JP5555277B2 - 内視鏡による角度分解低コヒーレンス干渉法のためのシステムおよび方法 - Google Patents
内視鏡による角度分解低コヒーレンス干渉法のためのシステムおよび方法 Download PDFInfo
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Description
Claims (26)
- サンプル内の散乱体の特性を決定するために、サンプル(18’、18’’)の深さ分解スペクトルを取得するための装置であって、
光ファイバを介して、光をサンプルビームおよび参照ビームに分離するためのファイバスプリッタに光を送出するように構成された光源と、
サンプルビームの偏光を維持するように適合された単一モード伝達ファイバ(16’、16’’)から構成される、サンプルビームの第1の光経路と、
事実上一致する経路長を有し、遠位端および近位端を有する複数の光ファイバ(94、116)から構成される、サンプルビームの第2の光経路と、
第3の光経路と、干渉計(108、134)と、プロセッサと、
によって特徴付けられ、
サンプルビームは、第1の光経路を通ってサンプルに誘導され、
光軸が第1の光経路から横方向に変位された第1の光学素子を通って、サンプルビームが第2の光経路の光軸に対して傾斜した角度で進むように、第1の光経路は、サンプルビームの第2の光経路の光軸からずらされ、
複数の光ファイバが、第1の光学要素のフーリエ変換特性を介して、散乱サンプルビームの角度散乱分布を受光するように、第2の光経路は、遠位端が第1光学素子(98、115)の一方の焦点に配置され、第1の光学要素の他方の焦点に配置されたサンプルから散乱サンプルビームを受光するように適合され、第2の光経路の近位端は、散乱サンプルビームを平行にして散乱サンプルビームを検出器まで送出するように適合された第2の光学要素および第3の光学要素に、散乱サンプルビームを送出するように配置され、
第3の光経路は、参照ビームをファイバスプリッタから伝達するように適合され、第3の光学素子(84、128)中で終端する光ファイバ(14’、14’’)から構成され、検出器による受光のために均一な照射を生成するように適合され、参照ビームの光経路は、サンプルビームの結合された第1および第2の光経路からなる光経路の基本モードに一致し、
干渉計(108、134)は、参照ビームおよび第2の光経路のサンプルビームを受光するように適合され、干渉計は、第2の光経路のサンプルビームおよび参照ビームを相互相関させ、角度分解相互相関信号を生成するように構成され、
検出器は、角度分解相互相関信号をスペクトル的に分散し、複数の角度の各々について、同時に並行して、角度分解、スペクトル分解プロファイルを生成するように適合され、
プロセッサは、角度分解、スペクトル分解プロファイルを受信し解析するように適合された、装置。 - プロセッサは、角度分解、スペクトル分解プロファイルから、サンプル内の散乱体の深さを決定するように適合される、請求項1に記載の装置。
- プロセッサは、角度分解、スペクトル分解プロファイルから、散乱体に関するサイズ情報を復元するように適合される、請求項1に記載の装置。
- プロセッサは、散乱サンプルビームの角度散乱分布を、サンプルの解析的または数値的に計算された予想角度散乱分布と比較することによって、サイズ情報を復元するように適合される、請求項3に記載の装置。
- プロセッサは、角度分解、スペクトル分解プロファイルから、表面下の散乱体に関する構造情報を復元するように適合されている、請求項1に記載の装置。
- 第1の光経路は、先端部で組み込まれた偏光制御を伴う単一モードファイバまたは単一モード偏光維持ファイバを備える、請求項1に記載の装置。
- 第2の光経路の複数の光ファイバは、単一モードまたは複数モードのファイバの線形アレイを備える、請求項1に記載の装置。
- 第2の光経路の複数の光ファイバは、散乱サンプルビームの角度散乱分布を収集するために、サンプルビームの異なる角度散乱を収集するとともに、複数の光ファイバが散乱サンプルビームの角度散乱分布の伝達に関して空間干渉性を有するように、複数の光ファイバの遠近端および近位端において、同一の空間配置を有するように、第2の光経路の複数の光ファイバは配置される、請求項1に記載の装置。
