JP5258144B2 - Method for producing solid coenzyme Q10 oral preparation with improved absorbability - Google Patents
Method for producing solid coenzyme Q10 oral preparation with improved absorbability Download PDFInfo
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- JP5258144B2 JP5258144B2 JP2004368737A JP2004368737A JP5258144B2 JP 5258144 B2 JP5258144 B2 JP 5258144B2 JP 2004368737 A JP2004368737 A JP 2004368737A JP 2004368737 A JP2004368737 A JP 2004368737A JP 5258144 B2 JP5258144 B2 JP 5258144B2
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- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 title claims description 75
- 235000017471 coenzyme Q10 Nutrition 0.000 title claims description 73
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 title claims description 72
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- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
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- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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Images
Description
本発明は、吸収性の改善されたコエンザイムＱ１０経口製剤、特にコエンザイムＱ１０の吸収性が悪い人に対しても良好な吸収性を示すコエンザイムＱ１０経口製剤に関する。 The present invention relates to a coenzyme Q10 oral preparation having improved absorbability, and particularly to a coenzyme Q10 oral preparation exhibiting good absorbability even for a person with poor absorbability of coenzyme Q10.
コエンザイムＱ１０は、生体内の細胞中におけるミトコンドリアの電子伝達系構成成分として存在する生理学的成分であり、生体内において酸化と還元を繰り返すことで電子伝達系における伝達成分としての機能を担っている。コエンザイムＱ１０は生体において、エネルギー生産、膜安定化および抗酸化活性を示すことから、その有用性は広く知られている。コエンザイムＱ１０は、ヒトの体内で生合成される分子であるが、加齢と共に生合成量が低下することや、様々な疾患において生体中のコエンザイムＱ１０が減少することが報告されている。そして、このような疾患では、外部からのコエンザイムＱ１０の供給が良好な結果をもたらすことも知られている。更に、罹患時だけではなく老人や肉体的に疲労したときなど、平常時でもコエンザイムＱ１０の補給が必要であると考えられている。 Coenzyme Q10 is a physiological component that exists as a constituent component of the mitochondrial electron transfer system in cells in the living body, and plays a role as a transfer component in the electron transfer system by repeating oxidation and reduction in the living body. Since coenzyme Q10 exhibits energy production, membrane stabilization and antioxidant activity in the living body, its usefulness is widely known. Coenzyme Q10 is a molecule that is biosynthesized in the human body, but it has been reported that the amount of biosynthesis decreases with age and that coenzyme Q10 in living bodies decreases in various diseases. And in such a disease, it is also known that supply of coenzyme Q10 from the outside brings about a favorable result. Furthermore, it is considered that coenzyme Q10 needs to be replenished not only at the time of illness but also at normal times such as when the elderly or physically fatigued.
コエンザイムＱ１０のうち、酸化型コエンザイムＱ１０は、鬱血性心不全薬として医療用途に用いられている。医薬用途以外では、ビタミン類同様、栄養剤、栄養補助剤として用いられる他、痴呆症などの老人性の疾患、アレルギー疾患に対する有効性、あるいは運動能力の増加なども報告されている。また、安全性が高いことから有用な栄養補給の手段として、各種の健康食品、サプリメント等としても使用されている。しかしながら、コエンザイムＱ１０は疎水性の分子であるため経口吸収性が悪く、充分な効果が得られにくいため期待されたほどの効果が得られていないのが現状である。 Of coenzyme Q10, oxidized coenzyme Q10 is used for medical use as a congestive heart failure drug. As well as vitamins, it is used as a nutritional supplement and a nutritional supplement, as well as vitamins, and it has been reported that it is effective for senile diseases such as dementia, effectiveness against allergic diseases, or increased exercise capacity. Moreover, since it is highly safe, it is also used as various health foods, supplements, and the like as a useful nutritional supplement. However, since coenzyme Q10 is a hydrophobic molecule, its oral absorbability is poor, and it is difficult to obtain a sufficient effect, so that the expected effect is not obtained.
