JP5483820B2 - Antibacterial composition and deodorant - Google Patents
Antibacterial composition and deodorant Download PDFInfo
- Publication number
- JP5483820B2 JP5483820B2 JP2008023715A JP2008023715A JP5483820B2 JP 5483820 B2 JP5483820 B2 JP 5483820B2 JP 2008023715 A JP2008023715 A JP 2008023715A JP 2008023715 A JP2008023715 A JP 2008023715A JP 5483820 B2 JP5483820 B2 JP 5483820B2
- Authority
- JP
- Japan
- Prior art keywords
- deodorant
- weight
- antibacterial
- triclosan
- odor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002781 deodorant agent Substances 0.000 title claims description 28
- 230000000844 anti-bacterial effect Effects 0.000 title claims description 27
- 239000000203 mixture Substances 0.000 title claims description 23
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 16
- 229960003500 triclosan Drugs 0.000 claims description 16
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 15
- 229960003333 chlorhexidine gluconate Drugs 0.000 claims description 15
- 241000894006 Bacteria Species 0.000 claims description 11
- 230000000694 effects Effects 0.000 description 15
- 235000019645 odor Nutrition 0.000 description 10
- 210000002374 sebum Anatomy 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- -1 chlorohydroxyaluminum Chemical compound 0.000 description 8
- 230000001877 deodorizing effect Effects 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- 210000004243 sweat Anatomy 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 229920001817 Agar Polymers 0.000 description 5
- 239000008272 agar Substances 0.000 description 5
- 230000000845 anti-microbial effect Effects 0.000 description 5
- 239000012895 dilution Substances 0.000 description 5
- 238000010790 dilution Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 230000001166 anti-perspirative effect Effects 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 239000003213 antiperspirant Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000013329 compounding Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000002054 inoculum Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 208000035985 Body Odor Diseases 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 206010040904 Skin odour abnormal Diseases 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 241000191963 Staphylococcus epidermidis Species 0.000 description 2
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 description 2
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000012258 culturing Methods 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000000873 masking effect Effects 0.000 description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000003352 sequestering agent Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 2
- 229940117972 triolein Drugs 0.000 description 2
- 229940031723 1,2-octanediol Drugs 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- HDYRYUINDGQKMC-UHFFFAOYSA-M acetyloxyaluminum;dihydrate Chemical compound O.O.CC(=O)O[Al] HDYRYUINDGQKMC-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- DIZPMCHEQGEION-UHFFFAOYSA-H aluminium sulfate (anhydrous) Chemical compound [Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O DIZPMCHEQGEION-UHFFFAOYSA-H 0.000 description 1
- 229940009827 aluminum acetate Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 229940009662 edetate Drugs 0.000 description 1
- 230000002289 effect on microbe Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910044991 metal oxide Inorganic materials 0.000 description 1
- 150000004706 metal oxides Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 235000019830 sodium polyphosphate Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- ZNVKGUVDRSSWHV-UHFFFAOYSA-L zinc;4-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=C(S([O-])(=O)=O)C=C1.OC1=CC=C(S([O-])(=O)=O)C=C1 ZNVKGUVDRSSWHV-UHFFFAOYSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Description
本発明は抗菌性組成物、並びに該抗菌性組成物を含有したデオドラント剤に関する。 The present invention relates to an antibacterial composition and a deodorant agent containing the antibacterial composition.
人に不快感を与える腋臭などの体臭は、特に、汗が皮脂と混ざり、それが腋臭原因菌により分解されることにより生じるとされている。 It is said that body odor such as odor that gives a person unpleasant feeling is caused by sweat mixed with sebum, which is decomposed by odor-causing bacteria.
そこで、従来から、体臭の発生を抑制するために、抗菌性化合物がデオドラント剤に用いられてきた（例えば、特許文献１〜３を参照）。 Therefore, conventionally, in order to suppress the generation of body odor, antibacterial compounds have been used as deodorant agents (see, for example, Patent Documents 1 to 3).
