JP5584524B2 - 水中油型乳化組成物及びその製造方法 - Google Patents
水中油型乳化組成物及びその製造方法 Download PDFInfo
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- JP5584524B2 JP5584524B2 JP2010129674A JP2010129674A JP5584524B2 JP 5584524 B2 JP5584524 B2 JP 5584524B2 JP 2010129674 A JP2010129674 A JP 2010129674A JP 2010129674 A JP2010129674 A JP 2010129674A JP 5584524 B2 JP5584524 B2 JP 5584524B2
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- 239000002453 shampoo Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000000475 sunscreen effect Effects 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000008307 w/o/w-emulsion Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/017—Mixtures of compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/42—Ethers, e.g. polyglycol ethers of alcohols or phenols
Landscapes
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
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- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Description
しかしながら、アルキル基又はアルケニル基の炭素数が20〜24で、エチレンオキサイドの平均付加モル数が1.5〜4であるポリオキシエチレンアルキル又はアルケニルエーテルを特定の油剤とともに乳化させた場合、アルキル基又はアルケニル基の炭素数が20〜24で、エチレンオキサイドの平均付加モル数が1.5〜4であるポリオキシエチレンアルキル又はアルケニルエーテルが油剤中に溶解してしまい、水相の水分蒸散抑制効果が低下するという問題が生じることが判明した。
従って、本発明の課題は、水中油型乳化組成物でありながら、水分蒸散抑制効果が高く、しかも使用感に優れる水中油型乳化化粧料及びその製造方法を提供することにある。
(A)アルキル基又はアルケニル基の炭素数が20〜24で、エチレンオキサイドの平均付加モル数が1.5〜4であるポリオキシエチレンアルキル又はアルケニルエーテル
(B)多価アルコール
(C)水溶性高分子
(A)アルキル基又はアルケニル基の炭素数が20〜24で、エチレンオキサイドの平均付加モル数が1.5〜4であるポリオキシエチレンアルキル又はアルケニルエーテル
(B)多価アルコール
本発明水中油型乳化組成物中のこれら油性成分の含有量の上限は、水中油型乳化系が形成できれば限定されないが、30質量%以下、特に20質量%以下が好ましい。
これらのうち、特に本発明のポリオキシエチレンアルキルエーテル(A)の溶解性及び使用性の点から、エチレングリコール、ジエチレングリコール、プロピレングリコール、ジプロピレングリコール、1,3−ブチレングリコールが好適に利用でき、特に好ましくはジプロピレングリコールである。
アニオン性高分子としては、具体的には、カルボキシビニルポリマー、カルボキシメチルセルロース、カラゲーナン、キサンタンガム、ポリスチレンスルホネート、寒天、ガッチガム、カラヤガム、ペクチン、アルギネート塩、同じくポリ(アクリル酸)およびアクリル酸、メタクリル酸のアルカリ金属およびアンモニウム塩などのアクリルまたメタクリル酸誘導体が挙げられる。
非イオン性高分子としては、具体的には、セルロースエーテル(ヒドロキシブチルメチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロール、エチルヒドロキシエチルセルロース、ヒドロキシエチルセルロース等)、プロピレングリコールアルギネート、ポリアクリルアミド、(アクリル酸Na/アクリロイルジメチルタウリンNa)コポリマー、ポリ(エチレンオキシド)、ポリビニルアルコール、ポリビニルピロリドン、ヒドロキシプロピルグアーゴム、ローカストビーンゴム、アミロース、ヒドロキシエチルアミロース、ヒアルロン酸及びそのアルカリ金属塩、澱粉および澱粉誘導体およびこれらの混合物などが挙げられる。
両性高分子又は双極性高分子として、具体的には、オクチルアクリルアミド/アクリレート/ブチルアミノエチルメタクリレートコポリマー、ポリクオタニウム−47、ポリクオタニウム−43などが挙げられる。
下記表1〜4に示す成分の実施例1〜7、比較例1〜3、参考例1〜4、及び下記コントロールを開口面積13.85cm2のシャーレに5g添加し、湿度30%、温度30℃下で1、3、5、7、12、18、24時間経過後の試料の重量変化を測定した。その重量変化の傾きを最小二乗法により算出される(nX+m;Xは時間h)のnを水分蒸散速度(単位:mg/h)とし、絶対値としてプロットした。尚、水分蒸散速度は、各試料計3回の平均値を求めた。
前記水分蒸散速度から、下記に定義する水分蒸散抑制率を算出した。水分蒸散抑制率が高いほど、水分蒸散を抑制したことになる。結果を表1〜4に合わせて記載する。
成分 含有量(%)
ジプロピレングリコール 10
2%カルボキシビニルポリマー(シンタレンK、和光純薬社製) 7.5
10%水酸化カリウム 0.7
エデト酸二ナトリウム 0.03
フェノキシエタノール 0.35
純水 残 量
(1)成分1及び成分2を60℃に加熱し、均一に混合させる。
(2)成分3〜10を80℃で均一に混合させる。
(3)成分11〜14を80℃で均一に混合させる。
(4)(2)に、(3)を80℃に加熱保持しながら、徐々に添加して均一に混合させる。
(5)(4)を40℃まで徐々に冷却し、(1)及び成分15を40℃で(4)に添加し、均一に混合させる。
(1)成分1〜9を80℃に加熱し、均一に混合する。
(2)成分10〜14を80℃に加熱し、均一に混合する。
(3)(1)に、(2)を80℃に加熱保持しながら、徐々に添加して均一に混合させる。
(4)(3)を40℃まで徐々に冷却し、成分15を40℃で添加し、均一に混合させる。
