-04 | Robert W. Gore | Porous products and process therefor |
US4329383A (en) | 1979-07-24 | 1982-05-11 | Nippon Zeon Co., Ltd. | Non-thrombogenic material comprising substrate which has been reacted with heparin |
US4415490A (en) | 1979-07-24 | 1983-11-15 | Nippon Zeon Co., Ltd. | Non-thrombogenic material |
US4326532A (en) | 1980-10-06 | 1982-04-27 | Minnesota Mining And Manufacturing Company | Antithrombogenic articles |
US4678671A (en) | 1981-12-15 | 1987-07-07 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
US4526714A (en) | 1982-12-13 | 1985-07-02 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
SE8200751L (sv) | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
SE456347B (sv) | 1982-02-09 | 1988-09-26 | Ird Biomaterial Ab | Ytmodifierat fast substrat samt forfarande for framstellning derav |
US4600652A (en) | 1985-04-01 | 1986-07-15 | Warner-Lambert Company | Permanently bonded antithrombogenic polyurethane surface |
IT1213023B (it) | 1986-01-16 | 1989-12-07 | Rolando Barbucci | Materiale capace di adsorbire stabilmente elevate quantita' di eparina, e suo procedimento di preparazione. |
SE452551B (sv) | 1986-05-27 | 1987-12-07 | Camurus Ab | Artikel belagd med heparinbaserat material samt forfarande for dess framstellning |
US4745180A (en) | 1986-06-27 | 1988-05-17 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using heparin fragments |
US5527524A (en) | 1986-08-18 | 1996-06-18 | The Dow Chemical Company | Dense star polymer conjugates |
US5308617A (en) | 1988-08-10 | 1994-05-03 | Halzyme Ltd. | Protein heparin conjugates |
US5130143A (en) | 1988-11-04 | 1992-07-14 | The Research Foundation Of State University Of New York | Use of a low affinity-heparin fraction in conjunction with t-pa for thrombolytic therapy |
US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
US5032666A (en) | 1989-06-19 | 1991-07-16 | Becton, Dickinson And Company | Amine rich fluorinated polyurethaneureas and their use in a method to immobilize an antithrombogenic agent on a device surface |
US5213898A (en) | 1989-10-12 | 1993-05-25 | Norsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
US5049403A (en) | 1989-10-12 | 1991-09-17 | Horsk Hydro A.S. | Process for the preparation of surface modified solid substrates |
WO1993005825A1 (en) | 1991-09-20 | 1993-04-01 | Baxter International Inc. | Processes for reducing the thrombogenicity of biomaterials |
SE470006B (sv) | 1991-09-26 | 1993-10-25 | Corline Systems Ab | Nytt konjugat, dess framställning och användning samt substrat preparerat med konjugatet |
US5532311A (en) | 1995-02-01 | 1996-07-02 | Minnesota Mining And Manufacturing Company | Process for modifying surfaces |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6120536A (en) | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US5583213A (en) | 1995-05-12 | 1996-12-10 | Minnesota Mining And Manufacturing Company | Process to activate sulfated polysaccharides |
US5767108A (en) | 1995-08-22 | 1998-06-16 | Medtronic, Inc. | Method for making improved heparinized biomaterials |
US5679659A (en) | 1995-08-22 | 1997-10-21 | Medtronic, Inc. | Method for making heparinized biomaterials |
US7045585B2 (en) | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