しかし、人の肌には汗腺や皮脂腺が存在し、その時々で汗と皮脂の量が異なり、汗（水分）が多い状態と皮脂が多い状態とでは、抗菌性化合物の抗菌活性が異なる可能性があった。従来のデオドラント剤では、このような肌状態の変化に対応できず、防臭・消臭効果を十分に発揮できないといった問題があった。さらには、肌状態の変化により、防臭・消臭効果が持続して得られないといった問題もあった。 However, there are sweat glands and sebaceous glands in human skin, and the amount of sweat and sebum varies from time to time. was there. Conventional deodorant agents cannot cope with such changes in skin condition, and there is a problem that the deodorizing and deodorizing effects cannot be fully exhibited. Furthermore, there has been a problem that the deodorizing / deodorizing effect cannot be obtained continuously due to changes in the skin condition.
一方、トリクロサン及びイソプロピルメチルフェノールを併用することにより、汗が多く分泌した肌状態に加え、皮脂が多く分泌した肌状態でも、腋臭原因菌に対する抗菌活性を維持できるデオドラント剤が報告されている（特許文献４を参照）。 On the other hand, by using triclosan and isopropylmethylphenol in combination, a deodorant agent has been reported that can maintain antibacterial activity against odor-causing bacteria even in a skin state that secretes a lot of sebum in addition to a skin state that secretes a lot of sweat (patent) (Ref. 4).
しかし、上記技術では、異なった肌状態でも腋臭原因菌に対する抗菌活性を維持できることに留まり、抗菌性化合物のそれぞれが有する抗菌活性を相乗的に増強できるものではなく、種々の肌状態でもより効果的に防臭・消臭効果を発揮できるデオドラント剤が望まれる。 However, the above-mentioned technique is not limited to synergistically enhancing the antibacterial activity of each antibacterial compound, and can be more effective in various skin conditions. In addition, a deodorant agent that can exhibit a deodorizing and deodorizing effect is desired.
本発明は、上記従来技術に鑑みてなされたものであって、汗や皮脂の量や比率が異なる様々な肌状態でも、グルコン酸クロルヘキシジンと、トリクロサンがそれぞれ有する抗菌活性を相乗的に増強できる抗菌性組成物、並びに該抗菌性組成物を含有するデオドラント剤を提供することを課題とする。 The present invention, said was made in view of the prior art, even with sweat and various skin conditions in which the amount and different proportions of sebum, antibacterial where the chlorhexidine gluconate, triclosan can be synergistically enhanced antibacterial activity having respectively It is an object of the present invention to provide a functional composition and a deodorant containing the antibacterial composition.
すなわち、本発明は、
〔１〕グルコン酸クロルヘキシジンと、トリクロサンとを含有することを特徴とする、抗腋臭原因菌用の抗菌性組成物、並びに
〔２〕前記〔１〕に記載の抗菌性組成物を含有してなるデオドラント剤
に関する。
That is, the present invention
[1] and chlorhexidine gluconate, characterized in that it contains a triclosan, comprising an antimicrobial composition according to the antimicrobial composition for anti armpit odor causing bacteria, and (2) above [1] It relates to a deodorant agent.
本発明にかかる抗菌性組成物は、汗や皮脂の量や比率が異なる様々な肌状態でも、グルコン酸クロルヘキシジンと、トリクロサンのそれぞれが本来有する抗菌活性を相乗的に増強することができるという効果を奏する。 Antimicrobial composition according to the present invention, even with sweat and various skin conditions that amount and different proportions of sebum, and chlorhexidine gluconate, the effect of each of triclosan can be synergistically enhanced antibacterial activity inherent Play.
しかも、腋臭原因菌に対して優れた抗菌活性を発揮することから、抗腋臭原因菌効果を発揮するデオドラント剤として有用である。 In addition, since it exhibits excellent antibacterial activity against odor-causing bacteria, it is useful as a deodorant agent that exhibits anti-odor-causing bacteria effects.
