JP5721973B2 - Oral composition - Google Patents
Oral composition Download PDFInfo
- Publication number
- JP5721973B2 JP5721973B2 JP2010147181A JP2010147181A JP5721973B2 JP 5721973 B2 JP5721973 B2 JP 5721973B2 JP 2010147181 A JP2010147181 A JP 2010147181A JP 2010147181 A JP2010147181 A JP 2010147181A JP 5721973 B2 JP5721973 B2 JP 5721973B2
- Authority
- JP
- Japan
- Prior art keywords
- mass
- acid
- sucralose
- cetylpyridinium chloride
- oral composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000000203 mixture Substances 0.000 title claims description 44
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 28
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 28
- 239000004376 Sucralose Substances 0.000 claims description 24
- 235000019408 sucralose Nutrition 0.000 claims description 24
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 24
- 210000000214 mouth Anatomy 0.000 claims description 16
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 8
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000811 xylitol Substances 0.000 claims description 8
- 235000010447 xylitol Nutrition 0.000 claims description 8
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 8
- 229960002675 xylitol Drugs 0.000 claims description 8
- 239000002324 mouth wash Substances 0.000 claims description 7
- 238000013329 compounding Methods 0.000 claims description 4
- 229940051866 mouthwash Drugs 0.000 claims description 3
- -1 fatty acid esters Chemical class 0.000 description 32
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 21
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
- 235000014113 dietary fatty acids Nutrition 0.000 description 13
- 239000000194 fatty acid Substances 0.000 description 13
- 229930195729 fatty acid Natural products 0.000 description 13
- 235000019640 taste Nutrition 0.000 description 13
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 11
- 238000011156 evaluation Methods 0.000 description 11
- 235000019658 bitter taste Nutrition 0.000 description 10
- 238000009472 formulation Methods 0.000 description 9
- 239000003205 fragrance Substances 0.000 description 8
- 235000015165 citric acid Nutrition 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 235000011187 glycerol Nutrition 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000004359 castor oil Substances 0.000 description 6
- 235000019438 castor oil Nutrition 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 6
- 238000007796 conventional method Methods 0.000 description 6
- 239000000551 dentifrice Substances 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 6
- 235000010449 maltitol Nutrition 0.000 description 6
- 239000000845 maltitol Substances 0.000 description 6
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 6
- 229940035436 maltitol Drugs 0.000 description 6
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- 239000001509 sodium citrate Substances 0.000 description 6
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 6
- 229940038773 trisodium citrate Drugs 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 235000003599 food sweetener Nutrition 0.000 description 5
- 239000000417 fungicide Substances 0.000 description 5
- 239000003765 sweetening agent Substances 0.000 description 5
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000003899 bactericide agent Substances 0.000 description 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 150000005846 sugar alcohols Chemical class 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 229960003237 betaine Drugs 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 3
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 229960002216 methylparaben Drugs 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 2
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 2
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- SVIJYLPSHPPVQF-UHFFFAOYSA-N 2-[2,2-diaminoethyl(dodecyl)amino]acetic acid Chemical compound CCCCCCCCCCCCN(CC(N)N)CC(O)=O SVIJYLPSHPPVQF-UHFFFAOYSA-N 0.000 description 2
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 244000228451 Stevia rebaudiana Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
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- 150000004665 fatty acids Chemical class 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 2
- 235000019204 saccharin Nutrition 0.000 description 2
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
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- 229960003500 triclosan Drugs 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、塩化セチルピリジニウムの不快な味を解消した、使用感に優れた口腔用組成物に関する。より詳細には、塩化セチルピリジニウムおよびスクラロースを含有する口腔用組成物に関する。 TECHNICAL FIELD The present invention relates to a composition for oral cavity that is excellent in feeling of use and eliminates the unpleasant taste of cetylpyridinium chloride. More specifically, the present invention relates to an oral composition containing cetylpyridinium chloride and sucralose.
