JP5171635B2 - 糖尿病性網膜症予防のためのフェノフィブラート又はその誘導体の使用 - Google Patents
糖尿病性網膜症予防のためのフェノフィブラート又はその誘導体の使用 Download PDFInfo
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- JP5171635B2 JP5171635B2 JP2008539447A JP2008539447A JP5171635B2 JP 5171635 B2 JP5171635 B2 JP 5171635B2 JP 2008539447 A JP2008539447 A JP 2008539447A JP 2008539447 A JP2008539447 A JP 2008539447A JP 5171635 B2 JP5171635 B2 JP 5171635B2
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- fenofibrate
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- retinopathy
- diabetic
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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Description
2型真性糖尿病は、益々増加している一般的な疾患であり、心血管系の高リスクを伴う。今日まで、脂質低下治療に関する試験のほとんどが、この疾患に焦点を当てておらず、特に、糖尿病のフィブラート治療に関する非常に大規模な試験は行われていなかった。実施されたフィブラート治療に関する試験は、以下の2例のみである。すなわち、the Veterans Low−HDL Cholesterol Intervention Trial(VA−HIT)Rubins HB,Robins SJ,Collins D,Fye CL,Anderson JW,Elam MB,Faas FH,Linares E,Schaefer EJ,Schectman G,Wilt TJ,Wittes J:Gemfibrozil for secondary prevention of coronary heart disease in men with low levels of high−density lipoprotein cholesterol. Veterans Affairs High−density liporotein cholesterol Intervention Trial study group.N.Engl J Med 1999,341:410−418)、及び、the Bezafibrate Infarct Prevention(BIP)trial(The BIP Study Group:Secondary Prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease. The Bezafibrate Infarct Prevention(BIP)Study. Circulation 2000,102:21−27)である。どちらの調査も、心筋梗塞(MI)の既往のある人に限定して行われ、ベースライン時には低HDL、且つ、高トリグリセリド(TG)であった被験者において、異常脂質血症でない被験者に同じフィブラートを使用した場合に比較すると高いものの、主要な心血管系イベントが減少することが報告されている。また、VA−HIT試験では、非致死的MIの割合に有意な変化は見られなかったものの、ゲムフィブロジルを摂取した糖尿病被験者において冠動脈性心疾患(CHD)による死亡率が低下したこと、及び、心血管系イベントの割合が低下したことが報告されている。第3の試験、the Diabetes Atherosclerosis Intervention Study(DAIS)では、対応するプラセボ群との3年にわたる比較により、無作為抽出したフェノフィブラート群において、発症した冠動脈硬化症の進行が抑えられることが示されている(Diabetes Atherosclerosis Intervention Study investigators:Effect of fenofibrate on progression of coronary artery disease in type 2 diabetes:the Diabetes Atherosclerosis intervention Study,a randomised study. Lancet 2001,357:905−910)。
Claims (6)
- 網膜症の治療用薬剤を製造するためのフェノフィブラート、フェノフィブリン酸、又は、フェノフィブリン酸の生理学的に許容される塩の使用。
- 糖尿病性網膜症の治療用薬剤を製造するための
請求項1に記載の使用。 - フェノフィブリン酸の前記生理学的に許容される塩は、コリン、エタノールアミン、ジエタノールアミン、ピペラジン、カルシウム、及び、トロメタミンからなる群から選択される、
請求項1又は2に記載の使用。 - 前記薬剤は、さらにスタチンを含む、
請求項1から3のいずれか1項に記載の使用。 - 前記薬剤は、200mg、160mg、145mg、又は130mgのフェノフィブラート又はその誘導体を含む、
請求項1から4のいずれか1項に記載の使用。 - 前記薬剤は、フェノフィブラート又はその誘導体の経口製剤である、
請求項1から5のいずれか1項に記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05292388A EP1785133A1 (en) | 2005-11-10 | 2005-11-10 | Use of fenofibrate or a derivative thereof for preventing diabetic retinopathy |
EP05292388.5 | 2005-11-10 | ||
PCT/EP2006/068352 WO2007054566A2 (en) | 2005-11-10 | 2006-11-10 | Use of fenofibrate or a derivative thereof for preventing diabetic retinopathy |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2009515856A JP2009515856A (ja) | 2009-04-16 |
JP5171635B2 true JP5171635B2 (ja) | 2013-03-27 |
Family
ID=36130110
Family Applications (1)
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JP2008539447A Active JP5171635B2 (ja) | 2005-11-10 | 2006-11-10 | 糖尿病性網膜症予防のためのフェノフィブラート又はその誘導体の使用 |
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US (1) | US20090170939A1 (ja) |
EP (3) | EP1785133A1 (ja) |
JP (1) | JP5171635B2 (ja) |
KR (1) | KR20080074877A (ja) |
CN (2) | CN101304742A (ja) |
AU (1) | AU2006313711B2 (ja) |
BR (1) | BRPI0618283A2 (ja) |
CA (1) | CA2628508C (ja) |
EA (1) | EA014755B1 (ja) |
ES (2) | ES2805227T3 (ja) |
HU (2) | HUE030936T2 (ja) |
IL (1) | IL191208A (ja) |
LT (1) | LT3167882T (ja) |
PL (2) | PL3167882T3 (ja) |
PT (2) | PT1954261T (ja) |
SI (1) | SI3167882T1 (ja) |