本発明にかかる抗菌性組成物は、必須成分としてグルコン酸クロルヘキシジンと、トリクロサンとを含有する。 Antimicrobial composition according to the present invention contains the chlorhexidine gluconate, and triclosan as an essential component.
グルコン酸クロルヘキシジンは、クロルヘキシジンのグルコン酸塩であり、広範囲の抗菌スペクトルをもつ殺菌剤である。 Chlorhexidine gluconate is a gluconate salt of chlorhexidine and is a fungicide with a broad antibacterial spectrum.
トリクロサンは、トリクロロヒドロキシジフェニルエーテルであり、広範囲の抗菌スペクトルをもつ殺菌剤である。 Triclosan is trichlorohydroxydiphenyl ether and is a fungicide with a broad antibacterial spectrum.
本発明にかかる抗菌性組成物は、第一の成分であるグルコン酸クロルヘキシジンと、第二の成分であるトリクロサンの含有量は特に限定されないが、好ましくは、重量比で０．１：１〜１０：１、より好ましくは０．２：１〜５：１、更に好ましくは０．５：１〜２：１となるように配合する。第一の成分の含有量が第二の成分の１０重量部を超えて配合すると、また、０．１重量部未満の場合、抗菌活性の相乗的な増強効果が期待できないために好ましくない。 In the antibacterial composition according to the present invention, the contents of chlorhexidine gluconate as the first component and triclosan as the second component are not particularly limited, but preferably 0.1: 1 to 10 by weight. : 1, more preferably 0.2: 1 to 5: 1, and still more preferably 0.5: 1 to 2: 1. When the content of the first component exceeds 10 parts by weight of the second component, and less than 0.1 part by weight, a synergistic enhancing effect of antibacterial activity cannot be expected, which is not preferable.
尚、本発明の抗菌性組成物には、第一の成分及び第二の成分の他、本発明の効果を阻害しない範囲で、溶剤、界面活性剤、酸化防止剤、金属イオン封鎖剤等を適宜配合することができる。 In addition to the first component and the second component, the antibacterial composition of the present invention contains a solvent, a surfactant, an antioxidant, a sequestering agent, etc., as long as the effects of the present invention are not impaired. It can mix | blend suitably.
本発明の抗菌性組成物は、デオドラント剤に配合して使用することができる。その配合量は、特に限定されないが、デオドラント剤中０．００１〜３重量％、好ましくは０．０１〜２重量％、より好ましくは０．１〜１重量％とするとよい。配合量が０．００１重量％未満の場合、抗菌効果に劣るために、また、３重量％を超えて配合すると、皮膚刺激性など安全性に問題が生じる場合があるために、いずれの場合も好ましくない。 The antibacterial composition of this invention can be mix | blended and used for a deodorant agent. Although the compounding quantity is not specifically limited, It is good to set it as 0.001 to 3 weight% in a deodorant agent, Preferably it is 0.01 to 2 weight%, More preferably, it is 0.1 to 1 weight%. When the blending amount is less than 0.001% by weight, the antibacterial effect is inferior. When the blending amount exceeds 3% by weight, there may be a problem in safety such as skin irritation. It is not preferable.
本発明では、更に制汗成分を含有することができる。本発明で用いられる制汗成分は、皮膚を収斂することにより汗の発生を抑制する薬剤であり、例えば、塩化アルミニウム、硫酸アルミニウムカリウム、硫酸アルミニウム、酢酸アルミニウム、クロロヒドロキシアルミニウム、アラントインクロロヒドロキシアルミニウム、パラフェノールスルホン酸亜鉛などを例示することができる。 In the present invention, an antiperspirant component can be further contained. The antiperspirant component used in the present invention is a drug that suppresses the generation of sweat by converging the skin, such as aluminum chloride, potassium aluminum sulfate, aluminum sulfate, aluminum acetate, chlorohydroxyaluminum, allantoin chlorohydroxyaluminum, Examples thereof include zinc paraphenol sulfonate.
