JP5646277B2 - 殺菌剤及びニキビの治療・予防剤 - Google Patents
殺菌剤及びニキビの治療・予防剤 Download PDFInfo
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- JP5646277B2 JP5646277B2 JP2010238734A JP2010238734A JP5646277B2 JP 5646277 B2 JP5646277 B2 JP 5646277B2 JP 2010238734 A JP2010238734 A JP 2010238734A JP 2010238734 A JP2010238734 A JP 2010238734A JP 5646277 B2 JP5646277 B2 JP 5646277B2
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- bactericidal
- skin
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Description
上記殺菌剤は、アクネ菌を殺菌するために用いられるものであることが好ましい。
本発明は金イオンを含有することを特徴とするニキビの治療・予防剤でもある。
そして、再蒸発乾固工程が完了し、耐高熱容器を常温まで冷却後、耐高熱容器内に精製水を注ぎ耐高熱容器内に残った最後の析出物を精製水に溶解させて金イオン水を得る。
金箔(純度99.99%)1gを耐高熱容器(チーゲル)内に入れたのち、王水(塩酸:硝酸=3:1)80ミリリットルをこの耐高熱容器内に投入し、金箔を王水に溶解させた。次に、この金溶解液入りの耐高熱容器をバーナーで1時間加熱し、金溶解液を蒸発乾固させた。
蒸発乾固後、耐高熱容器を常温になるまで放冷したのち、耐高熱容器内に再び上記王水80ミリリットルを投入し、耐高熱容器内に残った蒸発乾固物を王水に溶解した。この蒸発乾固物溶解液入りの耐高熱容器をバーナーで1時間加熱し、蒸発乾固物溶解液を再蒸発乾固させた。
耐高熱容器を再び常温まで放熱後、耐高熱容器内を精製水で繰り返し洗浄し、洗浄液を濾過しつつすべてビーカー内に移し総量を1リットルとし、金イオン水を得た。得られた金イオン水の金イオン濃度をICP発光分光分析装置でn数=5で測定し、その結果の平均値は764ppmであった。
試料にアクネ菌の菌液を接種後(以下「試験液」という。)、室温で嫌気保存し、1,3及び24時間後に試験液中の生菌数を測定した。なお、あらかじめ予備試験を行い、生菌数の測定方法について検討した。試験は、上述した方法によって得られた金イオン水をイオン交換水によって希釈することによって、金イオン濃度を10ppm、5ppm、2ppmとしたサンプルについて行った。
試験条件の詳細を以下に示す。
Propionibacterium acnes GAI 5419(アクネ菌)
2)菌数測定用培地及び培養条件
GAM寒天培地[日水製薬株式会社], 混釈平板培養法,35℃±1℃,5日間嫌気培養
3)試験菌液の調製
試験菌液をGAM寒天培地で35℃±1℃,18〜24時間嫌気培養した後、生理食塩水に浮遊させ、菌数が108〜109 /ml となるように調製し、試験菌液とした。
4)試験操作
検体原液及び検体希釈液(精製水で調製した検体の50及び20 V/V%希釈液)を嫌気状態で1晩保存したものを試料とした。試料10mlに試験菌液を0.1ml接種し、試験液とした。室温で嫌気保存し、1,3及び24時間後に試験液をSCDLP培地[日本製薬株式会社]で直ちに10倍に希釈し、試験液中の生菌数を菌数測定用培地を用いて測定した。
なお、対照として精製水を用いて同様に試験し、開始時についても生菌数を測定した。
なお、試験液をSCDLP培地で10倍に希釈することにより、検体の影響を受けずに生菌数が測定できることを予備試験により確認した。
試験試料を0.25mM nitroblue tetrazolium(NBT)、1mM hypoxanthineおよび0.1mM EDTAを含むHank’s bufferに添加した。次にxanthineoxidase(XOD)を加えて10分間インキュベート後、反応液の吸光度を測定した(O.D.=550nm)。一方、試験試料の吸光度ブランクとしてXOD未含有の反応液を作成し、同様に10分間インキュベート後の吸光度を各試薬含有の反応系における吸光度から差し引くことにより補正し、試験試料のスーパーオキサイドアニオン消去作用を評価した。結果は、試料未添加の吸光度を100%とした相対値にて示した。測定は、表1に示した種々の濃度に対して行った。更に、対照試験として、スーパーオキサイドアニオン消去能を有する化合物として公知であるアスコルビン酸及びテアフラビンについても、同様の試験を行った。結果を表2に示す。更に、濃度を横軸に、吸光度を縦軸にプロットし、吸光度が50となる値をID50としてグラフ上から読み取った。その値を表3に示す。なお、測定はn=5で行い、平均値と標準偏差を算出した。
Claims (2)
- 金イオンを有効成分とするアクネ菌を殺菌するために用いられるものである殺菌剤。
- 金イオンを含有することを特徴とする水性組成物であるニキビの治療・予防剤。
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