JP5328660B2 - 血球計算法による治療のための手段および方法 - Google Patents
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
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Description
本出願は、2006年11月1日および2006年12月7日にそれぞれ出願された米国特許仮出願第60/855,956号および同第60/873,314号の優先権を主張するものであり、いずれの出願もその全体が参照によって本明細書に組み込まれている。
本発明は、米国エネルギー省とU.T. Battelle, LLC社間の契約書第DE−AC05−00OR22725のもと、米国政府の支援によって行われた。
(実施例1)本発明のカテーテルの実施例
2 光送出ファイバ
3 蛍光および散乱測定ファイバ
4 減衰測定ファイバ
5 側部ポート
6 スタブ
7 ファイバ位置合わせ溝
8 内部構造チャンバ
9 結合点
10、11、52、53、54 光学信号
12 マイクロコイル
13 リード
14 シールド
15 連結点
16、17 材料の帯
18、32 ポート穴
19 患者
20 MR画像手段
21 神経カテーテル
22 神経カテーテル固定装置
23 運搬管
24 運搬シリンジ
25 駆動機構
26 光ファイバ
27 光変換器手段
28 測定手段
29 注入制御システム
31 カテーテル壁
33 励起光
34 自己蛍光細胞
35 光学的放射
36 検出システム
37 インタロゲーション光
38 細胞
39 ルミネセンス
40、41、42 励起およびインタロゲーション光線
43、44、45 細胞クラスタ
46、47、49 特有のルミネセンス信号
50 収集光ファイバ
51 スプリッタ
55 分光計
56 光電子増倍管
57 フォトダイオード
Claims (14)
- 内腔、遠位端および近位端を有しているカテーテル本体と、
前記カテーテル本体の遠位端に取り外し可能に結合されている遠位カテーテル先端部本体と、
前記遠位カテーテル先端部本体内に形成された少なくとも1つのポート穴と、
光ファイバを配置するために、前記カテーテル先端部本体内において軸方向に位置合わせされた複数の位置合わせ溝と、
前記遠位カテーテル先端部本体と前記カテーテル本体を結合させるための係合機構と、
前記内腔から少なくとも1つの前記ポート穴に材料を通過させるための少なくとも1つの内部構造チャンバと、
少なくとも1つの前記ポート穴近傍で光を送出し、少なくとも1つの前記ポート穴近傍で光を収集するために前記位置合わせ溝内に配設された複数の光ファイバであって、細胞が少なくとも1つの前記ポート穴を通過するとき、蛍光強度、蛍光励起、および蛍光散乱の変化を測定する複数の光ファイバと、
少なくとも1つの前記ポート穴近傍における前記光ファイバに、および前記光ファイバから光を導くために少なくとも1つのミラー端部を有している複数の光ファイバスタブとを備えていることを特徴とするカテーテル。 - 蛍光励起および蛍光散乱が、異なる波長で測定されることを特徴とする請求項1に記載のカテーテル。
- 前記係合機構が、管状機械スリーブ又はブッシュとされる少なくとも1つの連結装置を備えていることを特徴とする請求項1に記載のカテーテル。
- 前記遠位カテーテル先端部本体に取り外し可能に配設された少なくとも1つのマイクロコイルを備えていることを特徴とする請求項1に記載のカテーテル。
- 磁気共鳴コントラスト増強剤を備えていることを特徴とする請求項1に記載のカテーテル。
- X線不透過性材料を備えていることを特徴とする請求項1に記載のカテーテル。
- 複数の内部構造チャンバを備えていることを特徴とする請求項1に記載のカテーテル。
- 前記光ファイバスタブが、光学光線を制御するためにミラー表面を備えていることを特徴とする請求項1に記載のカテーテル。
- 前記光ファイバスタブが、凹状のミラー表面を備えていることを特徴とする請求項1に記載のカテーテル。
- 前記光ファイバスタブが、光学信号の焦点を変更するために回転することを特徴とする請求項1に記載のカテーテル。
- 複数のポート穴を備えていることを特徴とする請求項1に記載のカテーテル。
- カテーテルの遠位先端部の光ファイバと、少なくとも1つのポート穴近傍における前記光ファイバに、および前記光ファイバから光を導くために少なくとも1つのミラー端部を有している複数の光ファイバスタブと、を利用する測定制御システムであって、
カテーテルの遠位先端部に形成された1つ以上の前記ポート穴近傍に光を送出し、
細胞、他の材料、又は種が前記遠位先端部の前記ポート穴の領域を通じて輸送されることによって、発せられた蛍光信号を収集し、
前記細胞、前記他の材料、又は前記種が前記遠位先端部の前記ポート穴の前記領域を通じて輸送されることによって、散乱された散乱光を収集し、
前記細胞、前記他の材料、又は前記種が前記遠位先端部の前記ポート穴の前記領域を通じて輸送されることによって、減衰された減衰光を収集し、
光ファイバ内の前記散乱光および前記減衰光を、前記光学信号を電気信号に変換した後に前記電気信号を血球計算法による細胞計数に変換する測定手段に導き、及び
前記血球計算法による細胞計数に従って輸送手段を調節し、これにより前記細胞、前記他の材料、又は前記種を含有するスラリーを前記カテーテルの前記遠位先端部内に導くことを特徴とする、測定制御システム。 - 前記光ファイバが、患者の脳内で神経細胞および他の細胞のために神経ニッチを構成する間質性の空間内におけるドーパミン、他の神経伝達物質、作用物質、又は化学物質のレベルを感知することを特徴とする請求項12に記載の測定制御システム。
- 治療を実施する臨床医によって手動で動作されるか、又はコンピュータベース若しくは他の自動データ処理装置、システム、若しくは手段によって自動的に動作されることを特徴とする請求項12に記載の測定制御システム。
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