UA (1) | UA99093C2 (ja) |
WO (1) | WO2007054566A2 (ja) |
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CN102304103A (zh) * | 2011-06-03 | 2012-01-04 | 郑州泰基鸿诺药物科技有限公司 | 一种非诺贝特酸盐、制备方法、药物组合物及应用 |
CA2928702A1 (en) * | 2013-10-25 | 2015-04-30 | Children's Medical Center Corporation | Methods of treating or preventing vascular diseases of the retina |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
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FR2494112B1 (ja) | 1980-11-19 | 1986-01-10 | Laruelle Claude | |
FR2602423B1 (fr) | 1986-08-08 | 1989-05-05 | Ethypharm Sa | Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede |
FR2627696B1 (fr) | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
CA2052014A1 (en) * | 1990-10-19 | 1992-04-20 | Henry Y. Pan | Method for preventing diabetic complications employing a cholesterol lowering drug alone or in combination with an ace inhibitor |
SI9500173B (sl) | 1995-05-19 | 2002-02-28 | Lek, | Trofazna farmacevtska oblika s konstantnim in kontroliranim sproščanjem amorfne učinkovine za enkrat dnevno aplikacijo |
DE19608750A1 (de) | 1996-03-06 | 1997-09-11 | Durachemie Gmbh & Co Kg | Verfahren zur Herstellung von Fenofibrat-Präparaten |
FR2758459B1 (fr) | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
US6465011B2 (en) | 1999-05-29 | 2002-10-15 | Abbott Laboratories | Formulations comprising lipid-regulating agents |
PL361097A1 (en) * | 2000-10-12 | 2004-09-20 | Nissan Chemical Industries, Ltd. | Preventives and remedies for complications of diabetes |
IL155524A0 (en) * | 2000-10-26 | 2003-11-23 | Fournier Lab Ireland Ltd | Combination of fenofibrate and coenzyme q10 for the treatment of endothelial dysfunction |
ATE357216T1 (de) | 2001-02-22 | 2007-04-15 | Jagotec Ag | Fibrat-statin kombinationen mit verminderten von der nahrungsaufnahme abhängigen auswirkungen |
JP4590159B2 (ja) * | 2001-04-04 | 2010-12-01 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | グルコース再吸収阻害剤およびpparモジュレーターを含んで成る併用療法 |
CN100348189C (zh) * | 2002-12-10 | 2007-11-14 | 诺瓦提斯公司 | DPP-IV抑制剂与PPAR-α化合物的组合 |
US7259186B2 (en) | 2002-12-17 | 2007-08-21 | Abbott Laboratories | Salts of fenofibric acid and pharmaceutical formulations thereof |
EP1587535A4 (en) * | 2003-01-17 | 2010-02-24 | Merck & Co Inc | N-CYCLOHEXYLAMINOCARBONYL BENZENESULFONAMIDE DERIVATIVES |
EP1714648A4 (en) * | 2004-02-09 | 2010-05-26 | Aska Pharm Co Ltd | COMBINATION DRUGS |
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- 2006-11-10 BR BRPI0618283-6A patent/BRPI0618283A2/pt not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
HUE050045T2 (hu) | 2020-11-30 |
SI3167882T1 (sl) | 2020-09-30 |
PT3167882T (pt) | 2020-07-13 |
CN103417524A (zh) | 2013-12-04 |
ES2605025T3 (es) | 2017-03-10 |
HUE030936T2 (en) | 2017-06-28 |
WO2007054566A3 (en) | 2007-08-23 |
ES2805227T3 (es) | 2021-02-11 |
EA200801023A1 (ru) | 2008-10-30 |
IL191208A0 (en) | 2009-08-03 |
JP2009515856A (ja) | 2009-04-16 |
CA2628508C (en) | 2013-11-12 |
CN101304742A (zh) | 2008-11-12 |
EP3167882A1 (en) | 2017-05-17 |
KR20080074877A (ko) | 2008-08-13 |
CA2628508A1 (en) | 2007-05-18 |
PT1954261T (pt) | 2016-11-29 |
EP1785133A1 (en) | 2007-05-16 |
EP1954261B1 (en) | 2016-08-24 |
US20090170939A1 (en) | 2009-07-02 |
IL191208A (en) | 2017-08-31 |
AU2006313711A9 (en) | 2021-04-01 |
PL3167882T3 (pl) | 2020-11-16 |
EP3167882B1 (en) | 2020-04-08 |
BRPI0618283A2 (pt) | 2012-02-28 |
AU2006313711A1 (en) | 2007-05-18 |
EA014755B1 (ru) | 2011-02-28 |
LT3167882T (lt) | 2020-07-27 |
EP1954261A2 (en) | 2008-08-13 |
WO2007054566A2 (en) | 2007-05-18 |
AU2006313711B2 (en) | 2012-02-23 |
UA99093C2 (ru) | 2012-07-25 |
PL1954261T3 (pl) | 2017-07-31 |
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