JP5788715B2 - 酸素消費量及びエネルギー消費量の低減剤 - Google Patents
酸素消費量及びエネルギー消費量の低減剤 Download PDFInfo
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- JP5788715B2 JP5788715B2 JP2011121666A JP2011121666A JP5788715B2 JP 5788715 B2 JP5788715 B2 JP 5788715B2 JP 2011121666 A JP2011121666 A JP 2011121666A JP 2011121666 A JP2011121666 A JP 2011121666A JP 5788715 B2 JP5788715 B2 JP 5788715B2
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- orotic acid
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- oxygen consumption
- consumption
- oxygen
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Description
オロト酸が、非運動時の酸素消費量を低減させる効果を有しているかを調べるために、以下の試験を行った。まず、12時間毎の明暗周期(8時〜20時まで点灯)下に24±2℃の恒温動物室にて1週間以上飼育したddY雄マウス(6週齢)を32匹用意した。これらのマウスを2群に分け、一方の群(コントロール群:CTL)の各マウスには、0.5質量%のカルボキシメチルセルロース溶液(CMC溶液)を、マウスの体重1kgあたり10ml投与した。もう一方の群(オロト酸投与群:OA)の各マウスには、0.5質量%のCMC溶液に懸濁したオロト酸(50mg/mL)を、マウスの体重1kgあたり10ml投与した。これらの投与は、各マウスに対し、週に5回、4週間継続(合計20回)して行った。最後の投与日の19時に各マウスを代謝計測チャンバーに移して絶食を開始し、暗期である20時から翌日の8時までの酸素消費量(mL/min)及び二酸化炭素産生量(mL/min)を測定した。図1には、その酸素消費量を各群の平均値で示し、図2には、その二酸化炭素産生量を各群の平均値で示す。なお、統計処理にはt−検定を用い、p<0.05で有意差を示した項目を*で示した。また、各マウスの呼吸商は、二酸化炭素産生量を酸素消費量で除した値として算出した。図3には、その呼吸商を各群の平均値で示す。
オロト酸が、運動時の酸素消費量を低減させる効果を有しているかを調べるために、以下の試験を行った。まず、12時間毎の明暗周期(8時〜20時まで点灯)下に24±2℃の恒温動物室にて1週間以上飼育したddY雄マウス(6週齢)を24匹用意した。これらのマウスを2群に分け、一方の群(コントロール群:CTL)の各マウスには、0.5質量%のカルボキシメチルセルロース溶液(CMC溶液)を、マウスの体重1kgあたり10ml投与した。もう一方の群(オロト酸投与群:OA)の各マウスには、0.5質量%のCMC溶液に懸濁したオロト酸(50mg/mL)を、マウスの体重1kgあたり10ml投与した。これらの投与は、各マウスに対し、週に5回、3週間継続(合計15回)して行った。最後の投与日の17時に各マウスの絶食を開始し、翌日の10時からマウス用トレッドミルを用いて強制運動を行い、運動中の酸素消費量(mL/min)及び二酸化炭素産生量(mL/min)を測定した。なお、強制運動は30分間行い、0−5分を15m/min、6−10分を20m/min、11−30分を25m/minで行った。図4には、その酸素消費量を各群の平均値で示し、図5には、その二酸化炭素産生量を各群の平均値で示す。なお、統計処理にはt−検定を用い、p<0.05で有意差を示した項目を*で示した。また、各マウスの呼吸商は、二酸化炭素産生量を酸素消費量で除した値として算出した。図6には、その呼吸商を各群の平均値で示す。
被験物質としてオロト酸を用い、持久力向上効果を調べた。7週齢の雄ddYマウスを日本エスエルシー社より購入し、7日間馴化後、尻尾に重りをつけて強制遊泳させた。マウスが水上に上がってこられず、水面下に5秒間停滞した時点を限界遊泳時間とし、その時間を測定した。限界遊泳時間に群間差の無いように以下の通り群分けした。コントロール群(n=10、CTLと表記)、オロト酸250mg/kg投与群(n=10、OA250mg/kgと表記)、オロト酸500mg/kg投与群(n=10、OA500mg/kgと表記)。各群共に粗飼料(CE−2)を用いて飼育し、OA250mg/kg群にはオロト酸250mg/kg、OA500mg/kg群にはオロト酸500mg/kgを週に5回経口投与した。群分け後、3週間飼育しながら各群の限界遊泳時間を週に1回測定した。この時の限界遊泳時間を図7に示す。
Claims (1)
- オロト酸、ウリジン一リン酸、ウラシル、ウリジン、シチジン、及び、それらの塩からなる群から選択される1又は2以上の物質を有効成分として含有することを特徴とする酸素消費量及びエネルギー消費量の低減剤(ただし、運動に対する持久力の向上剤を除く)。
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