GB9526546D0 (en) | 1995-12-23 | 1996-02-28 | Pfizer Ltd | Compounds useful in therapy |
US5922690A (en) | 1996-04-25 | 1999-07-13 | Van Gorp; Cornelius L. | Dermatan disulfate, an inhibitor of thrombin generation and activation |
GB9608882D0 (en) | 1996-04-30 | 1996-07-03 | Luthra Ajay K | Non-thrombogenic and anti-thrombogenic polymers |
US5876433A (en) | 1996-05-29 | 1999-03-02 | Ethicon, Inc. | Stent and method of varying amounts of heparin coated thereon to control treatment |
US5916585A (en) | 1996-06-03 | 1999-06-29 | Gore Enterprise Holdings, Inc. | Materials and method for the immobilization of bioactive species onto biodegradable polymers |
US5914182A (en) | 1996-06-03 | 1999-06-22 | Gore Hybrid Technologies, Inc. | Materials and methods for the immobilization of bioactive species onto polymeric substrates |
US5728751A (en) | 1996-11-25 | 1998-03-17 | Meadox Medicals, Inc. | Bonding bio-active materials to substrate surfaces |
JPH114883A (ja) | 1997-06-18 | 1999-01-12 | Toray Ind Inc | 抗血栓性医療材料 |
CA2305726A1 (en) | 1997-10-07 | 1999-04-15 | Regents Of The University Of California | Treating occlusive peripheral vascular disease and coronary disease with combinations of heparin and an adenoside a2 agonist, or with adenosine |
FI974321A0 (fi) | 1997-11-25 | 1997-11-25 | Jenny Ja Antti Wihurin Rahasto | Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa |
US6361559B1 (en) | 1998-06-10 | 2002-03-26 | Converge Medical, Inc. | Thermal securing anastomosis systems |
GB9814420D0 (en) | 1998-07-03 | 1998-09-02 | Cancer Res Campaign Tech | Sequence analysis of saccharide material |
US6248127B1 (en) * | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
NO984143L (no) | 1998-09-09 | 2000-03-10 | Norsk Hydro As | Ny prosess for å fremstille overflatemodifiserende stoffer |
JP2003525916A (ja) | 1999-04-22 | 2003-09-02 | エイドゲントシッシュ テクニーシェ ホッシュール チューリッヒ | モディファイドタンパク質マトリクス |
US6936066B2 (en) | 1999-11-19 | 2005-08-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Complaint implantable medical devices and methods of making same |
US7736687B2 (en) | 2006-01-31 | 2010-06-15 | Advance Bio Prosthetic Surfaces, Ltd. | Methods of making medical devices |
SE515295C2 (sv) * | 1999-11-23 | 2001-07-09 | Medicarb Ab | Förfarande för framställning av konjugat av en biologiskt aktiv polysackarid och ett fast substrat, samt sådana konjugat |
GB9928956D0 (en) | 1999-12-07 | 2000-02-02 | Malik Navid | Internally supported biomimetic coating systems |
US6518244B2 (en) | 2000-03-09 | 2003-02-11 | Intimax Corporation | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof |
US7875283B2 (en) | 2000-04-13 | 2011-01-25 | Advanced Cardiovascular Systems, Inc. | Biodegradable polymers for use with implantable medical devices |
ATE390152T1 (de) | 2000-04-28 | 2008-04-15 | Baylor College Medicine | Dezellularisierte gefässprothesen |
DE60114406T2 (de) | 2000-05-12 | 2006-08-03 | Cordis Corp., Miami Lakes | Wirkstoffabgabesysteme zur behandlung von gefässerkrankungen |
US20050059068A1 (en) | 2001-05-23 | 2005-03-17 | Stratagene California | Compositions and methods using dendrimer-treated microassays |
US6787179B2 (en) | 2001-06-29 | 2004-09-07 | Ethicon, Inc. | Sterilization of bioactive coatings |
