JP5802930B2 - 刺激緩和剤及び低刺激性皮膚外用剤 - Google Patents
刺激緩和剤及び低刺激性皮膚外用剤 Download PDFInfo
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- JP5802930B2 JP5802930B2 JP2012012674A JP2012012674A JP5802930B2 JP 5802930 B2 JP5802930 B2 JP 5802930B2 JP 2012012674 A JP2012012674 A JP 2012012674A JP 2012012674 A JP2012012674 A JP 2012012674A JP 5802930 B2 JP5802930 B2 JP 5802930B2
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- Prior art keywords
- extract
- acid
- oil
- external preparation
- skin
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Description
本発明は、上記刺激緩和剤を含有することを特徴とする低刺激性皮膚外用剤でもある。
上記薬効成分としては、アボガドエキス、アマチャエキス、アルテアエキス、アルニカエキス、アンズエキス、アンズ核エキス、イチョウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、エチナシ葉エキス、オウバクエキス、オオムギエキス、オランダカラシエキス、オレンジエキス、加水分解コムギ末、加水分解シルク、カモミラエキス、カロットエキス、カワラヨモギエキス、カルカデエキス、キウイエキス、キナエキス、キューカンバーエキス、グアノシン、クマザサエキス、クルミエキス、グレープフルーツエキス、クレマティスエキス、酵母エキス、コンフリーエキス、コケモモエキス、サイコエキス、サイタイ抽出液、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、シイタケエキス、ジオウエキス、シコンエキス、シナノキエキス、シモツケソウエキス、ショウブ根エキス、シラカバエキス、スギナエキス、スイカズラエキス、セイヨウキズナエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、ゼニアオイエキス、センブリエキス、タイソウエキス、タイムエキス、チョウジエキス、チガヤエキス、トマトエキス、納豆エキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、パセリエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、フキタンポポエキス、フキノ蜂蜜、トウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、プロポリス、ヘチマエキス、ペパーミントエキス、ボダイジュエキス、ホップエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、モモ葉エキス、ヤグルマギクエキス、ユーカリエキス、リンゴエキス、レタスエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス等が挙げられる。
2.5%SDS(硫酸ドデシルナトリウム)含有水溶液、及び、0.5%ハバルディア・メキシカーナ樹皮の抽出物を含む2.5%SDS含有水溶液を2mlずつ洗浄カップに量り入れ、試験者4名の前腕内側に25分間押し当てて接触処理を行った。25分間処理後、洗浄カップを外し、6時間後にリン酸緩衝生理食塩水2mlを用いて処理部位を洗浄カップにて15分間処理したのち、処理液を回収し、処理液中のIL−1αを測定した。IL−1αの測定は、市販のIL-1α測定キットを用いて測定することにより行った。
(1)ラウリン酸 10.0
(2)ミリスチン酸 6.0
(3)パルミチン酸 3.0
(4)ステアリン酸 1.0
(5)水酸化カリウム 4.8
(6)プロピレングリコール 8.0
(7)ポリオキシエチレンラウリル硫酸ナトリウム(2E.O.) 1.0
(8)ヤシ油脂肪酸モノエタノールアミド 3.0
(9)2−アルキル−N−カルボキシメチル−
N−ヒドロキシエチルイミダゾリウムベタイン 1.0
(10)ポリオキシエチレン(7)ヤシ油脂肪酸グリセリン 2.0
(11)塩化ジメチルジアリルアンモニウム・アクリルアミド共重合体 0.1
(12)ヒドロキシプロピルメチルセルロース 0.1
(13)塩化O−[2−ヒドロキシ−
3−(トリメチルアンモニオ)プロピル]グァーガム 0.1
(14)ジステアリン酸エチレングリコール 2.0
(15)ハバルディア・メキシカーナ樹皮の抽出物 0.5
(16)オクテニルコハク酸トウモロコシデンプンエステルアルミニウム 0.1
(17)塩化ナトリウム 0.2
(18)エデト酸二ナトリウム 0.1
(19)香料 0.1
(20)精製水 to 100
Claims (2)
- マメ目マメ科ハバルディア属ハバルディア・メキシカーナ樹皮の抽出物を有効成分とする刺激緩和剤。
- 請求項1記載の刺激緩和剤を含有することを特徴とする低刺激性皮膚外用剤。
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