JP5653291B2 - 密封小線源収容容器 - Google Patents
密封小線源収容容器 Download PDFInfo
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- JP5653291B2 JP5653291B2 JP2011108769A JP2011108769A JP5653291B2 JP 5653291 B2 JP5653291 B2 JP 5653291B2 JP 2011108769 A JP2011108769 A JP 2011108769A JP 2011108769 A JP2011108769 A JP 2011108769A JP 5653291 B2 JP5653291 B2 JP 5653291B2
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- 238000002725 brachytherapy Methods 0.000 title claims description 76
- 230000005855 radiation Effects 0.000 claims description 43
- 239000000463 material Substances 0.000 claims description 27
- 229910001297 Zn alloy Inorganic materials 0.000 claims description 18
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 15
- 229910052725 zinc Inorganic materials 0.000 claims description 15
- 239000011701 zinc Substances 0.000 claims description 15
- 206010060862 Prostate cancer Diseases 0.000 claims description 12
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 11
- 206010028980 Neoplasm Diseases 0.000 description 14
- 201000011510 cancer Diseases 0.000 description 14
- 230000003902 lesion Effects 0.000 description 11
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000004033 plastic Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 5
- 238000003912 environmental pollution Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 5
- 229910052721 tungsten Inorganic materials 0.000 description 5
- 239000010937 tungsten Substances 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical group [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- -1 polypropylene Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 210000002307 prostate Anatomy 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- 238000004088 simulation Methods 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 238000005266 casting Methods 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 238000003754 machining Methods 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- MISZALMBODQYFT-URVXVIKDSA-N 125-69-9 Chemical compound Br.C([C@@H]12)CCC[C@]11CCN(C)[C@H]2CC2=CC=C(OC)C=C21 MISZALMBODQYFT-URVXVIKDSA-N 0.000 description 1
- 229910001369 Brass Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000000342 Monte Carlo simulation Methods 0.000 description 1
- 239000010951 brass Substances 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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Description
密封小線源収容容器として、図2に示す構造ものを用いた。すなわち、容器の上下面の厚さが4mm、側面が厚さ2mmの亜鉛合金(アルミニウム3.5〜4.3重量%、マグネシウム0.02〜0.06重量%、残り亜鉛)からなり、直径36mm、高さ32mmの円筒状のものであり、蓋の部分は胴の部分と印籠じゃくりに形成されている。密封小線源としては、長さ4.6mm、直径0.8mmの円柱形のチタン製のカプセル内に、銀製の短線に化学的に結合された125Iが密封されたものを用いた。1個10MBqの密封小線源5個をプラスチック製の内容器(ポリプロピレン製、厚さ1mm、直径30mm、高さ20mmの上蓋付円筒状)に入れ、該内容器を前記の密封小線源収容容器に入れ、更にプラスチック製の外容器(ポリプロピレン製、厚さ1mm、直径40mm、高さ36mmの上蓋付円筒状)に収納して、漏洩放射線量の測定に供した。測定地点は、密封小線源収容容器の上面、側面及び底面の各面に対し、密着した地点及び1m離れた地点で行った。漏洩放射線量の測定は、電離箱測定器(INOVISION社製451B−DE−S1)で行った。