従来より、塩化セチルピリジニウムのような第４級アンモニウム塩型殺菌剤は、歯周疾患の予防および治療に有効なことが知られており、幅広く使用されている。これら第４級アンモニウム塩型殺菌剤を配合した口腔用組成物は、殺菌剤に由来する苦味が知覚され、かつ殺菌剤の殺菌作用の強さと苦味の強さは正の相関が見られることから、配合に際しては製剤上の工夫が必要であった。この課題点に対して、従前より甘味剤や香料などの化合物を併せて配合するなどの種々の検討が重ねられている。例えば甘味剤については、口腔用組成物で一般的に用いられるサッカリンやステビアなどを配合し苦味を低減する方法（特許文献１）、香味のバランスを調整して苦味や辛味を助長しやすい香料成分を減量し、苦味の低減に有用な成分を増量する方法（特許文献２）、トレハロース、エリスリトール、パラチニットまたはマルチトールなどの糖アルコールを配合することで苦味を低減する方法（特許文献３）、香料関連化合物や糖アルコール、多価アルコールなどを配合することで苦味を低減する方法（特許文献４）、塩化ナトリウム（特許文献５）、塩化マグネシウム（特許文献６）、水溶性のカルシウム塩（特許文献７）などの塩類を配合することで苦味を低減する方法が提案されている。 Conventionally, quaternary ammonium salt type fungicides such as cetylpyridinium chloride are known to be effective for the prevention and treatment of periodontal diseases and are widely used. The oral composition containing these quaternary ammonium salt type fungicides has a perceived bitterness derived from the fungicides, and a positive correlation is found between the strength of the bactericidal action and the bitterness of the fungicides. In formulating, it was necessary to devise a formulation. Various investigations, such as mix | blending compounds, such as a sweetening agent and a fragrance | flavor, have been repeated conventionally from this subject point. For example, for sweeteners, a method of reducing bitterness by blending saccharin or stevia commonly used in oral compositions (Patent Document 1), a flavor component that easily promotes bitterness and pungent taste by adjusting the balance of flavor. A method for reducing the bitter taste by adding a sugar alcohol such as trehalose, erythritol, palatinit or maltitol (Patent Document 3), a fragrance Method of reducing bitterness by blending related compounds, sugar alcohol, polyhydric alcohol, etc. (Patent Document 4), sodium chloride (Patent Document 5), magnesium chloride (Patent Document 6), water-soluble calcium salt (Patent Document) A method of reducing bitterness by blending salts such as 7) has been proposed.
しかしながら、これら併用する化合物は、それ自身が異味を有する場合や、配合することで香味バランスが崩れたり、ベタツキなどが生じる場合があり、効果を奏する十分な量を配合できなかったり、配合した場合には新たな使用感の課題点が生じたりするため、未だ十分に満足できる解決策は見い出されていない。 However, these compounds that are used in combination may have an odd taste, or the flavor balance may be disrupted or may become sticky when blended, so that a sufficient amount cannot be blended or blended. However, there are still no satisfactory solutions because there are new problems in use.
本発明は、塩化セチルピリジニウムの有する不快な味を解消した口腔用組成物を提供することを課題とする。 This invention makes it a subject to provide the composition for oral cavity which eliminated the unpleasant taste which cetyl pyridinium chloride has.
本発明者らは、かかる事情に鑑み鋭意検討を重ねた結果、塩化セチルピリジニウムにスクラロース０．００５〜０．０５質量％を配合した場合、塩化セチルピリジニウムが有する苦味、刺激といった不快な味を解消し、さらにマルチトールやキシリトールを特定量配合するとさらに優れた使用感を有する口腔用組成物が得られることを見出し、本発明を完成するに至った。 As a result of intensive studies in view of such circumstances, the present inventors have solved the unpleasant taste such as bitterness and irritation of cetylpyridinium chloride when sucralose 0.005 to 0.05% by mass is added to cetylpyridinium chloride. Furthermore, when a specific amount of maltitol or xylitol is blended, it has been found that an oral composition having a better feeling of use can be obtained, and the present invention has been completed.
すなわち、本発明は、特に以下の項１〜３の口腔用組成物を提供するものである。
項１.
スクラロース０．００５〜０．０５質量％と塩化セチルピリジニウムを配合することを特徴とする口腔用組成物。
項２．
塩化セチルピリジニウムに対してスクラロースを０．０２〜５質量部配合することを特徴とする項１に記載の口腔用組成物。
項３．
さらに、キシリトールおよびマルチトールから選ばれる1種以上を、スクラロースの配合量に対して２００〜１０００質量部配合することを特徴とする項１または項２の何れか１項に記載の口腔用組成物。
That is, this invention provides the composition for oral cavity of the following items 1-3 especially.
Item 1.
An oral composition comprising 0.005 to 0.05% by mass of sucralose and cetylpyridinium chloride.
Item 2.
Item 2. The oral composition according to Item 1, wherein 0.02 to 5 parts by mass of sucralose is added to cetylpyridinium chloride.
Item 3.
Furthermore, 200 or 1000 mass parts of 1 or more types chosen from a xylitol and maltitol are mix | blended with respect to the compounding quantity of a sucralose, The composition for oral cavity of any one of claim | item 1 or claim | item 2 characterized by the above-mentioned. .
