JP5455924B2 - 速読ゲートアンペロメトリ - Google Patents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3273—Devices therefor, e.g. test element readers, circuitry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
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- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Description
本出願は、2007年12月10日出願の米国仮出願番号第61/012,729号、発明の名称“Rapid−read Gated Amperometry”の利益を主張し、参照により本明細書に組み入れられる。
Claims (35)
- 試料中の分析対象物の濃度を判定する方法であって、
10秒以内に少なくとも3つのデューティサイクルを含む入力信号であって、デューティサイクルのそれぞれが励起パルス及び緩和を含む、入力信号を試料に与えることと、
少なくとも1つのデューティサイクルの励起パルスの付与開始後のパルス幅の3/4以内に、測定可能種に反応する出力信号を測定することと、
測定された出力信号に応じて、試料中の分析対象物の濃度を判定することと、
を含む方法。 - 入力信号が、7秒以内に少なくとも4つの所定電圧レベルのデューティサイクルを含む、請求項1記載の方法。
- 0.1〜2秒の励起のパルス幅を含む、請求項1又は2記載の方法。
- 0.3〜0.8秒の励起のパルス幅を含む、請求項1又は2記載の方法。
- 少なくとも1つのデューティサイクルのパルス間隔が、3秒未満である、請求項1〜4のいずれか一項記載の方法。
- 励起のパルス幅が0.3〜0.5秒であり、パルス間隔が0.7〜2秒である、請求項1又は2記載の方法。
- 出力信号が、デューティサイクルのうち1つの励起パルスの付与の175ミリ秒未満以内に測定される、請求項1〜6のいずれか一項記載の方法。
- 出力信号が、デューティサイクルのうち1つの励起パルスの付与の60〜150ミリ秒以内に測定される、請求項1〜6のいずれか一項記載の方法。
- 出力信号が測定されるデューティサイクルが、試料への初期励起パルスの付与の11秒以下以内に適用される、請求項1〜8のいずれか一項記載の方法。
- 出力信号が測定されるデューティサイクルが、試料への初期励起パルスの付与の7秒以下以内に適用される、請求項1〜9のいずれか一項記載の方法。
- センサ片に試料を導入すること、及び、試料中の分析対象物からセンサ片内のメディエータに少なくとも1つの電子を移動することをさらに含み、入力信号が、測定可能種を電気化学的に励起し、測定可能種が、分析対象物、メディエータ及びそれらの組み合わせから構成される群から選択される、請求項1〜10のいずれか一項記載の方法。
- 励起が、実質的に一定の電圧を有する、請求項1〜11のいずれか一項記載の方法。
- 入力信号が、矩形波の励起を含む、請求項1〜12のいずれか一項記載の方法。
- 入力信号の付与中に、時間の関数として少なくとも1つの電流を記録することをさらに含む、請求項1〜13のいずれか一項記載の方法。
- 判定が、出力信号の少なくとも1つの電流に、少なくとも1つのデータ処理を施すことを含む、請求項1〜14のいずれか一項記載の方法。
- 作用電極に含まれて多孔質空間を提供する拡散障壁層の内側に測定可能種を励起させることと、
拡散障壁層の外に測定可能種を実質的に励起から除外することと、
をさらに含む、請求項1〜15のいずれか一項記載の方法。 - 緩和が開回路に対応する、請求項1〜16のいずれか一項記載の方法。
- 緩和が少なくとも0.5秒である、請求項1〜17のいずれか一項記載の方法。
- 出力信号が過渡的な減衰を含み、分析対象物濃度が過渡的な減衰から判定される、請求項1〜18のいずれか一項記載の方法。
- 試料が、生体液、生体液の派生物、及びそれらの組み合わせからなる群から選択される、請求項1〜19のいずれか一項記載の方法。
- 測定が、ハンディタイプの携帯型測定装置によって行われる、請求項1〜20のいずれか一項記載の方法。
- 試料中の分析対象物の濃度を判定するためのハンディ型測定装置であって、
装置がセンサ片を受けるように適合され、
装置が、
接点と、
少なくとも1つのディスプレイと、
接点とディスプレイとの間の電気的通信を確立する電気回路とを含み、
電気回路が、電気チャージャと、電気的に通信するプロセッサとを含み、コンピュータ可読ソフトウェアコードを含む記憶媒体と電気的に通信するプロセッサが、コンピュータ可読ソフトウェアコードがプロセッサによって実行されたときに、チャージャに10秒以内に少なくとも3つのデューティサイクルを含む入力信号を接点間で実施させ、デューティサイクルのそれぞれが励起及び緩和を含み、
プロセッサが、チャージャの励起付与開始後のパルス幅の3/4以内に少なくとも2つの接点で、少なくとも1つの電流値を測定するように動作可能であり、
プロセッサが、少なくとも1つの電流値に応じて、生体液中の分析対象物濃度を判定するように動作可能である、装置。 - 装置がハンディタイプの携帯型である、請求項22記載の装置。
- チャージャが、実質的に一定の電圧で励起を実施するように動作可能である、請求項22又は23記載の装置。
- プロセッサが、減衰の過渡的な部分の間に、少なくとも1つの電流値を測定するように動作可能である、請求項22〜24のいずれか一項記載の装置。
- 試料が、生体液、生体液の派生物、及びそれらの組み合わせからなる群から選択される、請求項22〜25のいずれか一項記載の装置。
- 試料中の分析対象物濃度を判定するためのバイオセンサシステムであって、
細片によって形成されたレザバに近接した試料インターフェイスを有するセンサ片と、
センサインターフェイスに接続されるプロセッサを有する測定装置であって、センサインターフェイスが試料インターフェイスとの電気的通信を有し、プロセッサが記憶媒体との電気的通信を有する、測定装置とを含み、
プロセッサが、試料インターフェイスへの励起パルスの付与開始後のパルス幅の3/4以内に、センサインターフェイスからの試料中の分析対象物濃度に応じて、出力信号値を判定し、
励起パルスが、10秒以内の少なくとも3つのデューティサイクルを含む入力信号の一部であり、デューティサイクルのそれぞれが励起及び緩和を含む、システム。 - 測定装置がハンディタイプの携帯型である、請求項27記載のシステム。
- 励起パルスが、実質的に一定の電圧を有する、請求項27又は28記載のシステム。
- 試料中の分析対象物の濃度に応じた出力信号値が、減衰の過渡的な部分の間に測定される、請求項27〜29のいずれか一項記載のシステム。
- 試料が、生体液、生体液の派生物、及びそれらの組み合わせからなる群から選択される、請求項27〜30のいずれか一項記載のシステム。
- 試料中の分析対象物の濃度の判定におけるバイアスを低減させる方法であって、
試料に入力信号を与えることであって、入力信号が10秒以内に少なくとも3つのデューティサイクルを含み、デューティサイクルのそれぞれが励起パルス及び緩和を含む、ことと、
少なくとも1つのデューティサイクルの励起パルスの付与開始後のパルス幅の3/4以内に、測定可能種に応じた出力信号を測定することと、
測定された出力信号に応じて、試料中の分析対象物の濃度を判定することと、
を含む方法。 - バイアスの少なくとも一部が、ヘマトクリット効果に起因する、請求項32記載の方法。
- 試料が、生体液、生体液の派生物、及びそれらの組み合わせからなる群から選択される、請求項32又は33記載の方法。
- 出力信号が過渡的な減衰を含み、分析対象物濃度が過渡的な減衰から判定される、請求項32〜34のいずれか一項記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1272907P | 2007-12-10 | 2007-12-10 | |
US61/012,729 | 2007-12-10 | ||
PCT/US2008/080865 WO2009075951A1 (en) | 2007-12-10 | 2008-10-23 | Rapid-read gated amperometry |
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JP2011506964A JP2011506964A (ja) | 2011-03-03 |
JP2011506964A5 JP2011506964A5 (ja) | 2011-11-24 |
JP5455924B2 true JP5455924B2 (ja) | 2014-03-26 |
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US (5) | US8147674B2 (ja) |
EP (3) | EP3395954B1 (ja) |
JP (1) | JP5455924B2 (ja) |
CN (2) | CN101896619B (ja) |
BR (1) | BRPI0820718A2 (ja) |
CA (1) | CA2707300C (ja) |
MX (1) | MX2010006393A (ja) |
RU (1) | RU2491549C2 (ja) |
TW (1) | TWI468679B (ja) |
WO (1) | WO2009075951A1 (ja) |
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AU2005212396A1 (en) | 2004-02-06 | 2005-08-25 | Bayer Healthcare Llc | Oxidizable species as an internal reference for biosensors and method of use |
JP5385607B2 (ja) * | 2005-07-20 | 2014-01-08 | バイエル・ヘルスケア・エルエルシー | ゲート化電流測定器 |
WO2008036516A1 (en) | 2006-09-22 | 2008-03-27 | Bayer Healthcare Llc | Biosensor system having enhanced stability and hematocrit performance |
WO2009076302A1 (en) | 2007-12-10 | 2009-06-18 | Bayer Healthcare Llc | Control markers for auto-detection of control solution and methods of use |
EP3395954B1 (en) * | 2007-12-10 | 2020-07-01 | Ascensia Diabetes Care Holdings AG | Rapid-read gated amperometry |
RU2546862C2 (ru) | 2008-12-08 | 2015-04-10 | БАЙЕР ХЕЛТКЭА ЭлЭлСи | Биосенсорная система и тестовые сенсоры для определения концентрации анализируемого вещества (варианты) |
US9233788B2 (en) | 2010-01-22 | 2016-01-12 | Bayer Healthcare Llc | Biosensor desiccant system having enhanced measurement performance |
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CN101896619A (zh) | 2010-11-24 |
CA2707300A1 (en) | 2009-06-18 |
US10345255B2 (en) | 2019-07-09 |
EP3395954A1 (en) | 2018-10-31 |
US10908112B2 (en) | 2021-02-02 |
RU2010128649A (ru) | 2012-01-20 |
MX2010006393A (es) | 2010-06-25 |
US20190331630A1 (en) | 2019-10-31 |
EP3690058A1 (en) | 2020-08-05 |
CN101896619B (zh) | 2017-04-05 |
EP3395954B1 (en) | 2020-07-01 |
EP2222867B1 (en) | 2018-07-11 |
US20090145779A1 (en) | 2009-06-11 |
TWI468679B (zh) | 2015-01-11 |
US8147674B2 (en) | 2012-04-03 |
EP3690058B1 (en) | 2021-12-29 |
RU2491549C2 (ru) | 2013-08-27 |
BRPI0820718A2 (pt) | 2015-06-16 |
US20120211361A1 (en) | 2012-08-23 |
CA2707300C (en) | 2017-09-26 |
CN107091870A (zh) | 2017-08-25 |
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