JP5372028B2 - 薬剤投与システム - Google Patents
薬剤投与システム Download PDFInfo
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- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
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Description
予想される1回呼吸量=Cx平均のピーク流量x吸息時間/60Cは定数であり、C=0.7であることが知られている。
Claims (31)
- 薬剤投与装置であって、
薬剤を含む空気と薬剤を含まない空気とを選択的に送達する薬剤投与デバイスであって、前記薬剤を含む空気を生成するために薬剤を噴霧する手段を有する、薬剤投与デバイスと、
患者の呼吸パターンを観察するセンサと、
前記患者が吸入を開始したと前記センサが観察した時に開始するパルスで薬剤を含んだ空気を送達するように前記薬剤投与デバイスを制御するように構成されたコントローラであって、前記パルスは前記患者の前記観察された呼吸パターンに基づいてコントローラによって調節された長さを有するコントローラと、
前記薬剤を含んだ空気の送達中に観察される前記呼吸パターンに従って、前記薬剤を含んだ空気の吸入が適切に行われているか行われていないかを当該吸入の最中に患者に示すフィードバックインジケータと、
患者に送達された投与量を計算する投与量計算器と、
所望の投与量の送達が終了したことを前記患者に示すインジケータとを備える装置。 - 前記コントローラは前記患者の観察された呼吸パターンに基づいて各パルスの長さを決定するパルス長生成装置を含む請求項1に記載の装置。
- 前記パルス長生成装置は、患者の呼吸パターンを分析し、患者が最終体積を吸入し始めた時を決定する呼吸パターン分析装置を含み、前記最終体積は、吸入の終了時に肺に到達しない空気の最終体積を含む患者の上部気道の体積である請求項2に記載の装置。
- 前記パルス長生成装置は薬剤を含んだ空気を前記最終体積に送達することを停止する長さを有するパルスを生成する請求項3に記載の装置。
- 前記呼吸パターン分析装置は、
患者の一回換気量を測定する一回換気量測定デバイスと、
前記患者の吸入の長さを測定するタイマと、
前記患者の上部気道の体積の推定値を記憶する推定値記憶デバイスと、
前記測定された一回換気量、測定された吸息の長さ、および前記記憶された患者の上部気道の体積の推定値に基づいて、前記患者が前記最終体積の吸入を開始した時を決定する最終体積推定装置とを含む請求項3または4のいずれか一項に記載の装置。 - 前記分析装置はさらに平均化デバイスを含み、前記平均化デバイスは、複数の呼吸に渡って前記分析装置が収集した値の平均値に基づいて、前記患者が前記最終体積の吸入を開始した時を決定する請求項5に記載の装置。
- 前記薬剤を含んだ空気の吸入が適切に行われていない場合、前記パルスの送達が停止される、請求項1から6のいずれか一項に記載の装置。
- 前記投与量計算器は処方入力を含み、前記処方入力を介して投与量計算器が行う計算で使用される、送達されている薬剤の処方が入力される請求項1から7のいずれか一項に記載の装置。
- 送達された投与量を含む、各処置に関する情報を記録するためのデータログをさらに備える請求項1から8のいずれか一項に記載の装置。
- 前記センサは圧力センサである請求項1から9のいずれか一項に記載の装置。
- 前記フィードバックインジケータは、前記装置を振動させて前記患者が効果的に吸入していることを示すバイブレータである請求項1から10のいずれか一項に記載の装置。
- 前記薬剤投与デバイスは、保持チャンバを画定する容器を含むスペーサであって、前記保持チャンバ内の空気は処置の前に薬剤を負荷される請求項1から11のいずれか一項に記載の装置。
- 前記薬剤投与デバイスは、前記患者に導かれる空気の流れを吸入している間、薬剤を噴霧する噴霧器である請求項1から11のいずれか一項に記載の装置。
- 前記薬剤投与デバイスはメッシュタイプの噴霧器である請求項13に記載の装置。
- 前記薬剤投与デバイスは薬剤の噴霧が圧縮空気で行われる空気式噴霧器である請求項13に記載の装置。
- 請求項1から15のいずれか一項に記載の薬剤投与装置において用いられる、約19mgのトブラマイシンが溶媒内に溶解されている薬剤。
- 前記溶媒は体積が約0.3mlである、請求項16に記載の薬剤。
- 前記投与装置のデッドボリュームを満たし、送達できる薬剤がすべて送達された後に残る、約0.1mlから0.8mlの溶液中に約6mgから50mgというさらなる量のトブラマイシンをさらに含む、請求項16または17に記載の薬剤。
- 前記トブラマイシンの濃度は約60mg/mlである、請求項16または18のいずれか一項に記載の薬剤。
- 請求項1から15のいずれか一項に記載の薬剤投与装置において用いられる、約187000Uのコリスチンを含む薬剤。
- 次の溶液のうち1つの中に約100万ユニット/2mlの濃度のコリスチンが含まれる請求項20に記載の薬剤であり、前記溶液は
a)0.9%の塩化ナトリウム2ml
b)0.9%の塩化ナトリウム0.75mlと、水1.275mlを含んだ2mlの溶媒
c)0.9%の塩化ナトリウム2.5mlにサルブタモール2.5mgを含んだ溶液
d)0.75%、0.9%の塩化ナトリウムと水1.275mlの中にサルブタモール2.5mgを含んだ溶液
e)0.9%の塩化ナトリウム2.5mlにデオキシリボヌクレアーゼ2.5mgを含んだ溶液、又は
f)0.9%の塩化ナトリウム2.5mlにデオキシリボヌクレアーゼ2.5mgとサルブタモール2.5mgを含んだ溶液
のいずれかである請求項20に記載の薬剤。 - 前記投与装置のデッドボリュームを満たし、送達できる薬剤がすべて送達された後に残る約0.1mlから0.8mlというさらなる量の薬剤をさらに含む請求項20または21に記載の薬剤。
- 請求項1から15のいずれか一項に記載の薬剤投与装置において用いられる、溶媒内に約0.156mgのデオキシリボヌクレアーゼを含む薬剤。
- 前記溶媒は約0.156mlの体積を有する、請求項23に記載の薬剤。
- 前記投与装置のデッドボリュームを満たし、送達できる薬剤がすべて送達された後に残る約0.1mlから0.8mlというさらなる量の薬剤をさらに含む請求項23または24に記載の薬剤。
- 請求項1から15のいずれか一項に記載の薬剤投与装置において用いられる、溶媒内に約12.5mgのA1ATを含む薬剤。
- 前記溶媒は約0.25mlの体積を有する、請求項26に記載の薬剤。
- 0.1mlから0.8mlというさらなる量の溶媒をさらに含む、請求項26または27に記載の薬剤。
- 請求項1から15のいずれか一項に記載の薬剤投与装置において用いられる、溶媒内に約25μgのブデソニドを含む薬剤。
- 前記溶媒の体積は約0.05mlである、請求項29に記載の薬剤。
- 請求項16から25のいずれか一項に記載の薬剤を供給するパッケージであって、前記パッケージは、複数の部分に分かれており、前記薬剤の送達の前に前記パッケージ内で薬剤成分が混合される、パッケージ。
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JP2001557622A Expired - Lifetime JP4777574B2 (ja) | 2000-02-11 | 2001-02-12 | 薬剤投与装置 |
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US (1) | US8464706B2 (ja) |
EP (2) | EP1944036A3 (ja) |
JP (2) | JP4777574B2 (ja) |
AT (1) | ATE444771T1 (ja) |
AU (2) | AU2001235009B2 (ja) |
CA (2) | CA2399464C (ja) |
DE (1) | DE60140121D1 (ja) |
NO (1) | NO20023727L (ja) |
NZ (1) | NZ521051A (ja) |
WO (1) | WO2001058514A1 (ja) |
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AU2001235009B2 (en) | 2004-10-07 |
DE60140121D1 (de) | 2009-11-19 |
NZ521051A (en) | 2003-07-25 |
EP1292347A1 (en) | 2003-03-19 |
JP4777574B2 (ja) | 2011-09-21 |
NO20023727D0 (no) | 2002-08-07 |
EP1944036A2 (en) | 2008-07-16 |
CA2635489A1 (en) | 2001-08-16 |
JP2011087968A (ja) | 2011-05-06 |
ATE444771T1 (de) | 2009-10-15 |
EP1292347B1 (en) | 2009-10-07 |
US8464706B2 (en) | 2013-06-18 |
AU3500901A (en) | 2001-08-20 |
NO20023727L (no) | 2002-09-18 |
US20030205229A1 (en) | 2003-11-06 |
WO2001058514A1 (en) | 2001-08-16 |
CA2399464A1 (en) | 2001-08-16 |
JP2003522003A (ja) | 2003-07-22 |
EP1944036A3 (en) | 2009-01-14 |
CA2399464C (en) | 2008-10-07 |
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