本発明の口腔用組成物は、不快な味を解消することにより、口腔用組成物の嗜好性を高め、継続的な使用を容易にすることや、口腔用組成物を口腔内に長くとどめることが容易になり、塩化セチルピリジニウムの効果を十分に引き出すことが可能となる。 The oral composition of the present invention improves the palatability of the oral composition by eliminating an unpleasant taste, facilitates continuous use, and keeps the oral composition long in the oral cavity. Thus, the effect of cetylpyridinium chloride can be sufficiently obtained.
本発明に用いる塩化セチルピリジニウムは、第四級アンモニウム化合物に含まれるカチオン性殺菌剤であり、口腔用組成物分野において広く使用されているものである。かかる塩化セチルピリジニウムは、本発明の口腔用組成物の全量に対して０．０１〜０.５質量％を配合することができ、０.０１〜０.３質量％が好ましく、０.０５〜０.１質量％が更に好ましく、０.０５質量％が最も好ましい。０.５質量％を超えると味覚障害や歯面の着色を引き起こす可能性が高くなるため好ましくなく、０.０１質量％に満たない場合には塩化セチルピリジニウムの効果が得られないため好ましくない。 Cetylpyridinium chloride used in the present invention is a cationic bactericidal agent contained in a quaternary ammonium compound and is widely used in the field of oral compositions. Such cetylpyridinium chloride can be blended in an amount of 0.01 to 0.5% by mass, preferably 0.01 to 0.3% by mass, and preferably 0.05 to 0.5% by mass with respect to the total amount of the oral composition of the present invention. 0.1% by mass is more preferable, and 0.05% by mass is most preferable. If it exceeds 0.5% by mass, the possibility of causing taste disorder and coloring of the tooth surface increases, which is not preferable. If the amount is less than 0.01% by mass, the effect of cetylpyridinium chloride cannot be obtained, which is not preferable.
本発明に用いるスクラロースは、トリクロロガラクトスクロースのことを指し、スクロースの水酸基3箇所が塩素に置き換わったスクロース誘導体である。砂糖に近い甘みを呈する高度甘味料として、食品分野において使用されている。かかるスクラロースは、本発明の口腔用組成物の全量に対して０．００５〜０.０５質量％配合する事ができ、０．００５〜０.０１質量％配合することが好ましい。０.０５質量％を超えると甘みが強すぎて香味のバランスを崩してしまうため好ましくなく、０.００５質量％に満たない場合には効果が得られないため好ましくない。さらに、スクラロースは塩化セチルピリジニウムの配合量に対して、０.０２〜５質量部配合する事が好ましく、０.０５〜０.５質量部配合する事が最も好ましい。 Sucralose used in the present invention refers to trichlorogalactosucrose and is a sucrose derivative in which three hydroxyl groups of sucrose are replaced with chlorine. It is used in the food field as an advanced sweetener that exhibits a sweetness similar to sugar. Such sucralose can be blended in an amount of 0.005 to 0.05 mass%, preferably 0.005 to 0.01 mass%, based on the total amount of the oral composition of the present invention. If it exceeds 0.05% by mass, the sweetness is too strong and the balance of the flavor is lost, which is not preferable. If it is less than 0.005% by mass, the effect cannot be obtained, which is not preferable. Furthermore, it is preferable to mix | blend sucralose with respect to the compounding quantity of a cetyl pyridinium chloride 0.02-5 mass part, and it is most preferable to mix | blend 0.05-0.5 mass part.
本発明に用いるマルチトールおよびキシリトールは、何れか一方を単独で使用しても併用してもよい。スクラロースの配合量に対して、２００〜１０００質量部配合するとスクラロースの効果を更に高めることができる。配合量は特に限定するものではないが、両者を併せた配合量が１０質量％を超えると糖アルコール特有の異味を呈する恐れがあるため、１０質量％以内の配合量とすることが好ましい。 Any one of maltitol and xylitol used in the present invention may be used alone or in combination. When the amount of sucralose is 200 to 1000 parts by mass, the effect of sucralose can be further enhanced. The blending amount is not particularly limited, but if the blending amount of both exceeds 10% by mass, there is a risk of having a peculiar taste unique to the sugar alcohol, so that the blending amount is preferably within 10% by mass.