AR038269A1 (es) | 2002-01-09 | 2005-01-12 | Novartis Ag | Articulos polimericos que tienen un recubrimiento lubrico, y metodo para fabricarlos |
US20030135195A1 (en) | 2002-01-16 | 2003-07-17 | Oscar Jimenez | Highly lubricious hydrophilic coating utilizing dendrimers |
ATE404232T1 (de) * | 2002-05-09 | 2008-08-15 | Hemoteq Ag | Hemokompatibel beschichtete medizinprodukte, deren herstellung und verwendung |
JP2005044408A (ja) * | 2003-07-24 | 2005-02-17 | Pioneer Electronic Corp | 光集積装置および光ピックアップ装置 |
AU2004266642A1 (en) | 2003-08-12 | 2005-03-03 | University Of Utah Research Foundation | Heparin binding proteins: sensors for heparin detection |
CN1255189C (zh) * | 2003-10-20 | 2006-05-10 | 北京理工大学 | 一种抗凝血性不溶性丝素材料的制备方法 |
CN1256991C (zh) * | 2003-12-27 | 2006-05-24 | 重庆大学 | 聚醚氨酯基肝素化高分子液晶抗凝血复合材料制备方法 |
DE602005015564D1 (de) | 2004-04-06 | 2009-09-03 | Surmodics Inc | Beschichtungszusammensetzungen für bioaktive mittel |
GB0422877D0 (en) | 2004-10-14 | 2004-11-17 | Univ Glasgow | Bioactive polymers |
CN101141948B (zh) | 2005-03-14 | 2011-08-24 | 佰威控股有限公司 | 药物递送组合物及相关方法 |
US7767420B2 (en) | 2005-11-03 | 2010-08-03 | Momenta Pharmaceuticals, Inc. | Heparan sulfate glycosaminoglycan lyase and uses thereof |
EP1834636A1 (en) | 2006-03-08 | 2007-09-19 | Sahajanand Medical Technologies PVT. ltd | Compositions comprising porous articles and uses in implantable medical devices |
ES2623602T3 (es) | 2006-05-12 | 2017-07-11 | W. L. Gore & Associates, Inc. | Entidades biológicamente activas inmovilizadas que tienen un alto grado de actividad biológica después de manipulación mecánica o esterilización |
US20080279909A1 (en) | 2006-05-12 | 2008-11-13 | Cleek Robert L | Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization |
US8986713B2 (en) | 2006-05-12 | 2015-03-24 | W. L. Gore & Associates, Inc. | Medical device capable of being compacted and expanded having anti-thrombin III binding activity |
US9114194B2 (en) | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
US20100028402A1 (en) | 2006-10-25 | 2010-02-04 | Marina Dobrovolskaia | Nanoparticle-based anticoagulant |
DE102008021894A1 (de) | 2008-05-02 | 2009-11-05 | Biotronik Vi Patent Ag | Implantat umfassend eine Oberfläche mit verringerter Thrombogenität |
GB0816783D0 (en) | 2008-09-15 | 2008-10-22 | Carmeda Ab | Immobilised biological entities |
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EP2477668B1 (en) | 2018-02-07 |
RU2576803C2 (ru) | 2016-03-10 |
CN102695530A (zh) | 2012-09-26 |
RU2012115097A (ru) | 2013-10-27 |
JP2016005773A (ja) | 2016-01-14 |
JP6290840B2 (ja) | 2018-03-07 |
WO2011035001A3 (en) | 2011-08-18 |
JP2017192801A (ja) | 2017-10-26 |
JP2013505070A (ja) | 2013-02-14 |
WO2011035001A8 (en) | 2012-04-19 |
US20140128544A1 (en) | 2014-05-08 |
ES2668220T3 (es) | 2018-05-17 |
CN102695530B (zh) | 2018-11-30 |
AU2010295601A1 (en) | 2012-05-10 |
BR112012006144A2 (pt) | 2016-06-28 |
CA2838352C (en) | 2018-04-24 |
US20110064781A1 (en) | 2011-03-17 |
US20110065085A1 (en) | 2011-03-17 |
WO2011035001A2 (en) | 2011-03-24 |
EP2477668A2 (en) | 2012-07-25 |
JP6538767B2 (ja) | 2019-07-03 |
CA2838352A1 (en) | 2011-03-24 |
US8591932B2 (en) | 2013-11-26 |
AU2010295601B2 (en) | 2014-02-13 |
CA2774494A1 (en) | 2011-03-24 |
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