制汗成分の配合量は、本発明の効果を発揮すれば特に限定されず、デオドラント剤中０．１〜２０重量％とするとよく、０．３〜１５重量％とすることがより好ましい。０．１重量％未満の配合量では、防臭・デオドラント効果の持続性の効果に劣るために、また、２０重量％を超えて配合すると、皮膚刺激性など安全性に問題が生じる場合があるために、いずれの場合も好ましくない。 The blending amount of the antiperspirant component is not particularly limited as long as the effect of the present invention is exerted, and is preferably 0.1 to 20% by weight in the deodorant agent, and more preferably 0.3 to 15% by weight. If the blending amount is less than 0.1% by weight, the effect of sustaining deodorant / deodorant effect is inferior. If the blending amount exceeds 20% by weight, safety problems such as skin irritation may occur. In either case, it is not preferable.
本発明にかかるデオドラント剤には、本発明の効果を損なわない範囲であれば、上記した成分の他に、消臭成分を配合することができる。消臭成分とは、臭いを発する物質と反応・吸着したり、臭いをマスクしたりして、臭いを消す効果を有する薬剤であり、例えば、酸化亜鉛などの金属酸化物、アルキルジエタノールアミド、ヒドロキシアパタイト、茶抽出物、香料、酸化防止剤などを例示することができる。 In the deodorant according to the present invention, a deodorizing component can be blended in addition to the above-described components as long as the effects of the present invention are not impaired. A deodorant component is a chemical that has the effect of eliminating odors by reacting and adsorbing substances that emit odors or masking odors. For example, metal oxides such as zinc oxide, alkyldiethanolamide, hydroxy Examples include apatite, tea extract, fragrance, and antioxidant.
消臭成分の配合量は、本発明の効果を発揮すれば特に限定されず、デオドラント剤中０．０１〜５重量％とするとよく、０．１〜２重量％とすることがより好ましい。０．０１重量％未満の配合量では、臭いのマスキングの効果に劣るために、また、５重量％を超えて配合すると、香りが強くなりすぎたり、肌への着色が生ずる場合があり、また、皮膚刺激性など安全性に問題が生じる場合があるために、いずれの場合も好ましくない。 The blending amount of the deodorant component is not particularly limited as long as the effect of the present invention is exhibited, and may be 0.01 to 5% by weight in the deodorant agent, and more preferably 0.1 to 2% by weight. If the blending amount is less than 0.01% by weight, the effect of masking the odor is inferior. If the blending amount exceeds 5% by weight, the scent may become too strong or the skin may be colored. In any case, it is not preferable because safety problems such as skin irritation may occur.
本発明のデオドラント剤には、本発明の効果を阻害しない範囲で、上記した成分の他、エタノール、イソプロピルアルコール等の低級アルコール；ラウリルアルコール、ステアリルアルコール等の高級アルコール；グリセリン、ジグリセリン、ジプロピレングリコール、１，３−ブタンジオール、１，２−ペンタンジオール、１，２−オクタンジオール等の多価アルコール；ベントナイト、カラギーナン、カルボキシビニルポリマー、ヒドロキシエチルセルロース等の増粘剤；トコフェロール及びその誘導体、アスコルビン酸及びその誘導体等の酸化防止剤；エデト酸塩、リン酸、ポリリン酸ナトリウム等の金属イオン封鎖剤；動物及び植物エキス、クエン酸、酒石酸等のｐＨ調整剤；シリコーン類、保湿剤、界面活性剤、防腐剤、粉体、着色剤、水等を適宜配合することもできる。 The deodorant of the present invention includes, within the range not inhibiting the effects of the present invention, lower alcohols such as ethanol and isopropyl alcohol; higher alcohols such as lauryl alcohol and stearyl alcohol; glycerin, diglycerin, dipropylene Polyhydric alcohols such as glycol, 1,3-butanediol, 1,2-pentanediol, 1,2-octanediol; thickeners such as bentonite, carrageenan, carboxyvinyl polymer, hydroxyethylcellulose; tocopherol and its derivatives, ascorbine Antioxidants such as acids and derivatives thereof; sequestering agents such as edetate, phosphoric acid and sodium polyphosphate; pH adjusters such as animal and plant extracts, citric acid and tartaric acid; silicones, moisturizers, surface activity Agent, preservative, powder, wear Agents may be appropriately blended water.
