JP5740300B2 - 経皮投与製剤 - Google Patents

経皮投与製剤 Download PDF

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Publication number: JP5740300B2
Authority: JP; Japan
Prior art keywords: preparation; citalopram; transdermal administration; mass; skin
Prior art date: 2009-02-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

JP2011501555A

Other languages

English (en)

Japanese (ja)

Other versions

JPWO2010098230A1 (ja

Inventor

昭雄竹内

健治新

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hisamitsu Pharmaceutical Co Inc

Original Assignee

Hisamitsu Pharmaceutical Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-02-27

Filing date

2010-02-16

Publication date

2015-06-24

2010-02-16 Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc

2010-02-16 Priority to JP2011501555A priority Critical patent/JP5740300B2/ja

2012-08-30 Publication of JPWO2010098230A1 publication Critical patent/JPWO2010098230A1/ja

2015-06-24 Application granted granted Critical

2015-06-24 Publication of JP5740300B2 publication Critical patent/JP5740300B2/ja

Status Active legal-status Critical Current

2030-02-16 Anticipated expiration legal-status Critical

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Preparation (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pain & Pain Management (AREA)

JP2011501555A 2009-02-27 2010-02-16 経皮投与製剤 Active JP5740300B2 (ja)

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JP2009046893		2009-02-27
JP2009046893		2009-02-27
PCT/JP2010/052249 WO2010098230A1 (fr)	2009-02-27	2010-02-16	Préparation transdermique
JP2011501555A JP5740300B2 (ja)	2009-02-27	2010-02-16	経皮投与製剤

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WO (1)	WO2010098230A1 (fr)

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CN105030733A (zh) *	2015-07-08	2015-11-11	成都易创思生物科技有限公司	一种复方曲安奈德涂膜剂及其制备方法
US10016502B2 (en)	2015-08-29	2018-07-10	Medrx Co., Ltd	Patch preparation containing an acid scavenger
WO2017037812A1 (fr) *	2015-08-29	2017-03-09	株式会社メドレックス	Préparation pharmaceutique sous forme de timbre comprenant un accepteur d'acide
TWI781370B (zh)	2019-01-31	2022-10-21	日商久光製藥股份有限公司	貼附劑

Citations (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0236177A (ja) *	1988-06-14	1990-02-06	H Lundbeck As	新規鏡像体及びその単離法
US6512010B1 (en) *	1996-07-15	2003-01-28	Alza Corporation	Formulations for the administration of fluoxetine
JP2004527551A (ja) *	2001-05-01	2004-09-09	ハー・ルンドベック・アクチエゼルスカベット	エナンチオ純粋なエスシタロプラムの使用方法
JP2006503905A (ja) *	2002-09-24	2006-02-02	コンビナトアールエックスインコーポレーティッド	炎症性サイトカインのレベルの増大と関連する病気および障害の治療のための方法および試薬
WO2006082888A1 (fr) *	2005-02-03	2006-08-10	Kyorin Pharmaceutical Co., Ltd.	Preparation pour absorption percutanee
WO2007103687A2 (fr) *	2006-03-01	2007-09-13	Tristrata, Inc.	Compositions et procédés pour le traitement topique de troubles dermatologiques répondants au goudron
WO2008050673A1 (fr) *	2006-10-27	2008-05-02	Hisamitsu Pharmaceutical Co., Inc.	Timbre transdermique adhésif
JP2008516928A (ja) *	2004-10-14	2008-05-22	シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト	損傷を受けていない皮膚の障壁機能を増強する方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5021952B2 (ja) *	2006-04-17	2012-09-12	ニプロパッチ株式会社	選択的セロトニン再取込阻害成分を含有する製剤

2010
- 2010-02-16 WO PCT/JP2010/052249 patent/WO2010098230A1/fr active Application Filing
- 2010-02-16 JP JP2011501555A patent/JP5740300B2/ja active Active

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0236177A (ja) *	1988-06-14	1990-02-06	H Lundbeck As	新規鏡像体及びその単離法
US6512010B1 (en) *	1996-07-15	2003-01-28	Alza Corporation	Formulations for the administration of fluoxetine
JP2004527551A (ja) *	2001-05-01	2004-09-09	ハー・ルンドベック・アクチエゼルスカベット	エナンチオ純粋なエスシタロプラムの使用方法
JP2006503905A (ja) *	2002-09-24	2006-02-02	コンビナトアールエックスインコーポレーティッド	炎症性サイトカインのレベルの増大と関連する病気および障害の治療のための方法および試薬
JP2008516928A (ja) *	2004-10-14	2008-05-22	シムライズ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・コンパニー・コマンジツト・ゲゼルシヤフト	損傷を受けていない皮膚の障壁機能を増強する方法
WO2006082888A1 (fr) *	2005-02-03	2006-08-10	Kyorin Pharmaceutical Co., Ltd.	Preparation pour absorption percutanee
WO2007103687A2 (fr) *	2006-03-01	2007-09-13	Tristrata, Inc.	Compositions et procédés pour le traitement topique de troubles dermatologiques répondants au goudron
WO2008050673A1 (fr) *	2006-10-27	2008-05-02	Hisamitsu Pharmaceutical Co., Inc.	Timbre transdermique adhésif

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