コエンザイムＱ１０の経口吸収性を改善するために種々の提案がなされており、例えばコエンザイムＱ１０を落花生油、大豆油、オリーブ油等の食用油に溶解させてカプセル化したものや（例えば特許文献１、２参照）、コエンザイムＱ１０を多価不飽和脂肪酸に配合してマヨネーズとしたものがある（特許文献３参照）。
これらの提案は、いずれも常温で液状の不飽和脂肪酸或いはそのエステル（グリセリンエステル）を主成分とする油脂類にコエンザイムＱ１０を溶解ないし分散させたものであり、コエンザイムＱ１０を錠剤としたものよりは一般に吸収性が良いと言われている。しかしながら、コエンザイムＱ１０の経口吸収性には人により大きな差異があり、これら従来の技術で得られたコエンザイムＱ１０では、経口吸収性の良い人と悪い人の間では５〜６倍の差異が生じると言われている。 また、コエンザイムＱ１０をソフトカプセル等の形態としたものは、老人や病人にとっては飲みにくく、より容易に経口摂取することのできるコエンザイムＱ１０製剤が求められていた。 In these proposals, coenzyme Q10 is dissolved or dispersed in an oil and fat mainly composed of an unsaturated fatty acid or an ester thereof (glycerin ester) which is liquid at room temperature. Generally, it is said that the absorbency is good. However, there is a large difference in the oral absorbability of coenzyme Q10, and in the case of coenzyme Q10 obtained by these conventional techniques, a difference of 5 to 6 times occurs between a person with good oral absorption and a bad person. It is said. In addition, when coenzyme Q10 is in the form of a soft capsule or the like, there has been a demand for a coenzyme Q10 preparation that is difficult for the elderly and sick to take and can be taken orally more easily.
したがって、本発明は上記従来技術の問題点を解消して、コエンザイムＱ１０の経口吸収性が悪い人にも効率良く経口吸収されるとともに、老人や病人でも容易に摂取することができる、経口吸収性の改善されたコエンザイムＱ１０製剤を提供することを目的とする。 Therefore, the present invention solves the above-mentioned problems of the prior art, and can be efficiently orally absorbed even by people with poor oral absorbability of coenzyme Q10, and can be easily ingested by the elderly and sick. It is an object of the present invention to provide an improved coenzyme Q10 preparation.
本発明者等は鋭意検討した結果、常温で固体の飽和脂肪酸多価アルコールエステルにコエンザイムＱ１０を分散させて製剤化することによって、上記課題が解決されることを見出し本発明を完成したものである。 As a result of intensive studies, the present inventors have found that the above problems can be solved by dispersing Coenzyme Q10 in a saturated fatty acid polyhydric alcohol ester that is solid at room temperature, thereby completing the present invention. .
すなわち、本発明はつぎの１又は２の構成をとるものである。
１．常温で固体の炭素数１６〜１８の飽和脂肪酸のトリグリセリンエステル１００重量部に、１〜１５重量部の粉末又は粒状のコエンザイムＱ１０を分散させて含有させることを特徴とする吸収性の改善された固形状のコエンザイムＱ１０経口製剤の製造方法。
２．経口製剤が固形状の加工食品であることを特徴とする１に記載の経口製剤の製造方法。
That is, the present invention has the following configuration 1 or 2.
1. To 100 parts by weight of triglycerol esters of saturated fatty acids of 16 to 18 carbon atoms in a solid state at room temperature, it was improved absorbent, characterized in that to contain dispersed coenzyme Q10 powder or granular 1-15 parts by weight A method for producing a solid coenzyme Q10 oral preparation.
2. 2. The method for producing an oral preparation according to 1, wherein the oral preparation is a solid processed food .
本発明によれば、従来のコエンザイムＱ１０製剤では経口吸収性の悪い人に対しても、著しく経口吸収性が改善されたコエンザイムＱ１０製剤を得ることができる。本発明のコエンザイムＱ１０製剤は、従来のコエンザイムＱ１０製剤で経口吸収性の良い人に対しても、同等以上の経口吸収性を示すとともに、食後に限らず空腹時に摂取した場合にも経口吸収性が低下しない。また、チョコレートやクッキー等の固形状の加工食品の形態とすることにより、老人や病人でもおやつを食べるような感覚で容易に摂取することができる。 According to the present invention, it is possible to obtain a coenzyme Q10 preparation having a significantly improved oral absorption even for a person with poor oral absorption in the conventional coenzyme Q10 preparation. The coenzyme Q10 preparation of the present invention exhibits an oral absorption equivalent to or better than that of the conventional coenzyme Q10 preparation, and also has an oral absorption when taken on an empty stomach as well as after meals. It does not decline. Moreover, by setting it as the form of solid processed foods, such as chocolate and a cookie, even an elderly person or a sick person can ingest easily with the feeling which eats a snack.
