JP5429855B2 - container - Google Patents

container Download PDF

Info

Publication number
JP5429855B2
JP5429855B2 JP2009066759A JP2009066759A JP5429855B2 JP 5429855 B2 JP5429855 B2 JP 5429855B2 JP 2009066759 A JP2009066759 A JP 2009066759A JP 2009066759 A JP2009066759 A JP 2009066759A JP 5429855 B2 JP5429855 B2 JP 5429855B2
Authority
JP
Japan
Prior art keywords
container
sample
outer cylinder
container body
sample holding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009066759A
Other languages
Japanese (ja)
Other versions
JP2010213660A (en
Inventor
実 上田
陽一 山田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nagoya University NUC
Tokai National Higher Education and Research System NUC
Original Assignee
Nagoya University NUC
Tokai National Higher Education and Research System NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nagoya University NUC, Tokai National Higher Education and Research System NUC filed Critical Nagoya University NUC
Priority to JP2009066759A priority Critical patent/JP5429855B2/en
Publication of JP2010213660A publication Critical patent/JP2010213660A/en
Application granted granted Critical
Publication of JP5429855B2 publication Critical patent/JP5429855B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Landscapes

  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Description

本発明は、容器に関し、特に生体試料を保存するのに適した容器に関する。   The present invention relates to a container, and more particularly to a container suitable for storing a biological sample.

近年、再生医療や細胞含有医薬、その他病理検査、遺伝子治療、臓器移植および自家移植など、生体試料を用いた医療分野において、容器に対する要望が高まっている。   In recent years, there has been a growing demand for containers in the medical field using biological samples such as regenerative medicine, cell-containing drugs, other pathological examinations, gene therapy, organ transplantation, and autotransplantation.

すなわち、これらの医療分野においては、生体試料に悪影響を与えることなく保存・輸送等することが非常に重要であり、そのような保存性に優れ、輸送する際に生体試料に悪影響を与えることのない容器が求められている。   That is, in these medical fields, it is very important to store and transport the biological sample without adversely affecting the biological sample. It is excellent in such preservation and has an adverse effect on the biological sample during transportation. There is no need for a container.

例えば、生体試料を保存するための容器として、雑菌やウイルスなどが容器内部に侵入することがなく、生物試料の注入や保存、解凍に適した凍結保存容器や（特許文献１）、生化学試験の際の液体・試薬・検体等の混合、希釈、攪拌、遠心分離、保存に用いる生化学試験容器（特許文献２）等が開発されている。   For example, as a container for storing a biological sample, a freezing container or a biochemical test suitable for injection, storage, and thawing of a biological sample without invasion of germs or viruses into the container (Patent Document 1) A biochemical test container (Patent Document 2) used for mixing, diluting, stirring, centrifuging, and storing liquids, reagents, specimens, and the like during development has been developed.

しかし、前記特許文献１や２に開示されている容器は、生体試料の密閉性等の保存性や、開封時に中の試料の飛散を防ぐためのキャップの開封操作性等については検討されているものの、保存した試料を容器と共に輸送する場合の安全性については考慮していない。すなわち、輸送する際、これらの容器内で生体試料が移動して衝撃を受けるなどのより悪影響を受けてしまう可能性がある。   However, the containers disclosed in Patent Documents 1 and 2 have been studied for preservability such as hermeticity of a biological sample, opening operability of a cap for preventing scattering of a sample during opening, and the like. However, the safety of transporting stored samples with containers is not considered. That is, when transporting, there is a possibility that the biological sample may be affected more adversely, such as being moved in these containers and receiving an impact.

特開２００７−３０２５６７号公報JP 2007-302567 A 特開２００７−２３２３９９号公報JP 2007-232399 A

以上に述べたように、従来の生体試料保存用の容器は、生体試料を輸送する場合の安全性については考慮しておらず、そのための構造を有していないため、何らかの別の方法で輸送時の安全性を確保する必要がある。   As described above, conventional biological sample storage containers do not consider safety when transporting biological samples and do not have a structure for that purpose, so they are transported by some other method. It is necessary to ensure the safety of time.

この発明は、このような課題に鑑みてなされたもので、収容した試料を安全に輸送することができる容器を提供することにある。   This invention is made | formed in view of such a subject, and is providing the container which can transport the accommodated sample safely.

上記課題を解決するため、本発明によれば、
容器本体と、
この容器本体を閉塞するように設けられているとともに上記容器本体の内部に投入する試料を保持するキャップとを有する容器であって、
前記キャップは、
一端開口と他端開口とを有し、一端開口を前記容器本体の内部と連通させた状態でこの容器本体に着脱自在に連結される外筒部材と、
内部に前記試料を保持すると共に、前記外筒部材内にその軸線方向に沿って移動自在に設けられ、前記外筒部材の一端開口から前記容器本体側に突出しない状態では前記容器本体の内部に連通せず、前記容器本体側に突出した状態では前記容器本体の内部に連通して前記試料を投入する試料投入通路を有する試料保持部材と、
前記試料保持部材を保持すると共に前記外筒部材若しくは上記容器本体に螺進自在に取り付けられ、前記試料保持部材を前記外筒部材の軸線方向に沿って駆動する栓部材と、
を有することを特徴とする容器が提供される。 In order to solve the above problems, according to the present invention,
A container body;
A container having a cap for holding a sample to be put into the container body and being provided to close the container body,
The cap is
An outer cylinder member that has one end opening and the other end opening, and is detachably connected to the container body in a state where the one end opening communicates with the inside of the container body;
The sample is held inside, and is provided in the outer cylinder member so as to be movable along the axial direction thereof. In a state where the sample does not protrude from the one end opening of the outer cylinder member toward the container body, A sample holding member having a sample introduction passage for introducing the sample in communication with the inside of the container main body in a state where it is not communicated and protrudes toward the container main body;
A stopper member that holds the sample holding member and is screwably attached to the outer cylinder member or the container body, and drives the sample holding member along the axial direction of the outer cylinder member;
A container characterized by having:

このような構成によれば、たとえば容器本体内に生体試料を投入して、前記キャップを上記容器本体に取り付け、上記栓部材を容器本体側に駆動することで、試料保持部材の上記試料通路を容器本体に連通させる。このことで、試料保持部材に保持されている試料を容器本体内に投入することができ、この試料として容器本体に投入された生体試料の周囲を凝固させるようなものを収納しておけば、この生体試料をこの容器本体内で固定することができる。   According to such a configuration, for example, a biological sample is put into a container body, the cap is attached to the container body, and the plug member is driven to the container body side, whereby the sample passage of the sample holding member is Communicate with the container body. In this way, the sample held in the sample holding member can be put into the container body, and if a sample that solidifies the periphery of the biological sample put into the container body is stored as this sample, The biological sample can be fixed in the container body.

この発明の１の実施例によれば、前記試料保持部材は、上記外筒部材の内面円形状に沿う形状の外壁を有し内部に試料保持空間を区画する本体を有し、前記試料投入通路は、上記外壁の所定位置に設けられ、この試料保持部材が前記外筒部材の一端開口から前記容器本体側に突出しない状態では上記外筒部材によって閉塞されており、この試料保持部材が前記容器本体側に突出した状態では解放され、上記試料保持空間を前記容器本体と連通させるものである。   According to one embodiment of the present invention, the sample holding member has an outer wall having a shape that follows the inner circular shape of the outer cylinder member, and has a main body that defines a sample holding space therein, and the sample insertion passage. Is provided at a predetermined position on the outer wall, and is closed by the outer cylinder member in a state where the sample holding member does not protrude from the one end opening of the outer cylinder member toward the container body, and the sample holding member is It is released in a state of projecting to the main body side, and communicates the sample holding space with the container main body.

この場合、上記試料保持部材は、この試料保持部材が前記外筒部材の一端開口から前記容器本体側に突出しない状態で、この試料保持部材の突出を規制するためのロック機構を有することが好ましい。さらにこの場合、上記ロック機構は、上記容器本体と外筒部材とを連結し、上記栓部材を所定以上の力で駆動することにより初めて連結を解除する連結部材を有することが好ましい。また、この連結部材は、上記試料保持部材が前記外筒部材の一端開口から前記容器本体側に突出しない状態で、この試料保持部材が上記容器本体に連通しないように上記外筒部材と容器本体の隙間を封止するものであることがさらに好ましい。   In this case, the sample holding member preferably has a lock mechanism for restricting the protrusion of the sample holding member in a state where the sample holding member does not protrude from the one end opening of the outer cylinder member toward the container body. . Furthermore, in this case, it is preferable that the lock mechanism has a connecting member that connects the container body and the outer cylinder member and only releases the connection by driving the plug member with a predetermined force or more. Further, the connecting member includes the outer cylinder member and the container main body so that the sample holding member does not communicate with the container main body in a state where the sample holding member does not protrude from the one end opening of the outer cylindrical member toward the container main body. More preferably, the gap is sealed.

また、この発明の他の１の実施形態によれば、前記試料投入通路は、上記試料保持部材の上記容器本体に対向する一端に設けられ、前記外筒部材は、前記一端開口を閉塞すると共に上記試料保持部材が突出していない状態で上記試料投入通路を閉塞する隔壁を有し、
前記試料保持部材が前記容器本体側に突出する際に、前記隔壁が上記外筒部材から離脱するか破られ、上記試料保持空間が前記容器本体と連通するものである。 According to another embodiment of the present invention, the sample insertion passage is provided at one end of the sample holding member facing the container body, and the outer cylinder member closes the one end opening. A partition that closes the sample insertion passage in a state in which the sample holding member does not protrude;
When the sample holding member protrudes toward the container main body, the partition wall is detached from the outer cylinder member or broken, and the sample holding space communicates with the container main body.

この場合、上記隔壁は、上記試料保持部材の前記試料投入通路を封止しているものであることが好ましい。また、さらに、前記栓部材の螺進を規制する規制部材を有することが望ましい。   In this case, it is preferable that the partition wall seals the sample insertion passage of the sample holding member. Furthermore, it is desirable to have a regulating member that regulates the screwing of the plug member.

また、この発明のさらなる別の１の実施形態によれば、前記外筒部材は、上記容器本体に螺着されるものである。   According to still another embodiment of the present invention, the outer cylinder member is screwed onto the container body.

さらなる別の１の実施形態によれば、この容器は、前記容器本体内に、前記キャップに保持された試料と反応することで凝固し、容器本体内に投入された生体試料をこの容器内に固定することのできる第２の試料を収納した状態で提供されるものであることが望ましい。   According to yet another embodiment, the container is solidified by reacting with the sample held in the cap in the container body, and the biological sample put in the container body is placed in the container. It is desirable that the second sample that can be fixed is provided in a stored state.

なお、本発明は、上述した以外の特徴及び顕著な効果を有するかもしれないが、以下で説明する発明の最良の実施形態および添付した図面により当業者によって理解することができるので、ここでは述べないこととする。   The present invention may have features and remarkable effects other than those described above, but can be understood by those skilled in the art from the best embodiment of the invention described below and the accompanying drawings. Suppose that there is no.

図１は、本発明の第１の実施形態に係る容器の初期状態を示す正面図である。FIG. 1 is a front view showing an initial state of the container according to the first embodiment of the present invention. 図２は、同じく、図１のＩ―Ｉ線に沿う断面図である。FIG. 2 is a cross-sectional view taken along the line II of FIG. 図３は、同じく、第１のねじ込み状態における正面図（図３Ａ）及びそのＩＩＩ−ＩＩＩ線に沿う断面図（図３Ｂ）である。FIG. 3 is also a front view (FIG. 3A) in a first screwed state and a cross-sectional view (FIG. 3B) along the line III-III. 図４は、同じく、第２のねじ込み状態における正面図（図４Ａ）及びそのＩＶ−ＩＶ線に沿う断面図である。FIG. 4 is also a front view (FIG. 4A) in the second screwed state and a cross-sectional view taken along the line IV-IV. 図５は、同じく、ロック機構を示す概略構成図である。FIG. 5 is also a schematic configuration diagram showing the lock mechanism. 図６は、同じく、第２のロック機構を示す概略構成図である。FIG. 6 is a schematic configuration diagram showing the second locking mechanism, similarly. 図７は、本発明の第２の実施形態に係る容器の初期状態を示す正面図である。FIG. 7 is a front view showing an initial state of the container according to the second embodiment of the present invention. 図８は、同じく、図５のＶ―Ｖ線に沿う断面図である。FIG. 8 is a cross-sectional view taken along line VV in FIG. 図９は、同じく、第１のねじ込み状態における正面図（図９Ａ）及びそのＶＩＩ−ＶＩＩ線に沿う断面図（図９Ｂ）である。FIG. 9 is a front view (FIG. 9A) and a cross-sectional view (FIG. 9B) along the VII-VII line in the first screwed state. 図１０は、同じく、第２のねじ込み状態における正面図（図１０Ａ）及びそのＶＩＩＩ−ＶＩＩＩ線に沿う断面図（図１０Ｂ）である。FIG. 10 is also a front view (FIG. 10A) in the second screwed state and a sectional view (FIG. 10B) along the line VIII-VIII.

以下、本発明の実施形態について詳細に説明する。
（第１の実施形態）
まず、図１〜図４を参照してこの発明の第１の実施形態について説明する。 Hereinafter, embodiments of the present invention will be described in detail.
(First embodiment)
First, a first embodiment of the present invention will be described with reference to FIGS.

（構成）
図１に符号１で示すのが本実施形態に係る容器である。この容器１は、第１の混合材料４を収容する容器本体２と、容器本体２に着脱自在に螺着されると共に上記第１の混合材料４と混合される第２の混合材料５（図２に図示）を保持するキャップ３とからなる。 (Constitution)
1 is a container according to the present embodiment. The container 1 includes a container main body 2 that contains a first mixed material 4 and a second mixed material 5 that is detachably screwed to the container main body 2 and mixed with the first mixed material 4 (see FIG. 2).

この容器１は、後で詳しく説明するように、容器本体２内に、図に６で示す生体試料（例えば「乳歯」）を投入した後、上記キャップ３をこの容器本体２に螺着することで、上記キャップ３から第２の混合材料５をリリースさせる。この実施形態では、上記第１の混合材料４は生理的食塩水等の溶液であり、第２の混合材料５は顆粒状のゲル化材料で、上記第１の混合材料４と混合することでこの第１の混合材料４をゲル化するものである。この作用により、この容器１は、上記容器本体２内で上記生体試料６を固定することができる。   As will be described in detail later, the container 1 has a biological sample (for example, “milk teeth”) shown in FIG. 6 placed in the container body 2 and then the cap 3 is screwed onto the container body 2. Then, the second mixed material 5 is released from the cap 3. In this embodiment, the first mixed material 4 is a solution such as physiological saline, and the second mixed material 5 is a granular gel material, and is mixed with the first mixed material 4. This first mixed material 4 is gelled. By this action, the container 1 can fix the biological sample 6 in the container body 2.

この図１は、キャップ３が容器本体２に螺着されていない初期状態を示し、図２は、この状態における上記キャップ３及び容器本体２の縦断面を示すものである。   FIG. 1 shows an initial state in which the cap 3 is not screwed to the container body 2, and FIG. 2 shows a longitudinal section of the cap 3 and the container body 2 in this state.

そして、図３は、キャップ３を上記容器本体２に螺着したが上記第２の混合材料５が容器本体２内にリリースされていない状態（以下、「第１のねじ込み状態」という）を示し、図４は、上記キャップ３をさらにねじ込み、上記第２の混合材料５を容器本体２内にリリースした状態（以下、「第２のねじ込み状態」という）を示すものである。   FIG. 3 shows a state in which the cap 3 is screwed to the container body 2 but the second mixed material 5 is not released into the container body 2 (hereinafter referred to as “first screwed state”). FIG. 4 shows a state where the cap 3 is further screwed and the second mixed material 5 is released into the container body 2 (hereinafter referred to as “second screwed state”).

図１及び図２に示すように、前記容器本体２は、下端が閉塞され上方に開放する試験管形状に形成されている。この容器本体２の上端開口部２ａの内面には、上記キャップ３を螺着するための第１の雌ねじ溝１２が形成されている。   As shown in FIG.1 and FIG.2, the said container main body 2 is formed in the test tube shape which obstruct | occluded a lower end and open | releases upwards. A first female thread groove 12 for screwing the cap 3 is formed on the inner surface of the upper end opening 2 a of the container body 2.

また、前記キャップ３は、図２に示すように、３つの部材、すなわち、符号７で示す外筒部材と、符号８で示す試料保持部材と、符号９で示す栓部材とからなる。   As shown in FIG. 2, the cap 3 includes three members, that is, an outer cylinder member indicated by a reference numeral 7, a sample holding member indicated by a reference numeral 8, and a plug member indicated by a reference numeral 9.

前記外筒部材７は、下端開口１０と上端開口１１とを有する円外筒部材であり、下端開口１０を容器本体２の上端開口部２ａと着脱自在に連結できるように、その外周部には、上記容器本体２の雌ねじ溝１２と螺合可能な雄ねじ突起１３が設けられている。また、この外筒部材７の高さ方向中途部の外周には、上記容器本体２への挿入量を規制するためのストッパとしての第１のフランジ部１４が突設されている。そして、この外筒部材７の上端部の外形部には、上記栓部材９と螺合するための第２のフランジ部１５が突設されている。   The outer cylinder member 7 is a circular outer cylinder member having a lower end opening 10 and an upper end opening 11. The outer cylinder member 7 has an outer peripheral portion so that the lower end opening 10 can be detachably connected to the upper end opening 2 a of the container body 2. A male screw projection 13 that can be screwed into the female screw groove 12 of the container body 2 is provided. Further, a first flange portion 14 as a stopper for restricting the amount of insertion into the container main body 2 is provided on the outer periphery of the intermediate portion in the height direction of the outer cylinder member 7. A second flange portion 15 is formed on the outer shape of the upper end portion of the outer cylinder member 7 so as to be screwed with the plug member 9.

一方、前記試料保持部材８は、下端が底壁板１７で閉塞された円筒部材であり、その外径寸法は、外筒部材７内で、その軸線方向に沿って上下方向に摺動するような大きさに形成されている。そして、この試料保持部材８の下端部には、径方向外側に向かって開口する連通通路１８が周方向に所定間隔で複数形成されている。この連通通路１８は、この保持部材８が外筒部材７の下端開口１０から容器本体２側に突出しない状態では容器本体２の内部に連通せず（図３に示す第１のねじ込み状態参照）、上記外筒部材７の内周面によって閉塞されている。そして、この通路１８は、上記試料保持部材８が容器本体２側に突出した状態（図４の第２のねじ込み状態参照）で、容器本体２の内部空間と上記試料保持部材８の内部空間とを連通させる。この状態にすることで、上記試料保持部材８内に保持した第２の混合材料５を容器本体２内にリリースできるように構成されている。   On the other hand, the sample holding member 8 is a cylindrical member whose lower end is closed by the bottom wall plate 17, and the outer diameter of the sample holding member 8 slides in the vertical direction along the axial direction in the outer cylindrical member 7. It is formed in a large size. A plurality of communication passages 18 that open toward the radially outer side are formed at predetermined intervals in the circumferential direction at the lower end of the sample holding member 8. The communication passage 18 does not communicate with the inside of the container body 2 when the holding member 8 does not protrude from the lower end opening 10 of the outer cylinder member 7 toward the container body 2 (see the first screwed state shown in FIG. 3). The outer cylinder member 7 is closed by the inner peripheral surface. The passage 18 is in a state where the sample holding member 8 protrudes toward the container body 2 (see the second screwed state in FIG. 4), and the internal space of the container body 2 and the internal space of the sample holding member 8. To communicate. In this state, the second mixed material 5 held in the sample holding member 8 can be released into the container body 2.

なお、この試料保持部材８の底壁板１７は、図２に示すように、この外筒部材７の内径よりも大きく形成されており、この外筒部材７の下端に形成された凹部１９と嵌合することで、この外筒部材７と試料保持部材８との間を液密にシールするように構成されている。また、この状態で、上記外筒部材７と試料保持部材８の下端（底壁板１７の下面）は面一になるように構成されている。   As shown in FIG. 2, the bottom wall plate 17 of the sample holding member 8 is formed to be larger than the inner diameter of the outer cylinder member 7, and a recess 19 formed at the lower end of the outer cylinder member 7 and By fitting, the outer cylinder member 7 and the sample holding member 8 are configured to be liquid-tightly sealed. Further, in this state, the outer cylinder member 7 and the lower end of the sample holding member 8 (the lower surface of the bottom wall plate 17) are configured to be flush with each other.

次に、前記栓部材９は、上壁下面部に図２において符号２０で示すリブが突設されており、このリブ２０を上記試料保持部材８の上端部に接着することでこの試料保持部材８を上端を閉塞した状態で保持できるようになっている。また、この栓部材９の外周部２１は、上記外筒部材７の外形よりも大きく形成され、その内周部には、上記外筒部材７の上端に形成された第２のフランジ部１５と螺合する第２の雌ねじ溝２２が形成されている。これにより、上記キャップ３を外筒部材７に対してねじ込むように下方向に螺進させることができ、これにより、試料保持部材８を外筒部材７の軸線方向に沿って下方向に駆動することができるようになっている。   Next, the stopper member 9 is provided with a rib indicated by reference numeral 20 in FIG. 2 on the lower surface of the upper wall, and this sample holding member 8 is bonded to the upper end of the sample holding member 8. 8 can be held with its upper end closed. Further, the outer peripheral portion 21 of the plug member 9 is formed to be larger than the outer shape of the outer cylindrical member 7, and the inner peripheral portion thereof has a second flange portion 15 formed at the upper end of the outer cylindrical member 7 and A second female screw groove 22 to be screwed is formed. As a result, the cap 3 can be screwed downward so as to be screwed into the outer cylinder member 7, thereby driving the sample holding member 8 downward along the axial direction of the outer cylinder member 7. Be able to.

なお、前記栓部材９若しくは外筒部材７と試料保持部材８との間には、これらが互いに回転方向に容易に回転しないように固定するロック機構（連結部材）が必要である。この実施形態では、図５に示すように、前記試料保持部材８の底壁板１７と、上記外筒部材７の前記凹部１９とに互いに噛み合ってお互いの回転方向の変位を規制する一対の噛合部１７ａ、１９ａが形成されている。これにより、後で詳しく説明するように、図１、図２に示す初期状態から図３に示す第１のねじ込み状態に至る間に誤って上記第２の混合材料８が上記試料保持部材８からリリースされてしまうことを防止できるように、上記外筒部材７と試料保持部材８とを連結できるようになっている。   A locking mechanism (a connecting member) is required between the plug member 9 or the outer cylinder member 7 and the sample holding member 8 so that they are not easily rotated in the rotation direction. In this embodiment, as shown in FIG. 5, a pair of engagements that engage with the bottom wall plate 17 of the sample holding member 8 and the recess 19 of the outer cylinder member 7 to restrict displacement in the rotational direction of each other. Portions 17a and 19a are formed. Thereby, as will be described in detail later, the second mixed material 8 is mistakenly removed from the sample holding member 8 during the period from the initial state shown in FIGS. 1 and 2 to the first screwed state shown in FIG. The outer cylinder member 7 and the sample holding member 8 can be connected so that they can be prevented from being released.

また、図６に示すように、この実施形態では、前記第２のねじ込み状態に至った後に、上記栓部材９を容器本体２にロックするための第２のロック機構２９が設けられている。このロック機構２９は、前記栓部材９側の外周部２１の下端面と上記外筒部材７の第１のフランジ部１４の上面との間に設けられた一対の第２の噛合部１４ａ、２１ａとからなる。これらが互いに噛み合うまで上記栓部材９を容器本体２に対してねじ込むことで、上記栓部材９を容器本体２に対して固定することができる。   Further, as shown in FIG. 6, in this embodiment, a second locking mechanism 29 for locking the stopper member 9 to the container body 2 after the second screwed state is provided. The locking mechanism 29 includes a pair of second meshing portions 14 a and 21 a provided between the lower end surface of the outer peripheral portion 21 on the plug member 9 side and the upper surface of the first flange portion 14 of the outer cylinder member 7. It consists of. The plug member 9 can be fixed to the container main body 2 by screwing the plug member 9 into the container main body 2 until they are engaged with each other.

（作用）
次に、この容器１を使用した生体試料６の収納動作について説明する。 (Function)
Next, the storing operation of the biological sample 6 using this container 1 will be described.

この実施形態においては、上記容器１は、容器本体２側に第１の混合材料４が収納され、かつ上記キャップ３内に第２の混合材料５が保持された状態で提供される。上述したように、この第１、第２の混合材料４，５は、たとえば、互いに接触することでゲル化反応を生じさせる材料であり、このゲル化により、上記容器本体２内に投入された生体材料６を固定することができるものである。   In this embodiment, the container 1 is provided in a state in which the first mixed material 4 is accommodated on the container body 2 side and the second mixed material 5 is held in the cap 3. As described above, the first and second mixed materials 4 and 5 are, for example, materials that cause a gelation reaction by being in contact with each other, and are charged into the container body 2 by the gelation. The biomaterial 6 can be fixed.

また、製品としては、この容器１は、図３に示すように、上記キャップ３を容器本体２に取り付けた状態で供給されることが好ましい。そして、上記キャップ３を、図１に示すように一旦容器本体２から取り外し、容器本体２内に生体材料６を投入したのち、再び取り付けるようにする。   As a product, the container 1 is preferably supplied with the cap 3 attached to the container body 2 as shown in FIG. Then, the cap 3 is once removed from the container main body 2 as shown in FIG. 1, and the biomaterial 6 is put into the container main body 2 and then attached again.

このとき、まず、栓部材９を保持してこのキャップ３を上記容器本体２に対してねじ込むことで、外筒部材７の下端部が、図３に示すように、上記第１のフランジ部１４が上記容器本体２の上端に当接するまで挿入される（第１のねじ込み状態）。   At this time, first, the cap member 9 is held and the cap 3 is screwed into the container main body 2 so that the lower end portion of the outer cylinder member 7 becomes the first flange portion 14 as shown in FIG. Is inserted until it comes into contact with the upper end of the container body 2 (first screwed state).

この状態から、さらに力を入れてキャップ３を回転させると、前記栓部材９と外筒部材７との間のロック機構（噛合部１７ａ、１９ａ）のロック力に抗して上記栓部材９が外筒部材７に対して回転し、試料保持部材８を下方向に駆動することになる。このことで、上記試料保持部材８の下端部が上記外筒部材７の下端開口から突出し、上記試料保持部材８の下端にある底壁板１７が上記外筒部材７の凹部１９から離脱してシール状態が解除されると共に、上記連通通路１８が容器本体２内に開放することになる。   When the cap 3 is further rotated from this state, the plug member 9 is against the locking force of the locking mechanism (meshing portions 17a and 19a) between the plug member 9 and the outer cylinder member 7. It rotates with respect to the outer cylinder member 7, and drives the sample holding member 8 downward. Thus, the lower end portion of the sample holding member 8 protrudes from the lower end opening of the outer cylinder member 7, and the bottom wall plate 17 at the lower end of the sample holding member 8 is detached from the concave portion 19 of the outer cylinder member 7. While the sealing state is released, the communication passage 18 opens into the container body 2.

これにより、この試料保持部材８内に保持されていた第２の混合材料５が上記容器本体２内にリリースされる。これにより、上記第２の混合材料５が第１の混合材料４と混合されると、上記のようにゲル化が起こり、上記生体試料６が容器本体２内で固定される。   As a result, the second mixed material 5 held in the sample holding member 8 is released into the container body 2. Thus, when the second mixed material 5 is mixed with the first mixed material 4, gelation occurs as described above, and the biological sample 6 is fixed in the container body 2.

なお、前述したように、上記栓部材９と外筒部材７とに設けられた第２の噛合部１４ａ、２１ａが互いに噛み合うまで上記栓部材９を容器本体２に対してさらに強い力でねじ込むことで、上記栓部材９を容器本体２に対して固定することができる。   As described above, the stopper member 9 is screwed into the container body 2 with a stronger force until the second engaging portions 14a and 21a provided on the stopper member 9 and the outer cylinder member 7 are engaged with each other. Thus, the stopper member 9 can be fixed to the container body 2.

上記第２の保持部材５を上記キャップ３にセットするための方法は、さまざまな方法が考えられるが、たとえば、上記試料保持部材８と外筒部材７が図２に示す状態に組み合わされた状態で、上記試料保持部材８の上端を開放させておき、上記第２の混合材料５を投入した後に栓部材９を固定して上記試料保持部材５を閉塞するようにすればよい。
（第２の実施形態）
次に、図７〜図１０を参照して、この発明の第２の実施形態について説明する。 Various methods are conceivable for setting the second holding member 5 to the cap 3. For example, the sample holding member 8 and the outer cylinder member 7 are combined in the state shown in FIG. Thus, the upper end of the sample holding member 8 may be opened, and after the second mixed material 5 is introduced, the plug member 9 is fixed to close the sample holding member 5.
(Second Embodiment)
Next, a second embodiment of the present invention will be described with reference to FIGS.

なお、上記第１の実施形態と同様の構成については、同様の参照符号を付してその詳しい説明は省略する。   In addition, about the structure similar to the said 1st Embodiment, the same referential mark is attached | subjected and the detailed description is abbreviate | omitted.

（構成）
図７は本発明の第２の実施形態に係る容器の全体構成を示すものである。 (Constitution)
FIG. 7 shows the overall configuration of the container according to the second embodiment of the present invention.

この第２の実施形態においても、図７に示すように、容器１'は、第１の混合材料４'を収容する容器本体２'と、容器本体２'に着脱自在に螺着されると共に上記第１の混合材料４'と混合される第２の混合材料５'（図８に図示）を保持するキャップ３'とからなる。そして、容器１'は、容器本体２'内に図に６'で示す生体試料（例えば「乳歯」）を投入した後、上記キャップ３'をこの容器本体２'に螺着することで上記キャップ３'から第２の混合材料５'をリリースさせ、上記容器本体２'内で上記生体試料６'を固定することができる。   Also in the second embodiment, as shown in FIG. 7, the container 1 ′ is detachably screwed to the container main body 2 ′ containing the first mixed material 4 ′ and the container main body 2 ′. It comprises a cap 3 'for holding a second mixed material 5' (shown in FIG. 8) to be mixed with the first mixed material 4 '. Then, the container 1 ′ is placed in the container body 2 ′ by inserting the biological sample (for example, “milk teeth”) indicated by 6 ′ in the figure, and then screwing the cap 3 ′ to the container body 2 ′. The second mixed material 5 ′ can be released from 3 ′, and the biological sample 6 ′ can be fixed in the container body 2 ′.

図８は、キャップ３'が容器本体２'に螺着されていない初期状態におけるキャップ３'と容器本体２'の縦断面を示し、図９はキャップ３'を上記容器本体２'に螺着したが第２の混合材料５'が容器本体２'内にリリースされていない「第１のねじ込み状態」（図７Ａ）とその縦断面（図７Ｂ）を示すものである。   FIG. 8 shows a longitudinal section of the cap 3 ′ and the container body 2 ′ in an initial state where the cap 3 ′ is not screwed to the container body 2 ′, and FIG. 9 shows that the cap 3 ′ is screwed to the container body 2 ′. However, the “first screwed state” (FIG. 7A) and the longitudinal section (FIG. 7B) in which the second mixed material 5 ′ is not released into the container body 2 ′ are shown.

また、図１０は、上記キャップ３'をさらに容器本体２'に対してねじ込むことで、上記第２の混合材料５'を容器本体２'内にリリースした「第２のねじ込み状態」（図８Ａ）とその縦断面（図８Ｂ）を示すものである。   FIG. 10 shows a “second screwed state” in which the second mixed material 5 ′ is released into the container body 2 ′ by further screwing the cap 3 ′ into the container body 2 ′ (FIG. 8A). ) And its longitudinal section (FIG. 8B).

図８に示すように、この実施形態においては、容器本体２'は、上端開口部の外周部に、前記キャップ３'と螺合可能なフランジ部２ｂが形成されている。   As shown in FIG. 8, in this embodiment, the container body 2 ′ has a flange portion 2 b that can be screwed with the cap 3 ′ on the outer peripheral portion of the upper end opening.

また、本発明の第２の実施形態におけるキャップ３'は、図６に示すように、試料保持部材８'と栓部材９'とが一体となって形成されている。また、外筒部材７'は、その下端が外筒部材７'の外径寸法と同じ径を有するフィルム状の底壁板１７'で閉塞された円外筒部材であり、この底壁板１７'と外筒部材７により、試料保持部材８'の内部空間が外部と隔離されるように構成されている。   Further, as shown in FIG. 6, the cap 3 ′ in the second embodiment of the present invention is formed integrally with a sample holding member 8 ′ and a plug member 9 ′. The outer cylinder member 7 ′ is a circular outer cylinder member whose lower end is closed by a film-like bottom wall plate 17 ′ having the same diameter as the outer diameter of the outer cylinder member 7 ′. The internal space of the sample holding member 8 ′ is separated from the outside by “and the outer cylinder member 7.

前記栓部材９'は、その内周部に前記容器本体２'の上端に形成されたフランジ部２ｂと螺合する雌ねじ溝２２'が形成され、これにより上記キャップ３'を容器本体２'に対してねじ込むように下方向に螺進させることができるように構成されている。   The plug member 9 'is formed with an internal thread groove 22' screwed with a flange portion 2b formed at the upper end of the container body 2 'on the inner peripheral portion thereof, whereby the cap 3' is formed in the container body 2 '. It is comprised so that it can be screwed down so that it may screw.

なお、雌ねじ溝２２'には、キャップ３'を必要以上に容器本体２'側にねじ込み、試料保持部材８'の内部空間に保持されていた第２の混合材料８'を容器本体２'の内部に誤ってリリースしてしまうことがないようにロック部材２６が設けられている。   In addition, the cap 3 'is screwed into the female main body 2' more than necessary in the female screw groove 22 ', and the second mixed material 8' held in the internal space of the sample holding member 8 'is placed in the container main body 2'. A lock member 26 is provided so as not to be accidentally released inside.

（作用）
本発明の第２の実施形態における容器においても、第１の実施形態における容器と同様に、容器本体２'側に第１の混合材料４'を収納し、かつ上記キャップ３'内に第２の混合材料５'を保持させた状態で容器１'を提供する。 (Function)
Also in the container according to the second embodiment of the present invention, the first mixed material 4 ′ is accommodated on the container body 2 ′ side and the second inside the cap 3 ′ similarly to the container according to the first embodiment. The container 1 ′ is provided in a state where the mixed material 5 ′ is held.

また、製品としては、容器１'は図７に示されるように、上記キャップ３'を容器本体２'に取り付けた状態で供給されることが好ましく、上記キャップ３'を、図５に示すように一旦容器本体２'から取り外し、容器本体２'内に生体材料６'を投入したのち、再び取り付けるようにする。   As a product, the container 1 ′ is preferably supplied with the cap 3 ′ attached to the container body 2 ′ as shown in FIG. 7, and the cap 3 ′ is shown in FIG. The container body 2 ′ is once removed and the biomaterial 6 ′ is put into the container body 2 ′ and then attached again.

そして、キャップ３'を、第１のねじ込み状態となるまで容器本体２'に対してねじ込む。この状態から、キャップ３'を上記ロック部材２６による抵抗力に抗して容器本体２'に対してさらに回転させると、下端に底壁部１７'を有する外筒部材７'に対して上記試料保持部材８’が下方向に駆動され、底壁部１７'は試料保持部材８'の下端と容器本体２'の上端による剪断応力を受けて破断される。その結果、試料保持部材８'内の空間が、図８に示されるように容器本体２'の内部空間と連通し、試料保持部材８'の内部に保持されていた第２の混合材料５'が容器本体２'内にリリースされる。これにより、上記第２の混合材料５'が第１の混合材料４と混合されると、上記のようにゲル化が起こり、上記生体試料６'が容器本体２'内で固定される。   And cap 3 'is screwed with respect to container main body 2' until it will be in a 1st screwed state. From this state, when the cap 3 ′ is further rotated with respect to the container body 2 ′ against the resistance force of the lock member 26, the sample is compared with the outer cylinder member 7 ′ having the bottom wall portion 17 ′ at the lower end. The holding member 8 ′ is driven downward, and the bottom wall portion 17 ′ is broken by receiving shear stress from the lower end of the sample holding member 8 ′ and the upper end of the container body 2 ′. As a result, the space inside the sample holding member 8 ′ communicates with the internal space of the container body 2 ′ as shown in FIG. 8, and the second mixed material 5 ′ held inside the sample holding member 8 ′. Is released into the container body 2 '. Thus, when the second mixed material 5 ′ is mixed with the first mixed material 4, gelation occurs as described above, and the biological sample 6 ′ is fixed in the container body 2 ′.

（効果）
上記本発明の実施形態において説明したような構成によれば、他に特別な材料を用意することなく、単にキャップを閉めるだけで、内部で生体試料を固定保持できる容器を得ることができる。 (effect)
According to the configuration described in the embodiment of the present invention, it is possible to obtain a container in which a biological sample can be fixed and held simply by closing the cap without preparing any other special material.

なお、従来、生体試料の保存容器ではないが、二剤を同時に且つ別々に収納でき、使用に当たって簡単な操作で二剤の混合、攪拌、抽出を行うことのできる容器として、下記の２つの文献が存在するので、それらとの比較で、本願発明の構造的な優位性を説明する。   Conventionally, although it is not a storage container for biological samples, the following two documents are available as containers that can store the two agents simultaneously and separately and can be used for mixing, stirring, and extracting the two agents with a simple operation. Therefore, the structural superiority of the present invention will be described in comparison with them.

特許文献３ 特開平８−９１４１８号公報
特許文献４ 特開２００４−７５１３３号公報
これらの文献に記載された構造は、キャップ内に混合材料を保持する点では本発明と共通した特徴を有するが、いずれも本発明の栓部材に相当する部品を上方向に引き上げることで上記混合材料を容器本体内にリリースするものである。すなわち、本発明の外筒部材に相当する部材に対して保持部材を突出方向ではなく没方向に駆動することで、その機能を発揮するように構成されているので、栓部材を引き上げという、キャップ装着時と反対の動作が必要になる。このため、たとえば、上記栓部材を引き上げるキャップが緩んだり脱落する可能性も考えられる。 Patent Document 3 Japanese Patent Application Laid-Open No. 8-91418 Patent Document 4 Japanese Patent Application Laid-Open Publication No. 2004-75133 The structure described in these documents has a feature common to the present invention in that the mixed material is held in the cap. In either case, the mixed material is released into the container body by pulling up the parts corresponding to the plug member of the present invention. That is, since the holding member is driven not in the protruding direction but in the sunk direction relative to the member corresponding to the outer cylindrical member of the present invention, the cap member is lifted because it is configured to perform its function. The operation opposite to that when wearing is required. For this reason, for example, the cap that pulls up the plug member may be loosened or dropped.

これに対して、本願発明の構造は、上記キャップ３を容器本体２に螺着して、混合材料５をリリースするには、上記栓部材９を引き上げる必要はなく、常に同じ方向に回転駆動すれば良く、簡単な動作でリリースまでを行うことができる。上記の特許文献では、栓を引き上げるために複雑な構造が必要であったが、この発明ではそのような構造が不要になるという効果がある。   On the other hand, in the structure of the present invention, in order to screw the cap 3 to the container body 2 and release the mixed material 5, it is not necessary to pull up the plug member 9 and it is always driven to rotate in the same direction. It can be done with a simple operation. In the above-mentioned patent document, a complicated structure is required to pull up the stopper. However, the present invention has an effect that such a structure is unnecessary.

また、上記で同じ方向に駆動するには、操作中の不注意により上記混合材料５が意図しないタイミングでリリースされてしまうことを防止する必要があるが、前記の実施形態では、ロック機構（１７ａ、１９ａ、２６、２９）を設けるようにしているので、それが達成される。   Further, in order to drive in the same direction as described above, it is necessary to prevent the mixed material 5 from being released at an unintended timing due to carelessness during operation. In the above embodiment, the locking mechanism (17a 19a, 26, 29), this is achieved.

なお、ロック機構は上記のものに限定されるものではない。例えば、上記第１の実施形態において、図２に２３で示す位置に、栓部材９と外筒部材７とを接着するためのロック部材（例えば熱可塑性の樹脂材料）を付着することにより、ロック機構を構成するようにしても良い。   The locking mechanism is not limited to the above. For example, in the first embodiment, a lock member (for example, a thermoplastic resin material) for bonding the plug member 9 and the outer cylinder member 7 is attached to the position indicated by 23 in FIG. You may make it comprise a mechanism.

また、本発明の容器を構成する各部材の材質としては、試料の保存や輸送などに適するものであれば特に制限されないが、凍結保存も可能な材質であることが好ましい。強度や成型性、密封性、滅菌性などの点にも鑑みて適切な材料を選択することが好ましい。本発明の容器を構成する各部材の材質は、すべて同じ材質であってもよいし、各部材ごとに異なる材質を用いてもよい。   Further, the material of each member constituting the container of the present invention is not particularly limited as long as it is suitable for storage and transportation of a sample, but is preferably a material that can be cryopreserved. It is preferable to select an appropriate material in view of strength, moldability, sealability, sterilization, and the like. The material of each member constituting the container of the present invention may be the same material, or a different material may be used for each member.

