JP5102024B2 - 心臓の不整脈を治療するための拡張可能な医療デバイス - Google Patents
心臓の不整脈を治療するための拡張可能な医療デバイス Download PDFInfo
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Description
本発明は、組織支持医療デバイスに関し、より詳細には、器官を支持して開放性(patency)を維持するために、生きている動物又はヒトの体腔内に埋め込まれると共に、有益な作用物質を介入部位に送出することのできる、拡張可能で、取り外しできないデバイスに関する。
これまで、身体通路の開放性を維持するために、身体通路内に埋め込まれる、永久的又は生分解性のデバイスが開発されてきた。これらのデバイスは、通常、経皮的に導入され、所望の位置に位置決めされるまで経腔的に輸送される。次いで、これらのデバイスは、デバイス内側に位置決めされたマンドレル又はバルーンの拡張のように機械的に拡張し、あるいは体内での作動時に蓄積されたエネルギーを放出することによって自ら拡張する。ステントと呼ばれるこれらのデバイスは、管腔内で一度拡張すると、体組織内に封入され、永久に埋め込まれたまま残る。
従来技術の欠点に鑑みて、切除剤(ablative agent)を含む有益な作用物質を血管内の部位に送出できるステントを提供することが有利であろう。
図1及び図2を参照すると、本発明の好ましい一実施形態による組織支持デバイスは、参照符号10によって示されている。組織支持デバイス10は、S状の架橋要素14によって接続された複数の円筒管12を含んでいる。架橋要素14によって、組織支持デバイスは、血管系の蛇行した経路を通過して配置部位に至るときに、軸方向に曲がることを可能にし、組織支持デバイスは、支持される血管壁の湾曲に一致するのに必要があるときに、曲がることを可能にする。円筒管12のそれぞれは、円筒管の端部表面から、対向する端部表面に向けて延びる複数の軸方向のスロット16を有している。
Claims (9)
- 第1生体再吸収性材料からなる生体再吸収性の埋め込み可能デバイスと、
該埋め込み可能デバイス内の複数の開口部と、
前記第1生体再吸収性材料とは異なる第2生体再吸収性材料及び化学的切除剤を含み、該開口部内に設けられた生分解性マトリクスと
を備え、
前記開口部は、該開口部内に作用物質を永久的に捕捉することなく、円筒形状の拡張可能な前記埋め込み可能デバイスの周囲の組織に対して前記化学的切除剤を送出するように構成されている、心臓の不整脈を治療する医療デバイス。 - 前記埋め込み可能デバイスの最も内側の表面に実質的に隣接して、前記開口部内に設けられた生分解性バリア層をさらに備える、請求項1に記載の心臓の不整脈を治療する医療デバイス。
- 前記バリア層は、前記化学的切除剤が前記開口部から血管内腔内に流れることを防止する、請求項2に記載の心臓の不整脈を治療する医療デバイス。
- 前記開口部は貫通開口部である、請求項1〜3のいずれか一項に記載の心臓の不整脈を治療する医療デバイス。
- 前記埋め込み可能デバイスの生体侵食可能材料は、前記生分解性マトリクスの侵食速度より遅い速度で侵食する、請求項1〜4のいずれか一項に記載の心臓の不整脈を治療する医療デバイス。
- 前記化学的切除剤は細胞毒性剤である、請求項1〜5のいずれか一項に記載の心臓の不整脈を治療する医療デバイス。
- 前記化学的切除剤は、複数の層内の前記開口部内に設けられ、
前記複数の層は、前記化学的切除剤を、プログラムされた放出速度で、且つ、所望の投与期間にわたって放出するように構成されている、請求項1〜6のいずれか一項に記載の心臓の不整脈を治療する医療デバイス。 - 前記医療デバイスを埋め込み位置へ送出する間、前記化学的切除剤の放出を防止するために、前記埋め込み可能デバイスの最も外側の表面に実質的に隣接して、前記開口部内に設けられた生分解性キャップ層をさらに備える、請求項1〜7のいずれか一項に記載の心臓の不整脈を治療する医療デバイス。
- 前記埋め込み可能デバイスはステントである、請求項1〜8のいずれか一項に記載の心臓の不整脈を治療する医療デバイス。
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US10/883,129 US20040249443A1 (en) | 2001-08-20 | 2004-07-01 | Expandable medical device for treating cardiac arrhythmias |
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-
2004
- 2004-07-01 US US10/883,129 patent/US20040249443A1/en not_active Abandoned
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2005
- 2005-06-22 AT AT05762778T patent/ATE491410T1/de not_active IP Right Cessation
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- 2005-06-22 DE DE602005025354T patent/DE602005025354D1/de active Active
- 2005-06-22 AU AU2005262445A patent/AU2005262445A1/en not_active Abandoned
- 2005-06-22 JP JP2007520333A patent/JP5102024B2/ja active Active
- 2005-06-22 WO PCT/US2005/022243 patent/WO2006007473A1/en active Application Filing
- 2005-06-22 CA CA2571791A patent/CA2571791C/en active Active
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EP1768610A1 (en) | 2007-04-04 |
CA2571791C (en) | 2013-10-15 |
JP2008504926A (ja) | 2008-02-21 |
ATE491410T1 (de) | 2011-01-15 |
EP1768610B1 (en) | 2010-12-15 |
WO2006007473A1 (en) | 2006-01-19 |
EP1768610A4 (en) | 2008-12-17 |
US20040249443A1 (en) | 2004-12-09 |
DE602005025354D1 (de) | 2011-01-27 |
CA2571791A1 (en) | 2006-01-19 |
AU2005262445A1 (en) | 2006-01-19 |
EP1768610B8 (en) | 2011-02-16 |
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