本発明では、常温で固体の炭素数１６〜１８の飽和脂肪酸のトリグリセリンエステルに粉末又は粒状のコエンザイムＱ１０を分散させることにより、吸収性の改善されたコエンザイムＱ１０経口製剤を調製する。
コエンザイムＱ１０としては酸化型、還元型或いはこれらの混合物のいずれでもよいが、通常は酸化型コエンザイムＱ１０を使用する。
In the present invention, a coenzyme Q10 oral preparation with improved absorbability is prepared by dispersing powder or granular coenzyme Q10 in a triglycerin ester of a saturated fatty acid having 16 to 18 carbon atoms that is solid at room temperature.
Coenzyme Q10 may be oxidized, reduced, or a mixture thereof, but usually oxidized coenzyme Q10 is used.
常温で固体の炭素数１６〜１８の飽和脂肪酸のトリグリセリンエステルを構成する脂肪酸の具体例としては、パルミチン酸、ヘプタデシル酸及びステアリン酸が挙げられる。Specific examples of the fatty acid constituting the triglycerin ester of a saturated fatty acid having 16 to 18 carbon atoms that is solid at normal temperature include palmitic acid, heptadecylic acid, and stearic acid.
前記飽和脂肪酸のトリグリセリンエステルは合成品、天然品のいずれでもよい。また、種類の異なる脂肪酸のトリグリセリンエステルを組み合わせて使用してもよい。また、飽和脂肪酸のトリグリセリンエステルの供給源として、カカオバターのような天然の油脂を使用してもよい。 The triglycerin ester of the saturated fatty acid may be a synthetic product or a natural product . Further, triglycerin esters of different types of fatty acids may be used in combination. Moreover, you may use natural fats and oils, such as cocoa butter, as a supply source of the triglycerin ester of saturated fatty acid.
常温で固体の炭素数１６〜１８の飽和脂肪酸のトリグリセリンエステルとコエンザイムＱ１０の配合割合は、常温で固体の炭素数１６〜１８の飽和脂肪酸のトリグリセリンエステル１００重量部に対してコエンザイムＱ１０を１〜１５重量部とする。
コエンザイムＱ１０の配合割合が少ない場合には、必要とされるコエンザイムＱ１０を摂取するために、多量の経口製剤をとることが必要となる。一方、コエンザイムＱ１０の配合割合が多い場合には、エステル中に均一に分散させることが困難になる。
The blending ratio of the triglycerin ester of saturated fatty acid having 16 to 18 carbon atoms and coenzyme Q10 that is solid at normal temperature is 1 coenzyme Q10 with respect to 100 parts by weight of triglycerin ester of saturated fatty acid having 16 to 18 carbon atoms that is solid at normal temperature. ˜15 parts by weight.
When the proportion of coenzyme Q10 is small, it is necessary to take a large amount of oral preparation in order to ingest the required coenzyme Q10. On the other hand, when the proportion of coenzyme Q10 is large, it becomes difficult to uniformly disperse in the ester.
本発明のコエンザイムＱ１０経口製剤は、常温で固体の炭素数１６〜１８の飽和脂肪酸のトリグリセリンエステルとコエンザイムＱ１０の配合物のみにより構成することができる。また、この配合物に、必要に応じてビタミンＡ、ビタミンＢ１、ビタミンＢ６、ビタミンＢ１２、ビタミンＣ、ビタミンＥ等のビタミン類やその誘導体；ミネラル類；生薬；ハーブ類や；乳糖、ショ糖、デキストリン、澱粉、結晶セルロース等の賦形剤；甘味料；香料等を添加することもできる。 The coenzyme Q10 oral preparation of the present invention can be composed only of a blend of a triglycerin ester of a saturated fatty acid having 16 to 18 carbon atoms that is solid at room temperature and coenzyme Q10. In addition, vitamins such as vitamin A, vitamin B1, vitamin B6, vitamin B12, vitamin C and vitamin E and their derivatives; minerals; herbal medicines; herbs; lactose, sucrose, Excipients such as dextrin, starch and crystalline cellulose; sweeteners; flavors and the like can also be added.