- 第1、第2、および第3の光学要素は、レンズまたは画像化光学要素から構成される、請求項1に記載の装置。
- 光源ビームが、アーク灯からの白色光、熱光源、LED、広帯域レーザからの干渉光、スーパールミネッセントダイオード、ダイオードレーザおよびスーパーコンティニューム光源からなるグループから選択される光から構成されている、請求項1に記載の装置。
- 検出器は、画像分光器から構成される、請求項1に記載の装置。
- サンプル内の散乱体の構造的特性を決定するために、サンプル(18’、18’’)の深さ分解スペクトルを取得する方法であって、
光をサンプルビームおよび参照ビーム(10’’)に分離するために光ファイバを通して光ビームをファイバスプリッタに放射することと、
サンプルビームの偏光を維持するように適合された単一モード送出ファイバ(16’、16’’)から構成される第1の光経路を通すとともに、実質上一致する経路長を有し、遠位端および近位端を有する複数の光ファイバから構成される第2の光経路(94、116)を通してサンプルビームを伝達することと、
第1の光経路を通してサンプルにサンプルビームを誘導することであって、第1の光経路は、サンプルビームの第2の光経路の光軸からずらされており、サンプルビームは光軸が第1の光経路から横方向に変位した第1の光学素子を通って、第2の光経路の光軸に対して傾斜した角度で伝わり、第2の光経路の遠位端は、第1の光学素子の一方の焦点にあり、サンプルは、第1の光学素子の他方の焦点に位置する、誘導することと、
複数の光ファイバが散乱サンプルビームの角度散乱分布を、第1の光学素子のフーリエ変換特性を介して受光するように、第2の光経路(94、116)を通して、サンプルから散乱された、散乱サンプルビームの角度散乱分布を受光することであって、第2の光経路の近位端は、散乱サンプルビームを第2の光学素子に送出するように配置され、第3の光学素子は、散乱サンプルビームを平行にし、散乱サンプルビームを検出器に送出するように適合された、受光することと、
ファイバスプリッタから参照ビームを伝達するように適用され、検出器による受信のために均一な照射を生成するように適合された第3の光学素子(84、128)で終端する光ファイバ(14’、14’’)から構成される第3の光経路を通して参照ビームを伝達することであって、参照ビームの光経路は、サンプルビームの結合された第1および第2の光経路からなる光経路の基本モードに一致する、伝達することと、
角度散乱分布を参照ビームと相互相関させ、サンプルについて角度分解、相互相関信号を提供することと、
角度分解、相互相関信号をスペクトル的に分散し、複数の角度の各々に対して、同時に並行して、角度分解、スペクトル分解プロファイルを生成することと、
角度分解、スペクトル分解プロファイルをフーリエ変換し、角度および深さの関数として、サンプルについての深さ分解構造情報を生成することと、
を備える方法。 - 角度分解、スペクトル分解プロファイルから、表面下の散乱体に関する構造情報を復元することをさらに備える、請求項12に記載の方法。
- 角度分解、スペクトル分解プロファイルから、散乱体に関するサイズ情報を復元することをさらに含む、請求項12に記載の方法。
- 散乱体のサイズ情報を復元することは、散乱サンプルビームの角度散乱分布を、サンプルの解析的または数値的に計算された予想角度散乱分布と比較することを備える、請求項14に記載の方法。
- インビボサンプル内の散乱体の構造特性を決定するために、前記サンプルの深さ分解スペクトルを取得するための装置のための光ファイバプローブであって、
前記装置が、光をサンプルビームと参照ビームとに分割するため、光ファイバを通じてファイバスプリッタに偏光を送出するように構成された偏光光源を備えるものにおいて、
光軸を有するレンズと、
サンプルビームを伝達し、サンプルビームの偏光を維持する、先端に偏光制御器が組み込まれた単一モード送出ファイバまたは偏光維持ファイバと、
経路長が一致し、近位端および遠位端を有する複数の光ファイバから構成されるファイバ束受光体であって、遠位端の表面は、レンズから1つの焦点距離にある位置に配置されるとともに、光軸上に中心が合わされている、ファイバ束受光体と、