また、参考例1として、遮蔽材が鉛である容器を用いたこと以外は実施例1と同様に行った。
測定結果を表1に示した。この表から明らかなように、実施例1、参考例1共に、全ての測定地点において、漏洩放射線は検出されなかった。この結果から、本発明による亜鉛合金を遮蔽材とする密封小線源収容容器は、鉛を遮蔽材とする密封小線源収容容器と同等の漏洩放射線遮蔽効果を有することがわかる。
放射線源が125Iである場合の測定結果をもとにして、放射線源が103Pdである場合の容器表面線量率をシミュレーションにより求めた。なお、シミュレーションに使用した計算コードは高エネルギー加速器研究機構から公開されている、電子・光子モンテカルロ法シミュレーションコード EGS5 (H.Hirayama,Y.Namito,A.F.Bielajew,S.J.Wilderman and W.R.Nelson:The EGS5 Code System.SLAC−R−730 and KEK Report 2005−8:2005)を用いた。
シミュレーションの結果を図3に示した。図3から、亜鉛合金を遮蔽材とする本発明の密封小線源収容容器は、放射線源が125Iである場合と同様、放射線源が103Pdである場合にも十分な漏洩放射線遮蔽効果を有することがわかる。
2 内容器(胴)(プラスチック)
3 内容器(蓋)(プラスチック)
4 密封小線源収容容器(胴)(亜鉛合金)
5 密封小線源収容容器(蓋)(亜鉛合金)
6 外容器(胴)(プラスチック)
7 外容器(蓋)(プラスチック)
Claims (5)
- 125I又は103Pdを放射線源とする密封小線源療法用の密封小線源を収容する容器であって、
前記密封小線源を収容する内容器と、
第一の開口を有する第一の胴部と、前記第一の開口を覆う第一の蓋部とを備え、前記内容器を前記第一の胴部に収容する密封小線源収容容器と、
第二の開口を有する第二の胴部と、前記第二の開口を覆う蓋部とを備え、前記密封小線源収容容器を前記第二の胴部に収容する外容器と、
を有し、
前記密封小線源収容容器の全面が放射線の遮蔽材からなり、前記遮蔽材の少なくとも一部が亜鉛及び/又は亜鉛合金であり、
前記第二の蓋部と前記第二の胴部とがネジ形式で密着することにより、前記第二の開口が前記第二の蓋部で覆われ、
前記第一の蓋部が前記第一の開口を覆い、前記第二の蓋部が前記第二の開口を覆うとき、前記第一の蓋部の上面と、前記第二の蓋部の下面とが接する構造を備える、容器。 - 前記遮蔽材のすべてが亜鉛及び/又は亜鉛合金である請求項1記載の容器。
- 前記密封小線源が、前立腺がんの治療用のものである請求項1又は2に記載の容器。
- 前記密封小線源が、前立腺がんの治療のために人体に挿入される前のものである請求項3記載の容器。
- 前記密封小線源が、前立腺がんの治療のために人体に挿入された後、人体から脱落したものである請求項3記載の容器。
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JP5653291B2 true JP5653291B2 (ja) | 2015-01-14 |
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HU195335B (en) * | 1984-11-05 | 1988-04-28 | Peter Teleki | Method and modifying body for influencing effect on a target sensitive to radiation exerted by x-ray or gamma radiation |
JPS63117286A (ja) * | 1986-11-04 | 1988-05-21 | Matsushita Electric Ind Co Ltd | 放射線検出器 |
JP3630772B2 (ja) * | 1994-07-15 | 2005-03-23 | 株式会社日本触媒 | 放射性薬液封入容器用輸送容器 |
GB2364120B (en) * | 1997-08-11 | 2002-04-03 | Siemens Plc | Personal radiation dosemeters providing audible signals indicative of a dose rate |
JP2002277588A (ja) * | 2001-03-09 | 2002-09-25 | Schering Ag | 放射性物質の包装ケース及び放射性溶液注射筒 |
JP2004028789A (ja) * | 2002-06-26 | 2004-01-29 | Toshiba Corp | 放射線遮蔽体、放射線検出器、および放射線診断装置 |
JP4469189B2 (ja) * | 2004-02-12 | 2010-05-26 | 日本メジフィジックス株式会社 | 放射性医薬品用輸送容器 |
US7425195B2 (en) * | 2004-08-13 | 2008-09-16 | Core Oncology, Inc. | Radiation shielding device |
ES2328853T3 (es) * | 2005-05-16 | 2009-11-18 | Mallinckrodt, Inc. | Contenedor radio-farmaceutico que tiene encapsulador de jeringas. |
CN101233579B (zh) * | 2005-07-27 | 2013-07-10 | 马林克罗特有限公司 | 放射屏蔽组件及其使用方法 |
WO2007070871A1 (en) * | 2005-12-15 | 2007-06-21 | Medi-Physics, Inc. | Seed-cartridge barrel assembler |
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