本発明のコエンザイムＱ１０経口製剤の形態には特に制限はないが、例えばチョコレートのような固形状の加工食品、或いはこのような加工食品を塗布又は含有するビスケット、クッキー等の加工食品とした場合には、おやつを食する感覚で容易に摂取することができるので好ましい。また、上記固形状の加工食品を、調味料のように各種の食品類に添加してもよい。 The form of the coenzyme Q10 oral preparation of the present invention is not particularly limited. For example, in the case of a solid processed food such as chocolate, or a processed food such as biscuits and cookies coated or containing such processed food. Is preferable because it can be easily ingested as if eating a snack. Moreover, you may add the said solid processed food to various foodstuffs like a seasoning.
本発明のコエンザイムＱ１０経口製剤の製造方法の具体例としては、例えば、（１）常温で固体の炭素数１６〜１８の飽和脂肪酸のトリグリセリンエステルを加熱溶解し、粉末或いは粒状のコエンザイムＱ１０を加えて加熱しながら充分に撹拌混合した後に冷却する、（２）微粉砕した常温で固体の炭素数１６〜１８の飽和脂肪酸のトリグリセリンエステル及びコエンザイムＱ１０を乳鉢等で混合し、加熱溶解後冷却する、等の方法が挙げられる。 As specific examples of the method for producing the coenzyme Q10 oral preparation of the present invention , for example, (1) a triglycerin ester of a saturated fatty acid having 16 to 18 carbon atoms that is solid at room temperature is dissolved by heating, and powdered or granular coenzyme Q10 is added. (2) Mix pulverized triglycerin ester of saturated fatty acid having 16 to 18 carbon atoms and coenzyme Q10 in a mortar or the like, and cool after heating and dissolving. And the like.
つぎに、実施例により本発明の経口製剤についてさらに説明するが、以下の具体例は本発明を限定するものではない。
（実施例１）
コエンザイムＱ１０粉末１０ｇ、カカオマス（カカオバターを、約５０重量％含有する）２５０ｇ、ショ糖２４０ｇを粉砕混合し、加熱溶解した後にアルミ箔からなる型枠に流し込み、冷却後冷蔵庫中で固化させて１個の重量が１５ｇのチョコレート様の経口製剤を調製した。この経口製剤１個には、３００ｍｇのコエンザイムＱ１０が含有されている。
Next, the oral preparation of the present invention will be further described with reference to examples, but the following specific examples do not limit the present invention.
Example 1
10 g of coenzyme Q10 powder, 250 g of cacao mass ( containing cacao butter, about 50% by weight) and 240 g of sucrose are pulverized and mixed, dissolved by heating, poured into a mold made of aluminum foil, solidified in a refrigerator after cooling, and 1 A chocolate-like oral formulation weighing 15 g was prepared. One oral preparation contains 300 mg of coenzyme Q10.
（経口吸収性試験）
４名の被験者を対象として、実施例１で得られた経口製剤を７日間投与し、８日目の午後３時頃に採血し、血漿中のコエンザイムＱ１０の濃度を、「Yamashita and Y. Yamamoto, Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress, Anal. Biochem., 250, 66-73(1997)」に記載の方法に準じて測定した。
被験者１〜３には、毎夕食後に３００ｍｇのコエンザイムＱ１０を含む経口製剤１個を投与し、被験者４には朝食前の空腹時に同じく経口製剤１個を投与した。
(Oral absorbability test)
For 4 subjects, the oral preparation obtained in Example 1 was administered for 7 days, blood was collected at about 3 pm on the 8th day, and the concentration of coenzyme Q10 in plasma was determined as “Yamashita and Y. Yamamoto , Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress, Anal. Biochem., 250, 66-73 (1997) ”.
Subjects 1 to 3 received one oral formulation containing 300 mg of coenzyme Q10 after supper, and Subject 4 also received one oral formulation on an empty stomach before breakfast.
比較のために、同様の投与方法で下記の市販のコエンザイムＱ１０ソフトカプセル３種類を、１日当りのコエンザイムＱ１０の投与量が３００ｍｇとなるように各被験者に投与し、同様にして血漿中のコエンザイムＱ１０の濃度を測定した。
（Ａ社市販品）：コエンザイムＱ１０をサフラワー油（リノール酸及びオレイン酸のトリグリセリドを主成分とする）に溶解して調製したソフトカプセル。
（Ｂ社市販品）：コエンザイムＱ１０を大豆油（オレイン酸、リノール酸、リノレン酸のトリグリセリドを主成分とし、少量の炭素数１４〜１６の飽和脂肪酸トリグリセリドを含有する）に溶解して調製したソフトカプセル。
（Ｃ社市販品）：コエンザイムＱ１０をオリーブ油（オレイン酸トリグリセリドを主成分とする）に溶解して調製したソフトカプセル。
For comparison, three types of the following commercially available coenzyme Q10 soft capsules were administered to each subject by the same administration method so that the daily dose of coenzyme Q10 was 300 mg, and the coenzyme Q10 in plasma was similarly administered. Concentration was measured.
(Commercial product of Company A): Soft capsule prepared by dissolving coenzyme Q10 in safflower oil (mainly composed of linoleic acid and oleic acid triglycerides).
(Commercial product of B company): Soft capsule prepared by dissolving coenzyme Q10 in soybean oil (containing oleic acid, linoleic acid, linolenic acid triglyceride as the main component and a small amount of saturated fatty acid triglyceride having 14 to 16 carbon atoms) .
(Commercially available from Company C): Soft capsule prepared by dissolving coenzyme Q10 in olive oil (mainly oleic acid triglyceride).
上記試験で得られた、各被験者の血漿中のコエンザイムＱ１０の濃度（１０６コエンザイムＱ１０／全コレステロール）を図１に示す。なお、コエンザイムＱ１０は元々生体中に存在する物質であるため、図１には各被験者の血漿中に元々存在した値（コエンザイムＱ１０製剤の摂取前に採血した血漿中の濃度）を差引いた、コエンザイムＱ１０の増加量を表記した。 FIG. 1 shows the concentration of coenzyme Q10 (10 6 coenzyme Q10 / total cholesterol) in the plasma of each subject obtained in the above test. Since coenzyme Q10 is a substance originally present in the living body, FIG. 1 shows the coenzyme obtained by subtracting the value originally present in the plasma of each subject (the concentration in blood collected before ingesting the coenzyme Q10 preparation). The increase amount of Q10 was described.
図１によれば、被験者１及び２は、被験者３に比較して、従来のコエンザイムＱ１０製剤を投与した場合には経口吸収性が不良であるが、本発明の経口製剤を投与した場合には経口吸収性が著しく改善されることが判明した。
被験者３では、従来のコエンザイムＱ１０製剤を投与した場合でも経口吸収性が良好であるが、本発明の経口製剤を投与した場合にも従来の経口製剤と同等以上の経口吸収性があることが判る。
According to FIG. 1, subjects 1 and 2 have poor oral absorbency when administered with the conventional coenzyme Q10 formulation compared to subject 3, but when administered with the oral formulation of the present invention. It has been found that oral absorption is significantly improved.
In test subject 3, oral absorption is good even when the conventional coenzyme Q10 formulation is administered, but it can be seen that oral administration of the present invention is equivalent to or better than that of the conventional oral formulation. .
また、空腹時にコエンザイムＱ１０製剤を投与した被験者４の場合には、従来の経口製剤を投与した場合に比較して、本発明の経口製剤を投与した場合には経口吸収性が大幅に改善されることが判明した。
したがって、本発明のコエンザイムＱ１０経口製剤は、食後に限らず空腹時に摂取した場合にも良好な経口吸収性を有することから、投与時間の制約がなくなり極めて実用性に富むものである。
Further, in the case of the subject 4 who was administered the coenzyme Q10 preparation on an empty stomach, the oral absorbability is significantly improved when the oral preparation of the present invention is administered, compared with the case where the conventional oral preparation is administered. It has been found.
Therefore, the coenzyme Q10 oral preparation of the present invention has a good oral absorbability not only after meals but also when taken on an empty stomach, so that there is no restriction on administration time and it is extremely practical.
（実施例２）
コエンザイムＱ１０粉末３ｇ、カカオバター１００ｇ、ショ糖９７ｇを粉砕混合し、加熱溶解した後にアルミ箔からなる型枠に流し込み、冷却後冷蔵庫中で固化させて１個の重量が２０ｇのチョコレート様の経口製剤を調製した。この経口製剤１個には、３００ｍｇのコエンザイムＱ１０が含有されている。この経口製剤は、実施例１の経口製剤と同様に、良好な経口吸収性を有する。
(Example 2)
3 g of Coenzyme Q10 powder, 100 g of cocoa butter and 97 g of sucrose are pulverized and mixed, heated and dissolved, poured into a mold made of aluminum foil, solidified in a refrigerator after cooling, and a chocolate-like oral preparation having a weight of 20 g. Was prepared. One oral preparation contains 300 mg of coenzyme Q10. Similar to the oral preparation of Example 1, this oral preparation has good oral absorbability.
（実施例３）
カカオバターに代えて、パルミチン酸トリグリセリド５０ｇとステアリン酸トリグリセリド５０ｇを使用した以外は、実施例２と同様にして、同様の経口製剤を調製した。この経口製剤は、実施例１の経口製剤と同様に、良好な経口吸収性を有する。
(Example 3)
A similar oral preparation was prepared in the same manner as in Example 2 except that 50 g of palmitic acid triglyceride and 50 g of stearic acid triglyceride were used instead of cocoa butter. Similar to the oral preparation of Example 1, this oral preparation has good oral absorbability.
上記のとおり、本発明によれば、従来のコエンザイムＱ１０製剤では経口吸収性の悪い人に対しても、著しく経口吸収性が改善されたコエンザイムＱ１０製剤を得ることができる。本発明のコエンザイムＱ１０製剤は、従来のコエンザイムＱ１０製剤で経口吸収性の良い人に対しても、同等以上の経口吸収性を示すとともに、食後に限らず空腹時に摂取した場合にも経口吸収性が低下しない。
また、そのままで、或いはチョコレートやクッキー等の固形状の加工食品の形態とすることにより、老人や病人でもおやつを食べるような感覚で容易に摂取することができるので、実用的価値が高いものである。
As described above, according to the present invention, it is possible to obtain a coenzyme Q10 preparation having a significantly improved oral absorption even for those who have poor oral absorption in the conventional coenzyme Q10 preparation. The coenzyme Q10 preparation of the present invention exhibits an oral absorption equivalent to or better than that of the conventional coenzyme Q10 preparation, and also has an oral absorption when taken on an empty stomach as well as after meals. It does not decline.
In addition, by making it as it is or in the form of a solid processed food such as chocolate or cookies, it can be easily ingested as if eating a snack even by an elderly or sick person, so it has high practical value. is there.
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| JPS5618914A (en) * | 1979-07-25 | 1981-02-23 | Eisai Co Ltd | Ubidecarenone composition having good absorbability |
| JPS61221131A (en) * | 1985-03-28 | 1986-10-01 | Eisai Co Ltd | Ubidecarenone-containing composition having promoted absorption |
| JPS63188623A (en) * | 1987-01-31 | 1988-08-04 | Taisho Pharmaceut Co Ltd | Ubidecarenone preparation having improved absorption |
| US5122377A (en) * | 1990-11-19 | 1992-06-16 | A.H. Robins, Company, Incorporated | Oral delivery system for veterinary drugs |
| SE9301112D0 (en) * | 1993-04-02 | 1993-04-02 | Orion-Yhtymae Oy | A NEW COMPOSITION |
| JPH10236952A (en) * | 1996-12-27 | 1998-09-08 | Takeda Chem Ind Ltd | Stable pharmaceutical composition |
| DE10026699A1 (en) * | 2000-05-30 | 2001-12-06 | Basf Ag | Formulation based on heparin, glycosaminoglycan or heparinoid and use of the formulation and the formulation base |
| JP4336099B2 (en) * | 2002-11-29 | 2009-09-30 | 東海カプセル株式会社 | Ubidecarenone-containing composition |
| JP4567945B2 (en) * | 2003-01-17 | 2010-10-27 | 太陽化学株式会社 | Ubidecarenone formulation |
-
2004
- 2004-12-21 JP JP2004368737A patent/JP5258144B2/en active Active
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