本発明の口腔用組成物は、特に限定するものではないが、歯磨剤、液体歯磨剤、洗口剤、マウススプレイ、ジェル剤、口腔乾燥防止剤、塗布剤、パスタ剤等として用いることができる。このなかでも、塩化セチルピリジニウムの異味を強く感じさせる液体、液状およびジェル状の剤形、例えば液体歯磨剤、洗口剤、マウススプレイ、ジェル剤、口腔乾燥防止剤が好ましく、その中でも液状や液体の液体歯磨剤、洗口剤、マウススプレイが最も好ましい。 The oral composition of the present invention is not particularly limited, but can be used as a dentifrice, liquid dentifrice, mouthwash, mouth spray, gel agent, anti-oral dry agent, coating agent, pasta agent, and the like. . Of these, liquid, liquid, and gel-like dosage forms that make the cetylpyridinium chloride taste strongly are preferred, such as liquid dentifrices, mouthwashes, mouth sprays, gels, and anti-oral dryness agents. Most preferred are liquid dentifrices, mouthwashes, and mouth sprays.
本発明の口腔用組成物は、塩化セチルピリジニウム及びスクラロースの他に、本発明の効果を損なわない範囲であれば、通常、口腔用組成物に配合し得る成分をさらに配合してもよい。 As long as the composition for oral cavity of this invention is a range which does not impair the effect of this invention other than cetylpyridinium chloride and sucralose, you may further mix | blend the component which can be normally mix | blended with an oral composition.
界面活性剤としては、ノニオン界面活性剤、アニオン界面活性剤または両性界面活性剤を配合することができる。具体的には、ノニオン界面活性剤としてはショ糖脂肪酸エステル、マルトース脂肪酸エステル、ラクトース脂肪酸エステル等の糖脂肪酸エステル、脂肪酸アルカノールアミド類、ソルビタン脂肪酸エステル、脂肪酸モノグリセライド、ポリオキシエチレン付加係数が４〜１５、アルキル基の炭素数が１０〜１８であるポリオキシエチレンアルキルエーテル系またはポリオキシエチレン付加係数が１０〜１８、アルキル基の炭素数が９であるポリオキシエチレンアルキルフェニルエーテル、セバシン酸ジエチル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、ポリエチレングリコール脂肪酸エステル、ポリエチレンラノリン、ポリエチレンステロール、ポリエチレンラノリンアルコール、アルキルグルコシド、ポリオキシエチレンポリオキシプロピレンブロックコポリマー等が挙げられる。アニオン界面活性剤としては、ラウリル硫酸ナトリウム、ポリオキシエチレンラウリルエーテル硫酸ナトリウム等の硫酸エステル塩、ラウリルスルホコハク酸ナトリウム、ポリオキシエチレンラウリルエーテルスルホコハク酸ナトリウム等のスルホコハク酸塩、ココイルサルコシンナトリウム、ラウロイルメチルアラニンナトリウム等のアシルアミノ酸塩、ココイルメチルタウリンナトリウム等が挙げられる。両性イオン界面活性剤としては、ラウリルジメチルアミノ酢酸ベタイン、ヤシ油脂肪酸アミドプロピルジメチルアミノ酢酸ベタイン等の酢酸ベタイン型活性剤、Ｎ−ココイル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルエチレンジアミンナトリウム等のイミダゾリン型活性剤、Ｎ−ラウリルジアミノエチルグリシン等のアミノ酸型活性剤等が挙げられる。これらの界面活性剤は、単独または２種以上を組み合わせて配合することができる。 As the surfactant, a nonionic surfactant, an anionic surfactant or an amphoteric surfactant can be blended. Specifically, nonionic surfactants include sugar fatty acid esters such as sucrose fatty acid esters, maltose fatty acid esters, and lactose fatty acid esters, fatty acid alkanolamides, sorbitan fatty acid esters, fatty acid monoglycerides, and polyoxyethylene addition coefficients of 4 to 15. A polyoxyethylene alkyl ether type having an alkyl group having 10 to 18 carbon atoms or a polyoxyethylene alkyl phenyl ether having a polyoxyethylene addition coefficient of 10 to 18 and an alkyl group having 9 carbon atoms, diethyl sebacate, poly Oxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene sorbit fatty acid ester, polyethylene glycol fatty acid ester, polyester Renranorin, polyethylene sterols, polyethylene lanolin alcohols, alkyl glucosides, polyoxyethylene polyoxypropylene block copolymers, and the like. Anionic surfactants include sulfate esters such as sodium lauryl sulfate and sodium polyoxyethylene lauryl ether sulfate, sodium lauryl sulfosuccinate, sulfosuccinate such as sodium polyoxyethylene lauryl ether sulfosuccinate, cocoyl sarcosine sodium, lauroylmethylalanine Examples include acyl amino acid salts such as sodium, cocoyl methyl taurine sodium and the like. Zwitterionic surfactants include betaine acetate type activators such as lauryl dimethylaminoacetic acid betaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid betaine, and imidazoline type such as N-cocoyl-N-carboxymethyl-N-hydroxyethylethylenediamine sodium. Examples include activators and amino acid type activators such as N-lauryldiaminoethylglycine. These surfactants can be blended alone or in combination of two or more.