本発明のデオドラント剤は、ローション、エアゾール、スティック、パウダー、ロールオン、クリーム、ジェル、乳液、シート剤などの種々の形態に用いることができ、製剤化については、一般に知られている方法により製造すればよい。 The deodorant agent of the present invention can be used in various forms such as lotion, aerosol, stick, powder, roll-on, cream, gel, emulsion, sheet, etc. That's fine.
＜試験例１＞
供試菌として、腋臭の原因菌であるスタフィロコッカス エピデルミディス（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ｅｐｉｄｅｒｍｉｄｉｓ ＩＡＭ１２９６）を用いた。
<Test Example 1>
As a test bacterium, Staphylococcus epidermidis IAM1296, which is a causative bacterium of odor, was used.
（接種菌液の調製）
接種用菌液としてスタフィロコッカス エピデルミディスを寒天培地で３５℃で培養後、更にブイヨン培地に移植して３５℃で培養した。得られた培養液をブイヨン培地で約１０７個／ｍＬに希釈したものを接種用菌液とした。
(Preparation of inoculum solution)
Staphylococcus epidermidis was cultured at 35 ° C. on an agar medium as an inoculum, and further transplanted to a bouillon medium and cultured at 35 ° C. A solution obtained by diluting the obtained culture solution with a bouillon medium to about 10 7 cells / mL was used as a bacterial solution for inoculation.
（希釈系列の調製）
グルコン酸クロルヘキシジン（比較例１）及びトリクロサン（比較例２）は、７０％エタノールを希釈溶媒として１５００μｇ／ｍＬに調製し、１０段階に倍倍希釈して希釈系列を調製した。
(Preparation of dilution series)
Chlorhexidine gluconate (Comparative Example 1) and triclosan (Comparative Example 2) were prepared to 1500 μg / mL using 70% ethanol as a diluent solvent, and diluted 10-fold to prepare a dilution series.
また、グルコン酸クロルヘキシジンとトリクロサンの等量混合物（実施例１）についても、同様に希釈系列を調製した。 Moreover, even with the equal mixture of chlorhexidine gluconate and triclosan (Example 1), a dilution series was prepared in the same manner.
（最小殺菌濃度（ＭＢＣ）の測定）
上記実施例１及び比較例１〜２の各被験物質を含む希釈系列１ｍＬに対して各寒天培地９ｍＬをシャーレに入れ、それぞれについて、上記接種用菌液を約１ｃｍの長さに画線した。培養は、３５℃で行い５日後の菌の生育の有無を判定した。このとき、生育が認められなかった濃度では、接種した画線から菌を採取し、新鮮寒天培地に移植し更に３日培養した。このとき、生育が認められなかった最小の濃度をＭＢＣとして求め、そのときの各成分の濃度を表１（トリオレイン非添加）に記した。
(Measurement of minimum bactericidal concentration (MBC))
9 mL of each agar medium was placed in a petri dish with respect to 1 mL of dilution series containing each test substance of Example 1 and Comparative Examples 1 and 2, and the above inoculum was streaked to a length of about 1 cm. Culturing was performed at 35 ° C., and the presence or absence of bacterial growth after 5 days was determined. At a concentration at which no growth was observed at this time, the bacteria were collected from the inoculated streak, transplanted to a fresh agar medium, and further cultured for 3 days. In this case, determining the minimum concentration of growth was observed as MBC, describing the concentration of each component at that time in table 1 (G Li oleic not added).