また、無機性値が2500以下、有機性値が5000以下であって、かつIOB値が0.3〜0.5の油性成分以外の油性成分を用いた参考例1〜4では、油性成分中にポリオキシエチレンアルキルエーテル(A)が溶解せず、水相中に分散されているため、水分蒸散効果の明らかな低下は認められなかった。
Claims (5)
- 無機性値が2500以下、有機性値が5000以下であって、かつIOB値が0.3〜0.5の油性成分を含有する水中油型乳化組成物であって、水相中に下記(A)〜(C)を含有し、成分(B)を成分(A)の含有量に対し、質量比で0.5〜50倍含有することを特徴とする水中油型乳化組成物。
(A)アルキル基又はアルケニル基の炭素数が20〜24で、エチレンオキサイドの平均付加モル数が1.5〜4であるポリオキシエチレンアルキル又はアルケニルエーテル 組成物全量に対して0.05〜20質量%
(B)多価アルコール
(C)水溶性高分子 - 無機性値が1500以下、有機性値が3000以下であって、IOB値が0.3〜0.5の油性成分を含有する請求項1に記載の水中油型乳化組成物。
- 成分(A)ポリオキシエチレンアルキル又はアルケニルエーテルが、エチレンオキサイドの平均付加モル数1.5〜3のポリオキシエチレンアルキル又はアルケニルエーテルである請求項1又は2に記載の水中油型乳化組成物。
- 水溶性高分子を含有する水中油型乳化組成物を形成し、次の成分(A)と(B)を、成分(B)を成分(A)の含有量に対し、質量比で0.5〜50倍含有する組成物と、前記水中油型乳化組成物を、45℃以下の温度で混合することを特徴とする水中油型乳化組成物の製造方法。
(A)アルキル基又はアルケニル基の炭素数が20〜24で、エチレンオキサイドの平均付加モル数が1.5〜4であるポリオキシエチレンアルキル又はアルケニルエーテル 組成物全量に対して0.05〜20質量%
(B)多価アルコール - 前記成分(A)と(B)を含有する組成物と、前記水中油型乳化組成物を、35〜45℃の温度で混合する請求項4に記載の製造方法。
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JP2010129674A JP5584524B2 (ja) | 2010-06-07 | 2010-06-07 | 水中油型乳化組成物及びその製造方法 |
CN201180026206.6A CN102917786B (zh) | 2010-06-07 | 2011-06-03 | 水包油型乳化组合物及其制造方法 |
EP11792361.5A EP2578310B1 (en) | 2010-06-07 | 2011-06-03 | Oil-in-water emulsion composition and method for producing same |
US13/702,484 US8815959B2 (en) | 2010-06-07 | 2011-06-03 | Oil-in-water emulsion composition and method for producing same |
PCT/JP2011/062787 WO2011155404A1 (ja) | 2010-06-07 | 2011-06-03 | 水中油型乳化組成物及びその製造方法 |
KR1020127030850A KR101848946B1 (ko) | 2010-06-07 | 2011-06-03 | 수중유형 유화 조성물 및 그 제조 방법 |
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JP6143914B2 (ja) | 2015-09-30 | 2017-06-07 | 株式会社 資生堂 | 日焼け止め化粧料 |
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FR2787703B1 (fr) * | 1998-12-29 | 2001-01-26 | Oreal | Nanoemulsion a base d'ethers gras ethoxyles ou d'esters gras ethoxyles, et ses utilisations dans les domaines cosmetique, dermatologique et/ou ophtalmologique |
JP2000265098A (ja) * | 1999-03-17 | 2000-09-26 | Fuji Xerox Co Ltd | 画像表示用記録液及び画像形成方法 |
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JP2009249325A (ja) * | 2008-04-04 | 2009-10-29 | Tokiwa Yakuhin Kogyo Kk | 皮膚外用剤 |
JP4406035B1 (ja) | 2008-07-09 | 2010-01-27 | 株式会社資生堂 | 水中油型乳化皮膚化粧料 |
JP2010102160A (ja) | 2008-10-24 | 2010-05-06 | Fujitsu Ltd | 液晶表示装置 |
JP5689288B2 (ja) | 2010-05-17 | 2015-03-25 | 花王株式会社 | 皮膚外用剤 |
JP5695339B2 (ja) | 2010-04-27 | 2015-04-01 | 花王株式会社 | 容器入り水系組成物 |
JP5581115B2 (ja) | 2010-05-27 | 2014-08-27 | 花王株式会社 | 容器入り水系組成物 |
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CN102917786A (zh) | 2013-02-06 |
TWI423825B (zh) | 2014-01-21 |
EP2578310A4 (en) | 2017-09-13 |
US20130102688A1 (en) | 2013-04-25 |
KR101848946B1 (ko) | 2018-04-13 |
JP2011256117A (ja) | 2011-12-22 |
KR20130086941A (ko) | 2013-08-05 |
US8815959B2 (en) | 2014-08-26 |
EP2578310A1 (en) | 2013-04-10 |
CN102917786B (zh) | 2016-03-09 |
EP2578310B1 (en) | 2020-03-25 |
WO2011155404A1 (ja) | 2011-12-15 |
TW201143813A (en) | 2011-12-16 |
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