を備え、
送出ファイバは、サンプルビームが送出ファイバから、送出ファイバの端部に対して横方向にずらされたレンズを介して伝搬し、サンプル上に光軸に対して傾斜した角度で入射するコリメートビームを提供するように、サンプルビームを誘導するため、光軸からずらされたファイバ束の遠位端に取り付けられ、当該ファイバ束の外縁に隣接して配置され、
ファイバ束受光体の遠位端は、複数の光ファイバがレンズのフーリエ変換特性を通じて散乱サンプルビームの角度分布を受け取るように、レンズの他の焦点に配置されたサンプルから散乱サンプルビームを受光するように構成される、光ファイバプローブ。 - ファイバ束受光体の複数の光ファイバは、散乱光を複数の角度において収集し、散乱サンプルビームの角度分布を同時に取得するように構成される、請求項16に記載の光ファイバプローブ。
- ファイバ束受光体の複数の光ファイバは、単一モードまたは複数モードの光ファイバの線形アレイを備える、請求項16に記載の光ファイバプローブ。
- 複数の光ファイバは、散乱サンプルビームの角度分布を伝達することに関して空間干渉性を有するように、ファイバ束受光体の複数の光ファイバの遠位端および近位端において、同一の空間配置を有する、請求項16に記載の光ファイバプローブ。
- レンズは、ドラムレンズまたはボールレンズから構成される、請求項16に記載の光ファイバプローブ。
- レンズは、光軸のまわりを半径方向に回転して、探求される領域の周辺走査を提供するように構成される、請求項16に記載の光ファイバプローブ。
- レンズの前側焦点平面内にサンプルを配置するのに使用される、透明シースをさらに備える、請求項16に記載の光ファイバプローブ。
- 複数のファイバは、光軸に対して30度の範囲に亘って収集される角度散乱を受光するように構成される、請求項16に記載の光ファイバプローブ。
- 参照ビームおよび散乱サンプルビームの角度分布を複数の光ファイバから受光するように構成されるビームスプリッタをさらに備え、ビームスプリッタは、サンプルビームおよび参照ビームを相互相関させて、角度分解された相互相関信号を生成する、請求項16〜23のいずれか一項に記載の光ファイバプローブ。
- 角度分解された相互相関信号をスペクトル的に分散し、複数の散乱角の各々について、同時に並行して、角度分解、スペクトル分解プロファイルを生成する結像分光計をさらに備える、請求項24に記載の光ファイバプローブ。
- 角度分解、スペクトル分解プロファイルを受信し、当該プロファイルをフーリエ変換して、構造特性を判定するために分析される角度分解、深さ分解プロファイルを生成するプロセッサをさらに備える、請求項25に光ファイバプローブ。
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CN101326428A (zh) | 2008-12-17 |
CA2786755C (en) | 2017-06-20 |
AU2006302086A1 (en) | 2007-04-19 |
EP2444783B1 (en) | 2015-03-04 |
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EP2444783A1 (en) | 2012-04-25 |
US7903254B2 (en) | 2011-03-08 |
WO2007044821A1 (en) | 2007-04-19 |
EP1934567A1 (en) | 2008-06-25 |
PT1934567E (pt) | 2013-04-24 |
JP2012198221A (ja) | 2012-10-18 |
AU2006302086B2 (en) | 2011-08-18 |
CA2967964A1 (en) | 2007-04-19 |
CA2626116C (en) | 2012-08-21 |
CA2786755A1 (en) | 2007-04-19 |
PT2444783E (pt) | 2015-06-17 |
JP2009511909A (ja) | 2009-03-19 |
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