JP5678373B2 - Atp産生促進剤、およびその利用 - Google Patents
Atp産生促進剤、およびその利用 Download PDFInfo
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- JP5678373B2 JP5678373B2 JP2010028795A JP2010028795A JP5678373B2 JP 5678373 B2 JP5678373 B2 JP 5678373B2 JP 2010028795 A JP2010028795 A JP 2010028795A JP 2010028795 A JP2010028795 A JP 2010028795A JP 5678373 B2 JP5678373 B2 JP 5678373B2
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- atp production
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Description
本発明に係るATP産生促進剤は、トリオースリン酸イソメラーゼ(TPI)、ホスホグルコムターゼ(PGM)、ATP合成酵素(ATP synthase)から選ばれる1種または2種以上の酵素の産生を促進することによりATP産生を促進することができる。
本発明に係るATP産生促進剤は、これを有効成分として含有させることにより、細胞増殖促進剤として用いることができる。
また、本発明に係るATP産生促進剤は、これを有効成分として用いることにより、アンチエイジングに有用である。
また、本発明に係るATP産生促進剤は、薬理学的に許容され得る添加剤を加え、医薬品組成物または化粧料組成物、あるいはアンチエイジング用飲食物として適用することができる。
本発明に係るATP産生促進剤、細胞増殖促進剤およびアンチエイジング剤は、モンスペリエンシス抽出物を有効成分とする。本発明に係るATP産生促進剤は、ATPの産生を促進することにより細胞増殖を促進することができる。即ち、高いATP産生促進効果を有することにより、細胞の機能や細胞***に必要なエネルギー源としてATPを用いることができ、その結果、細胞の増殖、代謝、修復などの機能の活性化およびアンチエイジングの効果を発揮する。
本発明に係るATP産生促進剤、細胞増殖促進剤およびアンチエイジング剤は、その優れたATP産生促進効果、細胞増殖促進効果およびアンチエイジング効果を利用して、医薬品組成物に好適に用いることができる。該医薬品組成物は、あらゆる剤型の医薬品に適用することができる。例えば、外用液剤、外用ゲル剤、クリーム剤、軟膏剤、スプレー剤、点鼻液剤、リニメント剤、ローション剤、ハップ剤、硬膏剤、噴霧剤、エアゾール剤、などの外用剤、散剤、細粒剤、顆粒剤、錠剤、カプセル剤、懸濁液、エマルジョン剤、シロップ剤、エキス剤、丸剤、などの経口剤、または注射剤に適用することができる。
本発明に係るATP産生促進剤、細胞増殖促進剤およびアンチエイジング剤は、その優れたATP産生促進効果、細胞増殖促進効果およびアンチエイジング効果を利用して、化粧料組成物に好適に用いることができる。該化粧料組成物は、あらゆる形態の化粧料に適用することができる。例えば、ローション、乳液、クリーム、美容液などのスキンケア化粧料、ファンデーション、コンシーラー、化粧下地、口紅、頬紅、アイシャドウ、アイライナーなどのメイクアップ化粧料、日焼け止め化粧料などに適用することができる。
本発明に係るATP産生促進剤、細胞増殖促進剤およびアンチエイジング剤は、その優れたATP産生促進効果、細胞増殖促進効果およびアンチエイジング効果を利用して、飲食物に好適に含有させることができる。例えば、牛乳、ジュース、スポーツ飲料、お茶、コーヒー、紅茶などの飲料、醤油などの調味料、スープ類、クリーム類、各種乳製品類、アイスクリームなどの冷菓、各種粉末食品(飲料を含む)、保存用食品、冷凍食品、パン類、菓子類などの加工食品など、あらゆる飲食物に用いることができる。また、保健機能食品(特定保健機能食品、栄養機能食品、飲料を含む)や、いわゆる健康食品(飲料を含む)、濃厚栄養剤、流動食、乳児・幼児食にも用いることができる。あるいは、口中に一時的に含むもの、例えば、歯磨剤、染口剤、チューインガム等に含有させることもできる。更に、牛、馬、豚などの家畜用哺乳類、鶏、ウズラなどの家禽類、爬虫類、鳥類あるいは小型哺乳類などのペット類、養殖魚類などの飼料にも使用することが可能である。
Rosmarinus officinalisの葉、Rhus tripartitaの葉、Juniperus oxycedrusの葉、Teucrium polliumの葉、Arbutus unedoの葉、Juniperus phoeniceaの葉、Cistus monspeliensisの葉、Myrtis communisの葉、Ceratonia siliquaの葉それぞれ1gを、10mlのエタノールを用いて常温で7日間抽出し、濾過を行い、各種植物抽出物(サンプル)を得た。
96穴のマイクロプレートに、Caco-2細胞を1×106cell/ml濃度で100μL/well播種し、各ウエルに、前記で得た各種植物抽出物を100μL/well添加し、24時間、37℃で静置培養した。
Claims (4)
- ハンニチバナ科(Cistaceae)ゴジアオイ属モンスペリエンシス(学名:Cistus monspeliensis)より、水、エタノールをそれぞれ単独、若しくはこれらを組み合わせて用いて抽出されたモンスペリエンシス抽出物を有効成分とするATP産生促進剤(抗酸化用途及び抗炎症用途を除く)。
- トリオースリン酸イソメラーゼ(TPI)、ホスホグルコムターゼ(PGM)、ATP合成酵素(ATP synthase)から選ばれる1種または2種以上の酵素の産生を促進する請求項1記載のATP産生促進剤。
- 請求項1または2に記載のATP産生促進剤を少なくとも含有する細胞増殖促進剤。
- 請求項1または2に記載のATP産生促進剤と、薬理学的に許容され得る添加剤と、を含有するATP産生促進用医薬品組成物(抗酸化用途及び抗炎症用途を除く)。
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