香味剤としては、例えばメントール、カルボン酸、アネトール、オイゲノール、サリチル酸メチル、リモネン、オシメン、ｎ−デシルアルコール、シトロネール、α−テルピネオール、メチルアセテート、シトロネニルアセタート、メチルオイゲノール、シネオール、リナロール、エチルリナロール、チモール、スペアミント油、ペパーミント油、レモン油、オレンジ油、セージ油、ローズマリー油、珪皮油、シソ油、冬緑油、丁子油、ユーカリ油、ピメント油などの香料を単独でまたは２種以上を組み合わせて使用することができる。 As a flavoring agent, for example, menthol, carboxylic acid, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronell, α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineol, linalool, ethyl Perfume such as linalool, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil, pimento oil alone or 2 More than one species can be used in combination.
増粘剤としては、例えばカルボキシメチルセルロースナトリウム、カルボキシメチルエチルセルロース塩、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロースなどのセルロース誘導体、キサンタンガム、ジェランガムなどの微生物産生高分子、トラガントガム、カラヤガム、アラビヤガム、カラギーナン、デキストリンなどの天然高分子または天然ゴム類、ポリビニルアルコール、ポリビニルピロリドンなどの合成高分子、塩化Ｏ−［２−ヒドロキシ−３−（トリメチルアンモニオ）プロピル］ヒドロキシエチルセルロースなどのカチオン性増粘剤が挙げられる。これら増粘剤は、単独でまたは２種以上を組み合わせて使用することができる。 Examples of the thickener include carboxymethylcellulose sodium, carboxymethylethylcellulose salt, cellulose derivatives such as hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, microbial polymer such as xanthan gum, gellan gum, tragacanth gum, karaya gum, arabiya gum, carrageenan, dextrin And natural thickeners such as natural rubber, synthetic polymers such as polyvinyl alcohol and polyvinylpyrrolidone, and cationic thickeners such as O- [2-hydroxy-3- (trimethylammonio) propyl] hydroxyethylcellulose chloride. . These thickeners can be used alone or in combination of two or more.
甘味剤としては、例えばサッカリン、サッカリンナトリウム、アセスルファームカリウム、ステビアエキス、ステビオサイド、ネオヘスペリジルジヒドロカルコン、グリチルリチン、ペリラルチン、ソウマチン、アスパルチルフェニルアラニンメチルエステル、メトキシシンナミックアルデヒド、パラチノース、パラチニット、エリスリトール、マルチトール、キシリトール、ラクチトールなどが挙げられる。これら甘味剤は、単独でまたは２種以上を組み合わせて使用することができる。 Sweetening agents include, for example, saccharin, saccharin sodium, acesulfame potassium, stevia extract, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, saumatine, aspartylphenylalanine methyl ester, methoxycinnamic aldehyde, palatinose, palatinit, erythritol, multi Tall, xylitol, lactitol and the like. These sweeteners can be used alone or in combination of two or more.
湿潤剤としては、例えばグリセリン、エチレングリコール、プロピレングリコール、ソルビット、ポリエチレングリコール、ポリプロピレングリコールなどを単独でまたは２種以上を組み合わせて使用することができる。 As the wetting agent, for example, glycerin, ethylene glycol, propylene glycol, sorbit, polyethylene glycol, polypropylene glycol and the like can be used alone or in combination of two or more.
保存剤としては、例えばメチルパラベン、プロピルパラベンなどのパラベン類、安息香酸ナトリウムなどの安息香酸塩などが挙げられる。これらの保存剤は、単独でまたは２種以上を組み合わせて使用することができる。 Examples of the preservative include parabens such as methylparaben and propylparaben, and benzoates such as sodium benzoate. These preservatives can be used alone or in combination of two or more.
またｐＨ調整剤としては、クエン酸、リン酸、リンゴ酸、グルコン酸、マレイン酸、アスパラギン酸、コハク酸、グルクロン酸、フマル酸、グルタミン酸、アジピン酸、およびこれらの塩や、塩酸、水酸化ナトリウム、水酸化カリウム、ケイ酸ナトリウムなどが挙げられる。これらの成分は単独または２種以上を組合せて本発明の口腔用組成物に含ませることができる。なお、本発明の口腔用組成物のｐＨは、口腔内で使用可能な範囲であれば特に制限されないが、通常、ｐＨ３．０〜１０．５、好ましくはｐＨ５．５〜８．０である。最も好ましくは６．０〜７．０である。 Examples of pH adjusters include citric acid, phosphoric acid, malic acid, gluconic acid, maleic acid, aspartic acid, succinic acid, glucuronic acid, fumaric acid, glutamic acid, adipic acid, and salts thereof, hydrochloric acid, sodium hydroxide , Potassium hydroxide, sodium silicate and the like. These components can be contained in the oral composition of the present invention alone or in combination of two or more. The pH of the composition for oral cavity of the present invention is not particularly limited as long as it can be used in the oral cavity, but is usually pH 3.0 to 10.5, preferably pH 5.5 to 8.0. Most preferably, it is 6.0-7.0.
薬効成分としては、殺菌剤として塩化セチルピリジニウム以外にも例えば塩酸クロルヘキシジン、グルコン酸クロルヘキシジン、塩化ベンゼトニウム、塩化ベンザルコニウムなどのカチオン性殺菌剤；ドデシルジアミノエチルグリシンなどの両性殺菌剤；イソプロピルメチルフェノール、トリクロサンなどの非イオン殺菌剤；デキストラナーゼ、アミラーゼ、プロテアーゼ、ムタナーゼ、リゾチーム、溶菌酵素（リテックエンザイム）などの酵素；抗炎症剤としてグリチルレチン酸、グリチルリチン酸ジカリウムなどのグリチルリチン酸塩；血行促進剤としてニコチン酸または酢酸トコフェロールなど；抗プラスミン剤としてトラネキサム酸、イプシロンアミノカプロン酸など；出血改善剤としてアスコルビン酸など；組織修復剤としてアラントインなど；再石灰化剤としてフッ化ナトリウムなどのフッ素化合物；その他、水溶性溶媒で抽出された植物抽出物、クロロフィル、塩化ナトリウム、カロペプタイド、塩化亜鉛、ヒノキチオールなどが挙げられ、これらを単独または２種以上を組み合わせて配合することができる。 As a medicinal component, in addition to cetylpyridinium chloride as a bactericidal agent, for example, cationic bactericides such as chlorhexidine hydrochloride, chlorhexidine gluconate, benzethonium chloride, benzalkonium chloride; amphoteric bactericides such as dodecyldiaminoethylglycine; isopropylmethylphenol, Nonionic fungicides such as triclosan; Enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme (lytechenzyme); Glycyrrhizic acid salts such as glycyrrhetinic acid and dipotassium glycyrrhizinate as anti-inflammatory agents; Nicotinic acid or tocopherol acetate, etc .; Tranexamic acid, epsilon aminocaproic acid, etc. as antiplasmin agent; Ascorbic acid, etc. as bleeding remedy; Fluorine compounds such as sodium fluoride as remineralization agents; plant extracts extracted with water-soluble solvents, chlorophyll, sodium chloride, caropeptides, zinc chloride, hinokitiol, etc. It can mix | blend combining a seed | species or more.
以下、本発明を具体的に説明するが、本発明は下記の例に限定されるものではない。なお、以下特に断りのない限り「％」は「質量％」を示す。 Hereinafter, the present invention will be specifically described, but the present invention is not limited to the following examples. In the following, “%” means “mass%” unless otherwise specified.
塩化セチルピリジニウムの不快味のマスキング評価方法１
表1に示す処方に従って洗口液（実施例及び比較例）を調製し、味覚テストを行った。味覚テストは、１３名の専門パネラーを用い、被検体約１０ｍＬを口に含んで約２０秒間口腔内を十分にいきわたらせた後に吐き出し、直後の苦味について下記の７段階の絶対評価で行なった。各々の評価結果に下記係数を乗じることにより１３名の評価結果の合計値を算出した。結果を表１に示す。
評価段階と係数
非常に強く感じる −８
強く感じる −４
やや強く感じる −１
どちらともいえない ０
やや弱く感じる １
弱く感じる ４
非常に弱く感じる ８
Masking evaluation method 1 for unpleasant taste of cetylpyridinium chloride
Mouthwashes (Examples and Comparative Examples) were prepared according to the formulation shown in Table 1, and taste tests were performed. The taste test was conducted using 13 specialist panelists, and after about 10 mL of the subject was included in the mouth, the mouth was thoroughly swirled for about 20 seconds, and then exhaled. The total value of the evaluation results of 13 persons was calculated by multiplying each evaluation result by the following coefficient. The results are shown in Table 1.
Evaluation stage and coefficient Feels very strong -8
Feel strongly -4
I feel a little strong -1
0
I feel a little weak 1
Feel weak 4
I feel very weak 8
塩化セチルピリジニウムの不快味のマスキング評価方法２
表２に示す処方に従って洗口液（実施例及び比較例）を調製し、味覚テストを行った。味覚テストは、５名の専門パネラーを用い、被検体約１０ｍＬを口に含んで約２０秒間口腔内を十分にいきわたらせた後に吐き出し、直後の「苦味」および「えぐ味」について下記の５段階の絶対評価で行なった。各々の評価結果に下記係数を乗じることにより得られる５名の評価結果の合計値を算出したのち、２つの評価の合計値（評価合計点）を算出した。結果を表２に示す。
評価段階と係数
強く感じる −４
やや強く感じる −１
どちらともいえない ０
やや弱く感じる １
弱く感じる ４
Masking evaluation method 2 for unpleasant taste of cetylpyridinium chloride
Mouthwashes (Examples and Comparative Examples) were prepared according to the formulation shown in Table 2, and taste tests were performed. The taste test was conducted using five specialist panelists. After about 10 seconds in the mouth, the mouth was thoroughly swirled for about 20 seconds, and then spit out. An absolute evaluation of After calculating the total value of the five evaluation results obtained by multiplying each evaluation result by the following coefficient, the total value (evaluation total point) of the two evaluations was calculated. The results are shown in Table 2.
Evaluation stage and coefficient Feel strongly -4
I feel a little strong -1
0
I feel a little weak 1
Feel weak 4
表１または２に示したとおり、塩化セチルピリジニウムにスクラロースを０．００５〜０．０５質量％配合することで、使用直後の苦味を低減させる効果が顕著であることがわかった。また、キシリトールやマルチトールをスクラロースに対して２００〜１０００質量部配合すると、使用直後の「苦味」や「えぐ味」をさらに低減させることがわかった。その効果は、スクラロースに対して５００〜１０００質量部配合した場合に顕著であった。 As shown in Table 1 or 2, it was found that the effect of reducing the bitterness immediately after use was remarkable by adding 0.005 to 0.05 mass% of sucralose to cetylpyridinium chloride. It was also found that when xylitol or maltitol is blended in an amount of 200 to 1000 parts by mass with respect to sucralose, “bitterness” and “eggu” immediately after use are further reduced. The effect was remarkable when 500-1000 mass parts was mix | blended with respect to sucralose.
処方例１
常法に従って、液体歯磨剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム ０．３
スクラロース ０．０１５
キシリトール ７．０
グリセリン １０．０
エタノール １０．０
ポリオキシエチレン
（６０ＥＯ）硬化ヒマシ油 ０．４
トラネキサム酸 ０．０５
クエン酸 ０．０１
クエン酸３ナトリウム ０．１
パラオキシ安息香酸メチル ０．１
香料 ０．２
精製水 残 部
合 計 １００．０
Formulation Example 1
A liquid dentifrice was prepared according to a conventional method.
Component content <br/> Cetylpyridinium chloride 0.3
Sucralose 0.015
Xylitol 7.0
Glycerin 10.0
Ethanol 10.0
Polyoxyethylene (60EO) hydrogenated castor oil 0.4
Tranexamic acid 0.05
Citric acid 0.01
Trisodium citrate 0.1
Methyl paraoxybenzoate 0.1
Fragrance 0.2
Purified water balance part Total 100.0
処方例２
常法に従って、ペースト状の歯磨剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム ０．０５
スクラロース ０．０５
グリセリン ２０．０
リン酸水素カルシウム ３０．０
ヒドロキシエチルセルロース ２．０
フッ化ナトリウム ０．２
ポリオキシエチレン
（４０ＥＯ）硬化ヒマシ油 ０．５
酸化チタン ０．５
メチルパラベン ０．５
酢酸トコフェロール ０．０２
クエン酸 ０．０１
クエン酸３ナトリウム ０．１
香料 １．０
精製水 残 部
合 計 １００．０
Formulation Example 2
A paste dentifrice was prepared according to a conventional method.
Component content <br/> Cetylpyridinium chloride 0.05
Sucralose 0.05
Glycerin 20.0
Calcium hydrogen phosphate 30.0
Hydroxyethyl cellulose 2.0
Sodium fluoride 0.2
Polyoxyethylene (40EO) hydrogenated castor oil 0.5
Titanium oxide 0.5
Methylparaben 0.5
Tocopherol acetate 0.02
Citric acid 0.01
Trisodium citrate 0.1
Fragrance 1.0
Purified water balance part Total 100.0
処方例３
常法に従って、ジェル剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム ０．１
スクラロース ０．０２
グリセリン １０．０
プロピレングリコール １０．０
ヒドロキシエチルセルロース １．０
ポリオキシエチレン
（６０ＥＯ）硬化ヒマシ油 ０．４
クエン酸 ０．０１
クエン酸３ナトリウム ０．１
香料 ０．１
メチルパラベン ０．１
精製水 残 部
合 計 １００．０
Formulation Example 3
A gel was prepared according to a conventional method.
Component content <br/> Cetylpyridinium chloride 0.1
Sucralose 0.02
Glycerin 10.0
Propylene glycol 10.0
Hydroxyethyl cellulose 1.0
Polyoxyethylene (60EO) hydrogenated castor oil 0.4
Citric acid 0.01
Trisodium citrate 0.1
Fragrance 0.1
Methylparaben 0.1
Purified water balance part Total 100.0
処方例４
常法に従って、洗口剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム ０．０１
スクラロース ０．００５
グリセリン ６．０
１，３−プロパンジオール ３．０
モノラウリン酸ショ糖脂肪酸エステル
０．３
イソプロピルメチルフェノール ０．０５
クエン酸 ０．０１
クエン酸３ナトリウム ０．１
安息香酸ナトリウム ０．２
香料 ０．１
精製水 残 部
合 計 １００．０
Formulation Example 4
A mouthwash was prepared according to a conventional method.
Component amount <br/> Cetylpyridinium chloride 0.01
Sucralose 0.005
Glycerin 6.0
1,3-propanediol 3.0
Monolauric acid sucrose fatty acid ester
0.3
Isopropyl methylphenol 0.05
Citric acid 0.01
Trisodium citrate 0.1
Sodium benzoate 0.2
Fragrance 0.1
Purified water balance part Total 100.0
処方例５
常法に従って、マウススプレイを調製した。
成 分 配 合 量
塩化セチルピリジニウム ０．０１
スクラロース ０．０１
マルチトール ２．０
エタノール １０．０
グリセリン ６．０
ポリオキシエチレン
（６０ＥＯ）硬化ヒマシ油 ２．０
クエン酸 ０．１
クエン酸３ナトリウム ０．２
ｌ−メントール ０．３
香料 ０．８
精製水 残 部
合 計 １００．０
Formulation Example 5
A mouse spray was prepared according to a conventional method.
Component amount <br/> Cetylpyridinium chloride 0.01
Sucralose 0.01
Maltitol 2.0
Ethanol 10.0
Glycerin 6.0
Polyoxyethylene (60EO) hydrogenated castor oil 2.0
Citric acid 0.1
Trisodium citrate 0.2
l-Menthol 0.3
Fragrance 0.8
Purified water balance part Total 100.0
処方例６
常法に従って、液状の口腔乾燥防止剤を調製した。
成 分 配 合 量
塩化セチルピリジニウム ０．０２
スクラロース ０．０３
グリセリン ５．０
ヒアルロン酸 ２．０
ポリオキシエチレン
（６０ＥＯ）硬化ヒマシ油 ０．１
クエン酸 ０．０２
クエン酸３ナトリウム ０．１
香料 ０．８
精製水 残 部
合 計 １００．０
Formulation Example 6
A liquid oral anti-drying agent was prepared according to a conventional method.
Component Amount <br/> Cetylpyridinium chloride 0.02
Sucralose 0.03
Glycerin 5.0
Hyaluronic acid 2.0
Polyoxyethylene (60EO) hydrogenated castor oil 0.1
Citric acid 0.02
Trisodium citrate 0.1
Fragrance 0.8
Purified water balance part Total 100.0
Claims (2)
スクラロース（Ａ）の配合量が０．００５〜０．０１質量％であり、かつ塩化セチルピリジニウム（Ｂ）の配合量に対して０．１〜０．２質量部であり、
塩化セチルピリジニウム（Ｂ）の配合量が０．０５質量％であり、
キシリトール（Ｃ）の配合量が、スクラロース（Ａ）の配合量に対して２００〜１０００質量部であり、かつ１０質量％以下
であることを特徴とする口腔用組成物。 In an oral composition containing sucralose (A), cetylpyridinium chloride (B) and xylitol (C),
The amount of sucralose (A) is 0.005 to 0.01% by mass, and 0.1 to 0.2 parts by mass with respect to the amount of cetylpyridinium chloride (B),
The blending amount of cetylpyridinium chloride (B) is 0.05% by mass,
The compounding quantity of xylitol (C) is 200-1000 mass parts with respect to the compounding quantity of sucralose (A), and is 10 mass% or less.
Oral composition characterized by being .
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| US4959225A (en) * | 1988-10-28 | 1990-09-25 | Warner-Lambert Company | Synergistic sweetening compositions containing chlorodeoxysugars and maltitol and methods for preparing same |
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