（皮脂成分の影響の検討）
皮脂成分の影響による殺菌効果を検討するために、皮脂成分としてトリオレインを添加して下記試験を実施した。即ち、上記各被験物質を含む希釈系列１ｍＬに対して、０．１重量％のトリオレインと寒天培地８．９ｍＬをシャーレに入れ、それぞれについて、上記と同様に接種用菌液を約１ｃｍの長さに画線した。培養は、３５℃で行い５日後の菌の生育の有無を判定した。このとき、生育が認められなかった濃度では、接種した画線から菌を採取し、新鮮寒天培地に移植しさらに３日培養した。このとき、生育が認められなかった最小の濃度をＭＢＣとして求め、そのときの各成分の濃度を表１（トリオレイン添加）に記した。
(Examination of the effects of sebum components)
In order to study the bactericidal effect due to the effect of sebum components, it was performed following tests by adding Application Benefits oleic as sebum components. That is, for each 1 mL of the dilution series containing each test substance, 0.1% by weight of triolein and 8.9 mL of agar medium were placed in a petri dish. I streaked. Culturing was performed at 35 ° C., and the presence or absence of bacterial growth after 5 days was determined. At a concentration at which no growth was observed at this time, the bacteria were collected from the inoculated streak, transplanted to a fresh agar medium, and further cultured for 3 days. At this time, it seeks growth minimal concentrations were observed as the MBC, the concentration of each component at that time noted in Table 1 (g Li oleic added).
尚、ＭＢＣによって、抗菌力を評価することができる。被験物質の濃度が薄いときには微生物への影響はないが、濃度を増していくと発育抑制が起こり、続いて発育は停止する。更に濃度が増すと、微生物は死滅していくことになる。このときの濃度がＭＢＣとして表される。 The antibacterial activity can be evaluated by MBC. When the test substance concentration is low, there is no effect on microorganisms, but as the concentration is increased, growth inhibition occurs, and then growth stops. As the concentration increases further, the microorganisms will die. The density at this time is expressed as MBC.
表１の結果から、グルコン酸クロルヘキシジン単独（比較例１）又はトリクロサン単独（比較例２）では皮脂成分であるトリオレインの存在により、ＭＢＣが高くなり、特にトリクロサン単独ではＭＢＣが１２μｇ／ｍＬから７５０μｇ／ｍＬにまで上昇し、殺菌力が著しく低下することが分かる。これに対して、グルコン酸クロルヘキシジンとトリクロサンとを併用（実施例１）すると、トリオレイン存在下及び非存在下共に、ＭＢＣが著しく低い値となり、両者の抗菌活性が相乗的に著しく増強されることが分かる。
From the results shown in Table 1, MBC increases with chlorhexidine gluconate alone (Comparative Example 1) or triclosan alone (Comparative Example 2) due to the presence of triolein, which is a sebum component. It can be seen that the sterilizing power is significantly reduced. In contrast, a combination of chlorhexidine gluconate and triclosan (Example 1), the Application Benefits oleic presence and absence together, MBC is remarkably low, both antimicrobial activity is enhanced synergistically significantly I understand that.
以上、表１の結果から、本発明の抗菌性用組成物は、汗が多い肌状態でも、皮脂が多い肌状態でも、グルコン酸クロルヘキシジンと、トリクロサンのそれぞれが本来有する抗菌効果を相乗的に増強し、様々な肌状態で腋臭原因菌に対して優れた相乗的な抗菌効果を発揮できることが分かる。 As described above, from the results of Table 1 , the antibacterial composition of the present invention synergistically enhances the antibacterial effect inherent in each of chlorhexidine gluconate and triclosan, even in a skin state with a lot of sweat and a skin with a lot of sebum. In addition, it can be seen that an excellent synergistic antibacterial effect can be exerted against the odor-causing bacteria in various skin conditions.
＜試験例２＞
（試料の調製）
表２に記した組成に従い、実施例２および比較例３〜４の各デオドラント剤を常法により調製し、下記評価に供した。尚、表中の配合量は重量％を表す。
<Test Example 2>
(Sample preparation)
According to the composition described in Table 2 , each deodorant agent of Example 2 and Comparative Examples 3 to 4 was prepared by a conventional method and subjected to the following evaluation. In addition, the compounding quantity in a table | surface represents weight%.
（試験例：デオドラント剤の評価）
腋臭が強いと判定された男子被験者１０名に、各試料を被験者の一方の腋下に塗布し、もう一方の腋下は比較対照として塗布しなかった。塗布前とその直後及び３時間後のそれぞれについて下記評価基準に従って臭いの判定をし、その平均値を採用した。結果を表２に示す。
(Test example: Evaluation of deodorant)
For 10 male subjects determined to have a strong odor, each sample was applied to one armpit of the subject, and the other armpit was not applied as a control. The odor was determined according to the following evaluation criteria before and immediately after application and after 3 hours, and the average value was adopted. The results are shown in Table 2 .
＜評価基準＞
臭わない・・・・・・・・０点
かすかに臭う・・・・・・１点
やや臭うが弱い・・・・・２点
はっきりと臭う・・・・・３点
非常に強く臭う・・・・・４点
<Evaluation criteria>
No odor ... 0 point Slightly smell ... 1 point Slightly weak smell ... 2 points Clear smell ... 3 points Very strong smell ... ... 4 points
表２の結果から、本発明のデオドラント剤は優れた防臭効果を有するとともに、その効果も長時間持続することが分かる。 From the results in Table 2 , it can be seen that the deodorant agent of the present invention has an excellent deodorizing effect and the effect also lasts for a long time.
以下、本発明にかかるデオドラント剤の処方例を示す。尚、配合量は重量％である。 Hereinafter, the formulation example of the deodorant agent concerning this invention is shown. In addition, a compounding quantity is weight%.
（処方例１：デオドラントスティック）
ステアリルアルコール ２５．０
ポリエチレングリコール １０．０
クロロヒドロキシアルミニウム ２０．０
環状ジメチルポリシロキサン ４４．６
トリクロサン ０．１５
グルコン酸クロルヘキシジン液 ０．１５
香料 ０．１
合 計 １００．０
(Formulation Example 1 : Deodorant Stick)
Stearyl alcohol 25.0
Polyethylene glycol 10.0
Chlorohydroxyaluminum 20.0
Cyclic dimethylpolysiloxane 44.6
Triclosan 0.15
Chlorhexidine gluconate solution 0.15
Fragrance 0.1
Total 100.0
（処方例２：ロールオンデオドラント）
エタノール ３０．０
ポリオキシエチレン硬化ヒマシ油（40E.O.） １．０
クロロヒドロキシアルミニウム １０．０
ヒドロキシプロピルメチルセルロース ０．５
トリクロサン ０．１
グルコン酸クロルヘキシジン液 ０．１
香料 適量
精製水 残分
合 計 １００．０
(Formulation example 2 : Roll-on deodorant)
Ethanol 30.0
Polyoxyethylene hydrogenated castor oil (40E.O.) 1.0
Chlorohydroxyaluminum 10.0
Hydroxypropyl methylcellulose 0.5
Triclosan 0.1
Chlorhexidine gluconate solution 0.1
Perfume
Purified water residue Total 100.0
（処方例３：デオドラントジェル）
エタノール ６０．０
カルボキシビニルポリマー ０．４
環状シリコーン １．０
ポリエーテル変性シリコーン ０．５
グルコン酸クロルヘキシジン液 ０．１
トリクロサン ０．２
トリエタノールアミン ０．４
シリコーンパウダー １．０
香料 適量
精製水 残分
合計 １００．０
(Prescription Example 3 : Deodorant Gel)
Ethanol 60.0
Carboxyvinyl polymer 0.4
Cyclic silicone 1.0
Polyether-modified silicone 0.5
Chlorhexidine gluconate solution 0.1
Triclosan 0.2
Triethanolamine 0.4
Silicone powder 1.0
Perfume
Purified water Total remaining 100.0
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008023715A JP5483820B2 (en) | 2007-11-29 | 2008-02-04 | Antibacterial composition and deodorant |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007308365 | 2007-11-29 | ||
| JP2007308365 | 2007-11-29 | ||
| JP2008023715A JP5483820B2 (en) | 2007-11-29 | 2008-02-04 | Antibacterial composition and deodorant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008111000A JP2008111000A (en) | 2008-05-15 |
| JP5483820B2 true JP5483820B2 (en) | 2014-05-07 |
Family
ID=39443710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008023715A Expired - Fee Related JP5483820B2 (en) | 2007-11-29 | 2008-02-04 | Antibacterial composition and deodorant |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5483820B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201513357A2 (en) * | 2015-10-26 | 2017-05-22 | Univ Yeditepe | SURFACE COATING MATERIAL WITH ANTIMICROBIAL FEATURES |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6503952B2 (en) * | 1995-11-13 | 2003-01-07 | The Trustees Of Columbia University In The City Of New York | Triple antimicrobial composition |
| US6147120A (en) * | 1999-02-16 | 2000-11-14 | Ecolab Inc. | Synergistic antimicrobial skin washing compositions |
| US6187327B1 (en) * | 1999-05-19 | 2001-02-13 | Kevin Stack | Antimicrobial sanitizing lotion with skin protection properties |
| JP2004203782A (en) * | 2002-12-25 | 2004-07-22 | Kanebo Ltd | Deodorant antiperspirant external preparation |
| JP4669683B2 (en) * | 2004-09-09 | 2011-04-13 | 高砂香料工業株式会社 | Antibacterial composition |
| JP2006096719A (en) * | 2004-09-30 | 2006-04-13 | Mandom Corp | Deodorizing composition and deodorant preparation |
| CA2637175C (en) * | 2006-01-20 | 2015-07-14 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing inflammation and hypersensitivity with oxidative reductive potential water solution |
-
2008
- 2008-02-04 JP JP2008023715A patent/JP5483820B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008111000A (en) | 2008-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2008110999A (en) | Antibacterial composition and deodorant agent | |
| JP2011513267A (en) | Combinations of active ingredients and their use | |
| JP2007145771A (en) | Antibacterial agent composition and deodorant agent | |
| KR20110139527A (en) | Self-preserving skin care formulation | |
| JP2011074082A (en) | Antiseptic sterilizer and composition for application to human body | |
| JP6474963B2 (en) | Cleaning composition | |
| JP3908244B2 (en) | Male deodorant deodorant | |
| JP2007145750A (en) | Antibacterial agent to osmidrosis bacterium, and osmidrosis-preventing agent and external preparation for skin, containing the antibacterial agent | |
| KR101914500B1 (en) | Cosmetic composition for inhibiting body odor | |
| JP5522819B2 (en) | Antibacterial composition and external preparation for skin | |
| JP4743704B2 (en) | Antibacterial agent for bad odor bacteria, anti-odor agent and external preparation for skin containing the antibacterial agent | |
| JP3886890B2 (en) | Odor prevention cosmetics | |
| JP2003081801A (en) | Deodorant cosmetic | |
| JP5025535B2 (en) | Antibacterial agent composition and deodorant composition | |
| JP5483820B2 (en) | Antibacterial composition and deodorant | |
| JP4381231B2 (en) | Body odor deodorant cosmetic | |
| JP4734293B2 (en) | Antiseptic disinfectant and human body composition | |
| WO2012131363A2 (en) | Deodorant formulations | |
| JP2019081763A (en) | Cleaning composition | |
| JP5393962B2 (en) | Antibacterial agent for odor-causing bacteria and anti-odor agent containing the antibacterial agent | |
| JP5275637B2 (en) | Topical skin preparation | |
| JP2019210250A (en) | Preservative composition containing isopentyldiol | |
| JP5189402B2 (en) | Antibacterial agent composition and deodorant composition | |
| JP2006096719A (en) | Deodorizing composition and deodorant preparation | |
| JP2010116376A (en) | Cosmetic |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080215 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20100518 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100615 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100804 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100809 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100903 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110329 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110527 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120110 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120405 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20120412 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20120615 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140218 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5483820 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |