JP5394220B2 - Cleaning composition - Google Patents
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Description
本発明は、短時間の使用においても高い殺菌効果を有する洗浄剤組成物に関する。より具体的には、特に食材を扱う従事者等を対象とする、油脂汚れに対して優れた洗浄効果を有する身体用の液体殺菌洗浄剤組成物に関する。 The present invention relates to a detergent composition having a high bactericidal effect even when used for a short time. More specifically, the present invention relates to a liquid sterilizing and cleaning composition for a body that has an excellent cleaning effect on fat and oil stains, particularly for workers who handle foodstuffs.
身体用洗浄剤組成物には、洗浄効果に加えて、病原菌の感染を防止、菌の伝播を防止する等の衛生的見地より殺菌効果も求められており、この要求に応えるべく殺菌効果を有する身体用洗浄剤組成物について多くの検討がなされている。 In addition to the cleaning effect, the body cleaner composition is also required to have a bactericidal effect from the standpoint of hygiene, such as preventing infection by pathogenic bacteria and preventing the spread of bacteria, and has a bactericidal effect to meet this requirement. Many studies have been made on body cleaner compositions.
例えば、身体用液体殺菌洗浄剤組成物としては、高い殺菌力と低温安定性を得る目的で、ポリオキシエチレンアルキルエーテル硫酸塩等のアニオン性界面活性剤を主基剤として、さらに殺菌剤を配合したものが知られている（例えば、特許文献１）。 For example, as a liquid sterilizing and cleaning composition for body use, an anionic surfactant such as polyoxyethylene alkyl ether sulfate is mainly used as a main base for the purpose of obtaining high sterilizing power and low-temperature stability. Is known (for example, Patent Document 1).
このような身体用液体殺菌洗浄剤組成物は、さらに、短時間の使用であっても高い殺菌効果を有することが求められており、加えて食材を扱う従事者を対象とした場面では、さらに油脂汚れに対しても優れた洗浄効果が求められている。 Such a body liquid sterilizing detergent composition is further required to have a high sterilizing effect even in a short time use, and in addition, in scenes targeting workers handling foodstuffs, There is a demand for an excellent cleaning effect against oil and fat stains.
油脂汚れに対する洗浄効果を高めようとする場合、洗浄剤組成物中の界面活性剤の含有量を多くすることが考えられる。しかしながら、洗浄剤組成物中の界面活性剤を増量すると、どういうわけか殺菌効果が低下することがあった。そのために、高い殺菌効果と油脂汚れに対する優れた洗浄効果との両者を兼ね備えた身体用液体殺菌洗浄剤組成物が切望されている。 In order to enhance the cleaning effect on oil and fat stains, it is conceivable to increase the content of the surfactant in the cleaning composition. However, when the amount of the surfactant in the cleaning composition is increased, the bactericidal effect may be lowered for some reason. Therefore, a body liquid sterilizing and cleaning composition having both a high sterilizing effect and an excellent cleaning effect on oily and dirt is desired.
従って、本発明の課題は、短時間で高い殺菌効果を発現し、かつ、油脂汚れに対しても優れた洗浄効果を有する洗浄剤組成物、より具体的には身体用液体殺菌洗浄剤組成物を提供することにある。 Accordingly, an object of the present invention is to provide a cleaning composition that exhibits a high bactericidal effect in a short time and has an excellent cleaning effect on oil and fat stains, more specifically, a liquid bactericidal cleaning composition for body use. Is to provide.
即ち、本発明の要旨は、
（ａ）成分：次式：ＲＯ（ＣＨ2ＣＨ2Ｏ）nＳＯ3・ＮＨ4
（式中、Ｒは炭素数８〜１８のアルキル基であり、ｎは平均付加モル数を示し、ｎ＝０〜１．２である。）で示されるアニオン性界面活性剤を３〜１０重量％、
（ｂ）成分：
トリクロサン(b1)、イソプロピルメチルフェノール(b2)及びパラクロロメタキシレノール(b3)からなる群より選択される少なくとも１種の成分を０．１〜１．０重量％、並びに
（ｃ）成分：グリセリルエーテルを０．５〜５．０重量％含有する洗浄剤組成物、に関するものである。
That is, the gist of the present invention is as follows.
Component (a): Formula: RO (CH 2 CH 2 O) n SO 3 .NH 4
(Wherein R is an alkyl group having 8 to 18 carbon atoms, n represents the average number of added moles, and n = 0 to 1.2) 3 to 10 wt. %,
(B) Component:
0.1 to 1.0% by weight of at least one component selected from the group consisting of triclosan (b1), isopropylmethylphenol (b2) and parachlorometaxylenol (b3), and (c) component: glyceryl ether Is about 0.5-5.0 weight% of cleaning composition.
本発明の洗浄剤組成物は、油脂汚れに対する洗浄効果に優れ、かつ短時間の使用であっても高い殺菌効果（特に大腸菌に対する高い殺菌効果）を発揮するという優れた効果を奏するものである。 The cleaning composition of the present invention is excellent in the cleaning effect against oil and fat stains, and exhibits an excellent effect of exhibiting a high bactericidal effect (particularly a high bactericidal effect on E. coli) even when used for a short time.
＜（ａ）成分＞
本発明の洗浄剤組成物における（ａ）成分は、次式：
ＲＯ（ＣＨ2ＣＨ2Ｏ）ｎＳＯ3・ＮＨ4
（式中、Ｒは炭素数８〜１８のアルキル基であり、ｎは平均付加モル数を示し、ｎ＝０〜１．２である。）で示されるアニオン性界面活性剤である。殺菌効果と油脂汚れに対する洗浄効果の両者を発揮させる観点から、（ａ）成分はアンモニウム塩である。アンモニウム塩以外の塩を用いると、たとえ所定量の（ｃ）成分を含有する組成物であっても組成物の殺菌効果が極めて小さくなってしまい、所望の効果が得られない。アルキル基の炭素数としては、１０〜１６が好ましい。さらに当該ｎの値については、殺菌効果と油脂汚れに対する洗浄効果の両者を発揮させる観点から、０〜１．２であり、０〜１．０が好ましい。当該ｎの値が１．２を超える場合、たとえ（ａ）成分がアンモニウム塩であっても、特に大腸菌に対する組成物の殺菌効果が極めて小さくなってしまい、所望の効果が得られない。
<(A) component>
The component (a) in the cleaning composition of the present invention has the following formula:
RO (CH 2 CH 2 O) nSO 3 .NH 4
(Wherein R represents an alkyl group having 8 to 18 carbon atoms, n represents an average number of added moles, and n = 0 to 1.2). From the viewpoint of exhibiting both a bactericidal effect and a cleaning effect against oil and fat stains, the component (a) is an ammonium salt. If a salt other than the ammonium salt is used, even if it is a composition containing a predetermined amount of component (c), the bactericidal effect of the composition becomes extremely small and the desired effect cannot be obtained. As carbon number of an alkyl group, 10-16 are preferable. Further, the value of n is from 0 to 1.2, preferably from 0 to 1.0, from the viewpoint of exhibiting both a bactericidal effect and a cleaning effect against oily and dirt. When the value of n exceeds 1.2, even if the component (a) is an ammonium salt, the bactericidal effect of the composition particularly on Escherichia coli becomes extremely small, and a desired effect cannot be obtained.
具体的には、（ａ）成分としては、ラウリル硫酸アンモニウム、ミリスチル硫酸アンモニウム等のアルキル硫酸アンモニウム塩；ポリオキシエチレン（１モル）ラウリルエーテル硫酸アンモニウム塩、ポリオキシエチレン（１モル）ミリスチルエーテル硫酸アンモニウム塩等のポリオキシエチレンアルキルエーテル硫酸アンモニウム塩等が挙げられる。なお、本明細書において、これらの化合物のかっこ内の数値はエチレンオキシドの平均付加モル数を意味する。（ａ）成分として、これらの化合物の一種類を単独で用いてもよく、又は複数の種類を組み合わせて用いてもよい。なお、（ａ）成分の商品としては、エマール１２５Ａ〔花王（株）製〕、エマールＡＤ−２５Ｒ〔花王（株）製〕等が挙げられる。 Specifically, as the component (a), an alkyl sulfate ammonium salt such as ammonium lauryl sulfate or ammonium myristyl sulfate; a polyoxyethylene such as polyoxyethylene (1 mol) ammonium lauryl ether sulfate, polyoxyethylene (1 mol) ammonium myristyl ether sulfate Examples include ethylene alkyl ether ammonium sulfate. In addition, in this specification, the numerical value in the parenthesis of these compounds means the average added mole number of ethylene oxide. As the component (a), one type of these compounds may be used alone, or a plurality of types may be used in combination. In addition, as a product of (a) component, Emar 125A [made by Kao Corporation], Emar AD-25R [made by Kao Corporation], etc. are mentioned.
（ａ）成分の洗浄剤組成物中の含有量は３〜１０重量％である。（ａ）成分の好ましい含有量は５．０〜９．０重量％であり、より好ましい含有量は５．５〜７．０重量％である。起泡性、洗浄性を十分に発揮させる観点から、当該含有量は３重量％以上が好ましく、（ｂ）成分による殺菌効果を十分に発揮させる観点から、当該含有量は１０重量％以下が好ましい。 The content of the component (a) in the cleaning composition is 3 to 10% by weight. The preferable content of the component (a) is 5.0 to 9.0% by weight, and the more preferable content is 5.5 to 7.0% by weight. The content is preferably 3% by weight or more from the viewpoint of sufficiently exhibiting foamability and detergency, and the content is preferably 10% by weight or less from the viewpoint of sufficiently exhibiting the bactericidal effect of the component (b). .
＜（ｂ）成分＞
本発明の洗浄剤組成物における（ｂ）成分は殺菌剤であり、トリクロサン(b1)、イソプロピルメチルフェノール(b2)及びパラクロロメタキシレノール(b3)からなる群より選択される少なくとも１種の成分である。これらの中では、高い殺菌効果を発現する観点から、トリクロサン(b1)及びイソプロピルメチルフェノール(b2)が好ましく、トリクロサン(b1)がより好ましい。
また、本発明の洗浄剤組成物における（ｂ）成分は、より高い殺菌効果を発現する観点から、トリクロサン(b1)を必須成分とし、さらに（ｂ）成分には、トリクロサン(b1)に加えて、イソプロピルメチルフェノール(b2)及び／又はパラクロロメタキシレノール(b3)が組み合わさって用いられることが好ましい。
<(B) component>
The component (b) in the cleaning composition of the present invention is a fungicide and is at least one component selected from the group consisting of triclosan (b1), isopropylmethylphenol (b2) and parachlorometaxylenol (b3). is there. Among these, triclosan (b1) and isopropylmethylphenol (b2) are preferable, and triclosan (b1) is more preferable from the viewpoint of exhibiting a high bactericidal effect.
In addition, the component (b) in the cleaning composition of the present invention has triclosan (b1) as an essential component from the viewpoint of developing a higher bactericidal effect, and the component (b) is added to triclosan (b1). In addition, isopropylmethylphenol (b2) and / or parachlorometaxylenol (b3) are preferably used in combination.
洗浄剤組成物中の（ｂ）成分の含有量（〔(b1)+(b2)＋(b3)〕）は０．１〜１．０重量％であり、好ましい含有量は０．２〜０．６重量％である。殺菌効果を十分に発揮させる観点から、当該含有量は０．２重量％以上が好ましく、組成物の安定性を確保する観点から、当該含有量は１．０重量％以下が好ましい。 The content ([(b1) + (b2) + (b3)]) of the component (b) in the cleaning composition is 0.1 to 1.0% by weight, and the preferable content is 0.2 to 0. .6% by weight. The content is preferably 0.2% by weight or more from the viewpoint of sufficiently exhibiting the bactericidal effect, and the content is preferably 1.0% by weight or less from the viewpoint of ensuring the stability of the composition.
＜（ｃ）成分＞
本発明の洗浄剤組成物における（ｃ）成分はグリセリルエーテルである。洗浄剤組成物に（ｃ）成分を配合することによって、洗浄剤組成物の油脂汚れに対する洗浄効果を低下させることなく、大腸菌等の細菌に対する殺菌効果をより一層発揮させるという効果が奏される。
<(C) component>
The component (c) in the cleaning composition of the present invention is glyceryl ether. By blending the component (c) into the cleaning composition, the effect of further exerting the bactericidal effect against bacteria such as Escherichia coli can be achieved without reducing the cleaning effect of the cleaning composition on oil and fat stains.
（ｃ）成分のグリセリルエーテルとしては、炭素数８〜１２の直鎖または分岐のアルキル基を有するモノアルキル体が好ましい。当該アルキル基としては、例えばｎ−オクチル基、２−エチルヘキシル基、ｎ−ノニル基、ｎ−デシル基、イソデシル基、ｎ−ウンデシル基、ｎ−ドデシル基が挙げられる。より好ましいアルキル基としては、炭素数８〜１２の分岐したアルキル基、さらに好ましくは炭素数８〜１０の分岐したアルキル基であり、具体的には２−エチルヘキシル基、イソデシル基が挙げられる。グリセリルエーテルの具体例としては、２−エチルヘキシルグリセリルエーテル、イソデシルグリセリルエーテル等が挙げられ、２−エチルヘキシルグリセリルエーテルが好ましい。（ｃ）成分のグリセリルエーテルは、１種を単独で用いてもよく、又は２種以上を組み合わせて用いてもよい。 As the glyceryl ether of the component (c), a monoalkyl body having a linear or branched alkyl group having 8 to 12 carbon atoms is preferable. Examples of the alkyl group include n-octyl group, 2-ethylhexyl group, n-nonyl group, n-decyl group, isodecyl group, n-undecyl group, and n-dodecyl group. More preferable alkyl groups are branched alkyl groups having 8 to 12 carbon atoms, more preferably branched alkyl groups having 8 to 10 carbon atoms, and specific examples include 2-ethylhexyl group and isodecyl group. Specific examples of glyceryl ether include 2-ethylhexyl glyceryl ether and isodecyl glyceryl ether, and 2-ethylhexyl glyceryl ether is preferred. (C) The glyceryl ether of a component may be used individually by 1 type, or may be used in combination of 2 or more type.
洗浄剤組成物中の（ｃ）成分の含有量は０．５〜５．０重量％であり、好ましい含有量は１〜３重量％であり、より好ましくは１．５〜２．５重量％である。油脂汚れに対する洗浄効果を低下させることなく、大腸菌等の細菌に対する殺菌効果を発揮させる観点から、当該含有量は０．５重量％以上が好ましく、油脂汚れに対する洗浄効果を低下させることなく、大腸菌等の細菌に対する殺菌効果を発揮させる観点と製品安定性の観点から、当該含有量は５．０重量％以下が好ましい。 The content of the component (c) in the cleaning composition is 0.5 to 5.0% by weight, preferably 1 to 3% by weight, more preferably 1.5 to 2.5% by weight. It is. From the viewpoint of exerting a bactericidal effect on bacteria such as Escherichia coli without reducing the cleaning effect on fat and oil stains, the content is preferably 0.5% by weight or more. The content is preferably 5.0% by weight or less from the viewpoint of exerting a bactericidal effect on the bacteria and the viewpoint of product stability.
（ａ）成分と（ｃ）成分との比率としては、重量比で（ａ）／（ｃ）＝１．５〜４．０の範囲が好ましく、１．５〜３．０の範囲がより好ましい。油脂汚れに対する洗浄効果を低下させることなく、大腸菌等の細菌に対する殺菌効果を発揮させる観点から、当該重量比は１．５以上が好ましく、製品安定性の観点から、当該重量比は４．０以下が好ましい。 The ratio of the component (a) to the component (c) is preferably in the range of (a) / (c) = 1.5 to 4.0 by weight ratio, more preferably in the range of 1.5 to 3.0. . The weight ratio is preferably 1.5 or more from the viewpoint of exerting a bactericidal effect against bacteria such as Escherichia coli without reducing the cleaning effect on fat and oil stains, and from the viewpoint of product stability, the weight ratio is 4.0 or less. Is preferred.
＜洗浄剤組成物＞
本発明の洗浄剤組成物は、水を媒体とする液状であることが望ましい。
<Cleaning agent composition>
The cleaning composition of the present invention is preferably in a liquid state using water as a medium.
さらに本発明の洗浄剤組成物は、通常の皮膚用洗浄剤組成物に用いられる成分、例えばエタノール等の低級アルコール類；グリセリン、プロピレングリコール、１，３−ブチレングリコール、ジプロピレングリコール、ソルビトール等の多価アルコール類；グアーガム等の植物由来の多糖類；キサンタンガム等の微生物由来の多糖類；ヒドロキシプロピルセルロース、カルボキシメチルセルロース等のセルロース類；染料、顔料等の着色剤；酢酸、クエン酸、リンゴ酸、乳酸、水酸化ナトリウム、水酸化カリウム等のｐＨ調整剤；塩化ナトリウム、硫酸ナトリウム等の無機塩類；植物エキス類；防腐剤；キレート剤；ビタミン剤；香料；抗炎症剤；酸化防止剤等を、本発明の効果を損なわない範囲で含有してもよい。 Furthermore, the cleaning composition of the present invention is a component used in a normal skin cleaning composition, for example, lower alcohols such as ethanol; glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol and the like. Polyhydric alcohols; polysaccharides derived from plants such as guar gum; polysaccharides derived from microorganisms such as xanthan gum; celluloses such as hydroxypropylcellulose and carboxymethylcellulose; colorants such as dyes and pigments; acetic acid, citric acid, malic acid, PH adjusters such as lactic acid, sodium hydroxide and potassium hydroxide; inorganic salts such as sodium chloride and sodium sulfate; plant extracts; antiseptics; chelating agents; vitamins; fragrances; anti-inflammatory agents; You may contain in the range which does not impair the effect of this invention.
本発明の洗浄剤組成物は、通常使用されている容器に充填して使用することが可能であるが、フォーマー容器に充填することにより、起泡性が良く、泡の安定性も良好となるため、フォーマー容器に充填することがより好ましい。 The cleaning composition of the present invention can be used by filling a container that is usually used, but by filling a former container, the foaming property is good and the foam stability is also good. Therefore, it is more preferable to fill the former container.
本発明の洗浄剤組成物は常法に従って製造することができる。さらに本発明の洗浄剤組成物は、身体用の液体殺菌洗浄剤として、例えばハンドソープ等の手指用の洗浄剤、ボディーシャンプー及びヘアーシャンプーとして用いられるのが好ましく、ハンドソープ等の手指用の洗浄剤として用いられるのがより好ましい。 The cleaning composition of the present invention can be produced according to a conventional method. Further, the cleaning composition of the present invention is preferably used as a liquid sterilizing cleaning agent for the body, for example, a cleaning agent for fingers such as hand soap, a body shampoo and a hair shampoo, and a cleaning for fingers such as hand soap. More preferably used as an agent.
以下、実施例を挙げてさらに詳細に説明する。なお、以下の実施例等における各成分の含有量は有効分を基準として示した。表１及び表２に、本発明品及び比較品の組成を示す。表１及び表２において、使用した成分は下記に示す番号で示した。 Hereinafter, an example is given and it demonstrates in detail. In addition, content of each component in a following example etc. was shown on the basis of the effective part. Tables 1 and 2 show the compositions of the product of the present invention and the comparative product. In Tables 1 and 2, the components used are indicated by the numbers shown below.
（ａ）成分〔ただし、説明の都合上、（ａ）成分との比較のために用いられる（ａ）成分の範囲外の成分も、表中では（ａ）成分の項目に記載した。〕
１：ポリオキシエチレン（１モル）アルキル（Ｃ10〜Ｃ16）エーテル硫酸アンモニウム、エマール１２５Ａ〔花王（株）製〕
２：ラウリル硫酸アンモニウム、エマールＡＤ−２５Ｒ〔花王（株）製〕
３：ポリオキシエチレン（２モル）アルキル（Ｃ10〜Ｃ16）エーテル硫酸アンモニウム、エマール２７０Ｓ−Ａ〔花王（株）製〕
４：ポリオキシエチレン（１モル）アルキル（Ｃ10〜Ｃ16）エーテル硫酸ナトリウム、エマール１７０−Ｊ〔花王（株）製〕
５：ポリオキシエチレン（２モル）アルキル（Ｃ10〜Ｃ16）エーテル硫酸ナトリウム、エマール２２７〔花王（株）製〕
６：ポリオキシエチレン（３モル）ラウリルエーテル硫酸トリエタノールアミン、エマール２０Ｔ〔花王（株）製〕
７：アルキル（Ｃ10〜Ｃ12）ポリグルコシド、ＡＧ−１０ＬＫ〔花王（株）製〕
Component (a) [However, for the sake of explanation, components outside the range of component (a) used for comparison with component (a) are also listed in the item of component (a) in the table. ]
1: polyoxyethylene (1 mol) alkyl (C 10 -C 16) ether sulfate, Emal 125A [manufactured by Kao Corporation]
2: Ammonium lauryl sulfate, Emar AD-25R [manufactured by Kao Corporation]
3: Polyoxyethylene (2 mol) alkyl (C 10 -C 16) ether sulfate, Emal 270 s-A [manufactured by Kao Corporation]
4: polyoxyethylene (1 mol) alkyl (C 10 -C 16) ether sulfate, Emal 170-J [manufactured by Kao Corporation]
5: Polyoxyethylene (2 mol) alkyl (C 10 -C 16) ether sulfate, Emal 227 [manufactured by Kao Corporation]
6: Polyoxyethylene (3 mol) lauryl ether triethanolamine sulfate, EMAL 20T [manufactured by Kao Corporation]
7: alkyl (C 10 -C 12) polyglucosides, AG-10LK [manufactured by Kao Corporation]
（ｂ）成分
８：トリクロサン、イルガサンＤＰ３００〔チバスペシャリティーケミカルズ（株）製〕
９：イソプロピルメチルフェノール、〔大阪化成（株）製〕
１０：パラクロロメタキシレノール、〔クラリアント（株）製〕
(B) Component 8: Triclosan, Irgasan DP300 [manufactured by Ciba Specialty Chemicals Co., Ltd.]
9: Isopropylmethylphenol [Osaka Kasei Co., Ltd.]
10: Parachlorometaxylenol, [manufactured by Clariant Co., Ltd.]
（ｃ）成分
１１：２−エチルヘキシルグリセリルエーテル、ペネトールＧＥ−ＥＨ〔花王（株）製〕
(C) Component 11: 2-ethylhexyl glyceryl ether, penetol GE-EH [manufactured by Kao Corporation]
（殺菌効果の試験方法と評価基準）
供試菌として、大腸菌（Escherichia coli NBRC3972）と黄色ブドウ球菌（Staphylococcus aureus NBRC13276）を用いた。予め、ＳＣＤ培地〔日本製薬（株）製〕にて前培養した培養液を準備した。培養液０．１ｍＬ（１０9〜１０10ｃｅｌｌ／ｍＬ）を、滅菌水で所定の濃度（組成物希釈倍率×１、×３、×１０、×４０）に希釈された４ｍＬの各洗浄剤組成物の希釈溶液に接種した。一定時間（１５秒、３０秒、４５秒、６０秒）毎に、各希釈溶液から一白金耳をとり、１ｍＬの生育用液体培地（ＳＣＤＬＰ培地〔日本製薬（株）製〕）に接種した。生育用液体培地を３７℃で２４時間培養した後、菌の生育の有無を観察した。
(Test method and evaluation criteria for bactericidal effect)
As test bacteria, Escherichia coli NBRC3972 and Staphylococcus aureus NBRC13276 were used. A culture solution pre-cultured in an SCD medium [manufactured by Nippon Pharmaceutical Co., Ltd.] was prepared in advance. 4 mL of each detergent composition obtained by diluting 0.1 mL (10 9 to 10 10 cells / mL) of the culture solution to a predetermined concentration (composition dilution ratio × 1, × 3, × 10, × 40) with sterilized water Inoculated into a diluted solution of the product. Every fixed time (15 seconds, 30 seconds, 45 seconds, 60 seconds), one platinum loop was taken from each diluted solution and inoculated into 1 mL of a growth medium (SCDLP medium [manufactured by Nippon Pharmaceutical Co., Ltd.]). After the growth liquid medium was cultured at 37 ° C. for 24 hours, the presence or absence of growth of the bacteria was observed.
菌の生育の有無の判定は目視で行った。即ち、培養後の培地に濁りが見られた場合、菌が生育したと判定した。一種類の洗浄剤組成物につき、４つの希釈濃度と４つの接触時間で殺菌効果の試験を行っているので、合計１６の生育用培地が用いられた。殺菌効果の判定は、菌の生育が認められなかった生育用培地の個数に応じて次のように行った。全希釈濃度、全反応時間に菌の生育が認められなかった場合（即ち、１６の生育用培地の全てについて菌の生育が認められなかった場合）を最高点（満点）の１６とし、全希釈濃度、全反応時間に菌の生育が認められた場合（即ち、１６の生育用培地の全てについて菌の生育が認められた場合）を最低点の０とした。即ち、０〜１６の間で値が高いほど、当該洗浄剤組成物の殺菌効果が高いことを意味する。 The presence or absence of fungal growth was determined visually. That is, when turbidity was observed in the cultured medium, it was determined that the bacteria had grown. Since one type of detergent composition was tested for bactericidal effect at 4 dilution concentrations and 4 contact times, a total of 16 growth media were used. The determination of the bactericidal effect was performed as follows according to the number of growth media in which the growth of bacteria was not observed. When no growth of bacteria was observed at all dilution concentrations and all reaction times (that is, when no growth of bacteria was observed on all 16 growth media), the maximum score (full score) was 16, and total dilution When the growth of bacteria was observed at the concentration and the total reaction time (that is, the growth of bacteria was observed on all 16 growth media), the lowest score was 0. That is, the higher the value between 0 and 16, the higher the bactericidal effect of the cleaning composition.
（洗浄効果の試験方法と評価基準）
下記の試料１及び試料２を油脂汚れのモデルとした。
試料１の油脂試料を０．５ｍＬ取り、掌に均一に塗布した。各洗浄剤組成物の１ｍＬで手を洗い（洗浄、すすぎ各１５秒、水温約３０℃、水道水、水量一定）油脂試料の残留感触により以下のように評価した。続いて試料２も同様な方法で評価した。
試料１：スクアラン（深海鮫肝臓抽出油）、試薬、〔東京化成工業（株）製〕
試料２：綿実油、試薬、〔関東化学（株）製〕
(Cleaning effect test method and evaluation criteria)
Samples 1 and 2 below were used as a model for oily and dirt stains.
0.5 mL of the oil / fat sample of Sample 1 was taken and applied uniformly to the palm. Hands were washed with 1 mL of each cleaning composition (washing and rinsing for 15 seconds each, water temperature of about 30 ° C., tap water, constant amount of water), and the following evaluation was made according to the residual feel of the oil and fat sample. Subsequently, Sample 2 was also evaluated in the same manner.
Sample 1: Squalane (deep sea bream liver extract oil), reagent, [manufactured by Tokyo Chemical Industry Co., Ltd.]
Sample 2: Cottonseed oil, reagent, [manufactured by Kanto Chemical Co., Ltd.]
洗浄効果の評価は５名のパネラーが行った。パネラーには、全ての洗浄剤組成物について、手洗い操作を同様に行うように指示し、各洗浄剤組成物のどれが本発明品でどれが比較品に該当するかを知らせなかった。油脂汚れが完全に落ちた場合を５とし、全く落ちなかったものを１として、１〜５の間の整数で洗浄効果を官能評価した。値が高いほど当該洗浄剤組成物の油脂汚れに対する洗浄効果が高いことを意味する。数値は試料１と試料２の平均値で判定し、小数第一位を四捨五入して整数で示した。 The cleaning effect was evaluated by five panelists. The panelist was instructed to perform the hand washing operation in the same manner for all the cleaning compositions, and did not inform which cleaning composition was the product of the present invention and which was a comparative product. The case where fat and oil stains were completely removed was set to 5, and the case where no oily stains were removed was set to 1, and the cleaning effect was sensory evaluated with an integer between 1 and 5. It means that the higher the value, the higher the cleaning effect of the cleaning composition against oil stains. The numerical value was determined by the average value of Sample 1 and Sample 2, and the first decimal place was rounded to the nearest whole number.
実施例１及び比較例１
表１及び表２に示す組成の洗浄剤組成物を常法に従い調製し、殺菌効果の試験と洗浄効果の試験を行った。結果を表１及び表２に示す。表中の配合成分の量を重量％で示した。また、本発明品と比較品の各組成物の２５℃のｐＨは、いずれも６であった。
Example 1 and Comparative Example 1
Cleaning compositions having the compositions shown in Tables 1 and 2 were prepared according to a conventional method, and a bactericidal effect test and a cleaning effect test were conducted. The results are shown in Tables 1 and 2. The amounts of the blending components in the table are shown in wt%. In addition, each of the compositions of the present invention and the comparative product had a pH of 6 at 25 ° C.
本発明品は、大腸菌及び黄色ブドウ球菌に対して高い殺菌効果を有し、かつ油脂汚れに対する洗浄効果も高いことが分かった。一方、比較品は殺菌効果が劣るかあるいは、黄色ブドウ球菌に効果があっても大腸菌に対して効果を示すものはなかった。 It was found that the product of the present invention has a high bactericidal effect against Escherichia coli and Staphylococcus aureus, and also has a high cleaning effect against fat and oil stains. On the other hand, the comparative product was inferior in bactericidal effect or had no effect on Escherichia coli even though it was effective against Staphylococcus aureus.
このように、本発明品は短時間（１分以内）の接触で、大腸菌及び黄色ブドウ球菌を効果的に殺滅していることが分かった。 Thus, it was found that the product of the present invention effectively killed Escherichia coli and Staphylococcus aureus in a short contact (within 1 minute).
界面活性剤の含有量が比較的多い洗浄剤組成物の場合、洗浄剤組成物に配合された殺菌剤の効果が阻害される傾向にあることが、本発明品及び比較品との比較で明らかになった。本発明者らは、これは界面活性剤の含有量が増加することによりミセルが形成され、殺菌剤がミセル中に取り込まれることが理由であると推定した。しかしながら本発明品のように、（ｃ）成分を洗浄剤組成物に配合することにより、配合された殺菌剤の効果が十分に発揮されることが分かった。 In the case of a detergent composition having a relatively high surfactant content, it is clear from the comparison between the present invention product and the comparative product that the effect of the disinfectant compounded in the detergent composition tends to be inhibited. Became. The inventors presume that this is because micelles are formed by increasing the surfactant content, and the bactericide is incorporated into the micelles. However, as in the present invention product, it was found that the effect of the blended bactericidal agent was sufficiently exhibited by blending the component (c) into the cleaning composition.
さらに、本発明品３及び６と比較品３とを対比すると、（ａ）成分がアンモニウム塩であってもそのエチレンオキシドの平均付加モル数が１．２を超える組成物では、所定量の（ｃ）成分を含有していても、殺菌効果が大きく低下することが分かった。 Furthermore, when the products 3 and 6 of the present invention and the comparative product 3 are compared, even if the component (a) is an ammonium salt, in a composition in which the average added mole number of ethylene oxide exceeds 1.2, a predetermined amount of (c ) It was found that the bactericidal effect is greatly reduced even if the component is contained.
本発明品３と比較品５とを対比すると、（ａ）成分のエチレンオキシドの平均付加モル数が０〜１．２の範囲であってもアンモニウム塩以外の塩である組成物では、所定量の（ｃ）成分を含有していても、殺菌効果が大きく低下することが分かった。 When the product 3 of the present invention is compared with the product 5 of comparison, the composition which is a salt other than the ammonium salt even if the average added mole number of the ethylene oxide of the component (a) is in the range of 0 to 1.2, (C) Even if it contained a component, it turned out that a bactericidal effect falls large.
本発明品３と比較品１とを対比すると、（ａ）成分が本発明の範囲内の成分であっても（ｃ）成分の量が本発明の範囲外である組成物では、大腸菌に対する殺菌効果が大きく低下することが分かった。 When the product 3 of the present invention is compared with the product 1 of comparison, the composition in which the amount of the component (c) is outside the scope of the present invention, even if the component (a) is within the scope of the present invention, is sterilized against Escherichia coli. It was found that the effect was greatly reduced.
比較品２と３、比較品４と５、比較品６と７及び比較品８と９をそれぞれ対比すると、（ａ）成分が本発明の範囲外の成分であれば、所定量の（ｃ）成分の有無に関わらず、（ｂ）成分による殺菌効果が十分に発揮されないことが分かった。 When comparing the comparative products 2 and 3, the comparative products 4 and 5, the comparative products 6 and 7, and the comparative products 8 and 9, respectively, if the component (a) is outside the scope of the present invention, a predetermined amount of (c) It was found that the bactericidal effect of the component (b) was not sufficiently exhibited regardless of the presence or absence of the component.
さらに、本発明品１１〜１３からは、（ｂ）成分としてトリクロサン(b1)、イソプロピルメチルフェノール(b2)又はパラクロロメタキシレノール(b3)を単独で用いた場合であっても、優れた殺菌効果と洗浄効果が発揮されることが分かった。一方、比較品１１及び１２からは、（ｂ）成分としてトリクロサン(b1)を用いた場合であっても、（ｃ）成分が存在しない組成物の殺菌効果は不十分であることが分かった。 Further, from the products 11 to 13 of the present invention, even when triclosan (b1), isopropylmethylphenol (b2) or parachlorometaxylenol (b3) is used alone as the component (b), an excellent bactericidal effect is obtained. It was found that the cleaning effect was exhibited. On the other hand, from comparative products 11 and 12, it was found that even when triclosan (b1) was used as the component (b), the bactericidal effect of the composition without the component (c) was insufficient.
このように、本発明の構成を完全に満たすことによって初めて、洗浄効果を低下させることなく殺菌効果に優れた洗浄剤組成物が提供できることが分かった。 Thus, it was found that only when the configuration of the present invention was completely satisfied, a cleaning composition having an excellent bactericidal effect could be provided without reducing the cleaning effect.
実施例２（ハンドソープ）
以下に示す組成のハンドソープを常法により製造した。得られたハンドソープはｐＨ６．５（２５℃）であり、洗浄性に優れかつ殺菌効果の高いものであった。
Example 2 (hand soap)
A hand soap having the following composition was produced by a conventional method. The obtained hand soap had a pH of 6.5 (25 ° C.), was excellent in cleanability and had a high bactericidal effect.
・ポリオキシエチレン（１モル）アルキルエーテル硫酸アンモニウム：５．０（重量％）
・２−エチルヘキシルグリセリルエーテル：２．５（重量％）
・エタノール：２．０（重量％）
・トリクロサン：０．３（重量％）
・イソプロピルメチルフェノール：０．２（重量％）
・エチレンジアミン四酢酸ナトリウム：０．１（重量％）
・メチルパラベン：０．２（重量％）
・色素：０．００１（重量％）
・香料：０．０１（重量％）
・リンゴ酸：適量
・精製水：バランス
・合計：１００（重量％）
・ Polyoxyethylene (1 mole) alkyl ether ammonium sulfate: 5.0 (% by weight)
2-ethylhexyl glyceryl ether: 2.5 (% by weight)
・ Ethanol: 2.0 (% by weight)
・ Triclosan: 0.3 (% by weight)
・ Isopropylmethylphenol: 0.2 (% by weight)
・ Sodium ethylenediaminetetraacetate: 0.1 (% by weight)
・ Methylparaben: 0.2 (% by weight)
-Dye: 0.001 (wt%)
-Fragrance: 0.01 (% by weight)
・ Malic acid: appropriate amount ・ Purified water: balance ・ Total: 100 (% by weight)
本発明の洗浄剤組成物は、短い使用時間で高い殺菌効果が奏され、かつ油脂汚れに対する優れた洗浄効果を有するため、身体用の液体殺菌洗浄剤組成物として好適に使用し得る。 Since the cleaning composition of the present invention has a high sterilizing effect in a short use time and has an excellent cleaning effect against oil and fat stains, it can be suitably used as a liquid sterilizing cleaning composition for the body.
Claims (4)
ＲＯ（ＣＨ2ＣＨ2Ｏ）nＳＯ3・ＮＨ4
（式中、Ｒは炭素数８〜１８のアルキル基であり、ｎは平均付加モル数を示し、ｎ＝０〜１．２である。）で示されるアニオン性界面活性剤を３〜１０重量％、
（ｂ）成分：
トリクロサン(b1)、イソプロピルメチルフェノール(b2)及びパラクロロメタキシレノール(b3)からなる群より選択される少なくとも１種の成分を０．１〜１．０重量％、並びに
（ｃ）成分：グリセリルエーテルを０．５〜５．０重量％
含有する洗浄剤組成物。 (A) Component:
RO (CH 2 CH 2 O) n SO 3 .NH 4
(Wherein R is an alkyl group having 8 to 18 carbon atoms, n represents the average number of added moles, and n = 0 to 1.2) 3 to 10 wt. %,
(B) Component:
0.1 to 1.0% by weight of at least one component selected from the group consisting of triclosan (b1), isopropylmethylphenol (b2) and parachlorometaxylenol (b3), and (c) component: glyceryl ether 0.5 to 5.0% by weight
A cleaning composition to contain.
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