本発明の容器の内容積や形状は、保存性や輸送時の安定性、取り扱いや試料調整の容易性などに応じて当業者が適宜設定できるものであり、特に限定されるものではない。容器の形状については、例えば、容器本体の形状は、円柱状、角柱状、円錐状または角錐状などが挙げられる。さらに、取り扱い性向上のため、容器本体や外筒部材の周囲に滑り止め手段や転倒防止手段を設けてもよい。   The internal volume and shape of the container of the present invention can be appropriately set by those skilled in the art according to storage stability, stability during transportation, ease of handling and sample preparation, and is not particularly limited. As for the shape of the container, for example, the shape of the container main body may be a columnar shape, a prismatic shape, a conical shape, or a pyramid shape. Further, for improving the handleability, anti-slip means and fall prevention means may be provided around the container main body and the outer cylinder member.

本発明の容器に保存される試料としては、生体試料、環境試料、食品試料、高分子/低分子有機物試料、岩石や金属等の無機物試料、コンビナトリアル試料等が挙げられ、限定はされないが、本願発明の容器は特に生体試料の保存性等に優れる。   Examples of the sample stored in the container of the present invention include biological samples, environmental samples, food samples, polymer / low molecular organic samples, inorganic samples such as rocks and metals, combinatorial samples, and the like. The container of the invention is particularly excellent in preservability of biological samples.

本発明の容器に保存される生体試料としては、生体由来のものであれば特に限定されず、動物由来のものや微生物なども含まれる。例えば、乳歯、永久歯、網膜、毛髪、各種細胞、血液成分、臓器組織、***、卵子、唾液等が挙げられる。   The biological sample stored in the container of the present invention is not particularly limited as long as it is derived from a living body, and includes animal-derived materials and microorganisms. Examples include deciduous teeth, permanent teeth, retina, hair, various cells, blood components, organ tissues, sperm, eggs, saliva, and the like.

本発明の容器本体に保持される第１の混合材料と、本発明のキャップに保持される第２の混合材料は、それらを混合することで容器に保存する試料を固定保持することができ、かつ保存試料に対して損傷等の悪影響を及ぼさないものであれば特に制限されない。   The first mixed material held in the container body of the present invention and the second mixed material held in the cap of the present invention can fix and hold the sample stored in the container by mixing them, And if it does not have a bad influence, such as damage, with respect to a preservation | save sample, it will not restrict | limit.

１、１' 本発明に係る容器
２、２' 容器本体
２ａ 容器本体２の上端開口部
３、３' キャップ
４、４' 第１の混合材料
５、５' 第２の混合材料
７、７' 外筒部材
８、８' 試料保持部材
９、９' 栓部材
１０、１０' 下端開口
１１、１１' 上端開口
１２ 第１の雌ねじ溝
１３ 雄ねじ突起
１４ 第１のフランジ部
１５ 第２のフランジ部
１７、１７' 底壁板
１８ 連通通路
１９ 凹部
１９、１９' 側壁部
２０' リブ
２１ 栓部材９の外周部
２２ 第２の雌ねじ溝
２３ ロック機構
２５ フランジ部
２６ ロック部材 DESCRIPTION OF SYMBOLS 1, 1 'Container 2, 2' Container main body 2a Upper end opening part of container main body 3, 3 'Cap 4, 4' 1st mixed material 5, 5 '2nd mixed material 7, 7' Outer cylinder member 8, 8 'Sample holding member 9, 9' Plug member 10, 10 'Lower end opening 11, 11' Upper end opening 12 First female screw groove 13 Male screw protrusion 14 First flange portion 15 Second flange portion 17 , 17 ′ Bottom wall plate 18 Communicating passage 19 Recess 19, 19 ′ Side wall portion 20 ′ Rib 21 Outer portion of plug member 9 22 Second female screw groove 23 Lock mechanism 25 Flange portion 26 Lock member

Claims (10)

容器本体と、この容器本体を閉塞するように設けられているとともに上記容器本体の内部に投入する試料を保持するキャップとを有する容器であって、
前記試料は、前記容器本体内に保持した生体試料の周囲を凝固させて当該生体試料を固定するものであり、
前記キャップは、
一端開口と他端開口とを有し、一端開口を前記容器本体の内部と連通させた状態でこの容器本体に着脱自在に連結される外筒部材と、
内部に前記試料を保持すると共に、前記外筒部材内にその軸線方向に沿って移動自在に設けられ、前記外筒部材の一端開口から前記容器本体側に突出しない状態では前記容器本体の内部に連通せず、前記容器本体側に突出した状態では前記容器本体の内部に連通して前記試料を投入する試料投入通路を有する試料保持部材と
前記試料保持部材を保持すると共に前記外筒部材若しくは上記容器本体に螺進自在に取り付けられ、前記試料保持部材を前記外筒部材の軸線方向に沿って駆動する栓部材と、
を有することを特徴とする容器。 A container having a container body and a cap that is provided so as to close the container body and holds a sample to be put into the container body;
The sample is to solidify the periphery of the biological sample held in the container body and fix the biological sample,
The cap is
An outer cylinder member that has one end opening and the other end opening, and is detachably connected to the container body in a state where the one end opening communicates with the inside of the container body;
The sample is held inside, and is provided in the outer cylinder member so as to be movable along the axial direction thereof. In a state where the sample does not protrude from the one end opening of the outer cylinder member toward the container body, In a state where the sample does not communicate and protrudes toward the container body, the sample holding member having a sample insertion passage that communicates with the inside of the container body and inputs the sample and holds the sample holding member and the outer cylinder member or the above A stopper member that is screwably attached to the container body, and that drives the sample holding member along the axial direction of the outer cylinder member;
A container characterized by comprising: 請求項１記載の容器において、
前記試料保持部材は、
上記外筒部材の内面円形状に沿う形状の外壁を有し内部に試料保持空間を区画する本体を有し、
前記試料投入通路は、上記外壁の所定位置に設けられ、この試料保持部材が前記外筒部材の一端開口から前記容器本体側に突出しない状態では上記外筒部材によって閉塞されており、この試料保持部材が前記容器本体側に突出した状態では解放され、上記試料保持空間を前記容器本体と連通させるものである
ことを特徴とする容器。 The container of claim 1,
The sample holding member is
It has an outer wall having a shape along the inner circular shape of the outer cylinder member, and has a main body that defines a sample holding space inside,
The sample insertion passage is provided at a predetermined position on the outer wall, and is closed by the outer cylinder member when the sample holding member does not protrude from the one end opening of the outer cylinder member toward the container body. The container is released when the member protrudes toward the container main body, and communicates the sample holding space with the container main body. 請求項２記載の容器において、
上記試料保持部材は、
この試料保持部材が前記外筒部材の一端開口から前記容器本体側に突出しない状態で、この試料保持部材の突出を規制するためのロック機構を有する
ことを特徴とする容器。 The container according to claim 2,
The sample holding member is
A container having a lock mechanism for restricting the protrusion of the sample holding member in a state where the sample holding member does not protrude from the one end opening of the outer cylinder member toward the container main body. 請求項３記載の容器において、
上記ロック機構は、
上記容器本体と外筒部材とを連結し、上記栓部材を所定以上の力で駆動することにより初めて連結を解除する連結部材を有する
ことを特徴とする容器。 The container according to claim 3,
The locking mechanism is
A container comprising: a connecting member that connects the container body and the outer cylinder member, and that releases the connection only by driving the plug member with a predetermined force or more. 請求項４記載の容器において、
前記連結部材は、上記試料保持部材が前記外筒部材の一端開口から前記容器本体側に突出しない状態で、この試料保持部材が上記容器本体に連通しないように上記外筒部材と容器本体の隙間を封止するものである
ことを特徴とする容器。 The container according to claim 4,
The connecting member includes a gap between the outer cylinder member and the container body so that the sample holding member does not communicate with the container body in a state where the sample holding member does not protrude from the one end opening of the outer cylinder member toward the container body. A container characterized by being sealed. 請求項１記載の容器において、
前記試料投入通路は、上記試料保持部材の上記容器本体に対向する一端に設けられ、 前記外筒部材は、前記一端開口を閉塞すると共に上記試料保持部材が突出していない状態で上記試料投入通路を閉塞する隔壁を有し、
前記試料保持部材が前記容器本体側に突出する際に、前記隔壁が上記外筒部材から離脱するか破られ、上記試料保持空間が前記容器本体と連通するものである
ことを特徴とする容器。 The container of claim 1,
The sample input passage is provided at one end of the sample holding member facing the container body, and the outer cylinder member closes the opening of the one end and the sample input passage without the sample holding member protruding. Having a septum to close,
The container is characterized in that when the sample holding member protrudes toward the container main body, the partition wall is detached from the outer cylinder member or broken, and the sample holding space communicates with the container main body. 請求項６記載の容器において、
上記隔壁は、上記試料保持部材の前記試料投入通路を封止しているものである
ことを特徴とする容器。 The container according to claim 6,
The container is characterized in that the partition wall seals the sample input passage of the sample holding member. 請求項１記載の容器において、
前記栓部材の螺進を規制する規制部材を有する
ことを特徴とする容器。 The container of claim 1,
A container having a restricting member for restricting screwing of the stopper member. 請求項１記載の容器において、
前記外筒部材は、上記容器本体に螺着されるものである
ことを特徴とする容器。 The container of claim 1,
The said outer cylinder member is screwed by the said container main body. The container characterized by the above-mentioned. 請求項１記載の容器において、
この容器は、
前記容器本体内に、前記キャップに保持された試料と反応することで凝固し、容器本体内に投入された生体試料をこの容器内に固定することのできる第２の試料を収納した状態で提供される
ことを特徴とする容器。
The container of claim 1,
This container
Provided in the container body in a state in which a second sample that can be solidified by reacting with the sample held in the cap and that can be fixed in the container body is stored in the container body. A container characterized by being made.
JP2009066759A 2009-03-18 2009-03-18 container Expired - Fee Related JP5429855B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009066759A JP5429855B2 (en) 2009-03-18 2009-03-18 container

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009066759A JP5429855B2 (en) 2009-03-18 2009-03-18 container

Publications (2)

Publication Number Publication Date
JP2010213660A JP2010213660A (en) 2010-09-30
JP5429855B2 true JP5429855B2 (en) 2014-02-26

Family

ID=42973202

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009066759A Expired - Fee Related JP5429855B2 (en) 2009-03-18 2009-03-18 container

Country Status (1)

Country Link
JP (1) JP5429855B2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3150702B1 (en) * 2011-06-19 2021-05-19 DNA Genotek, Inc. Devices, solutions and methods for sample collection
WO2015112496A2 (en) 2014-01-20 2015-07-30 Abogen, Inc. Devices, solutions and methods for sample collection
MX2019010800A (en) 2017-03-15 2020-07-28 Ancestry Com Dna Llc Sample collection device and method.
US11543330B2 (en) 2017-10-24 2023-01-03 Bioneer Corporation Bio sample collection device
EP3713498A4 (en) * 2017-11-22 2021-08-04 Ancestry.com DNA, LLC Sample collection kit including cap having selectively movable sleeve
US11426734B2 (en) 2017-11-22 2022-08-30 Ancestry.Com Dna, Llc Sample collection kit including cap having selectively movable sleeve
AU2019384801A1 (en) * 2018-11-20 2021-06-10 Spectrum Solutions, Llc Sample collection system including sealing cap and valve
JP7266796B2 (en) * 2019-02-26 2023-05-01 ヤマト科学株式会社 Storage containers and thawing equipment
CA3133991A1 (en) * 2019-03-19 2020-09-24 Ancestry.Com Dna, Llc Sample collection kit including cap having selectively movable sleeve

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7700276B2 (en) * 2003-07-10 2010-04-20 Universite Libre De Bruxelles Device, kit and method for pulsing biological samples with an agent and stabilising the sample so pulsed
CN101472622B (en) * 2006-04-19 2014-11-26 国立大学法人名古屋大学 Composition for regeneration of periodontal soft tissue and method for producing the same
ITMI20062272A1 (en) * 2006-11-27 2008-05-28 Genedia S R L REACTOR FOR BIOCHEMICAL PROCESSES PARTICULARLY EXTRACTION PURIFICATION ENRICHMENT SEDIMENTATION
JP2008137697A (en) * 2006-12-01 2008-06-19 Fancl Corp Storage container

Also Published As

Publication number Publication date
JP2010213660A (en) 2010-09-30

Similar Documents

Publication Publication Date Title
JP5429855B2 (en) container
ES2774919T3 (en) Closure, container apparatus and method of use thereof
CN108348396B (en) Connection and container system
AU621553B2 (en) Improved system
US8932539B2 (en) Saliva sample collection systems
JP5916148B2 (en) Container, seal for container, and bottom for container
CN104411353B (en) Syringe accommodating container
KR101211320B1 (en) Hanger cover and multiple chamber infusion bag
US7243807B2 (en) Fluid-tight dilution bottle and cap
CA2670679C (en) System for marking a non-human biological object and for taking a sample of the biological object
US8815597B2 (en) Baglike container for centrifugation and method of gene transfer using the same
AU2015374322B2 (en) Container for mixing and dispensing components
BR112017027336B1 (en) CONNECTION SYSTEM AND CONTAINER
ES2782348T3 (en) Assembly for storing and mixing two substances
EP3010826B1 (en) Container and method for the storage and extemporaneous reconstitution of a mixture of compounds in fixed proportions
TR201810533T4 (en) Flexible packaging that can be sterilized for the reconstitution and delivery of medical or nutritional liquids which can be injected or inoculated into a patient's body.
JP6256352B2 (en) Blood component separation and storage device and method for preparing platelet-rich plasma
IL250453A (en) Container unit comprising two containers
CN108024906B (en) Connection and container system
US11148142B2 (en) System and method for visual verification of secure closure of collection bottle through chemiluminescence
US11119010B2 (en) Aseptic tamper evident sampling container
US20050187533A1 (en) Needle guide
JP5742120B2 (en) Connecting device
CN208393987U (en) A kind of cell cycle detection kit
KR20160067391A (en) Fixing holder of syringe for preventing unlock with formation of negative pressure

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120316

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20121206

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20121211

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130212

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20131029

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20131128

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

Ref document number: 5429855

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees